公开(公告)号：US20240216581A1

公开(公告)日：2024-07-04

申请号：US17911188

申请日：2021-09-17

申请人： SHANDONG UNIVERSITY ,  YANSHAN UNIVERSITY

发明人： Chuanzhen HUANG ,  Xu HAN ,  Hanlian LIU ,  Peng YAO ,  Hongtao ZHU ,  Bin ZOU ,  Jun WANG

IPC分类号： A61L27/52 ,  A61L27/20 ,  A61L27/22 ,  B33Y10/00 ,  B33Y80/00 ,  C08J3/075

CPC分类号： A61L27/52 ,  A61L27/20 ,  A61L27/222 ,  B33Y10/00 ,  B33Y80/00 ,  C08J3/075 ,  C08J2305/04 ,  C08J2401/28 ,  C08J2405/00 ,  C08J2405/08

摘要： A photocurable composite hydrogel matrix precursor, a preparation method thereof and a scaffold with same. The photocurable composite hydrogel matrix precursor includes gelatin methacrylate, sodium alginate, sodium carboxymethyl cellulose and chondroitin sulfate, where the mass ratio of a photoinitiator to the gelatin methacrylate to the sodium alginate to the sodium carboxymethyl cellulose to the chondroitin sulfate is (0.2-0.3):(8-10):(1-3):(0.6-0.8):(0.05-0.07). By adoption of the precursor, a cell-loaded printing hydrogel scaffold can be obtained through an extrusion-based 3D bio-printing technology, and the scaffold is controllable in form, good in moldability, high in precision, and has good stability; the biocompatibility and bioactivity are high, so that a good growing environment can be provided for fibroblasts; and the preparation process is simple and can be completed within a short time, moreover, the porosity and mechanical performance of the 3D printing hydrogel scaffold can be adjusted by adjusting the raw material ratio.

公开(公告)号：US20240302352A1

公开(公告)日：2024-09-12

申请号：US18182091

申请日：2023-03-10

申请人： SHANDONG UNIVERSITY ,  YANSHAN UNIVERSITY

发明人： Chuanzhen HUANG ,  Zhuang CHEN ,  Hanlian LIU ,  Peng YAO ,  Dun LIU ,  Hongtao ZHU ,  Bin ZOU ,  Zhen WANG ,  Jun WANG ,  Longhua XU ,  Shuiquan HUANG ,  Meina QU ,  Zhengkai XU ,  Minting WANG ,  Yabin GUAN

IPC分类号： G01N33/50 ,  B33Y70/00 ,  B33Y80/00 ,  C12N5/079 ,  C12N5/0793 ,  C12N5/0797

CPC分类号： G01N33/5082 ,  B33Y70/00 ,  B33Y80/00 ,  C12N5/0618 ,  C12N5/0619 ,  C12N5/0623 ,  C12N2501/13 ,  C12N2513/00 ,  C12N2533/54 ,  C12N2533/74

摘要： A method of rapid constructing human cerebral cortical organoids by 3D bioprinting and an application including preparing microfluidic chips, preparation of hydrogel of human cerebral cortical organoids, and printing of human cerebral cortical organoids. The microfluidic chip comprises a mixed-flow channel layer, liquid pool layer, microporous array layer, human cerebral cortical organoid culture layer, and culture medium recovery layer; the human cerebral cortical organoid hydrogel has gelatin, alginate, and hyaluronic acid; printing directly human cerebral cortical organoids in microfluidic chips by FRESH printing method, obtaining human cerebral cortical organoid chips after packaging. The application directly constructs large-scale human cerebral cortex-like with three layers of mutually connected structures in situ in organ chip through 3D bioprinting, simulates cerebrospinal fluid circulation through perfusion culture.

公开(公告)号：US20240108784A1

公开(公告)日：2024-04-04

申请号：US18081964

申请日：2022-12-15

申请人： SHANDONG UNIVERSITY ,  YANSHAN UNIVERSITY

发明人： Chuanzhen HUANG ,  Zhuang CHEN ,  Hanlian LIU ,  Peng YAO ,  Zhenyu SHI ,  Dun LIU ,  Hongtao ZHU ,  Bin ZOU ,  Zhen WANG ,  Minting WANG ,  Longhua XU ,  Shuiquan HUANG ,  Meina QU ,  Zhengkai XU ,  Yabin GUAN

IPC分类号： A61L26/00 ,  B29C64/118 ,  B33Y10/00 ,  B33Y70/00 ,  B33Y80/00

CPC分类号： A61L26/008 ,  A61L26/0052 ,  B29C64/118 ,  B33Y10/00 ,  B33Y70/00 ,  B33Y80/00 ,  B29K2005/00 ,  B29L2031/753

摘要： A hydrogel for cell-laden bioprinting, bioink, and a preparation method and an application thereof, relates to the technical field of biomedical polymer hydrogels. The hydrogel for cell-laden bioprinting is polymer gel formed by adding a cell-specific material into a matrix of alginate and gelatin and crosslinking and curing, wherein the cell-specific material is polypeptide selected according to different laden cells. The structures printed using the hydrogel may have the advantages such as adjustable mechanical properties, adjustable porosity, high biocompatibility, high printing accuracy, and high customizability, which may widely support the printing of human tissues and organs such as spinal cord, cartilage, and heart, and has good prospects for applications in tissue repair, organ transplantation and so on.

公开(公告)号：US20230405874A1

公开(公告)日：2023-12-21

申请号：US17941726

申请日：2022-09-09

申请人： SHANDONG UNIVERSITY ,  YANSHAN UNIVERSITY

发明人： Chuanzhen HUANG ,  Xuefei LIU ,  Hanlian LIU ,  Peng YAO ,  Hongtao ZHU ,  Bin ZOU ,  Dun LIU ,  Jun WANG ,  Zhen WANG ,  Longhua XU ,  Shuiquan HUANG

IPC分类号： B28D5/04 ,  G02B1/118 ,  G02B1/113 ,  B23K26/0622

CPC分类号： B28D5/04 ,  G02B1/118 ,  G02B1/113 ,  B23K26/0624 ,  B23K2103/56

摘要： A monocrystalline silicon micro-nano dual-scale anti-reflection texture and a preparation method therefor. The preparation method combines nanosecond-laser-assisted waterjet near-damage-free processing and femtosecond laser scanning, and subsurface damage caused by a re-cast layer phenomenon and a hot crack in a monocrystalline silicon laser texturing process can be effectively reduced by combining a nanosecond-laser-assisted waterjet near-damage-free processing technology and an ultra-short pulse femtosecond laser cold processing technology; and meanwhile, a micro-scale frame structure and a nano-scale structure can be flexibly modified respectively by adjusting nanosecond-laser-assisted waterjet technological parameters and femtosecond laser technological parameters, a geometry light trapping effect and an effective dielectric effect can be achieved in a micro-nano dual-scale hybrid structure at the same time, and surface reflection is reduced.

公开(公告)号：US20230219856A1

公开(公告)日：2023-07-13

申请号：US17706045

申请日：2022-03-28

申请人： SHANDONG UNIVERSITY ,  YANSHAN UNIVERSITY

发明人： Chuanzhen HUANG ,  Yan ZHANG ,  Hanlian LIU ,  Zhenyu SHI ,  Peng YAO ,  Zhen WANG ,  Longhua XU ,  Shuiquan HUANG ,  Jun WANG ,  Hongtao ZHU ,  Bin ZOU

IPC分类号： C04B35/58 ,  C04B35/626 ,  C04B35/645 ,  B23B27/14

CPC分类号： C04B35/58 ,  C04B35/6261 ,  C04B35/6264 ,  C04B35/645 ,  B23B27/148 ,  C04B2235/3856 ,  C04B2235/3886 ,  C04B2235/404 ,  C04B2235/405 ,  C04B2235/6581 ,  C04B2235/6562 ,  C04B2235/6567 ,  B23B2226/18

摘要： The present invention relates to the field of new materials technology, in particular to carbon nitride composite ceramic tool materials, preparation method and cutting tools thereof. The raw materials comprise carbon nitride, titanium carbonitride, molybdenum, nickel and cobalt, carbon nitride as the matrix phase, titanium carbonitride as the reinforcing phase are added to the carbon nitride based composite ceramic materials, with molybdenum, nickel and cobalt as a suitable sintering aid, dense composite tool material is obtained with vacuum hot press sintering method. The prepared carbon nitride based composite ceramic tool materials boast the advantages of low cost, high hardness, high bending strength and high fracture toughness, which is an important way to promote the innovation, development and popularization of carbon nitride materials.

公开(公告)号：US20240067567A1

公开(公告)日：2024-02-29

申请号：US17955237

申请日：2022-09-28

申请人： SHANDONG UNIVERSITY ,  YANSHAN UNIVERSITY

发明人： Chuanzhen HUANG ,  Zexin LI ,  Hanlian LIU ,  Zhenyu SHI ,  Peng YAO ,  Dun LIU ,  Hongtao ZHU ,  Bin ZOU ,  Jun WANG ,  Zhen WANG ,  Longhua XU ,  Shuiquan HUANG ,  Meina QU ,  Zhengkai XU

IPC分类号： C04B35/117 ,  B23B27/14 ,  C04B35/626 ,  C04B35/645

CPC分类号： C04B35/117 ,  B23B27/148 ,  C04B35/6261 ,  C04B35/6264 ,  C04B35/62655 ,  C04B35/645 ,  C04B2235/3206 ,  C04B2235/3217 ,  C04B2235/3224 ,  C04B2235/3258 ,  C04B2235/3856 ,  C04B2235/3886 ,  C04B2235/606 ,  C04B2235/656 ,  C04B2235/6581 ,  C04B2235/9607

摘要： An alumina-based ceramic tool material with low thermal expansion and a preparation process thereof, accordingly, the ceramic tool material may have both the high hardness of alumina ceramics after the hot pressing sintering, and reduces the thermal expansion coefficient of the overall ceramic material by adding the Sc2W3O12 as the negative thermal expansion phase, which improves the thermal shock resistance of ceramic tools in high-speed cutting engineering and meets the requirements of large temperature range during the machining of nickel-based superalloys. Moreover, the composite material does not use metal binder and has strong thermal stability even in the high-speed machining under extreme heat-force-chemistry coupling, so it has a high machining compatibility for nickel-based superalloys.

公开(公告)号：US20230405187A1

公开(公告)日：2023-12-21

申请号：US17939524

申请日：2022-09-07

申请人： YANSHAN UNIVERSITY ,  SHANDONG UNIVERSITY

发明人： Chuanzhen HUANG ,  Xu HAN ,  Hanlian LIU ,  Zhenyu SHI ,  Peng YAO ,  Hongtao ZHU ,  Bin ZOU ,  Dun LIU ,  Zhen WANG ,  Longhua XU ,  Shuiquan HUANG

IPC分类号： A61L27/52 ,  C08J3/075 ,  C12N5/00 ,  A61L27/26 ,  B33Y70/00 ,  B33Y80/00 ,  B33Y40/00 ,  B33Y10/00

CPC分类号： A61L27/52 ,  C08J3/075 ,  C12N5/0062 ,  A61L27/26 ,  B33Y70/00 ,  B33Y80/00 ,  B33Y40/00 ,  B33Y10/00 ,  C08J2489/04 ,  C08J2301/28 ,  C12N2513/00 ,  C12N2533/54 ,  C12N2533/78

摘要： A composite hydrogel for light-cured 3D cell-laden printing and a preparation method and application thereof. The composite hydrogel of the present disclosure combines advantages of gelatin methacryloyl, sodium carboxymethylcellulose, hyaluronic acid-glutamic acid polymer, and the like. The provided composite hydrogel for 3D printing has the characteristics of low toxicity, good biocompatibility and adjustable mechanical properties, can provide cells with a three-dimensional living environment, promotes cell adhesion and migration on gradient scaffolds, and is suitable for tissue engineering scaffolds and cell-laden printing of tissues. The printing process of a scaffold is simple and can be completed within a short time, and the porosity and mechanical properties of the 3D printed hydrogel scaffold can be adjusted by adjusting the proportion of HA-Glu and Col in the hydrogel system.

公开(公告)号：US20230303453A1

公开(公告)日：2023-09-28

申请号：US17943596

申请日：2022-09-13

申请人： SHANDONG UNIVERSITY ,  YANSHAN UNIVERSITY

发明人： Chuanzhen HUANG ,  Xinyao CUI ,  Hanlian LIU ,  Zhenyu SHI ,  Peng YAO ,  Xiaolan BAI ,  Zhen WANG ,  Longhua XU ,  Dun LIU ,  Shuiquan HUANG ,  Hongtao ZHU ,  Bin ZOU

IPC分类号： C04B35/58 ,  C04B35/626 ,  C04B35/645

CPC分类号： C04B35/58021 ,  C04B35/6261 ,  C04B35/645 ,  C04B35/6264 ,  C04B2235/3886 ,  C04B2235/3843 ,  C04B2235/3891 ,  C04B2235/405 ,  C04B2235/404 ,  C04B2235/75 ,  C04B2235/786 ,  C04B2235/785 ,  C04B2235/604 ,  C04B2235/6562 ,  C04B2235/6567 ,  B26D2001/002

摘要： A crack self-healing functionally gradient material for ceramic cutting tools and a preparation method thereof. The material for ceramic cutting tools has a symmetrical gradient structure, and based on the percentage by mass, components of each layer include 50%-80% of Ti(C7,N3), 25%-5% of (W7,Ti3)C and 20%-0% of TiSi2; contents of components of layers that are symmetrical relative to a central layer are the same and a thickness is symmetrically distributed; a content of Ti(C7,N3) gradually increases from the surface layer to the central layer, contents of (W7,Ti3)C and Ti Si2 gradually decrease by 5% from the surface layer to the central layer, and the contents of Ni and Mo gradually increase from the surface layer to the central layer.

公开(公告)号：US20230279345A1

公开(公告)日：2023-09-07

申请号：US17851731

申请日：2022-06-28

申请人： SHANDONG UNIVERSITY ,  YANSHAN UNIVERSITY

发明人： Chuanzhen HUANG ,  Zhichao WANG ,  Hanlian LIU ,  Zhenyu SHI ,  Peng YAO ,  Dun LIU ,  Zhen WANG ,  Longhua XU ,  Shuiquan HUANG ,  Minting WANG ,  Hongtao ZHU ,  Bin ZOU

IPC分类号： C12N5/00 ,  B33Y10/00 ,  B33Y80/00 ,  B29C64/106

CPC分类号： C12N5/0068 ,  B33Y10/00 ,  B33Y80/00 ,  B29C64/106 ,  C12N2533/30 ,  B29L2031/7534

摘要： A vascular structure-containing large-scale biological tissue and a construction method thereof. In the existing three-dimensional cell culture, it is contradictory for the elastic modulus of the scaffold material in ensuring structural stability and biocompatibility, and the vascular structure is required to provide channels for nutrient exchange when a large-scale structure is prepared. A cell-laden matrix material is poured into a hollow scaffold serving as a supporting scaffold. The overall stability of the scaffold structure can be ensured by regulating the mechanical properties of the supporting scaffold, thereby resolving the contradiction in ensuring structural stability and biocompatibility for the mechanical properties of the scaffold material in the conventional three-dimensional cell culture. A coaxially printing outer material contains a thermosensitive material. The removal of the outer thermosensitive material can increase the porosity of the vascular walls, and further increase the diffusion in the hollow vascular ducts.

公开(公告)号：US20220105682A1

公开(公告)日：2022-04-07

申请号：US16479828

申请日：2018-10-17

申请人： SHANDONG UNIVERSITY

发明人： Chuanzhen HUANG ,  Zhen WANG ,  Jun WANG ,  Bin ZOU ,  Hanlian LIU ,  Hongtao ZHU ,  Peng YAO

IPC分类号： B29C64/35 ,  B08B3/12 ,  B08B3/08 ,  B33Y40/20

摘要： A self-rotation cleaning device has outer and inner housings, a workpiece rotating system, an ultrasonic cleaning system and a fluid perfusion system. The inner housing is in the outer housing in a horizontal direction. A cylindrical cavity is inside the inner housing. One end of the inner housing has a sealing cover detachably connected thereto, and the other end is closed. The workpiece rotating system is in the cavity for fixing a member to be cleaned, and realizes self-rotation of the member. The ultrasonic cleaning system supplies mechanical energy to the cleaning liquid in the inner housing to generate bubbles therein. The bubbles remove residual resin attached to the cleaned member surface by continuous vibration and burst. The fluid perfusion system provides self-rotation power for the cleaned member, and continuously delivers the cleaning liquid to the inside of the cleaned member, and the cleaning liquid is carried out after cleaning.