公开(公告)号：US20200215069A1

公开(公告)日：2020-07-09

申请号：US16820773

申请日：2020-03-17

Applicant: SHOWA DENKO K.K.

Inventor： Daisuke YAGYU ,  Yuko NAKAGAMI ,  Ryota NIIBAYASHI ,  Eiko KATO

IPC: A61K31/513 ,  A61Q19/02 ,  A61Q19/08 ,  A61P17/16 ,  A61K8/49

Abstract: The present invention provides an agent containing an orotic acid derivative that has high solubility in solvent and has superior physiological activity. The agent of the present invention is a melanin production inhibitor, whitening agent, fibroblast activator, collagen and/or elastin production promoter or wrinkle ameliorant containing as an active ingredient thereof an orotic acid derivative represented by the following general formula (1) or a salt thereof. In formula (1), R preferably represents a side chain of glutamic acid, glycine, histidine or aspartic acid. [In formula (1), R represents a side chain of a naturally-occurring amino acid and R may form, together with a nitrogen atom adjacent thereto through a single carbon atom, a hetero ring.]

公开(公告)号：US20190382676A1

公开(公告)日：2019-12-19

申请号：US16480483

申请日：2018-01-05

Applicant: SHOWA DENKO K.K.

Inventor： Yuta YAMAGUCHI ,  Daisuke YAGYU ,  Naoya FUKUMOTO ,  Shoko UETAKE ,  Tsuyoshi KATO ,  Hiroyuki TOMITA ,  Ryuuta MIYASAKA ,  Katsumi MUROFUSHI

IPC: C10M107/46 ,  C08G65/334 ,  C08G65/333 ,  C10M107/44 ,  C07D333/16 ,  C07D231/12 ,  C07D277/24 ,  C07D409/12 ,  C07D213/68 ,  G11B5/725

Abstract: A fluorine-containing ether compound represented by Formula (1) is provided. R1—R2—CH2—R3—CH2—R4—R5   (1) (In Formula (1), R1 and R5 each represents a group having a heterocyclic ring and may be the same as or different from each other, R2 and R4 each represents a divalent linking group having a polar group and play be the same as or different from each other, and R3 represents a perfluoropolyether chain.)

公开(公告)号：US20240002743A1

公开(公告)日：2024-01-04

申请号：US18009371

申请日：2021-06-07

Applicant: SHOWA DENKO K.K.

Inventor： Tsuyoshi KATO ,  Ayano ASANO ,  Natsumi SHIBATA ,  Daisuke YAGYU ,  Takuma KURODA ,  Naoya FUKUMOTO

IPC: C10M131/10 ,  C07C43/12 ,  G11B5/725

CPC classification number: C10M131/10 ,  C07C43/126 ,  C10N2040/18 ,  C10M2211/0425 ,  G11B5/7257

Abstract: What is provided is a fluorine-containing ether compound represented by the following formula. R1—R2—O—CH2—R3—CH2—O—R4—R5
(R3 is a perfluoropolyether chain; R2 is represented by Formula (2), R4 is represented by Formula (3), R1 and R5 are hydrogen atoms or Formula (4); a and b in Formula (2) are an integer of 0 to 2, c in Formula (2) is an integer of 2 to 5, d and e in Formula (3) are an integer of 0 to 2, f in Formula (3) is an integer of 2 to 5; at least one of b in Formula (2) and e in Formula (3) is 1 or more; and k in Formula (4) is an integer of 3 to 6.)

公开(公告)号：US20180047419A1

公开(公告)日：2018-02-15

申请号：US15664013

申请日：2017-07-31

Applicant: SHOWA DENKO K.K.

Inventor： Naoya FUKUMOTO ,  Daisuke YAGYU ,  Yuta YAMAGUCHI ,  Shoko UETAKE ,  Tsuyoshi KATO ,  Hiroyuki TOMITA ,  Ryuta MIYASAKA ,  Katsumi MUROFUSHI

IPC: G11B5/725 ,  C10M105/54 ,  C08G65/26 ,  C07C43/13

Abstract: A fluorine-containing ether compound of the present invention is represented by Formula (1). R1—CH2—R2—CH2—R3  (1) (In Formula (1), R1 is an organic end group having 3 or more carbon atoms which includes two or more polar groups with each polar group being bonded to different carbon atoms and the carbon atoms to which the polar groups are bonded being bonded to each other via a linking group including the carbon atoms which are not bonded to the polar groups, R2 includes a perfluoropolyether chain represented by Formula (3), and R3 is a hydroxyl group or R1) —(CF2)y-1—O—((CF2)yO)z—(CF2)y-1—  (3) (In Formula (3), y represents an integer of 2 to 4, and z represents an integer of 1 to 30).

公开(公告)号：US20170369425A1

公开(公告)日：2017-12-28

申请号：US15543261

申请日：2016-01-15

Applicant: SHOWA DENKO K.K.

Inventor： Toru TACHIBANA ,  Ryota NIIBAYASHI ,  Daisuke YAGYU

IPC: C07C235/12 ,  A61K8/67 ,  A23L33/15 ,  A61Q19/00

CPC classification number: C07C235/12 ,  A23L33/15 ,  A23V2002/00 ,  A61K8/44 ,  A61K8/673 ,  A61K31/197 ,  A61K2800/10 ,  A61Q19/00

Abstract: Provided is a compound represented by Formula (1) or a salt thereof (in the formula, R1 and R2 each independently represent a hydrogen atom or a linear or branched acyl group having 11 to 30 carbon atoms, a hydrocarbon group bonded to a carbonyl carbon of the acyl group is a saturated or unsaturated hydrocarbon group, and at least one of R1 and R2 represents the acyl group).

公开(公告)号：US20230115042A1

公开(公告)日：2023-04-13

申请号：US17797177

申请日：2021-02-02

Applicant: SHOWA DENKO K.K.

Inventor： Daisuke YAGYU ,  Tsuyoshi KATO ,  Ayano ASANO ,  Natsumi SHIBATA ,  Naoya FUKUMOTO

IPC: G11B5/725 ,  C10M105/54 ,  C10M105/72 ,  C10M105/70 ,  C07D407/12 ,  C07D309/12 ,  C07D303/28 ,  C07D409/12 ,  C07D405/12

Abstract: A fluorine-containing ether compound represented by a formula (1) shown below. R1—(O(CH2)a)b-[A]-[B]—O—CH2—R2—CH2—R3  (1) (In the formula (1), R1 is an alkyl group which may have a substituent, or an organic group having at least one double bond or triple bond. Further, a represents an integer of 2 to 4, and b is 0 or 1. [A] is represented by a formula (2): —(OCH2CH(OH)CH2)c— (wherein c is 1 or 2). [B] is represented by a formula (3): —(O(CH2)eCH(OH)CH2)d— (wherein d is 0 or 1, and e represents an integer of 2 to 4). However, the sum of c in the formula (2) and d in the formula (3) is 2. R2 is a perfluoropolyether chain. R3 is represented by a formula (4): —(OCH2CH(OH)CH2)2—O—CH2(CH2)fOH (wherein f represents an integer of 2 to 5).

公开(公告)号：US20230099918A1

公开(公告)日：2023-03-30

申请号：US17788169

申请日：2020-12-17

Applicant: SHOWA DENKO K.K.

Inventor： Naoya FUKUMOTO ,  Tsuyoshi KATO ,  Katsumi MUROFUSHI ,  Daisuke YAGYU ,  Shunya SUZUKI ,  Ayano ASANO

IPC: C07C69/708 ,  C07C219/06 ,  C10M105/54

Abstract: There is provided a fluorine-containing ether compound represented by the following formula. R1—R2—CH2—R3—CH2—OCH2CH(OH)CH2O—CH2—R3—CH2—R4—R5 (in the formula. R3 represents a perfluoropolyether chain; R2 and R4 represent a divalent linking group having a polar group; R1 and R5 represent a terminal group bonded to an oxygen atom of R2 or R4; and at least one of R1 and R5 is any one selected from the group consisting of an alkenyl group having 2 to 8 carbon atoms, an alkynyl group having 3 to 8 carbon atoms, an aromatic hydrocarbon-containing group, and an aromatic heterocycle-containing group).

公开(公告)号：US20230002696A1

公开(公告)日：2023-01-05

申请号：US17772043

申请日：2020-11-06

Applicant: SHOWA DENKO K.K.

Inventor： Tsuyoshi KATO ,  Ayano ASANO ,  Natsumi SHIBATA ,  Daisuke YAGYU

IPC: C10M105/54 ,  C07C43/13 ,  C07D309/12 ,  G11B5/725

Abstract: This fluorine-containing ether compound is represented by formula (1) shown below. R1—CH2—R2—CH2—R3  (1) In formula (1), R2 is a perfluoropolyether chain represented by a formula (2) shown below. R1 is a terminal group that is bonded to R2 via a CH2 group, and is represented by a formula (3) shown below. R3 is bonded to R2 via a CH2 group, is a terminal group having at least one hydroxyl group, and may be the same as, or different from, R1. —(CF2)p-1—O—((CF2)pO)q—(CF2)p-1—  (2) In formula (2), p represents an integer of 2 to 3, and q indicates the average polymerization degree and is a number within a range from 1 to 20. —O(CH2—CH(OH)—CH2—O)2—CH2—(CH2)n,—OH  (3) In formula (3), n represents an integer of 1 to 8.

公开(公告)号：US20220169941A1

公开(公告)日：2022-06-02

申请号：US17437251

申请日：2020-03-12

Applicant: SHOWA DENKO K.K.

Inventor： Natsumi SHIBATA ,  Tsuyoshi KATO ,  Daisuke YAGYU ,  Shunya SUZUKI ,  Masaki NANKO ,  Naoya FUKUMOTO

IPC: C10M107/38 ,  C08G65/22 ,  G11B5/725

Abstract: This fluorine-containing ether compound is a fluorine-containing ether compound represented by formula (1). R1—X—R2—CH2—R3—CH2—R4  (1) (In formula (1), R1 is an alkenyloxy group of 2 to 8 carbon atoms or an alkynyloxy group of 3 to 8 carbon atoms. R2 is represented by formula (2) shown below. In formula (2), a represents an integer of 1 to 3. X is represented by formula (3) shown below. In formula (3), b represents an integer of 1 to 5, Y is a divalent linking group that is bonded to a carbon atom in formula (2), and R represents an alkyl group of 1 to 6 carbon atoms or H. R3 represents a perfluoropolyether chain. R4 represents a terminal group containing two or three polar groups, wherein each polar group is bonded to a different carbon atom, and the carbon atoms to which the polar groups are bonded are bonded to each other via a linking group containing a carbon atom to which a polar group is not bonded.)

公开(公告)号：US20210062102A1

公开(公告)日：2021-03-04

申请号：US16644586

申请日：2018-08-23

Applicant: SHOWA DENKO K.K.

Inventor： Tsuyoshi KATO ,  Daisuke YAGYU ,  Naoya FUKUMOTO ,  Masaki NANKO ,  Masumi KURITANI ,  Katsumi MUROFUSHI

IPC: C10M105/54 ,  C07C43/23 ,  C07D333/16 ,  G11B5/73

Abstract: A fluorine-containing ether compound represented by R1—R2—CH2—R3—CH2—R4—R5 is provided. (R3 is a perfluoropolyether chain; R1 and R5 are each independently any one of an alkyl group that may have a substituent, an organic group having at least one double bond or at least one triple bond, and a hydrogen atom; and —R2—CH2—R3 is represented by Formula (2), and R3—CH2—R4— is represented by Formula (3)) -[A]-[B]—O—CH2—R3   (2) R3—CH2—O—[C]-[D]-   (3) ([A] is represented by Formula (4), [B] is represented by Formula (5), [C] is represented by Formula (6), [D] is represented by Formula (7), and in the formula, a and b are integers of 0 to 2, c is an integer of 2 to 5, d and f are integers of 0 to 2, and e is an integer of 2 to 5, and at least one of b and d in the formula is 1 or more)