公开(公告)号：US20190041379A1

公开(公告)日：2019-02-07

申请号：US16074587

申请日：2016-11-14

Applicant: Sony Corporation

Inventor： Kenzo Machida ,  Shinji Omori ,  Yoshihito Hayashi ,  Marcaurele Brun

IPC: G01N33/49 ,  G01N27/12 ,  G01N33/86

Abstract: To provide a technique which is useful in verification of measurement accuracy before measurement in the measurement of electric characteristics of a blood sample.There is provided a sample for measurement of electric characteristics at least including a liquid containing a blood coagulation factor, and micro particles. The density of each of the micro particles is different from the density of the liquid containing the blood coagulation factor. In addition, there is provided an electric characteristic measuring apparatus and an electric characteristic measuring method as well each using the sample for measurement of electric characteristics.

公开(公告)号：US20160282366A1

公开(公告)日：2016-09-29

申请号：US14778277

申请日：2014-02-18

Applicant: SONY CORPORATION

Inventor： Yoshihito Hayashi ,  Yoichi Katsumoto ,  Marcaurele Brun

IPC: G01N33/86 ,  G01N27/02

CPC classification number: G01N33/86 ,  G01N27/026 ,  G01N33/4905

Abstract: A blood state evaluation device, blood state evaluation system, blood state evaluation method, and program that enable evaluation of the risk of thrombosis easily and precisely is provided. An electrical characteristic of blood being an evaluation target is chronologically measured in two or more frequencies or two or more frequency bands. On the basis of chronological change data of the measured electrical characteristic of the blood, a state of blood is evaluated.

Abstract translation: 提供了能够容易且精确地评价血栓形成风险的血液状态评价装置，血液状态评价系统，血液状态评价方法和程序。 以两个或更多个频率或两个或更多个频带按时间顺序测量作为评估目标的血液的电特性。 根据测定的血液电特性的时间顺序变化数据，对血液的状态进行评价。

公开(公告)号：US10948478B2

公开(公告)日：2021-03-16

申请号：US14777906

申请日：2014-02-18

Applicant: Sony Corporation

Inventor： Marcaurele Brun ,  Yoshihito Hayashi

IPC: G01N33/49 ,  G01N27/02 ,  G01N33/487

Abstract: A blood state analysis device, blood state analysis system, blood state analysis method, and program that enable analysis of the state of blood easily and precisely is provided. The blood state analysis device includes: an extraction unit configured to extract at least one feature from chronological change data of an electrical characteristic of blood in two or more frequency bands; an evaluation unit configured to evaluate a state of the blood on the basis of the at least one feature extracted by the extraction unit; and a classification unit configured to classify the blood on the basis of a result of evaluation conducted by the evaluation unit.

公开(公告)号：US10816493B2

公开(公告)日：2020-10-27

申请号：US15560039

申请日：2016-02-29

Applicant: SONY CORPORATION

Inventor： Seungmin Lee ,  Kenzo Machida ,  Kaori Kawaguchi ,  Marcaurele Brun

IPC: G01N27/02 ,  G01N33/49 ,  G01N33/86 ,  G01N33/80

Abstract: Provided is a technique that allows high-accuracy electrical measurement without the influence of blood sedimentation in a case where various measurements or evaluations are performed using blood samples containing a blood cell component and a plasma component. Provided is an electrical measurement method for electrically measuring a blood sample including at least a blood cell component and a plasma component, the electrical measurement method including the step of adding a blood sedimentation inhibitor to the blood sample. Also provided is a blood sedimentation inhibitor for use in electrical measurement of a blood sample including at least a blood cell component and a plasma component, the blood sedimentation inhibitor including a non-cationic water-soluble compound and being capable of increasing specific gravity and/or viscosity of the plasma component.

公开(公告)号：US10794896B2

公开(公告)日：2020-10-06

申请号：US16071663

申请日：2016-11-16

Applicant: Sony Corporation

Inventor： Yoshihito Hayashi ,  Marcaurele Brun ,  Shinji Omori

IPC: G01N33/86 ,  G01N33/49 ,  G01N27/22

Abstract: Disclosed are a blood coagulation system examination module, a blood coagulation system examination system, and a blood coagulation system examination method, all of which enable to simply and easily measure thrombin potential with a whole blood sample.The blood coagulation system examination module includes a thrombin potential examination unit configured to examine thrombin potential on the basis of an electrical property of blood as measured at a specific frequency and predetermined time intervals in a predetermined period after reversal of an anticoagulation action working on the blood.

公开(公告)号：US20190106666A1

公开(公告)日：2019-04-11

申请号：US16087162

申请日：2017-02-17

Applicant: Sony Corporation

Inventor： Tomohiko Nakamura ,  Marcaurele Brun

IPC: C12M1/00 ,  C12M1/34 ,  C12M1/32 ,  G01N33/50 ,  G01N21/01 ,  G01N21/47 ,  C12N5/078

Abstract: Provided are a method for quantitatively evaluating the activity of individual cells, and a device used therefor.A cell observation device includes: a cell introduction section; a cell arrangement section; an observation section; and an analysis section, in which the cell introduction section introduces one or a plurality of cells into the cell arrangement section, the cell arrangement section arranges the introduced one or plurality of cells, the observation section makes an observation of a temporal event arising from cell contact in the cell arrangement section, and the analysis section analyzes the temporal event arising from the cell contact.

公开(公告)号：US10234469B2

公开(公告)日：2019-03-19

申请号：US15302914

申请日：2015-04-09

Applicant: Sony Corporation

Inventor： Yoshihito Hayashi ,  Marcaurele Brun ,  Kenzo Machida

IPC: G01N33/86 ,  G01N33/49

Abstract: A blood state analysis device (1) that analyzes a state of a blood sample, as used for clotting time testing, said blood sample comprising a plasma and at least one reagent, including a correction unit (11) configured to correct a measured blood coagulation evaluation result of the blood sample based on a relation between reference concentrations of the at least one reagent in plasma and reference blood coagulation evaluation results, the at least one reagent is an anticoagulation treatment releasing agent, a coagulation activator, an anticoagulant, a platelet activator, an antiplatelet drug, or a combination thereof and is present in the blood sample. For instance, such device (1) allows to correct blood clotting time results with respect to concentrations of an anti-coagulant drug present in the blood sample.

公开(公告)号：US20170023597A1

公开(公告)日：2017-01-26

申请号：US15302562

申请日：2015-02-19

Applicant: Sony Corporation

Inventor： Yoshihito Hayashi ,  Marcaurele Brun ,  Kenzo Machida

IPC: G01N33/86 ,  G01N33/49 ,  G01N27/02

Abstract: To provide a technology that allows for simple and highly accurate evaluation of the condition of blood.Provided is a blood condition analysis device, for analyzing the condition of a blood sample having added thereto at least one kind of drug selected from the group consisting of anticoagulation treatment canceling agents, coagulation activators, anticoagulants, platelet activators, and antiplatelet agents, the device including a drug dosage control unit for controlling the dosage of the drug to be added to the blood sample on the basis of the hematocrit and/or hemoglobin content of the blood sample.

Abstract translation: 本发明提供一种血液分析装置，用于分析添加了选自抗凝治疗消除剂，凝血激活剂，抗凝剂，血小板活化剂和抗血小板剂中的至少一种药物的血液样品的状态，该装置 包括用于基于血液样品的血细胞比容和/或血红蛋白含量控制待添加到血液样品中的药物的剂量的药物剂量控制单元。

公开(公告)号：US20160299124A1

公开(公告)日：2016-10-13

申请号：US14777906

申请日：2014-02-18

Applicant: SONY CORPORATION

Inventor： Marcaurele Brun ,  Yoshihito Hayashi

IPC: G01N33/49 ,  G01N33/487 ,  G01N27/02

Abstract: A blood state analysis device, blood state analysis system, blood state analysis method, and program that enable analysis of the state of blood easily and precisely is provided. The blood state analysis device includes: an extraction unit configured to extract at least one feature from chronological change data of an electrical characteristic of blood in two or more frequency bands; an evaluation unit configured to evaluate a state of the blood on the basis of the at least one feature extracted by the extraction unit; and a classification unit configured to classify the blood on the basis of a result of evaluation conducted by the evaluation unit.

Abstract translation: 提供了能够容易且精确地分析血液状态的血液状态分析装置，血液状态分析系统，血液状态分析方法和程序。 血液分析装置包括：提取单元，被配置为从两个或更多个频带中的血液的电特性的时间变化数据提取至少一个特征; 评估单元，被配置为基于由所述提取单元提取的所述至少一个特征来评估血液的状态; 以及分类单元，其被配置为基于由评估单元执行的评估结果对血液进行分类。

公开(公告)号：US20150346125A1

公开(公告)日：2015-12-03

申请号：US14760238

申请日：2013-12-03

Applicant: SONY CORPORATION

Inventor： Yoshihito Hayashi ,  Yoichi Katsumoto ,  Marcaurele Brun ,  Teppei Toyoizumi

IPC: G01N27/02 ,  G01N33/49

CPC classification number: G01N27/028 ,  G01N27/026 ,  G01N33/4905

Abstract: There is provided an electrical characteristic measuring device including a rotating mechanism that rotates a sample container to be filled with blood to be measured, to any angle, and a measurement unit that applies a voltage between a pair of electrodes installed in the sample container, and chronologically measures electrical characteristics of the blood.

Abstract translation: 提供了一种电特性测量装置，其包括旋转机构，该旋转机构使待测量的血液的样品容器旋转任何角度，以及在安装在样品容器中的一对电极之间施加电压的测量单元，以及 按时间顺序测量血液的电气特性。