公开(公告)号：US11761034B2

公开(公告)日：2023-09-19

申请号：US17159028

申请日：2021-01-26

Applicant: STMICROELECTRONICS S.r.l.

Inventor： Lucio Renna ,  Clelia Carmen Galati ,  Natalia Maria Rita Spinella

IPC: C12Q1/686 ,  C12Q1/6816 ,  C12Q1/6844 ,  C12Q1/6851 ,  B01L7/00 ,  C12Q1/6825

CPC classification number: C12Q1/686 ,  B01L7/52 ,  C12Q1/6816 ,  C12Q1/6825 ,  C12Q1/6844 ,  C12Q1/6851 ,  B01L2200/10 ,  B01L2300/0663 ,  B01L2300/0829 ,  B01L2300/0887 ,  B01L2300/12 ,  B01L2300/18 ,  C12Q2561/113 ,  C12Q2563/107 ,  C12Q2563/143 ,  C12Q2563/107 ,  C12Q2561/113 ,  C12Q2563/143

Abstract: A method for real-time quantitative detection of single-type, target nucleic acid sequences amplified using a PCR in a microwell, comprising introducing in the microwell a sample comprising target nucleic acid sequences, magnetic primers, and labelling probes; performing an amplification cycle to form labelled amplicons; attracting the magnetic primers to a surface through a magnetic field to form a layer including labelled amplification products and free magnetic primers; and detecting the labelled amplification products in the layer with a surface-specific reading method.

公开(公告)号：US10897171B1

公开(公告)日：2021-01-19

申请号：US16517147

申请日：2019-07-19

Applicant: STMicroelectronics S.r.l.

Inventor： Lucio Renna

IPC: H02K3/24 ,  H02K41/03 ,  H02K11/00 ,  B25J9/12 ,  H02K9/19 ,  H02K11/33 ,  H02K15/06

Abstract: An artificial muscle fiber includes an external fiber and an internal fiber. The external fiber includes a first linear array of actuators having protrusions directed in a first direction. The internal fiber includes a second linear array of actuators having protrusions directed in a second direction opposite to the first direction. The internal fiber further includes a channel attached to the second linear array of actuators.

公开(公告)号：US20190071713A1

公开(公告)日：2019-03-07

申请号：US16181274

申请日：2018-11-05

Applicant: STMICROELECTRONICS S.R.L.

Inventor： Lucio Renna ,  Clelia Carmen Galati ,  Natalia Maria Rita Spinella

IPC: C12Q1/686 ,  C12Q1/6816 ,  C12Q1/6825 ,  C12Q1/6844 ,  C12Q1/6851 ,  B01L7/00

Abstract: A method for real-time quantitative detection of single-type, target nucleic acid sequences amplified using a PCR in a microwell, comprising introducing in the microwell a sample comprising target nucleic acid sequences, magnetic primers, and labelling probes; performing an amplification cycle to form labelled amplicons; attracting the magnetic primers to a surface through a magnetic field to form a layer including labelled amplification products and free magnetic primers; and detecting the labelled amplification products in the layer with a surface-specific reading method.

公开(公告)号：US20150267248A1

公开(公告)日：2015-09-24

申请号：US14732487

申请日：2015-06-05

Applicant: STMicroelectronics S.r.l.

Inventor： Lucio Renna ,  Clelia Carmen Galati ,  Natalia Maria Rita Spinella

IPC: C12Q1/68 ,  B01L7/00

CPC classification number: C12Q1/686 ,  B01L7/52 ,  B01L2200/10 ,  B01L2300/0663 ,  B01L2300/0829 ,  B01L2300/0887 ,  B01L2300/12 ,  B01L2300/18 ,  C12Q1/6816 ,  C12Q1/6825 ,  C12Q1/6844 ,  C12Q1/6851 ,  C12Q2561/113 ,  C12Q2563/107 ,  C12Q2563/143

Abstract: A method for real-time quantitative detection of single-type, target nucleic acid sequences amplified using a PCR in a microwell, comprising introducing in the microwell a sample comprising target nucleic acid sequences, magnetic primers, and labelling probes; performing an amplification cycle to form labelled amplicons; attracting the magnetic primers to a surface through a magnetic field to form a layer including labelled amplification products and free magnetic primers; and detecting the labelled amplification products in the layer with a surface-specific reading method.

Abstract translation: 一种用于在微孔中使用PCR扩增的单型靶核酸序列的实时定量检测方法，包括在微孔中引入包含靶核酸序列，磁性引物和标记探针的样品; 进行扩增循环以形成标记的扩增子; 通过磁场将磁性引物吸引到表面以形成包括标记的扩增产物和游离磁性引物的层; 并用表面特异性读取方法检测该层中标记的扩增产物。