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公开(公告)号:US20150010572A1
公开(公告)日:2015-01-08
申请号:US14322343
申请日:2014-07-02
Applicant: Samsung Electronics Co., Ltd.
Inventor: Yoon Sook LEE , Chung Ho Kim , Kyung Eun Kim , Hyung-Chan Kim , Kwang Hoon Lee , Hyo Seon Lee , Sang Yeul Han
CPC classification number: C07K16/22 , C07K2317/34 , C07K2317/76 , C07K2317/92 , G01N33/74 , G01N2333/515 , G01N2800/7014
Abstract: Provided are an anti-Ang-2 antibody or antigen-binding fragment thereof that specifically binds to an angiogenesis-inducing factor Angiopoietin-2 (Ang-2), related compositions and pharmaceutical compositions, and methods for using such compositions and pharmaceutical compositions.
Abstract translation: 提供特异性结合血管发生诱导因子促血管生成素-2(Ang-2),相关组合物和药物组合物的抗Ang-2抗体或其抗原结合片段,以及使用这些组合物和药物组合物的方法。
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公开(公告)号:US11174309B2
公开(公告)日:2021-11-16
申请号:US15823272
申请日:2017-11-27
Applicant: Samsung Electronics Co., Ltd
Inventor: Kyung Eun Kim , Seung Ja Oh , Hyo Seon Lee , Sang Yeul Han
IPC: A61K39/395 , A61K39/00 , C07K16/22 , A61K38/18 , G01N33/74
Abstract: An anti-Ang2 antibody or an antigen-binding fragment thereof that specifically binds to an angiogenesis-inducing factor Angiopoietin-2 (Ang2) and complexes with a Tie2 receptor and Ang2, and related methods and compositions.
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公开(公告)号:US20180273613A1
公开(公告)日:2018-09-27
申请号:US16004622
申请日:2018-06-11
Applicant: Samsung Electronics Co., Ltd.
Inventor: Seok Kyun Kim , Sunghyun Kim , Sang Yeul Han , Seung Hyun Lee , Su Jin Kim , Yong In Kim , Hyung-Chan Kim , Kwang Hoon Lee , Hyo Seon Lee
IPC: C07K16/22 , G01N33/68 , A61K39/395 , C07K14/705 , C07K14/515 , A61K39/00 , A61K38/00
CPC classification number: C07K16/22 , A61K38/00 , A61K39/3955 , A61K2039/505 , C07K14/515 , C07K14/705 , C07K2317/24 , C07K2317/567 , C07K2317/622 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/92 , G01N33/6887 , G01N33/6893 , G01N2333/515
Abstract: An anti-Ang2 antibody or an antigen-binding fragment thereof that specifically binds to an angiogenesis-inducing factor Angiopoietin-2 (Ang2) and complexes with a Tie2 receptor through Ang2, and methods of using the same.
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公开(公告)号:US20170342153A1
公开(公告)日:2017-11-30
申请号:US15667424
申请日:2017-08-02
Applicant: Samsung Electronics Co., Ltd.
Inventor: Kwang Hoon Lee , Hyung-Chan Kim , Sang Yeul Han , Seok Kyun Kim , Kyung Eun Kim
CPC classification number: C07K16/2863 , C07K14/71 , C07K2317/73 , C07K2317/92 , C07K2318/20 , C07K2319/30
Abstract: A fusion polypeptide capable of binding simultaneously to angiopoietin 2, VEGF-C and VEGF-D; or capable of binding simultaneously to VEGF-C and VEGF-D, and methods for the preparation and use thereof.
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公开(公告)号:US09828422B2
公开(公告)日:2017-11-28
申请号:US14446228
申请日:2014-07-29
Applicant: Samsung Electronics Co., Ltd.
Inventor: Kyung Eun Kim , Seung Ja Oh , Hyo Seon Lee , Sang Yeul Han
CPC classification number: C07K16/22 , A61K38/1891 , A61K39/395 , A61K39/3955 , A61K2039/505 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/74 , G01N2333/515 , G01N2333/71 , G01N2500/02
Abstract: An anti-Ang2 antibody or an antigen-binding fragment thereof that specifically binds to an angiogenesis-inducing factor Angiopoietin-2 (Ang2) and complexes with a Tie2 receptor and Ang2, and related methods and compositions.
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公开(公告)号:US09527910B2
公开(公告)日:2016-12-27
申请号:US14322343
申请日:2014-07-02
Applicant: Samsung Electronics Co., Ltd.
Inventor: Yoon Sook Lee , Chung Ho Kim , Kyung Eun Kim , Hyung-Chan Kim , Kwang Hoon Lee , Hyo Seon Lee , Sang Yeul Han
CPC classification number: C07K16/22 , C07K2317/34 , C07K2317/76 , C07K2317/92 , G01N33/74 , G01N2333/515 , G01N2800/7014
Abstract: Provided are an anti-Ang-2 antibody or antigen-binding fragment thereof that specifically binds to an angiogenesis-inducing factor Angiopoietin-2 (Ang-2), related compositions and pharmaceutical compositions, and methods for using such compositions and pharmaceutical compositions.
Abstract translation: 提供特异性结合血管发生诱导因子促血管生成素-2(Ang-2),相关组合物和药物组合物的抗Ang-2抗体或其抗原结合片段,以及使用这些组合物和药物组合物的方法。
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公开(公告)号:US09505841B2
公开(公告)日:2016-11-29
申请号:US14446199
申请日:2014-07-29
Inventor: Kyung Eun Kim , Sang Yeul Han , Gou Young Koh , Hyo Seon Lee , Chan Kim
CPC classification number: C07K16/28 , A61K38/17 , A61K45/06 , A61K2039/505 , C07K16/22 , C07K2317/32 , C07K2317/565 , C07K2317/74 , C07K2317/75 , C07K2317/77 , C07K2317/92
Abstract: A method of preventing or treating cancer using an anti-Ang2 antibody or an antigen-binding fragment thereof that specifically binds to an angiogenesis-inducing factor Angiopoietin-2 (Ang2) and complexes to a Tie2 receptor while bound with Ang2.
Abstract translation: 使用Ang2抗体或其抗原结合片段预防或治疗癌症的方法,所述抗Ang2抗体或其抗原结合片段特异性结合血管发生诱导因子促血管生成素-2(Ang2),并与Ang2结合时与Tie2受体复合。
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公开(公告)号:US20150030603A1
公开(公告)日:2015-01-29
申请号:US14446228
申请日:2014-07-29
Applicant: Samsung Electronics Co., Ltd.
Inventor: Kyung Eun KIM , Seung Ja Oh , Hyo Seon Lee , Sang Yeul Han
IPC: C07K16/22 , A61K38/18 , G01N33/74 , A61K39/395
CPC classification number: C07K16/22 , A61K38/1891 , A61K39/395 , A61K39/3955 , A61K2039/505 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/74 , G01N2333/515 , G01N2333/71 , G01N2500/02
Abstract: An anti-Ang2 antibody or an antigen-binding fragment thereof that specifically binds to an angiogenesis-inducing factor Angiopoietin-2 (Ang2) and complexes with a Tie2 receptor and Ang2, and related methods and compositions.
Abstract translation: 特异性结合血管发生诱导因子促血管生成素-2(Ang2促血管素-2)和与Tie2受体和Ang2复合的抗Ang2抗体或其抗原结合片段,以及相关方法和组合物。
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公开(公告)号:US20180086825A1
公开(公告)日:2018-03-29
申请号:US15823272
申请日:2017-11-27
Applicant: Samsung Electronics Co., Ltd
Inventor: Kyung Eun Kim , Seung Ja Oh , Hyo Seon Lee , Sang Yeul Han
CPC classification number: C07K16/22 , A61K38/1891 , A61K39/395 , A61K39/3955 , A61K2039/505 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/74 , G01N2333/515 , G01N2333/71 , G01N2500/02
Abstract: An anti-Ang2 antibody or an antigen-binding fragment thereof that specifically binds to an angiogenesis-inducing factor Angiopoietin-2 (Ang2) and complexes with a Tie2 receptor and Ang2, and related methods and compositions.
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公开(公告)号:US09902767B2
公开(公告)日:2018-02-27
申请号:US14446256
申请日:2014-07-29
Applicant: Samsung Electronics Co., Ltd.
Inventor: Hyo Seon Lee , Kyung Eun Kim , Seung Ja Oh , Sang Yeul Han
IPC: A61K39/395 , C07K16/22 , A61K38/18 , G01N33/74 , A61K39/00
CPC classification number: C07K16/22 , A61K38/1891 , A61K39/395 , A61K39/3955 , A61K2039/505 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/74 , G01N2333/515 , G01N2333/71 , G01N2500/02
Abstract: A method for the prevention and/or treatment of a disease accompanied by vascular leakage and/or vascular inflammation comprising administering an anti-Ang2 antibody or an antigen-binding fragment thereof that specifically binds to an angiogenesis-inducing factor Angiopoietin-2 (Ang2) and forms a complex with a Tie2 receptor and Ang2.
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