公开(公告)号：US4701559A

公开(公告)日：1987-10-20

申请号：US334986

申请日：1981-12-28

申请人： Satoshi Horii ,  Yukihiko Kameda ,  Hiroshi Fukase

发明人： Satoshi Horii ,  Yukihiko Kameda ,  Hiroshi Fukase

IPC分类号： C07D213/38 ,  C07D307/52 ,  C07D333/20 ,  C07C91/16

CPC分类号： C07D213/38 ,  C07D307/52 ,  C07D333/20

摘要： A compound of the formula: ##STR1## wherein A is a chain hydrocarbon group having 1 to 10 carbon atoms optionally substituted by hydroxyl, phenoxy, thienyl, furyl, pyridyl, cyclohexyl or an optionally substituted phenyl group, or a cyclic hydrocarbon group having 3 to 7 carbon atoms optionally substituted by hydroxyl, B is hydrogen or hydroxyl, and their production and use.These compounds exhibit excellent inhibitory activity against .alpha.-glucoside hydrolase, thus are useful for hyperglycemic symptoms and various disorders caused by hyperglycemia.

摘要翻译： 下式的化合物：其中A是任选被羟基，苯氧基，噻吩基，呋喃基，吡啶基，环己基或任选取代的苯基取代的具有1-10个碳原子的链烃基，或具有3个 至7个碳原子，任选被羟基取代，B是氢或羟基，以及它们的生产和使用。 这些化合物对α-葡糖苷水解酶表现出优异的抑制活性，因此可用于高血糖症状和由高血糖引起的各种疾病。

公开(公告)号：US20130041522A1

公开(公告)日：2013-02-14

申请号：US13571163

申请日：2012-08-09

申请人： Tetsuya Mori ,  Daiyu Mikita ,  Satoshi Horii

发明人： Tetsuya Mori ,  Daiyu Mikita ,  Satoshi Horii

IPC分类号： G06F17/00

CPC分类号： H04L9/3271 ,  G07C5/0808 ,  G07C5/085 ,  G07C2205/02 ,  H04L9/002 ,  H04L63/0428 ,  H04L63/1416 ,  H04L2209/043 ,  H04W12/12

摘要： An information obtaining system in a vehicle is provided. The information obtaining system includes a nonvolatile memory built into the vehicle, vehicle information relating to the vehicle being stored in the nonvolatile memory; a portable reader device which is not incorporated into the vehicle and can be carried by a person, the portable reader device being configured to read out the vehicle information from the nonvolatile memory, encrypt the vehicle information, and store the encrypted vehicle information, and being capable of outputting the encrypted vehicle information; and an analyzing device which is not incorporated into the vehicle, the analyzing device being separate from the portable reader device, and configured to decrypt the encrypted vehicle information output from the portable reader device into the vehicle information.

摘要翻译： 提供车辆中的信息获取系统。 信息获取系统包括内置于车辆中的非易失性存储器，与车辆相关的车辆信息存储在非易失性存储器中; 便携式阅读器装置，其不被并入车辆并且可以由人携带，便携式阅读器装置被配置为从非易失性存储器读出车辆信息，加密车辆信息并存储加密的车辆信息，并且被存储 能够输出加密的车辆信息; 该分析装置与便携式读取装置分离，并且将从便携式读取装置输出的加密车辆信息解密为车辆信息。

公开(公告)号：US08725312B2

公开(公告)日：2014-05-13

申请号：US13571163

申请日：2012-08-09

申请人： Tetsuya Mori ,  Daiyu Mikita ,  Satoshi Horii

发明人： Tetsuya Mori ,  Daiyu Mikita ,  Satoshi Horii

IPC分类号： G06F17/00 ,  H04L9/32 ,  H04L9/00 ,  H04W12/12 ,  H04L29/06

CPC分类号： H04L9/3271 ,  G07C5/0808 ,  G07C5/085 ,  G07C2205/02 ,  H04L9/002 ,  H04L63/0428 ,  H04L63/1416 ,  H04L2209/043 ,  H04W12/12

摘要： An information obtaining system in a vehicle is provided. The information obtaining system includes a nonvolatile memory built into the vehicle, vehicle information relating to the vehicle being stored in the nonvolatile memory; a portable reader device which is not incorporated into the vehicle and can be carried by a person, the portable reader device being configured to read out the vehicle information from the nonvolatile memory, encrypt the vehicle information, and store the encrypted vehicle information, and being capable of outputting the encrypted vehicle information; and an analyzing device which is not incorporated into the vehicle, the analyzing device being separate from the portable reader device, and configured to decrypt the encrypted vehicle information output from the portable reader device into the vehicle information.

摘要翻译： 提供车辆中的信息获取系统。 信息获取系统包括内置于车辆中的非易失性存储器，与车辆相关的车辆信息存储在非易失性存储器中; 便携式阅读器装置，其不被并入车辆并且可以由人携带，便携式阅读器装置被配置为从非易失性存储器读出车辆信息，加密车辆信息并存储加密的车辆信息，并且被存储 能够输出加密的车辆信息; 该分析装置与便携式读取装置分离，并且将从便携式读取装置输出的加密车辆信息解密为车辆信息。

公开(公告)号：US5004838A

公开(公告)日：1991-04-02

申请号：US414247

申请日：1989-09-29

申请人： Satoshi Horii ,  Hiroshi Fukase

发明人： Satoshi Horii ,  Hiroshi Fukase

IPC分类号： C07C45/29 ,  C07C45/65 ,  C07C45/67 ,  C07C49/255 ,  C07C49/517 ,  C07C49/753 ,  C07D309/12

CPC分类号： C07D309/12 ,  C07C215/44 ,  C07C323/22 ,  C07C45/29 ,  C07C45/65 ,  C07C45/67 ,  C07C45/673 ,  C07C49/255 ,  C07C49/517 ,  C07C49/753 ,  C07C2101/14 ,  Y02P20/55

摘要： Disclosed is a novel inosose compound represented by the general formula: ##STR1## wherein X.sup.1 and X.sup.2 are both halogen; X.sup.1 is hydrogen and X.sup.2 is halogen; or X.sup.1 is --SQ.sup.1 and X.sup.2 is --SQ.sup.2 (each of Q.sup.1 and Q.sup.2 is lower alkyl or Q.sup.1 and Q.sup.2 may form lower alkylene), R.sup.1 is a protective group for hydroxyl and Y is .dbd.O, .dbd.N--Z (Z is hydroxyl which may be protected) or ##STR2## (A is hydrogen or an amine residue), particularly to the compound wherein the symbol Y is oxygen.The inosose compound is useful as intermediates for production of valiolamine and the N-substituted derivatives thereof, which have potent .alpha.-glucosidase inhibiting activities and are useful as preventives or therapeutics for symptoms of hyperglycemia and various diseases derived therefrom in human and animals, such as diabetes, obesity and hyperlipemia.

公开(公告)号：US4463172A

公开(公告)日：1984-07-31

申请号：US235998

申请日：1981-02-19

申请人： Satoshi Horii ,  Nariakira Mizokami ,  Yutaka Kuwada

发明人： Satoshi Horii ,  Nariakira Mizokami ,  Yutaka Kuwada

IPC分类号： A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D501/00 ,  C07D501/04 ,  C07D501/14 ,  C07D501/16 ,  C07D501/18 ,  C07D501/36 ,  C07D501/60

CPC分类号： C07D501/04 ,  C07D501/14

摘要： Novel 2-methylcephalosporin derivatives and production thereof. These cephalosporin derivatives exhibit excellent antibacterial activities against gram-positive and gram-negative bacteria, thus being of value as a prophylactic or therapeutic agent for infections observed in man and animals.

摘要翻译： 新型2-甲基头孢菌素衍生物及其制备方法。 这些头孢菌素衍生物对革兰氏阳性菌和革兰氏阴性细菌表现出优异的抗菌活性，因此作为在人和动物中观察到的感染的预防或治疗剂是有价值的。

公开(公告)号：US4575489A

公开(公告)日：1986-03-11

申请号：US300285

申请日：1981-09-08

申请人： Eiji Higashide ,  Satoshi Horii

发明人： Eiji Higashide ,  Satoshi Horii

IPC分类号： C12P21/02 ,  A61K38/00 ,  A61P31/04 ,  A61P43/00 ,  C07K5/06 ,  C07K14/195 ,  C07K14/41 ,  C12R1/47 ,  C07D207/00 ,  C12N1/20

CPC分类号： C12R1/465 ,  C07K5/06026 ,  A61K38/00 ,  Y10S435/886 ,  Y10S435/887

摘要： Novel peptide B-52653 having the formula: ##STR1## which is produced by cultivating a microorganism belonging to the genus Streptomyces and being capable of producing B-52653 in a culture medium, whereby B-52653 is elaborated and accumulated in the cultured broth and is recovered.B-52653 is useful as a germicide or disinfectant, and a possibility of the present substance as an antifibrotic agent is suggested.

摘要翻译： 具有下式的新型肽B-52653：其通过培养属于链霉菌属的微生物并能够在培养基中产生B-52653产生，由此将B-52653精制并积累在培养的肉汤中， 被收回。 B-52653可用作杀菌剂或消毒剂，建议本物质作为抗纤维化剂的可能性。

公开(公告)号：US4436918A

公开(公告)日：1984-03-13

申请号：US340337

申请日：1982-01-18

申请人： Satoshi Horii ,  Hiroshi Fukase ,  Eiji Higashide

发明人： Satoshi Horii ,  Hiroshi Fukase ,  Eiji Higashide

IPC分类号： A61K38/00 ,  C07C67/00 ,  C07C231/00 ,  C07C231/12 ,  C07D207/40 ,  C07D207/416 ,  C07K1/113 ,  C07K5/06 ,  C07K14/195 ,  C07K14/41

CPC分类号： C07D207/40 ,  C07D207/416 ,  A61K38/00 ,  Y02P20/55

摘要： The peptide compound represented by the formula: ##STR1## which is useful as a germicide or disinfectant, is produced by reducing a compound of the formula: ##STR2## wherein Y is amino group which may optionally be protected; R.sup.1 is hydrogen or protective group; and R.sup.2 is hydrogen or protective group; and subjecting the reduction product compound to deprotection reaction when required. A compound of the formula: ##STR3## wherein Z is amino group which may optionally be protected; R.sup.1 is hydrogen or protective group; and R.sup.2 is hydrogen or protective group, is a useful as intermediate for production of the first-mentioned compound.

摘要翻译： 可用作杀菌剂或消毒剂的由下式表示的肽化合物是通过还原下式的化合物制备的：其中Y是可以任选被保护的氨基; R1是氢或保护基; R2是氢或保护基; 并在需要时使还原产物化合物脱保护反应。 下式的化合物：其中Z是可以任选被保护的氨基; R1是氢或保护基; 并且R 2为氢或保护基，可用作生产上述化合物的中间体。

公开(公告)号：US4824943A

公开(公告)日：1989-04-25

申请号：US021745

申请日：1987-03-04

申请人： Satoshi Horii ,  Hiroshi Fukase

发明人： Satoshi Horii ,  Hiroshi Fukase

IPC分类号： C07C45/60 ,  C07C45/67 ,  C07C49/517 ,  C07C49/753 ,  C07H1/00 ,  C07G3/00 ,  C07H3/00 ,  C08B37/00

CPC分类号： C07C49/753 ,  C07C45/60 ,  C07C45/673 ,  C07C49/517 ,  Y02P20/55

摘要： The novel inosose derivatives ##STR1## wherein Y.sup.1 stands for hydroxyl group and Y.sup.2 stands for hydrogen atom, or Y.sup.1 and Y.sup.2 are joined to form a bond between carbon and carbon atoms, and R.sup.1 and is a protective group for hydroxyl group, are useful as a starting material for producing valienamine, valiolamine and their N-substituted derivatives.

公开(公告)号：US4465844A

公开(公告)日：1984-08-14

申请号：US526051

申请日：1983-08-23

申请人： Satoshi Horii ,  Hiroshi Fukase ,  Eiji Higashide

发明人： Satoshi Horii ,  Hiroshi Fukase ,  Eiji Higashide

IPC分类号： A61K38/00 ,  C07C67/00 ,  C07C231/00 ,  C07C231/12 ,  C07D207/40 ,  C07D207/416 ,  C07K1/113 ,  C07K5/06 ,  C07K14/195 ,  C07K14/41 ,  C07D207/26 ,  A61K31/40

CPC分类号： C07D207/40 ,  C07D207/416 ,  A61K38/00 ,  Y02P20/55

摘要： The peptide compound represented by the formula: ##STR1## which is useful as a germicide or disinfectant, is produced by reducing a compound of the formula: ##STR2## wherein Y is amino group which may optionally be protected; R.sup.1 is hydrogen or protective group; and R.sup.2 is hydrogen or protective group; and subjecting the reduction product compound to deprotection reaction when required. A compound of the formula: ##STR3## wherein Z is amino group which may optionally be protected; R.sup.1 is hydrogen or protective group; and R.sup.2 is hydrogen or protective group, is a useful as intermediate for production of the first-mentioned compound.

摘要翻译： 可用作杀菌剂或消毒剂的由下式表示的肽化合物是通过还原下式的化合物制备的：其中Y是可以任选被保护的氨基; R1是氢或保护基; R2为氢或保护基; 并在需要时使还原产物化合物脱保护反应。 下式的化合物：其中Z是可以任选被保护的氨基; R1是氢或保护基; 并且R 2为氢或保护基，可用作生产上述化合物的中间体。

公开(公告)号：US4898986A

公开(公告)日：1990-02-06

申请号：US90974

申请日：1987-08-31

申请人： Satoshi Horii ,  Hiroshi Fukase

发明人： Satoshi Horii ,  Hiroshi Fukase

IPC分类号： C07C45/29 ,  C07C45/65 ,  C07C45/67 ,  C07C49/255 ,  C07C49/517 ,  C07C49/753 ,  C07D309/12

CPC分类号： C07D309/12 ,  C07C215/44 ,  C07C323/22 ,  C07C45/29 ,  C07C45/65 ,  C07C45/67 ,  C07C45/673 ,  C07C49/255 ,  C07C49/517 ,  C07C49/753 ,  C07C2101/14 ,  Y02P20/55

摘要： Disclosed is a novel inosose compound represented by the general formula: ##STR1## wherein X.sup.1 and X.sup.2 are both halogen; X.sup.1 is hydrogen and X.sup.2 is halogen; or X.sup.1 is --SQ.sup.1 and X.sup.2 is --SQ.sup.2 (each of Q.sup.1 and Q.sup.2 is lower alkyl or Q.sup.1 and Q.sup.2 may form lower alkylene), R.sup.1 is a protective group for hydroxyl and Y is .dbd.O, .dbd.N--Z (Z is hydroxyl which may be protected) or ##STR2## (A is hydrogen or an amine residue), particularly to the compound wherein the symbol Y is oxygen.The inosose compound is useful as intermediates for production of valiolamine and the N-substituted derivatives thereof, which have potent .alpha.-glucosidase inhibiting activities and are useful as preventives or therapeutics for symptoms of hyperglycemia and various diseases derived therefrom in human and animals, such as diabetes, obesity and hyperlipemia.

摘要翻译： 公开了一种由通式如下的新型无味化合物：其中X1和X2都是卤素; X1是氢，X2是卤素; 或X1为-SQ1，X2为-SQ2（Q1和Q2各自为低级烷基或Q1和Q2可形成低级亚烷基），R1为羟基的保护基，Y为= O，= NZ（Z为羟基， 被保护）或（A是氢或胺残基），特别是其中符号Y是氧的化合物。 该无味化合物可用作生产具有强效α-葡糖苷酶抑制活性的有效的戊酰胺及其N-取代衍生物的中间体，并且可用作预防药物或治疗剂，用于在人和动物中从其衍生的高血糖症和各种疾病，例如 糖尿病，肥胖和高脂血症。