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31 条记录 (耗时 0.029 秒)

    Process for producing optically active carboxylic acid
    11.
    发明授权
    Process for producing optically active carboxylic acid 失效
    光学活性羧酸的制备方法

    公开(公告)号：US4962230A

    公开(公告)日：1990-10-09

    申请号：US121247

    申请日：1987-11-16

    申请人： Hidemasa Takaya ,  Tetsuo Ohta ,  Ryoji Noyori ,  Noboru Sayo ,  Hidenori Kumobayashi ,  Susumu Akutagawa

    发明人： Hidemasa Takaya ,  Tetsuo Ohta ,  Ryoji Noyori ,  Noboru Sayo ,  Hidenori Kumobayashi ,  Susumu Akutagawa

    IPC分类号： C07C51/36 ,  C07F15/00

    CPC分类号： C07F15/0053 ,  C07C51/36

    摘要： A process for producing an optically active carboxylic acid represented by formula (I): ##STR1## wherein R.sup.1, and R.sup.2, and R.sup.3 each represents a hydrogen atom, an alkyl group, an alkenyl group, or a phenyl or naphthyl group which may have a substituent, provided that all of R.sup.1, R.sup.2, and R.sup.3 are not simultaneously a hydrogen atom; when R.sup.1 and R.sup.2 are simultaneously a hydrogen atom, then R.sup.3 is not a methyl group; and that when R.sup.3 is a hydrogen atom, then R.sup.1 and R.sup.2 are each a group other then a hydrogen atom,is disclosed, comprising asymmetrically hydrogenating an .alpha.,.beta.-unsaturated carboxylic acid represented by formula (II): ##STR2## wherein R.sup.1, R.sup.2, and R.sup.3 are the same as defined above, in the presence of a ruthenium-optically active phosphine complex as a catalyst.According to the process of the invention, the desired optically active carboxylic acids which can be widely used as raw materials for synthesizing various useful compounds, for example, as intermediates for synthesizing physiologically active substances of natural materials and also as liquid crystal materials can be industrially advantageously produced.

    Process for preparing N-acyltetrahydroisoquinoline
    13.
    发明授权
    Process for preparing N-acyltetrahydroisoquinoline 失效
    制备N-酰基四氢异喹啉的方法

    公开(公告)号：US4851537A

    公开(公告)日：1989-07-25

    申请号：US38571

    申请日：1987-04-15

    申请人： Ryoji Noyori ,  Masato Kitamura ,  Hidemasa Takaya ,  Hidenori Kumobayashi ,  Susumu Akutagawa

    发明人： Ryoji Noyori ,  Masato Kitamura ,  Hidemasa Takaya ,  Hidenori Kumobayashi ,  Susumu Akutagawa

    IPC分类号： C07B61/00 ,  B01J31/00 ,  B01J31/24 ,  C07D217/06 ,  C07D217/20

    CPC分类号： C07D217/06 ,  C07D217/20

    摘要： A process for preparing an N-acyltetrahydroisoquinoline represented by formula (II) ##STR1## wherein A represents a phenylene ring substituted with a hydroxyl group, a lower alkoxy group, an acetoxy group, or a benzyloxy group; R represents a hydrogen atom, a lower alkyl group, or a phenyl group; and X represents a hydrogen atoms, a phenyl group, or a phenyl group substituted with a hydroxyl group, a lower alkoxy group, or an acetoxy group, which comprises asymmetrically hydrogenating an N-acyl-1-methylenetetrahydroisoquinoline or N-acyl-1-benzylidenetetrahydroisoquinoline represented by formula (I) ##STR2## wherein A, R, and X are as defined above, in the presence of an optically active ruthenium-phosphine complex as a catalyst. The process exclusively and efficiently provides a useful isomer of the N-acyltetrahydroisoquinoline of high purity which is useful as an intermediate for synthesizing isoquinoline type alkaloids as pharmaceuticals without involving optical resolution of a racemate.

    摘要翻译： 制备由式（II）表示的N-酰基四氢异喹啉的方法其中A表示被羟基，低级烷氧基，乙酰氧基或苄氧基取代的亚苯基环; R表示氢原子，低级烷基或苯基; X表示氢原子，苯基或被羟基，低级烷氧基或乙酰氧基取代的苯基，其包括不对称地氢化N-酰基-1-亚甲基四氢异喹啉或N-酰基-1- 由式（I）表示的亚苄基四氢异喹啉，其中A，R和X如上所定义，在光学活性钌 - 膦配合物作为催化剂存在下进行。 该方法专门有效地提供了高纯度的N-酰基四氢异喹啉的有用异构体，其可用作合成异喹啉类生物碱作为药物而不涉及外消旋物的光学拆分的中间体。

    Ruthenium-phosphine complex
    15.
    发明授权
    Ruthenium-phosphine complex 失效
    钌膦络合物

    公开(公告)号：US4766225A

    公开(公告)日：1988-08-23

    申请号：US130577

    申请日：1987-12-09

    申请人： Noboru Sayo ,  Takanao Taketomi ,  Hidenori Kumobayashi ,  Susumu Akutagawa

    发明人： Noboru Sayo ,  Takanao Taketomi ,  Hidenori Kumobayashi ,  Susumu Akutagawa

    IPC分类号： B01J31/24 ,  C07B61/00 ,  C07C51/36 ,  C07F15/00

    CPC分类号： C07F15/0053 ,  C07C51/36

    摘要： A ruthenium-phosphine complex represented by formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom, a methyl group, or a methoxy group; and R.sup.2 represents a lower alkyl group, a halogenated lower alkyl group, a phenyl group, or a phenyl group substituted with a lower alkyl group. The complex is inexpensive and exhibits excellent performance as a catalyst for various organic syntheses, particularly for asymmetric hydrogenation.

    摘要翻译： 由式（I）表示的钌膦络合物：其中R 1表示氢原子，甲基或甲氧基; R 2表示低级烷基，卤代低级烷基，苯基或被低级烷基取代的苯基。 该复合物是便宜的，并且作为各种有机合成的催化剂表现出优异的性能，特别是用于不对称氢化。

    Rhodium-phosphine complex
    17.
    发明授权
    Rhodium-phosphine complex 失效
    铑膦络合物

    公开(公告)号：US4604474A

    公开(公告)日：1986-08-05

    申请号：US714281

    申请日：1985-03-21

    申请人： Hidenori Kumobayashi ,  Susumu Akutagawa

    发明人： Hidenori Kumobayashi ,  Susumu Akutagawa

    IPC分类号： C07F9/50 ,  B01J31/00 ,  B01J31/28 ,  C07B61/00 ,  C07C45/51 ,  C07C209/68 ,  C07F15/00

    CPC分类号： C07F15/008 ,  C07C209/68 ,  C07C45/516

    摘要： A novel rhodium-phosphine complex represented by the formula[Rh(p-Tolyl BINAP).sub.2 ].sup.+ Y.sup.-wherein p-Tolyl BINAP represents 2,2'-bis(di-p-tolylphosphino)-1,1'-binaphthyl, and Y represents ClO.sub.4, PF.sub.6, BF.sub.4 or PCl.sub.6 is described. This complex can be used as a catalyst for various organic syntheses and also for asymmetric syntheses such as an asymmetric isomerization reaction and an asymmetric hydrogenation reaction. Due to its high activity, the complex is very useful as a catalyst.

    摘要翻译： 由式[Rh（对甲苯基BINAP）2] + Y-表示的新型铑 - 膦配合物，其中对甲苯基BINAP表示2,2'-双（二对甲苯基膦基）-1,1'-联萘， 并描述Y表示ClO 4，PF 6，BF 4或PCl 6。 该络合物可用作各种有机合成的催化剂，也可用作不对称异构化反应和不对称氢化反应的不对称合成。 由于其活性高，络合物作为催化剂是非常有用的。

    Optical resolution of the racemic modification of 2,2'-bis(diphenylphosphino)-1,1'-binaphthyldioxide
    19.
    发明授权
    Optical resolution of the racemic modification of 2,2'-bis(diphenylphosphino)-1,1'-binaphthyldioxide 失效
    2,2'-双（二苯基膦基）-1,1'-二萘基二氧化物的外消旋改性的光学拆分

    公开(公告)号：US4564708A

    公开(公告)日：1986-01-14

    申请号：US582710

    申请日：1984-02-23

    申请人： Misao Yagi ,  Susumu Akutagawa

    发明人： Misao Yagi ,  Susumu Akutagawa

    IPC分类号： C07B57/00 ,  C07B31/00 ,  C07C67/00 ,  C07F9/53

    CPC分类号： C07F9/5329

    摘要： D-2,2'-bis(diphenylphosphino)-1,1'-binaphthyldioxide and 1-2,2'-bis(diphenylphosphino)-1,1'-binaphthyldioxide are produced by reacting d1-2,2'-bis(diphenylphosphino)-1,1'-binaphthyldioxide with optically active camphor-10-sulfonic acid or optically active 3-bromo-camphor-10-sulfonic acid as a resolving agent in a lower alkyl ester of acetic acid containing a lower alkyl carboxylic acid, thereby forming diastereomeric salts, and optically resolving said diastereomeric salts.

    摘要翻译： 通过使d1-2,2'-双（二苯基膦基）-1,1'-二萘基二氧化物和1-2,2'-双（二苯基膦基）-1,1'-二萘基二氧化物 二苯基膦基）-1,1'-二萘基二氧化物与光学活性樟脑-10-磺酸或光学活性3-溴 - 樟脑-10-磺酸作为拆分剂在含低级烷基羧酸的乙酸的低级烷基酯中， 从而形成非对映异构盐，并光学拆分所述非对映异构盐。