公开(公告)号：US5089481A

公开(公告)日：1992-02-18

申请号：US613971

申请日：1990-11-15

申请人： Shigeaki Muto ,  Koichi Niimura ,  Minoru Oohara ,  Yoshiharu Oguchi ,  Kenichi Matsunaga ,  Kunitaka Hirose ,  Junji Kakuchi ,  Norifumi Sugita ,  Takao Furusho ,  Chikao Yoshikumi ,  Masaaki Takahashi

发明人： Shigeaki Muto ,  Koichi Niimura ,  Minoru Oohara ,  Yoshiharu Oguchi ,  Kenichi Matsunaga ,  Kunitaka Hirose ,  Junji Kakuchi ,  Norifumi Sugita ,  Takao Furusho ,  Chikao Yoshikumi ,  Masaaki Takahashi

IPC分类号： A61K35/66 ,  A61K35/74 ,  A61K36/02 ,  A61K36/03 ,  A61K36/04 ,  A61K36/05 ,  A61K38/00 ,  C07K4/08 ,  C08B37/00 ,  C12P19/26 ,  C12P21/00

CPC分类号： C12P21/005 ,  A61K36/03 ,  A61K36/04 ,  A61K36/05 ,  C08B37/0087 ,  Y10S435/946 ,  Y10S514/885

摘要： Disclosed herein are polysaccharides extracted from marine algae and an antiviral drug containing as active ingredient polysaccharides extracted from seaweeds.

摘要翻译： 本文公开了从海藻提取的多糖和含有作为活性成分的从海藻提取的多糖的抗病毒药物。

公开(公告)号：US4985543A

公开(公告)日：1991-01-15

申请号：US207836

申请日：1988-06-17

申请人： Norifumi Sugita ,  Koichi Niimura ,  Yoshiharu Oguchi ,  Kunitaka Hirose ,  Kenichi Matsunaga ,  Minoru Oohara ,  Shigeaki Muto ,  Junji Kakuchi ,  Takao Furusho ,  Chikao Yoshikumi ,  Masaaki Takahashi

发明人： Norifumi Sugita ,  Koichi Niimura ,  Yoshiharu Oguchi ,  Kunitaka Hirose ,  Kenichi Matsunaga ,  Minoru Oohara ,  Shigeaki Muto ,  Junji Kakuchi ,  Takao Furusho ,  Chikao Yoshikumi ,  Masaaki Takahashi

IPC分类号： A61K36/00 ,  A61K36/07 ,  A61K36/18 ,  A61K36/36 ,  A61K36/47 ,  A61K36/48 ,  A61K38/00 ,  A61P31/12 ,  C07K1/14 ,  C07K14/415 ,  C07K14/42

CPC分类号： C07K14/42 ,  A61K36/36 ,  A61K36/47 ,  A61K36/48

摘要： Disclosed herein are lectins extracted form a plant of the class Dicotyledoneae and an antiretoviral drug comprising as an active ingredient an effective amount of the lectins.

公开(公告)号：US4820689A

公开(公告)日：1989-04-11

申请号：US898900

申请日：1986-08-22

申请人： Masanori Ikuzawa ,  Yoshiharu Oguchi ,  Kenichi Matsunaga ,  Noriyuki Toyoda ,  Takao Furusho ,  Takayoshi Fujii ,  Chikao Yoshikumi

发明人： Masanori Ikuzawa ,  Yoshiharu Oguchi ,  Kenichi Matsunaga ,  Noriyuki Toyoda ,  Takao Furusho ,  Takayoshi Fujii ,  Chikao Yoshikumi

IPC分类号： A61K38/00 ,  C07K14/375 ,  A61K37/02 ,  A61K35/70

CPC分类号： C07K14/375 ,  A61K38/00 ,  Y10S435/911

摘要： Disclosed herein is a pharmaceutical composition having antirheumatic activity, antithrombotic activity, analgetic activity, antipyretic activity, anti-hyperlipemic activity and anti-inflammatory activity and activities of reducing the level of blood sugar, raising the coronary blood flow, improving the capability of deformation of erythrocytes, reducing the blood pressure, ameliorating proteinuria and proteinemia and regulating production or metabolism of prostaglandins in a mammal in dosage unit form, which comprises a dosage effective to produce said activities of a glycoprotein having a molecular weight of 5000 to 300000 as determined by ultracentrifugal method and about 18 to 38% by weight of proteins, produced by culturing a basidiomycetous fungal species belonging to the genus Coriolus, extracting the thus proliferated mycelia or fruit bodies with hot water or aqueous alkali solution and removing low molecular weight substances having a molecular weight of less than 5000 from the extract.

摘要翻译： 本文公开了具有抗风湿活性，抗血栓活性，止痛活性，解热活性，抗高血脂活性和抗炎活性以及降低血糖水平的活性，提高冠状动脉血流量，提高变形能力的药物组合物 红细胞，降低血压，改善蛋白尿和蛋白血症，并以剂量​​单位形式调节哺乳动物中前列腺素的产生或代谢，其包括有效产生分子量为5000至300000的糖蛋白的活性的剂量，其通过超速离心 方法和约18〜38重量％的蛋白质，通过培养属于科氏菌属的嗜碱性真菌属真菌属物种，用热水或碱性水溶液提取如此增殖的菌丝体或果实体并除去分子量低的分子量物质 从不到5000 e提取。

公开(公告)号：US5008243A

公开(公告)日：1991-04-16

申请号：US285664

申请日：1988-12-16

申请人： Masanori Ikuzawa ,  Yoshiharu Oguchi ,  Kenichi Matsunaga ,  Noriyuki Toyoda ,  Takao Furusho ,  Takayoshi Fujii ,  Chikao Yoshikumi

发明人： Masanori Ikuzawa ,  Yoshiharu Oguchi ,  Kenichi Matsunaga ,  Noriyuki Toyoda ,  Takao Furusho ,  Takayoshi Fujii ,  Chikao Yoshikumi

IPC分类号： A61K38/00 ,  C07K14/375

CPC分类号： C07K14/375 ,  A61K38/00 ,  Y10S435/911

摘要： Disclosed herein is a pharmaceutical composition having antirheumatic activity, antithrombotic activity, analgetic activity, antipyretics activity, anti-hyperlipemic activity and anti-inflammatory activity and activities of reducing the level of blood sugar, raising the coronary blood flow, improving the capability of deformation of erythrocytes, reducing the blood pressure, ameliorating proteinuria and proteinemia and regulating production or metabolism of prostaglandins in a mammal in dosage unit form, which comprises a dosage effective to produce said activities of a glycoprotein having a molecular weight of 5000 to 300,000 as determined by ultracentrifugal method and about 18 to 38% by weight of proteins, produced by culturing a basidiomycetous fungal species belonging to the genus Coriolus, extracting the thus proliferated mycelia or fruit bodies with hot water or aqueous alkali solution and removing low molecular weight substances having a molecular weight of less than 5000 from the extract.

公开(公告)号：US4663438A

公开(公告)日：1987-05-05

申请号：US715816

申请日：1985-03-25

申请人： Chikao Yoshikumi ,  Takayoshi Fujii ,  Takao Furusho ,  Kenichi Matsunaga ,  Minoru Ohara ,  Akira Kobayashi

发明人： Chikao Yoshikumi ,  Takayoshi Fujii ,  Takao Furusho ,  Kenichi Matsunaga ,  Minoru Ohara ,  Akira Kobayashi

IPC分类号： C12P21/00 ,  A61K36/07 ,  A61K38/00 ,  A61P35/00 ,  C07K14/00 ,  C07K14/37 ,  C07K14/375 ,  C07K14/41 ,  C12N1/00 ,  C12P1/06 ,  C12P9/00 ,  C07K15/14

CPC分类号： C07K14/375 ,  A61K38/00

摘要： Disclosed herein is a nucleic acid-containing glycoprotein having molecular weight of 5,000 to 300,000 as determined by ultracentrifugal method; the weight ratio of protein moiety thereof determined by Lowry-Folin's method to saccharide moiety thereof determined by phenol-sulfuric acid method of in the range of 50/50 to 80/20; N-terminal amino acid thereof consisting essentially of tyrosine, leucine or alanine; leucine-phenylalanine-valine as amino acid sequence at C-terminal thereof; the elementary composition consisting essentially of 35.2 to 49.3% of C, 4.8 to 8.0% of H, 4.3 to 12.3% of N, trace to 2.5% of S, trace to 1.2% of P and the balance of O; the isoelectric point of in the range of pH 2.5 to 5.0; and nucleic acid as a component.

摘要翻译： 本文公开了通过超速离心法测定的分子量为5,000〜300,000的含核酸的糖蛋白; 通过Lowry-Folin法测定的蛋白质部分的重量比通过酚 - 硫酸法测定的糖部分在50/50至80/20范围内; 其N-末端氨基酸主要由酪氨酸，亮氨酸或丙氨酸组成; 亮氨酸 - 苯丙氨酸 - 缬氨酸作为C末端的氨基酸序列; 基本组成基本上由C的35.2至49.3％，H的4.8至8.0％，N的4.3至12.3％，S的2.5％，P的1.2％和O的余量组成。 等电点在2.5〜5.0的范围内; 和核酸作为组分。

公开(公告)号：US4673669A

公开(公告)日：1987-06-16

申请号：US786851

申请日：1985-10-11

申请人： Chikao Yoshikumi ,  Yoshio Ohmura ,  Fumio Hirose ,  Masanori Ikuzawa ,  Kenichi Matsunaga ,  Takayoshi Fujii ,  Minoru Ohhara ,  Takao Ando

发明人： Chikao Yoshikumi ,  Yoshio Ohmura ,  Fumio Hirose ,  Masanori Ikuzawa ,  Kenichi Matsunaga ,  Takayoshi Fujii ,  Minoru Ohhara ,  Takao Ando

IPC分类号： C07H15/203 ,  A61K31/70

CPC分类号： C07H15/203

摘要： Disclosed is a pharmaceutical composition containing an aminobenzoic acid derivative as an active ingredient represented by the following general formula: ##STR1## wherein .sup.1 R donotes one member selected from the group consisting of the residual groups formed by removing OH at 1(alpha) or 1(beta) position from arabinose, glucose, galactose and mannose, or a pharmaceutically acceptable salt thereof.

摘要翻译： 本发明公开了含有氨基苯甲酸衍生物作为活性成分的药物组合物，其由以下通式表示：其中，R 1表示选自由1（α）或1（α） β）位置，或其药学上可接受的盐。

公开(公告)号：US4657895A

公开(公告)日：1987-04-14

申请号：US772477

申请日：1985-09-04

申请人： Chikao Yoshikumi ,  Yoshio Ohmura ,  Fumio Hirose ,  Masanori Ikuzawa ,  Kenichi Matsunaga ,  Takayoshi Fujii ,  Minoru Ohhara ,  Takao Ando

发明人： Chikao Yoshikumi ,  Yoshio Ohmura ,  Fumio Hirose ,  Masanori Ikuzawa ,  Kenichi Matsunaga ,  Takayoshi Fujii ,  Minoru Ohhara ,  Takao Ando

IPC分类号： C07H15/203 ,  A61K31/70

CPC分类号： C07H15/203

摘要： Disclosed is a pharmaceutical composition containing p-aminobenzoic acid-N-L-rhamonoside or a pharmaceutically acceptable salt thereof as an active ingredient.

摘要翻译： 公开了含有对氨基苯甲酸-N-L-鼠李糖苷或其药学上可接受的盐作为活性成分的药物组合物。

公开(公告)号：US4569842A

公开(公告)日：1986-02-11

申请号：US352858

申请日：1982-02-26

申请人： Chikao Yoshikumi ,  Yoshio Ohmura ,  Fumio Hirose ,  Masanori Ikuzawa ,  Kenichi Matsunaga ,  Takayoshi Fujii ,  Minoru Ohhara ,  Takao Ando

发明人： Chikao Yoshikumi ,  Yoshio Ohmura ,  Fumio Hirose ,  Masanori Ikuzawa ,  Kenichi Matsunaga ,  Takayoshi Fujii ,  Minoru Ohhara ,  Takao Ando

IPC分类号： C07H15/203 ,  A61K31/70

CPC分类号： C07H15/203

摘要： Disclosed is a pharmaceutical composition containing an aminobenzoic acid derivative as an active ingredient represented by the following general formula: ##STR1## wherein .sup.1 R denotes one member selected from the group consisting of the residual groups formed by removing OH at 1(alpha) or 1(beta) position from arabinose, glucose, galactose and mannose, or a pharmaceutically acceptable salt thereof.

公开(公告)号：US4801581A

公开(公告)日：1989-01-31

申请号：US714354

申请日：1985-03-22

申请人： Chikao Yoshikumi ,  Yoshio Ohmura ,  Fumio Hirose ,  Masanori Ikuzawa ,  Kenichi Matsunaga ,  Takayoshi Fujii ,  Minoru Ohara ,  Takao Ando

发明人： Chikao Yoshikumi ,  Yoshio Ohmura ,  Fumio Hirose ,  Masanori Ikuzawa ,  Kenichi Matsunaga ,  Takayoshi Fujii ,  Minoru Ohara ,  Takao Ando

IPC分类号： C07H15/203 ,  A61K31/70

CPC分类号： C07H15/203

摘要： Disclosed is a pharmaceutical composition containing p-aminobenzoic acid-N-D-xyloside or a pharmaceutically a acceptable salt thereof as an active ingredient.

摘要翻译： 公开了含有对氨基苯甲酸-N-D-木糖苷或其药学上可接受的盐作为活性成分的药物组合物。

公开(公告)号：US4649133A

公开(公告)日：1987-03-10

申请号：US780211

申请日：1985-09-26

申请人： Chikao Yoshikumi ,  Yoshio Ohmura ,  Fumio Hirose ,  Masanori Ikuzawa ,  Kenichi Matsunaga ,  Takayoshi Fujii ,  Minoru Ohhara ,  Takao Ando

发明人： Chikao Yoshikumi ,  Yoshio Ohmura ,  Fumio Hirose ,  Masanori Ikuzawa ,  Kenichi Matsunaga ,  Takayoshi Fujii ,  Minoru Ohhara ,  Takao Ando

IPC分类号： C07H15/203 ,  A61K31/70

CPC分类号： C07H15/203

摘要： Disclosed is a method for the treatment of hyperglycemia, hyperlipemia, inflammatory diseases, pains due to the accentuation of central nerve, pyrexia due to the accentuation of central nerve or tumor, which comprises administering to a patient suffering therefrom a pharmaceutically effective amount of p-aminobenzoic acid-N-L-rhamnoside or a pharmaceutically acceptable salt thereof.

摘要翻译： 本发明公开了一种治疗高血糖症，高脂血症，炎症性疾病，由于中枢神经突出而引起的疼痛，由于中枢神经或肿瘤引起的发热，其包括向患有其的药物有效量的对 - 氨基苯甲酸-NL-鼠李糖苷或其药学上可接受的盐。