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公开(公告)号：US06596720B1
公开(公告)日：2003-07-22
申请号：US10111396
申请日：2002-05-03
IPC分类号： A61K31535
CPC分类号： A61K31/7072 , A61K31/506 , A61K31/513 , A61K45/06 , A61K2300/00
摘要： The present invention provides: an anti-HIV composition comprising at least one member selected from the group consisting of trifluridine and derivatives thereof, and a pharmaceutically acceptable carrier; an anti-HIV composition comprising (a) at least one member selected from the group consisting of trifluridine and derivatives thereof, (b) a thymidine phosphorylase inhibitor, and a pharmaceutically acceptable carrier; and a composition for potentiating the anti-HIV activity of trifluridine and derivatives thereof, comprising a thymidine phosphorylase inhibitor and a pharmaceutically acceptable carrier.
摘要翻译： 本发明提供：抗HIV组合物，其包含选自三氟尿苷及其衍生物中的至少一种和药学上可接受的载体;抗HIV组合物，其包含（a）至少一种选自以下的成员： 的三氟尿苷及其衍生物，（b）胸苷磷酸化酶抑制剂和药学上可接受的载体; 以及用于增强三氟尿苷及其衍生物的抗HIV活性的组合物，其包含胸苷磷酸化酶抑制剂和药学上可接受的载体。
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公开(公告)号：US4866337A
公开(公告)日：1989-09-12
申请号：US15378
申请日：1987-02-17
CPC分类号： H01J29/74
摘要： In an electromagnetic focusing electrostatic type image pick-up tube the electrostatic deflecting electrodes formed on the inner surface of the tube consist of 2 pairs of electrodes. Each of these electrostatic deflecting electrodes has a zig-zag shape from the electron gun towards the target. This zig-zag shape is twisted in the circumferential direction around the axis of the tube and variation rates of this twist amount are different, depending on the position in the axial direction.
摘要翻译： 在电磁聚焦静电型图像拾取管中，形成在管的内表面上的静电偏转电极由2对电极组成。 这些静电偏转电极中的每一个具有从电子枪朝向目标的之字形。 这种锯齿形状围绕管的轴线在圆周方向上扭曲，并且该扭转量的变化率根据轴向方向上的位置而不同。
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13.发明授权Cylindrical image pickup tube having electrostatic deflection electrodes formed of straight line pattern yokes 失效具有由直线图案轭形成的静电偏转电极的圆柱形图像拾取管
公开(公告)号：US4701668A
公开(公告)日：1987-10-20
申请号：US867155
申请日：1986-05-27
CPC分类号： H01J29/74
摘要： A magnetic focusing and electrostatic deflecting image pickup tube comprises electrostatic deflection electrodes each constituted by a straight arrow pattern yoke composed of straight line segments arrayed in a linear zigzag pattern. The pattern yoke has a twist angle set at a value not greater than 105.degree.. An average value of angles formed by each upper apex and two lower apices adjacent to the upper apex of the zigzag pattern yoke with reference to the axis of the tube lies within a range of 116.degree. to 127.degree..
摘要翻译： 磁聚焦和静电偏转图像拾取管包括静电偏转电极，每个静电偏转电极由以直线形之字形图案排列的直线段组成的直箭头图案磁轭构成。 图案磁轭的扭转角设定在105度以下。 相对于管的轴线，每个上顶点和相邻于之字形图形磁轭的上顶点的两个下顶点形成的角度的平均值在116°至127°的范围内。
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公开(公告)号：US4663560A
公开(公告)日：1987-05-05
申请号：US668844
申请日：1984-11-06
申请人： Kentaro Oku , Masakazu Fukushima
发明人： Kentaro Oku , Masakazu Fukushima
摘要： A magnetic focus and electrostatic deflection type image pick-up tube in which electrostatic deflection electrodes assuming a cylindrical shape as a whole are twisted about the axis of the cylinder at an angle selected so as to range from 21.degree. to 60.degree.. The spot of the electron beam is less enlarged in an oval shape at the corners of target in the imaging tube.
摘要翻译： 一种磁焦点和静电偏转型图像拾取管，其中呈圆柱形状的静电偏转电极整体以围绕气缸轴线的角度以21°至60°的角度被选定。 电子束的斑点在成像管中的靶的角落处以椭圆形较小的扩大。
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公开(公告)号：US4467243A
公开(公告)日：1984-08-21
申请号：US315869
申请日：1981-10-28
CPC分类号： H01J29/488
摘要： An electron gun is disclosed which includes a thermionic cathode for emitting an electron beam, a grid having a first aperture for controlling the diameter of the electron beam, and an anode having a second aperture for catching a part of the electron beam having passed through the first aperture; and in which the diameter of the first aperture is smaller than or equal to the diameter of the second aperture, and the grid and the anode are applied with positive potentials relative to a cathode potential, for example, with a voltage of 5 to tens of volts and a voltage of 100 to 500 volts, respectively, to form a uniform axial field between the grid and the anode, thereby generating a laminar flow electron beam having a constant current density.
摘要翻译： 公开了一种电子枪，其包括用于发射电子束的热离子阴极，具有用于控制电子束的直径的第一孔的栅格，以及具有用于捕获已通过电子束的电子束的一部分的第二孔的阳极 第一光圈; 并且其中第一孔的直径小于或等于第二孔的直径，并且栅极和阳极相对于阴极电位施加正电位，例如以5至几十的电压施加 伏特和100至500伏的电压，以在格栅和阳极之间形成均匀的轴向场，由此产生具有恒定电流密度的层流电子束。
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16.发明授权
公开(公告)号：US4354138A
公开(公告)日：1982-10-12
申请号：US192995
申请日：1980-10-02
CPC分类号： H01J29/566 , H01J29/46
摘要： A television camera tube with electrostatic focusing and magnetic deflection comprises in an cylindrical envelope a beam current control, a main lens section and a sixth grid in the form of a mesh electrode. The beam current control section includes a cathode, a first grid and a second grid with an electron beam limiting diaphragm in this order. The main lens section includes third, fourth and fifth grids in the form of cylindrical electrodes disposed in this order. Around the cylindrical envelope is mounted a magnetic deflection coil whose length along the envelope axis is 0.18 to 0.40 times the distance from the beam limiting diaphragm to the mesh electrode.
摘要翻译： 具有静电聚焦和磁偏转的电视摄像机管包括圆柱形外壳，光束电流控制，主透镜部分和网状电极形式的第六格栅。 束电流控制部分依次包括阴极，第一栅格和具有电子束限制膜的第二栅极。 主透镜部分包括依次布置的圆柱形电极形式的第三，第四和第五格栅。 在圆柱形外壳周围安装有磁偏转线圈，其沿着包络线的长度是从束限制膜片到网状电极的距离的0.18至0.40倍。
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公开(公告)号：US08148381B2
公开(公告)日：2012-04-03
申请号：US12306628
申请日：2007-06-28
申请人： Masakazu Fukushima
发明人： Masakazu Fukushima
IPC分类号： A01N43/54 , C07D239/42 , C07D401/04
CPC分类号： C07D403/06 , A61K31/513 , A61K31/7072
摘要： A radiation therapy potentiator, which, when employed in combination with cancer radiation therapy, can reduce radiation dose and can mitigate adverse effects, the radiation therapy potentiator containing, as an effective ingredient, a uracil derivative represented by formula (1) the substitutents of which are defined in the specification.
摘要翻译： 一种放射治疗增强剂，当与癌症放射治疗结合使用时，可以减少辐射剂量并减轻不良反应，该放射治疗增强剂含有作为有效成分的式（1）表示的尿嘧啶衍生物，其代用品为 在本说明书中定义。
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公开(公告)号：US20090286755A1
公开(公告)日：2009-11-19
申请号：US12306628
申请日：2007-06-28
申请人： Masakazu Fukushima
发明人： Masakazu Fukushima
IPC分类号： A61K31/7072 , C07D403/06 , A61K31/513 , A61P35/00
CPC分类号： C07D403/06 , A61K31/513 , A61K31/7072
摘要： To provide a radiation therapy potentiator, which, when employed in combination with cancer radiation therapy, can reduce radiation dose and can mitigate adverse effects.The invention provides a radiation therapy potentiator containing, as an effective ingredient, a uracil derivative represented by formula (1) (wherein R1 represents a halogen atom or a cyano group; and R2 represents a 4- to 8-membered heterocyclic group having 1 to 3 nitrogen atoms and optionally having as a substituent a lower alkyl group, an imino group, a hydroxyl group, a hydroxymethyl group, a methanesulfonyloxy group, or an amino group; an amidinothio group in which a hydrogen atom attached to a nitrogen atom may be substituted by a lower alkyl group; a guanidino group in which a hydrogen atom attached to a nitrogen atom may be substituted by a lower alkyl group or a cyano group; a lower alkylamidino group; or a 1-pyrrolidinylmethyl group) or a pharmaceutically acceptable salt thereof.
摘要翻译： 提供放射治疗增强剂，当与癌症放射治疗组合使用时，可以减少辐射剂量并减轻不良反应。 本发明提供一种放射治疗增效剂，其含有作为有效成分的式（1）表示的尿嘧啶衍生物（其中，R1表示卤素原子或氰基; R2表示具有1〜 3个氮原子，任选具有低级烷基，亚氨基，羟基，羟甲基，甲磺酰氧基或氨基作为取代基;其中与氮原子连接的氢原子可以是 被低级烷基取代;其中与氮原子连接的氢原子可以被低级烷基或氰基取代的胍基，低级烷基脒基或1-吡咯烷基甲基）或其药学上可接受的盐 其中。
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公开(公告)号：US06569634B1
公开(公告)日：2003-05-27
申请号：US09530453
申请日：2000-05-01
IPC分类号： G01N33574
CPC分类号： G01N33/573 , G01N2333/91011
摘要： This invention relates to a method for immunologically measuring human thymidylate synthase with an anti-human thymidylate synthase antibody, wherein as the antibody, at least an anti-human thymidylate synthase polyclonal antibody immobilized on an insoluble matrix is used; a method for evaluating sensitivity of cancer cells to a fluoropyrimidine antitumor drug from the results of the measurement by the measuring method; and a human thymidylate synthase measuring kit comprising an insoluble matrix with at least one anti-human thymidylate synthase polyclonal antibody immobilized thereon. By a simple immunological measuring method, human TS in a sample can be measured with high sensitivity.
摘要翻译： 本发明涉及一种用抗人胸苷酸合酶抗体免疫测定人胸苷酸合酶的方法，其中使用至少一种固定在不溶性基质上的抗人胸苷酸合酶多克隆抗体作为该抗体; 通过测量方法从测量结果评估癌细胞对氟嘧啶抗肿瘤药物的敏感性的方法; 和人胸苷酸合酶测定试剂盒，其包含固定有至少一种抗人胸苷酸合酶多克隆抗体的不溶性基质。 通过简单的免疫学测量方法，可以高灵敏度地测量样品中的人TS。
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20.发明授权Thiazolidinedione derivatives or salts thereof and pharmaceutical compositions containing the same 失效噻唑烷二酮衍生物或其盐和含有它们的药物组合物
公开(公告)号：US5990139A
公开(公告)日：1999-11-23
申请号：US655644
申请日：1996-05-30
申请人： Shingo Yano , Kazuo Ogawa , Masakazu Fukushima
发明人： Shingo Yano , Kazuo Ogawa , Masakazu Fukushima
IPC分类号： A61K31/425 , A61K31/44 , A61P3/08 , A61P3/10 , C07D207/26 , C07D207/27 , C07D231/12 , C07D233/32 , C07D233/54 , C07D401/04 , C07D403/04 , C07D417/12 , C07D417/14
CPC分类号： C07D207/27 , C07D231/12 , C07D233/32 , C07D233/56 , C07D233/64 , C07D401/04 , C07D403/04 , C07D417/12 , C07D417/14
摘要： This invention relates to a thiazolidinedione derivative represented by the following formula (1): ##STR1## wherein R.sup.1 and R.sup.2 individually represent H, a halogen atom, or a halogen-substituted or -unsubstituted lower alkyl or alkoxy group, and R.sup.1 and R.sup.2 may be coupled together to form a ring of an alkylenedioxy chain, X represents a nitrogen atom or a CH group, A represents a substituted or unsubstituted imidazolidinone, pyrrolidinone, imidazole or pyrazole ring, or a salt thereof; and a pharmaceutical composition containing the thiazolidinedione derivative or a salt thereof. The above compound has excellent blood sugar-lowering action and blood lipid-lowering action and is useful as a therapeutic agent for diabetes.
摘要翻译： 本发明涉及由下式（1）表示的噻唑烷二酮衍生物：其中R1和R2分别表示H，卤素原子或卤素取代或取代的低级烷基或烷氧基，R1和R2可以连接在一起 形成亚烷基二氧基环的环，X表示氮原子或CH基团，A表示取代或未取代的咪唑啉酮，吡咯烷酮，咪唑或吡唑环或其盐; 和含有噻唑烷二酮衍生物或其盐的药物组合物。 上述化合物具有优异的降血糖作用和降血脂作用，可用作糖尿病治疗剂。
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