公开(公告)号：US08403306B2

公开(公告)日：2013-03-26

申请号：US12725708

申请日：2010-03-17

申请人： Stefan Stahl ,  Corinne Keiser ,  Jochen Ganz ,  Adrian Burri

发明人： Stefan Stahl ,  Corinne Keiser ,  Jochen Ganz ,  Adrian Burri

IPC分类号： B01F3/04

CPC分类号： A47J31/4489

摘要： A device for foaming liquid foods in a container, particularly milk, is provided having a vapor generator for generating vapors, particularly steam, and a vapor lance to be at least partially inserted into the container, with the vapor lance being connected to the vapor generator in a fluid-guiding fashion and including at least one vapor outlet opening such that steam can be discharged from the vapor generator via the vapor lance out of the vapor outlet opening. The device further includes at least one motion element which is connected to the vapor lance and/or a holder for the container such that the vapor lance and the container are movable relative to each other via the motion element.

摘要翻译： 提供了一种用于在容器，特别是牛奶中发泡液体食品的装置，其具有用于产生蒸气，特别是蒸汽的蒸汽发生器和至少部分地插入容器中的蒸汽喷枪，其中蒸气喷枪连接到蒸气发生器 以流体引导方式并且包括至少一个蒸汽出口开口，使得蒸汽可以经由蒸汽喷枪从蒸汽出口开口从蒸气发生器排出。 该装置还包括至少一个运动元件，其连接到蒸汽喷枪和/或用于容器的保持器，使得蒸汽喷枪和容器可以经由运动元件相对于彼此移动。

公开(公告)号：US20100237517A1

公开(公告)日：2010-09-23

申请号：US12725708

申请日：2010-03-17

申请人： Stefan Stahl ,  Corinne Keiser ,  Jochen Ganz ,  Adrian Burri

发明人： Stefan Stahl ,  Corinne Keiser ,  Jochen Ganz ,  Adrian Burri

IPC分类号： B01F3/04

CPC分类号： A47J31/4489

摘要： A device for foaming liquid foods in a container, particularly milk, is provided having a vapor generator for generating vapors, particularly steam, and a vapor lance to be at least partially inserted into the container, with the vapor lance being connected to the vapor generator in a fluid-guiding fashion and including at least one vapor outlet opening such that steam can be discharged from the vapor generator via the vapor lance out of the vapor outlet opening. The device further includes at least one motion element which is connected to the vapor lance and/or a holder for the container such that the vapor lance and the container are movable relative to each other via the motion element.

摘要翻译： 提供了一种用于在容器，特别是牛奶中发泡液体食品的装置，其具有用于产生蒸气，特别是蒸汽的蒸汽发生器和至少部分地插入容器中的蒸汽喷枪，其中蒸气喷枪连接到蒸气发生器 以流体引导方式并且包括至少一个蒸汽出口开口，使得蒸汽可以经由蒸汽喷枪从蒸汽出口开口从蒸气发生器排出。 该装置还包括至少一个运动元件，其连接到蒸汽喷枪和/或用于容器的保持器，使得蒸汽喷枪和容器可以经由运动元件相对于彼此移动。

公开(公告)号：US5434290A

公开(公告)日：1995-07-18

申请号：US203022

申请日：1994-02-28

申请人： Stefan Stahl ,  Wolfgang Harder ,  Arthur Hoehn

发明人： Stefan Stahl ,  Wolfgang Harder ,  Arthur Hoehn

IPC分类号： B01J31/20 ,  C07B61/00 ,  C07C253/30 ,  C07C255/19

CPC分类号： C07C255/19 ,  C07C253/30

摘要： Preparation of 5-cyanovalerates (I) by the carbonylation of a 1-cyanobutene with carbon monoxide and an alkanol (II) corresponding to the ester radical at an elevated temperature and under superatmospheric pressure in the presence of a cobalt catalyst as well as in the presence of an activating solvent, in which the activating solvent used is an effective amount of a carbonic diester, a carbamate, or a urea of the general formula IIIa, IIIb, or IIIcR--O--CO--O--R (IIIa)R.sub.2 N--CO--O--R (IIIb)R.sub.2 N--CO--NR.sub.2 (IIIc)or a mixture of these compounds (R's same or different, C.sub.1 -C.sub.6 alkyl, C.sub.5 -C.sub.7 cycloalkyl groups or together form 5-membered to 7-membered rings).The end products I serve as intermediates, chiefly for the preparation of .epsilon.-caprolactam.

摘要翻译： 在钴催化剂存在下，在升高的温度和超大气压下，通过与一氧化碳和对应于酯基的链烷醇（II）的1-氰基丁腈的羰基化制备5-氰基戊酸酯（I） 活化溶剂的存在，其中使用的活化溶剂是有效量的通式IIIa，IIIb或IIIc的CO 2二酯，氨基甲酸酯或脲，RO-CO-OR（IIIa）R2N-CO-OR （IIIb）R2N-CO-NR2（IIIc）或这些化合物的混合物（R相同或不同，C1-C6烷基，C5-C7环烷基或一起形成5元至7员环）。 最终产品我作为中间体，主要用于制备ε-己内酰胺。

公开(公告)号：US09182169B2

公开(公告)日：2015-11-10

申请号：US12836824

申请日：2010-07-15

申请人： Stefan Stahl ,  Mariano Turi ,  Heinz Vetterli

发明人： Stefan Stahl ,  Mariano Turi ,  Heinz Vetterli

IPC分类号： A47J31/057 ,  A47J31/44 ,  F25D31/00

CPC分类号： F25D31/005 ,  A47J31/44

摘要： The invention relates to a device (1, 10) for the production of cooled coffee, comprising a brewing unit (4) for the production of coffee, a cooling assembly (11) and a coffee cooler (14) formed as a heat exchanger, wherein the coffee cooler (14) has at least one first and one second flow path that are connected thermally but not in a fluid-conducting manner, wherein a coolant can flow through the first flow path and the second flow path is connected in a fluid-conducting manner with a coffee outlet (5) of the brewing unit (4). It is essential that the device furthermore has a fresh-water supply (2) and a fresh-water cooler (13) formed as an additional heat exchanger, wherein the fresh-water cooler (13) has at least one first and one second flow path that are connected thermally but not in a fluid conducting manner and the fresh-water supply (2) is connected in a fluid-conducting manner downstream with the second flow path of the fresh-water cooler (13), further downstream with the first flow path of the coffee cooler (14), and further downstream with the brewing unit (4) and the first flow path of the fresh-water cooler (13) is connected in a fluid-conducting manner with a coolant circuit of the cooling assembly. The invention further relates to a method for the production of cooled coffee.

摘要翻译： 本发明涉及用于生产冷咖啡的装置（1,10），其包括用于生产咖啡的冲泡单元（4），形成为热交换器的冷却组件（11）和咖啡冷却器（14） 其中所述咖啡冷却器（14）具有至少一个第一和第二第二流动路径，所述至少一个第一和第二流动路径热连接但不以流体传导方式连接，其中冷却剂可以流过所述第一流动路径，并且所述第二流动路径连接在流体 与酿造单元（4）的咖啡出口（5）进行导通。 重要的是，该装置还具有作为另外的热交换器形成的淡水供应源（2）和淡水冷却器（13），其中所述淡水冷却器（13）具有至少一个第一和第二流 路径，其热连接但不以流体传导方式连接，并且淡水供应源（2）以流体导通的方式与淡水冷却器（13）的第二流动路径下游连接，在下游具有第一 咖啡冷却器（14）的流动路径以及进一步下游的冲泡单元（4）和淡水冷却器（13）的第一流动路径以流体传导方式连接到冷却组件的冷却剂回路 。 本发明还涉及一种生产冷咖啡的方法。

公开(公告)号：US20140178301A1

公开(公告)日：2014-06-26

申请号：US14055443

申请日：2013-10-16

申请人： Fredrik Nilsson ,  Tove Eriksson ,  Andreas Jonsson ,  Stefan Stahl ,  Mikaela Friedman

发明人： Fredrik Nilsson ,  Tove Eriksson ,  Andreas Jonsson ,  Stefan Stahl ,  Mikaela Friedman

IPC分类号： A61K51/08 ,  A61K49/14

CPC分类号： A61K51/088 ,  A61K38/1808 ,  A61K49/14 ,  C07K14/31 ,  C07K14/485 ,  C07K2319/20 ,  C07K2319/21 ,  C07K2319/22

摘要： This invention relates to polypeptides which bind to EGFR family receptors and to applications of those polypeptides in medicine, veterinary medicine, diagnosis, diagnostics, and imaging.

摘要翻译： 本发明涉及结合EGFR家族受体的多肽以及这些多肽在医药，兽医学，诊断，诊断和成像中的应用。

公开(公告)号：US08598113B2

公开(公告)日：2013-12-03

申请号：US13549588

申请日：2012-07-16

申请人： Fredrik Nilsson ,  Tove Eriksson ,  Andreas Jonsson ,  Stefan Stahl ,  Mikaela Friedman

发明人： Fredrik Nilsson ,  Tove Eriksson ,  Andreas Jonsson ,  Stefan Stahl ,  Mikaela Friedman

IPC分类号： A61K38/22 ,  C07K14/485

CPC分类号： A61K51/088 ,  A61K38/1808 ,  A61K49/14 ,  C07K14/31 ,  C07K14/485 ,  C07K2319/20 ,  C07K2319/21 ,  C07K2319/22

摘要： This invention relates to polypeptides which bind to EGFR family receptors and to applications of those polypeptides in medicine, veterinary medicine, diagnosis diagnostics and imaging.

公开(公告)号：US20120304983A1

公开(公告)日：2012-12-06

申请号：US13519641

申请日：2010-12-24

申请人： Jochen Ganz ,  Josefine Lacour ,  Alexander Panos ,  Stefan Stahl

发明人： Jochen Ganz ,  Josefine Lacour ,  Alexander Panos ,  Stefan Stahl

IPC分类号： A61M11/00 ,  A24F47/00 ,  B65D83/00

CPC分类号： B05B11/0078 ,  B05B11/0044 ,  B05B11/0081 ,  B05B11/3001 ,  B05B11/3052 ,  B05B11/3081 ,  B05B11/3083 ,  B05B15/30

摘要： A container for holding and dispensing a liquid and/or dissolved active substance, for example a pharmaceutical or cosmetic active substance, has at least one dispensing organ (5) for dispensing, preferably in a portioned manner, the one active substance. Provision is also made for at least two holding chambers (9, 11) separated from one another, at least one of which contains the one active substance and at least one of which contains an at least largely active-substance-free liquid and/or a further active substance differing from the one active substance, wherein the dispensing organ is connected to the at least one chamber containing the active substance for dispensing purposes.

摘要翻译： 用于保持和分配液体和/或溶解的活性物质（例如药物或化妆品活性物质）的容器具有至少一个分配器官（5），优选以一种分配方式分配一种活性物质。 还提供了至少两个彼此分离的保持室（9,11），其中至少一个包含一种活性物质，并且其中至少一种含有至少主要不含活性物质的液体和/或 另一种不同于一种活性物质的活性物质，其中分配器官连接至含有活性物质的至少一个室，用于分配目的。

公开(公告)号：US20100048868A1

公开(公告)日：2010-02-25

申请号：US10563310

申请日：2004-06-30

申请人： Jorgen Carlsson ,  Stefan Stahl ,  Tove Eriksson ,  Elin Gunneriusson ,  Fredrik Nilsson

发明人： Jorgen Carlsson ,  Stefan Stahl ,  Tove Eriksson ,  Elin Gunneriusson ,  Fredrik Nilsson

IPC分类号： C07K14/705 ,  C07K14/31 ,  C12N1/21 ,  A61K38/16 ,  C07H21/04 ,  C12P21/06

CPC分类号： C07K14/31 ,  A61K38/00 ,  C07K2319/20 ,  C07K2319/21 ,  C07K2319/22

摘要： A polypeptide is provided, which has a binding affinity for HER2 and which is related to a domain of staphylococcal protein A (SPA) in that the sequence of the polypeptide corresponds to the sequence of the SPA domain having from 1 to about 20 substitution mutations. Nucleic acid encoding the polypeptide, as well as expression vector and host cell for expressing the nucleic acid, are also provided. Also provided is the use of such a polypeptide as a medicament, and as a targeting agent for directing substances conjugated thereto to cells overexpressing HER2. Methods, and kits for performing the methods, are also provided, which methods and kits rely on the binding of the polypeptide to HER2.

摘要翻译： 提供了多肽，其具有对HER2的结合亲和力，并且其与葡萄球菌蛋白A（SPA）的结构域相关，因为多肽的序列对应于具有1至约20个取代突变的SPA结构域的序列。 还提供了编码多肽的核酸，以及用于表达核酸的表达载体和宿主细胞。 还提供了作为药物的这种多肽的用途，以及用于将与其缀合的物质引导至过表达HER2的细胞的靶向剂。 还提供了用于进行方法的方法和试剂盒，哪些方法和试剂盒依赖于多肽与HER2的结合。

公开(公告)号：US06574640B1

公开(公告)日：2003-06-03

申请号：US09638780

申请日：2000-08-15

申请人： Stefan Stahl

发明人： Stefan Stahl

IPC分类号： G06F1730

CPC分类号： G06F17/30011 ,  Y10S707/99953 ,  Y10S707/99955

摘要： The present invention relates to flexible facilities for supplying documents where the index to the documents is stored in a central archive but the documents themselves are stored in an external archiving system. The solution according to the invention is based on management of the addresses in the external archiving systems which is undertaken at the central archive. The approach adopted supports the specifying of any desired number of backup servers and, by allowing the configurable supply either of the address relation itself and/or of server address information attached to the list of search results, it provides a facility which supports the full range of document supply capabilities available when a central archive system is being used.

摘要翻译： 本发明涉及用于提供文档的索引的文档的灵活设施，其中文档的索引被存储在中央归档中，但文档本身存储在外部存档系统中。 根据本发明的解决方案是基于在中央归档中进行的外部归档系统中的地址的管理。 所采用的方法支持指定任何所需数量的备份服务器，并且通过允许可配置的供应地址关系本身和/或附加到搜索结果列表的服务器地址信息，它提供了支持全范围的设施 当使用中央归档系统时，文档供应能力可用。

公开(公告)号：US5264580A

公开(公告)日：1993-11-23

申请号：US39573

申请日：1993-03-23

申请人： Volker Maywald ,  Thomas Kuekenhoehner ,  Peter Muenster ,  Stefan Stahl

发明人： Volker Maywald ,  Thomas Kuekenhoehner ,  Peter Muenster ,  Stefan Stahl

IPC分类号： C07D261/18 ,  C97D261/08

CPC分类号： C07D261/18

摘要： A process for preparing isoxazole-3,4-dicarboxylic acid derivatives of the formula I ##STR1## where R.sup.1 is hydrogen, alkyl, cycloalkyl or phenyl, or a 5- to 6-membered heterocyclic radical, and the organic radicals can have substituents which are inert under the reaction conditions;R.sup.2 is hydrogen, alkyl, cycloalkyl, benzyl or C.sub.3 -C.sub.6 -alkenyl;A is NR.sup.3 R.sup.4 where R.sup.3 is hydrogen or an aliphatic or cycloaliphatic radical and R.sup.4 is an aliphatic or cycloaliphatic radical or unsubstituted or substituted phenyl, or R.sup.3 forms together with R.sup.4 a 4- to 7-membered alkylene chain which can be interrupted by oxygen, sulfur or N-methyl, or is OR.sup.5 where R.sup.5 is alkyl, cycloalkyl, benzyl or alkenyl;by deprotonation of a CH-acid compound of the formula II ##STR2## using a base and reacting with hydroximyl chlorides of the formula III ##STR3## wherein a magnesium alcoholate of the formula IVMg(OR.sup.6 ).sub.2 IVwhere R.sup.6 is an aliphatic or cycloaliphatic radical is used for the deprotonation.

摘要翻译： 制备式I的异恶唑-3,4-二羧酸衍生物，其中R1是氢，烷基，环烷基或苯基，或5-至6-元杂环基，并且有机基团可以具有取代基 在反应条件下是惰性的; R2是氢，烷基，环烷基，苄基或C3-C6-烯基; A是NR 3 R 4，其中R 3是氢或脂族或脂环族基团，R 4是脂族或脂环族基团或未取代或取代的苯基，或R 3与R 4一起形成可被氧，硫中断的4-至7-元亚烷基链 或N-甲基，或是OR 5，其中R 5是烷基，环烷基，苄基或烯基; 通过使用碱将式II II的CH-酸化合物去质子化，并与式III的氢氯化物反应，其中式IV的醇镁盐（OR 6）2 IV，其中R 6是 脂肪族或脂环族基团用于去质子化。