公开(公告)号：US20070292301A1

公开(公告)日：2007-12-20

申请号：US10599298

申请日：2005-03-09

Applicant: Francisco Fernandez ,  Miren Iniguez ,  Stephen Mitchell

Inventor： Francisco Fernandez ,  Miren Iniguez ,  Stephen Mitchell

IPC: C22C38/00 ,  B22F3/12 ,  C22C33/02

CPC classification number: C22C33/0207 ,  B22F2003/023 ,  B22F2003/145 ,  B22F2999/00 ,  B22F1/0003 ,  B22F9/082

Abstract: A method of making high-density (>7.0 g/ml) sintered iron-based alloy parts by using boron-containing Master Alloys comprises the steps of mixing an atomised, boron-containing master alloy powder, or a plurality of master alloy powders at least one of which is boron-containing, with a conventional iron or iron alloy powder; optionally adding graphite and a lubricant in conventional amounts as used in powder metallurgy technology; and pressing and sintering the mix to an increased density, preferably in a reducing, inert or vacuum atmosphere at 1050 to 1300° C., to produce the part required. The invention also includes parts produced by the above defined method.

Abstract translation: 通过使用含硼母合金制备高密度（> 7.0g / ml）烧结铁基合金部件的方法包括以下步骤：将雾化的含硼母合金粉末或多种母合金粉末混合在 其中至少一种是含硼的，具有常规的铁或铁合金粉末; 任选地添加用于粉末冶金技术的常规量的石墨和润滑剂; 并将混合物压制和烧结至增加的密度，优选在还原惰性或真空气氛中在1050至1300℃下，以产生所需的部分。 本发明还包括通过上述方法制备的部件。

公开(公告)号：US20070098729A1

公开(公告)日：2007-05-03

申请号：US11546008

申请日：2006-10-10

Applicant: Daniel Afar ,  Rene Hubert ,  Arthur Raitano ,  Douglas Saffran ,  Stephen Mitchell

Inventor： Daniel Afar ,  Rene Hubert ,  Arthur Raitano ,  Douglas Saffran ,  Stephen Mitchell

IPC: A61K39/395 ,  C07H21/04 ,  C12P21/06 ,  C07K16/46 ,  C07K16/30 ,  C07K14/82

CPC classification number: C07K16/30 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/505 ,  C07K14/705 ,  C07K14/82 ,  C07K16/3038 ,  C07K16/3069 ,  C07K2317/34 ,  C07K2319/00 ,  C07K2319/30 ,  C12N2799/027 ,  G01N33/57434 ,  Y10S435/975

Abstract: Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed “STEAP” (Six Transmembrane Epithelial Antigen of the Prostate). Four particular human STEAPs are described and characterized herein. The human STEAPs exhibit a high degree of structural conservation among them but show no significant structural homology to any known human proteins. The prototype member of the STEAP family, STEAP-1, appears to be a type IIIa membrane protein expressed predominantly in prostate cells in normal human tissues. Structurally, STEAP-1 is a 339 amino acid protein characterized by a molecular topology of six transmembrane domains and intracellular N- and C-termini, suggesting that it folds in a “serpentine” manner into three extracellular and two intracellular loops. STEAP-1 protein expression is maintained at high levels across various stages of prostate cancer. Moreover, STEAP-1 is highly over-expressed in certain other human cancers.

公开(公告)号：US20060102419A1

公开(公告)日：2006-05-18

申请号：US10987606

申请日：2004-11-12

Applicant: Stephen Mitchell ,  Jay Benson ,  Glen Royal

Inventor： Stephen Mitchell ,  Jay Benson ,  Glen Royal

IPC: G10K11/04 ,  E04B1/82 ,  E04B2/02 ,  E04B1/00 ,  E04B9/00

CPC classification number: F02C7/24 ,  E04B1/8218 ,  E04B2001/748 ,  E04B2001/8461 ,  F02K1/827 ,  F05D2260/96 ,  F23M20/005

Abstract: An enclosure for apparatus that, during operation, generates heat and/or sound energy comprises at least one wall defining at least a portion of the enclosure hollow interior. The wall comprises in sequence outwardly from the enclosure hollow interior an inner panel, an outer panel, a support frame between the inner and outer panels to hold the inner and outer panels spaced apart, and a vibrator isolator between the support frame and the panels. Panels or panel segments of the wall primarily are made of non-metallic composites to provide a structurally strong, lightweight enclosure that includes enhanced acoustic characteristics and reduced heat transfer through enclosure walls, along with fire protection and in-plane shear loading capabilities.

Abstract translation: 一种用于在操作期间产生热和/或声能的装置的外壳，包括限定所述外壳中空内部的至少一部分的至少一个壁。 所述壁从所述封闭空间内部向外包括内板，外板，在所述内板和外板之间的支撑框架，以将所述内板和外板间隔开，以及在所述支撑框架和所述板之间的振动隔离器。 壁的面板或面板主要由非金属复合材料制成，以提供结构坚固，重量轻的外壳，其包括增强的声学特性和减少的通过外壳壁的热传递，以及防火和平面内的剪切加载能力。

公开(公告)号：US20050063975A1

公开(公告)日：2005-03-24

申请号：US10752421

申请日：2004-01-05

Applicant: Daniel Afar ,  Rene Hubert ,  Arthur Raitano ,  Douglas Saffran ,  Stephen Mitchell

Inventor： Daniel Afar ,  Rene Hubert ,  Arthur Raitano ,  Douglas Saffran ,  Stephen Mitchell

IPC: A61K38/00 ,  A61K39/00 ,  C07K14/705 ,  C07K16/30 ,  C12Q1/68 ,  A61K39/395 ,  C07H21/04 ,  G01N33/574

CPC classification number: C07K16/30 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/505 ,  C07K14/705 ,  C07K14/82 ,  C07K16/3038 ,  C07K16/3069 ,  C07K2317/34 ,  C07K2319/00 ,  C07K2319/30 ,  C12N2799/027 ,  G01N33/57434 ,  Y10S435/975

Abstract: Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed “STEAP” (Six Transmembrane Epithelial Antigen of the Prostate). Four particular human STEAPs are described and characterized herein. The human STEAPs exhibit a high degree of structural conservation among them but show no significant structural homology to any known human proteins. The prototype member of the STEAP family, STEAP-1, appears to be a type IIIa membrane protein expressed predominantly in prostate cells in normal human tissues. Structurally, STEAP-1 is a 339 amino acid protein characterized by a molecular topology of six transmembrane domains and intracellular N- and C-termini, suggesting that it folds in a “serpentine” manner into three extracellular and two intracellular loops. STEAP-1 protein expression is maintained at high levels across various stages of prostate cancer. Moreover, STEAP-1 is highly over-expressed in certain other human cancers.

Abstract translation: 描述了一种新型的细胞表面蛇纹石跨膜抗原家族。 该家族中的两个蛋白质完全或主要地在前列腺中表达，也包括在前列腺癌中，因此该家族成员被称为“STEAP”（前列腺的六跨膜上皮抗原）。 本文描述和表征了四种特定的人STEAP。 人类STEAP在其中表现出高度的结构保守性，但与任何已知的人类蛋白质没有显着的结构同源性。 STEAP家族的原型成员STEAP-1似乎是主要在正常人体组织中的前列腺细胞中表达的IIIa型膜蛋白。 在结构上，STEAP-1是一种339个氨基酸的蛋白质，其特征在于六个跨膜结构域和细胞内N-和C-末端的分子拓扑结构，表明它以“蛇纹石”的方式折叠成三个胞外和两个细胞内环。 STEAP-1蛋白表达在前列腺癌的各个阶段保持在高水平。 此外，STEAP-1在某些其他人类癌症中高度过度表达。

公开(公告)号：US20080280684A1

公开(公告)日：2008-11-13

申请号：US11828019

申请日：2007-07-25

Applicant: Susan McBride ,  Stephen Mitchell

Inventor： Susan McBride ,  Stephen Mitchell

IPC: A63F9/24

CPC classification number: A63F13/31 ,  A63F9/24 ,  A63F13/12 ,  A63F13/235 ,  A63F13/335 ,  A63F13/35 ,  A63F13/825 ,  A63F13/92 ,  A63F2009/2457 ,  A63F2300/204 ,  A63F2300/405 ,  A63F2300/407 ,  A63F2300/5533 ,  A63F2300/5553

Abstract: An electronic game for playing on a portable handheld game unit and on-line includes a dynamic animated virtual character that can be customized and updated both visually and functionally through game play and that can translate from a two dimensional visual presentation on a game unit to a higher order visual presentation in an interactive multi-player virtual world on-line and back while retaining any customization or upgrades is provided. Different versions of the electronic game produce different virtual characters that can interact on-line or through wireless linkage between game units.

Abstract translation: 一种用于在便携式手持游戏单元上播放的电子游戏，包括动态的动画虚拟角色，其可以在视觉上和功能上通过游戏进行定制和更新，并且可以从游戏单元上的二维视觉呈现转换为 提供了在互动式多玩家虚拟世界中的在线和背面的高阶视觉呈现，同时保留任何定制或升级。 电子游戏的不同版本产生不同的虚拟角色，可以在线或通过游戏单元之间的无线连接互动。

公开(公告)号：US20070256126A1

公开(公告)日：2007-11-01

申请号：US11404299

申请日：2006-04-14

Applicant: Craig Erickson ,  Stephen Mitchell

Inventor： Craig Erickson ,  Stephen Mitchell

IPC: H04L9/32

CPC classification number: H04N7/163 ,  G06F21/34 ,  G06F21/35 ,  H04L63/0428 ,  H04L63/10 ,  H04N7/17318 ,  H04N21/25875 ,  H04N21/42204 ,  H04N21/441 ,  H04N21/6125

Abstract: The invention is a method, system, and apparatus providing access to media content via an internet-like connection, such as television programming, games. A paired remote control and dongle can connected via an intermediary computer and the internet to a remote director. The dongle contains an access code, which may include an identification code and/or password. In response to receiving the access code from the dongle, the remote director provides the dongle and/or intermediary computer with access to the requested media content. The dongle may provide the access code only in response to an appropriate query. The appropriate query may be provided by the remote director and/or intermediary computer.

Abstract translation: 本发明是一种通过诸如电视节目，游戏等因特网连接提供对媒体内容的访问的方法，系统和装置。 配对的遥控器和加密狗可以通过中间电脑和互联网连接到遥控器。 加密狗包含一个访问代码，其中可能包含一个识别码和/或密码。 响应于从加密狗接收到访问代码，远程控制器向加密狗和/或中介计算机提供对所请求的媒体内容的访问。 加密狗只能在适当的查询响应中提供访问代码。 适当的查询可由遥控器和/或中间计算机提供。

公开(公告)号：US20070194599A1

公开(公告)日：2007-08-23

申请号：US11678631

申请日：2007-02-26

Applicant: Gordon Paton ,  Stephen Mitchell

Inventor： Gordon Paton ,  Stephen Mitchell

IPC: B60J5/00

CPC classification number: B60J5/101 ,  E05F1/1058 ,  E05F1/1083 ,  E05F15/622 ,  E05Y2201/434 ,  E05Y2201/72 ,  E05Y2800/242 ,  E05Y2900/546 ,  E05Y2900/548

Abstract: An electromechanical strut is provided for moving a pivotal lift gate between an open position and a closed position relative to a motor vehicle body. The electromechanical strut includes a housing connected to one of the lift gate and the motor vehicle body. An extensible shaft is slidably mounted to the housing. The extensible shaft is connected to the other of the lift gate and the motor vehicle body. A drive mechanism includes a rotatable power screw. The drive mechanism converts rotary motion of the power screw into linear motion of the extensible shaft to move the extensible shaft between a retracted position corresponding to the closed position of the lift gate and an extended position corresponding to the open position of the lift gate. A power spring includes one end connected to the extensible shaft and another end connected to the housing for providing a mechanical counterbalance to the weight of the lift gate.

Abstract translation: 提供了一种机电支柱，用于使枢转升降门相对于机动车体在打开位置和关闭位置之间移动。 机电支柱包括连接到提升门和机动车体之一的壳体。 可伸缩轴可滑动地安装在壳体上。 可伸长轴连接到提升门和机动车体中的另一个。 驱动机构包括可旋转的动力螺钉。 驱动机构将动力螺杆的旋转运动转换成可延伸轴的直线运动，以使可延伸轴在对应于提升门的关闭位置的缩回位置和对应于提升门的打开位置的延伸位置之间移动。 动力弹簧包括连接到可延伸轴的一端和连接到壳体的另一端，用于提供对升降门重量的机械平衡。

公开(公告)号：US20070134253A1

公开(公告)日：2007-06-14

申请号：US11647988

申请日：2006-12-29

Applicant: Daniel Afar ,  Rene Hubert ,  Atthur Raitano ,  Douglas Saffran ,  Stephen Mitchell

Inventor： Daniel Afar ,  Rene Hubert ,  Atthur Raitano ,  Douglas Saffran ,  Stephen Mitchell

IPC: A61K48/00 ,  C12Q1/68 ,  G01N33/574 ,  C07H21/04 ,  C12P21/06 ,  A61K39/395 ,  A61K39/00

CPC classification number: C07K16/30 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/505 ,  C07K14/705 ,  C07K14/82 ,  C07K16/3038 ,  C07K16/3069 ,  C07K2317/34 ,  C07K2319/00 ,  C07K2319/30 ,  C12N2799/027 ,  G01N33/57434 ,  Y10S435/975

Abstract: Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed “STEAP” (Six Transmembrane Epithelial Antigen of the Prostate). Four particular human STEAPs are described and characterized herein. The human STEAPs exhibit a high degree of structural conservation among them but show no significant structural homology to any known human proteins. The prototype member of the STEAP family, STEAP-1, appears to be a type IIIa membrane protein expressed predominantly in prostate cells in normal human tissues. Structurally, STEAP-1 is a 339 amino acid protein characterized by a molecular topology of six transmembrane domains and intracellular N- and C-termini, suggesting that it folds in a “serpentine” manner into three extracellular and two intracellular loops. STEAP-1 protein expression is maintained at high levels across various stages of prostate cancer. Moreover, STEAP-1 is highly over-expressed in certain other human cancers.

公开(公告)号：US20070104720A1

公开(公告)日：2007-05-10

申请号：US11580538

申请日：2006-10-12

Applicant: Daniel Afar ,  Rene Hubert ,  Kahan Leong ,  Arthur Raitano ,  Douglas Saffran ,  Stephen Mitchell

Inventor： Daniel Afar ,  Rene Hubert ,  Kahan Leong ,  Arthur Raitano ,  Douglas Saffran ,  Stephen Mitchell

IPC: A61K39/395 ,  C07H21/04 ,  C12P21/06 ,  C07K14/82 ,  C07K16/30 ,  C07K16/46

CPC classification number: C07K14/4748 ,  C07K14/705 ,  C07K14/723 ,  C07K16/28 ,  C07K16/3069 ,  C07K2317/34 ,  C07K2319/00 ,  Y10T436/143333

Abstract: Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed “STEAP” (SIX Transmembrane Epithelial Antigens of the Prostate). Four particular human STEAPs are described and characterized herein. The human STEAPs exhibit a high degree of structural conservation among them but show no significant structural homology to any known human proteins. The prototype member of the STEAP family, STEAP-1, appears to be a type IIIa membrane protein expressed predominantly in prostate cells in normal human tissues. Structurally, STEAP-1 is a 339 amino acid protein characterized by a molecular topology of six transmembrane domains and intracellular N— and C-termini, suggesting that it folds in a “serpentine” manner into three extracellular and two intracellular loops. STEAP-1 protein expression is maintained at high levels across various stages of prostate cancer. Moreover, STEAP-1 is highly over-expressed in certain other human cancers.

Abstract translation: 描述了一种新型的细胞表面蛇纹石跨膜抗原家族。 该家族中的两种蛋白质仅在或主要地在前列腺中表达，并且在前列腺癌中，因此该家族的成员被称为“STEAP”（前列腺的第六跨膜上皮原体）。 本文描述和表征了四种特定的人STEAP。 人类STEAP在其中表现出高度的结构保守性，但与任何已知的人类蛋白质没有显着的结构同源性。 STEAP家族的原型成员STEAP-1似乎是主要在正常人体组织中的前列腺细胞中表达的IIIa型膜蛋白。 在结构上，STEAP-1是一种339个氨基酸的蛋白质，其特征在于六个跨膜结构域和细胞内N-和C-末端的分子拓扑结构，表明它以“蛇纹石”的方式折叠成三个胞外和两个细胞内环。 STEAP-1蛋白表达在前列腺癌的各个阶段保持在高水平。 此外，STEAP-1在某些其他人类癌症中高度过度表达。

公开(公告)号：US20070081887A1

公开(公告)日：2007-04-12

申请号：US11020483

申请日：2004-12-23

Applicant: Ming Xie ,  Stephen Mitchell ,  Donald LaChapelle ,  Lee Blanton ,  Richard Price ,  David Crall ,  Frank Worthoff

Inventor： Ming Xie ,  Stephen Mitchell ,  Donald LaChapelle ,  Lee Blanton ,  Richard Price ,  David Crall ,  Frank Worthoff

IPC: F01D21/00

CPC classification number: F01D21/045 ,  D04C1/02 ,  D10B2505/02 ,  F01D25/24 ,  F05D2300/44 ,  F05D2300/603 ,  F05D2300/702 ,  Y02T50/672

Abstract: A composite fan casing for a gas turbine engine is provided includes, in an exemplary embodiment, a core having a plurality of core layers of reinforcing fiber bonded together with a thermosetting polymeric resin. Each core layer includes a plurality of braided reinforcing fibers with the braids of reinforcing fibers aligned in a circumferential direction.

Abstract translation: 提供一种用于燃气涡轮发动机的复合风扇壳体，在示例性实施例中包括具有多个与热固性聚合物树脂结合在一起的增强纤维芯层的芯。 每个芯层包括多个编织增强纤维，其中增强纤维的编织物沿圆周方向排列。