公开(公告)号：US20080171016A1

公开(公告)日：2008-07-17

申请号：US12046107

申请日：2008-03-11

申请人： Guo-Liang Yu ,  Jian Ni ,  Reiner L. Gentz ,  Patrick J. Dillon

发明人： Guo-Liang Yu ,  Jian Ni ,  Reiner L. Gentz ,  Patrick J. Dillon

IPC分类号： A61K38/20 ,  C07K16/00 ,  A61K39/395 ,  A61K38/21 ,  C07K14/00 ,  A61P35/04 ,  A61P29/00

CPC分类号： C07K14/4747 ,  A61K38/00 ,  A61K48/00 ,  C07K14/705 ,  C07K14/70578 ,  C07K16/2878 ,  C07K2317/21 ,  C12N2799/026

摘要： The present invention relates to novel Death Domain Containing Receptor (DR3 and DR3-V1) proteins that are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR3 and DR3-V1 proteins. DR3 and DR3-V1 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Also provided are antibodies and fragments thereof that bind to polypeptides of the invention. The invention further relates to screening methods for identifying agonists and antagonists of DR3 and DR3-V1 activity.

摘要翻译： 本发明涉及作为肿瘤坏死因子（TNF）受体家族成员的新型死亡域含有受体（DR3和DR3-V1）蛋白。 特别地，提供编码人DR3和DR3-V1蛋白的分离的核酸分子。 还提供DR3和DR3-V1多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。 还提供了结合本发明多肽的抗体及其片段。 本发明还涉及用于鉴定DR3和DR3-V1活性的激动剂和拮抗剂的筛选方法。

公开(公告)号：US06713061B1

公开(公告)日：2004-03-30

申请号：US09557908

申请日：2000-04-21

申请人： Guo-Liang Yu ,  Jian Ni ,  Vishva M. Dixit ,  Reiner L. Gentz ,  Patrick J. Dillon

发明人： Guo-Liang Yu ,  Jian Ni ,  Vishva M. Dixit ,  Reiner L. Gentz ,  Patrick J. Dillon

IPC分类号： A61K3900

CPC分类号： C07K14/4747 ,  A61K38/00 ,  A61K48/00 ,  C07K14/705 ,  C07K14/70578 ,  C07K16/2878 ,  C07K2317/21 ,  C12N2799/026

摘要： The present invention relates to novel Death Domain Containing Receptor (DR3 and DR3-V1) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR3 and DR3-V1 proteins. DR3 and DR3-V1 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR3 and DR3-V1 activity.

摘要翻译： 本发明涉及作为肿瘤坏死因子（TNF）受体家族成员的新型死亡域含有受体（DR3和DR3-V1）蛋白。 特别地，提供编码人DR3和DR3-V1蛋白的分离的核酸分子。 还提供DR3和DR3-V1多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。 本发明还涉及用于鉴定DR3和DR3-V1活性的激动剂和拮抗剂的筛选方法。

公开(公告)号：US06610829B2

公开(公告)日：2003-08-26

申请号：US09854549

申请日：2001-05-15

申请人： Jian Ni ,  Ping Feng ,  Patrick J. Dillon ,  Reiner L. Gentz ,  Joseph Merregaert ,  Patrick Smits

发明人： Jian Ni ,  Ping Feng ,  Patrick J. Dillon ,  Reiner L. Gentz ,  Joseph Merregaert ,  Patrick Smits

IPC分类号： C07K100

CPC分类号： C12Q1/6883 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/51 ,  C07K14/47 ,  C07K14/51 ,  C12N2799/026 ,  C12Q2600/156 ,  Y10T436/143333

摘要： A human ECM-1 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for stimulating the differentiation in growth of osteoblasts and osteoclasts, which may be used to promote the healing of bone fractures and de novo bone formation, for osteoporosis, for and to promote angiogenesis. Antagonists to the polypeptide of the present invention are also disclosed which may be utilized to treat osteodystrophy, osteohypertrophy, osteoma, osteoblastoma and cancers. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention.

摘要翻译： 公开了编码这种多肽的人ECM-1多肽和DNA（RNA），以及通过重组技术产生此类多肽的方法。 还公开了利用这种多肽刺激成骨细胞和破骨细胞生长分化的方法，其可用于促进骨折愈合和从头骨形成，用于骨质疏松症，促进血管生成。 还公开了本发明多肽的拮抗剂，其可用于治疗骨营养不良，骨质肥大，骨瘤，成骨细胞瘤和癌症。 用于鉴定编码本发明多肽的核酸序列中的突变的诊断测定。

公开(公告)号：US20080200391A1

公开(公告)日：2008-08-21

申请号：US12105768

申请日：2008-04-18

申请人： Jian Ni ,  Ping Feng ,  Patrick J. Dillon ,  Reiner L. Gentz ,  Joseph Merregaert ,  Patrick Smits

发明人： Jian Ni ,  Ping Feng ,  Patrick J. Dillon ,  Reiner L. Gentz ,  Joseph Merregaert ,  Patrick Smits

IPC分类号： A61K38/16 ,  C07H21/00 ,  C12N15/63 ,  C12N5/00 ,  C12P21/00 ,  A61P19/00 ,  C07K16/00 ,  G01N33/00 ,  C07K14/00

CPC分类号： C12Q1/6883 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/51 ,  C07K14/47 ,  C07K14/51 ,  C12N2799/026 ,  C12Q2600/156 ,  Y10T436/143333

摘要： A human ECM-1 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for stimulating the differentiation in growth of osteoblasts and osteoclasts, which may be used to promote the healing of bone fractures and de novo bone formation, for osteoporosis, for and to promote angiogenesis. Antagonists to the polypeptide of the present invention are also disclosed which may be utilized to treat osteodystrophy, osteohypertrophy, osteoma, osteoblastoma and cancers. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention.

摘要翻译： 公开了编码这种多肽的人ECM-1多肽和DNA（RNA），以及通过重组技术产生此类多肽的方法。 还公开了利用这种多肽刺激成骨细胞和破骨细胞生长分化的方法，其可用于促进骨折愈合和从头骨形成，用于骨质疏松症，促进血管生成。 还公开了本发明多肽的拮抗剂，其可用于治疗骨营养不良，骨质肥大，骨瘤，成骨细胞瘤和癌症。 用于鉴定编码本发明多肽的核酸序列中的突变的诊断测定。

公开(公告)号：US07071312B2

公开(公告)日：2006-07-04

申请号：US10915596

申请日：2004-08-11

申请人： Jian Ni ,  Ping Feng ,  Patrick J. Dillon ,  Reiner L. Gentz ,  Joseph Merregaert ,  Patrick Smits

发明人： Jian Ni ,  Ping Feng ,  Patrick J. Dillon ,  Reiner L. Gentz ,  Joseph Merregaert ,  Patrick Smits

IPC分类号： C07K14/475

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K48/00 ,  C12N2799/026

摘要： A human epidermal differentiation factor polypeptide and DNA (RNA) encoding such polypeptide and procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for treating and/or preventing skin diseases. Diagnostic assays for detecting mutations in a nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.

公开(公告)号：US06759513B2

公开(公告)日：2004-07-06

申请号：US09333966

申请日：1999-06-16

申请人： Guo-Liang Yu ,  Jian Ni ,  Reiner L. Gentz ,  Patrick J. Dillon

发明人： Guo-Liang Yu ,  Jian Ni ,  Reiner L. Gentz ,  Patrick J. Dillon

IPC分类号： C07K14705

CPC分类号： C07K14/70578 ,  A61K38/00

摘要： The present invention relates to novel Death Domain Containing Receptor (DR3 and DR3-V1) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR3 and DR3-V1 proteins. DR3 and DR3-V1 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR3 and DR3-V1 activity.

公开(公告)号：US06541224B2

公开(公告)日：2003-04-01

申请号：US09879919

申请日：2001-06-14

申请人： Guo-Liang Yu ,  Jian Ni ,  Reiner L. Gentz ,  Patrick J. Dillon

发明人： Guo-Liang Yu ,  Jian Ni ,  Reiner L. Gentz ,  Patrick J. Dillon

IPC分类号： C12N1500

CPC分类号： A61K49/0004 ,  A61K47/6849 ,  A61K2039/505 ,  C07K14/52 ,  C07K14/70575 ,  C07K16/2875 ,  C07K2317/21 ,  C07K2317/622 ,  C07K2317/74 ,  G01N33/564 ,  G01N33/6863 ,  G01N2333/525

摘要： The invention relates to human TNF delta and TNF epsilon polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.

摘要翻译： 本发明涉及人TNFδ和TNFε多肽，编码多肽的多核苷酸，产生多肽的方法，特别是通过表达多核苷酸，多肽的激动剂和拮抗剂。 本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。

公开(公告)号：US07708996B2

公开(公告)日：2010-05-04

申请号：US12046107

申请日：2008-03-11

申请人： Guo-Liang Yu ,  Jian Ni ,  Reiner L. Gentz ,  Patrick J. Dillon

发明人： Guo-Liang Yu ,  Jian Ni ,  Reiner L. Gentz ,  Patrick J. Dillon

IPC分类号： A61K39/395 ,  C07K16/18 ,  C07K16/28

CPC分类号： C07K14/4747 ,  A61K38/00 ,  A61K48/00 ,  C07K14/705 ,  C07K14/70578 ,  C07K16/2878 ,  C07K2317/21 ,  C12N2799/026

摘要： The present invention relates to novel Death Domain Containing Receptor (DR3 and DR3-V1) proteins that are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR3 and DR3-V1 proteins. DR3 and DR3-V1 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Also provided are antibodies and fragments thereof that bind to polypeptides of the invention. The invention further relates to screening methods for identifying agonists and antagonists of DR3 and DR3-V1 activity.

摘要翻译： 本发明涉及作为肿瘤坏死因子（TNF）受体家族成员的新型死亡域含有受体（DR3和DR3-V1）蛋白。 特别地，提供编码人DR3和DR3-V1蛋白的分离的核酸分子。 还提供DR3和DR3-V1多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。 还提供了结合本发明多肽的抗体及其片段。 本发明还涉及用于鉴定DR3和DR3-V1活性的激动剂和拮抗剂的筛选方法。

公开(公告)号：US07357927B2

公开(公告)日：2008-04-15

申请号：US10189189

申请日：2002-07-05

申请人： Guo-Liang Yu ,  Jian Ni ,  Reiner L. Gentz ,  Patrick J. Dillon

发明人： Guo-Liang Yu ,  Jian Ni ,  Reiner L. Gentz ,  Patrick J. Dillon

IPC分类号： A61K39/395 ,  A61K39/00 ,  C07K16/18 ,  C07K16/28

CPC分类号： C07K14/4747 ,  A61K38/00 ,  A61K48/00 ,  C07K14/705 ,  C07K14/70578 ,  C07K16/2878 ,  C07K2317/21 ,  C12N2799/026

摘要： The present invention relates to novel Death Domain Containing Receptor (DR3 and DR3-V1) proteins that are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR3 and DR3-V1 proteins. DR3 and DR3-V1 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Also provided are antibodies and fragments thereof that bind to polypeptides of the invention. The invention further relates to screening methods for identifying agonists and antagonists of DR3 and DR3-V1 activity.

摘要翻译： 本发明涉及作为肿瘤坏死因子（TNF）受体家族成员的新型死亡域含有受体（DR3和DR3-V1）蛋白。 特别地，提供编码人DR3和DR3-V1蛋白的分离的核酸分子。 还提供DR3和DR3-V1多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。 还提供了结合本发明多肽的抗体及其片段。 本发明还涉及用于鉴定DR3和DR3-V1活性的激动剂和拮抗剂的筛选方法。

公开(公告)号：US06951735B2

公开(公告)日：2005-10-04

申请号：US09314889

申请日：1999-05-19

申请人： Guo-Liang Yu ,  Jian Ni ,  Vishva Dixit ,  Reiner L. Gentz ,  Patrick J. Dillon

发明人： Guo-Liang Yu ,  Jian Ni ,  Vishva Dixit ,  Reiner L. Gentz ,  Patrick J. Dillon

IPC分类号： C12N15/09 ,  A61K38/00 ,  A61P29/00 ,  A61P31/04 ,  A61P31/12 ,  A61P35/00 ,  A61P37/00 ,  A61P43/00 ,  C07H21/04 ,  C07K14/705 ,  C07K14/715 ,  C12N1/21 ,  C12N5/00 ,  C12N5/10 ,  C12N15/12 ,  C12P21/02 ,  C12R1/19 ,  C12R1/91 ,  C12N15/63

CPC分类号： C07K14/70578 ,  A61K38/00

摘要： The present invention relates to novel Death Domain Containing Receptor (DR3 and DR3-V1) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR3 and DR3-V1 proteins. DR3 and DR3-V1 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR3 and DR3-V1 activity.

摘要翻译： 本发明涉及作为肿瘤坏死因子（TNF）受体家族成员的新型死亡域含有受体（DR3和DR3-V1）蛋白。 特别地，提供编码人DR3和DR3-V1蛋白的分离的核酸分子。 还提供DR3和DR3-V1多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。 本发明还涉及用于鉴定DR3和DR3-V1活性的激动剂和拮抗剂的筛选方法。