公开(公告)号：US09353108B2

公开(公告)日：2016-05-31

申请号：US14505907

申请日：2014-10-03

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Shizuo Kasai ,  Hideki Hirose ,  Takeshi Yamasaki ,  Tohru Yamashita ,  Asato Kina

IPC: C07D471/04

CPC classification number: C07D471/04

Abstract: A compound having an SSTR5 antagonist action and use of the compound as a medicament are provided. Specifically, a compound represented by the following formula: wherein each symbol is as defined herein, or a salt thereof, a medicament comprising the compound or a salt thereof, and use of the compound or a salt thereof as an agent for the prophylaxis or treatment of diabetes mellitus are provided.

Abstract translation: 提供具有SSTR5拮抗作用的化合物和该化合物作为药物的用途。 具体地，由下式表示的化合物或其盐，其中每个符号如本文所定义，或其盐，包含该化合物或其盐的药物，以及该化合物或其盐作为预防或治疗剂的用途 的糖尿病。

公开(公告)号：US09120777B2

公开(公告)日：2015-09-01

申请号：US14525593

申请日：2014-10-28

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Shizuo Kasai ,  Asato Kina ,  Hideki Hirose ,  Takeshi Yamasaki ,  Tohru Yamashita ,  Yoichi Nishikawa

IPC: C07D401/12 ,  C07D211/86 ,  C07D239/22

CPC classification number: C07D401/12 ,  C07D211/86 ,  C07D239/22 ,  C07D401/04 ,  C07D401/14

Abstract: A compound having an SSTR5 antagonist action and use of the compound as a medicament are provided. Specifically, a compound represented by the following formula: wherein each symbol is as defined herein, or a salt thereof, a medicament comprising the compound or a salt thereof, and use of the compound or a salt thereof as an agent the prophylaxis or treatment of diabetes mellitus are provided.

Abstract translation: 提供具有SSTR5拮抗作用的化合物和该化合物作为药物的用途。 具体地，由下式表示的化合物或其盐，其中每个符号如本文所定义，或其盐，包含该化合物或其盐的药物，以及该化合物或其盐的用途作为预防或治疗 提供糖尿病。

公开(公告)号：US11186565B2

公开(公告)日：2021-11-30

申请号：US16499432

申请日：2018-03-29

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Seiji Miwatashi ,  Yasufumi Miyamoto ,  Koji Watanabe ,  Yayoi Nakayama ,  Yuko Hitomi ,  Jumpei Aida ,  Nobuyuki Takakura ,  Hideki Furukawa ,  Naoyoshi Noguchi ,  Yasuhiro Hirata ,  Kazuaki Takami ,  Norihito Tokunaga ,  Tomohiro Okawa ,  Akito Shibuya ,  Shizuo Kasai ,  Toshitake Kobayashi ,  Tsuyoshi Maekawa

IPC: C07D401/12 ,  C07C59/72 ,  C07D211/22 ,  C07D213/64 ,  C07D401/10 ,  C07D401/14 ,  C07D413/10

Abstract: Provided is a novel aromatic ring compound which may have a GPR40 agonist activity and a GLP-1 secretagogue action. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof may have a GPR40 agonist activity and a GLP-1 secretagogue action, may be useful for the prophylaxis or treatment of cancer, obesity, diabetes, hypertension, hyperlipidemia, cardiac failure, diabetic complications, metabolic syndrome, sarcopenia and the like, and may afford superior efficacy.

公开(公告)号：US09751878B2

公开(公告)日：2017-09-05

申请号：US15139531

申请日：2016-04-27

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Shizuo Kasai ,  Hideki Hirose ,  Takeshi Yamasaki ,  Tohru Yamashita ,  Asato Kina ,  Yoichi Nishikawa

IPC: C07D471/04

CPC classification number: C07D471/04

Abstract: A compound having an SSTR5 antagonist action and use of the compound as a medicament are provided. Specifically, a compound represented by the following formula: wherein each symbol is as defined herein, or a salt thereof, a medicament comprising the compound or a salt thereof, and use of the compound or a salt thereof as an agent for the prophylaxis or treatment of diabetes mellitus are provided.

公开(公告)号：US09505772B2

公开(公告)日：2016-11-29

申请号：US14399396

申请日：2013-05-09

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Shizuo Kasai ,  Hideyuki Igawa ,  Masashi Takahashi ,  Asato Kina

IPC: A61K31/50 ,  C07D491/048

CPC classification number: C07D491/048

Abstract: The present invention provides an aromatic ring compound having a melanin-concentrating hormone receptor antagonistic action and useful as an agent for the prophylaxis or treatment of obesity and the like. The present invention relates to a compound represented by the formula wherein each symbol as defined in the specification, or a salt thereof.

公开(公告)号：US20150119412A1

公开(公告)日：2015-04-30

申请号：US14525593

申请日：2014-10-28

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Shizuo Kasai ,  Takashi Nakahata ,  Asato Kina ,  Hideki Hirose ,  Takeshi Yamasaki ,  Tohru Yamashita ,  Yoichi Nishikawa

IPC: C07D401/12 ,  C07D239/22 ,  C07D211/86

CPC classification number: C07D401/12 ,  C07D211/86 ,  C07D239/22 ,  C07D401/04 ,  C07D401/14

Abstract: A compound having an SSTR5 antagonist action and use of the compound as a medicament are provided. Specifically, a compound represented by the following formula: wherein each symbol is as defined herein, or a salt thereof, a medicament comprising the compound or a salt thereof, and use of the compound or a salt thereof as an agent the prophylaxis or treatment of diabetes mellitus are provided.

Abstract translation: 提供具有SSTR5拮抗作用的化合物和该化合物作为药物的用途。 具体地，由下式表示的化合物或其盐，其中每个符号如本文所定义，或其盐，包含该化合物或其盐的药物，以及该化合物或其盐的用途作为预防或治疗 提供糖尿病。

公开(公告)号：US20150018363A1

公开(公告)日：2015-01-15

申请号：US14371824

申请日：2013-01-11

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Shizuo Kasai ,  Hideyuki Igawa ,  Masashi Takahashi ,  Tsuyoshi Maekawa ,  Keiko Kakegawa ,  Tsuneo Yasuma ,  Asato Kina ,  Jumpei Aida ,  Uttam Khamrai ,  Mrinalkanti Kundu

IPC: C07D401/04 ,  C07D401/14 ,  C07D413/14 ,  C07D409/14 ,  C07D417/14 ,  C07D471/04 ,  C07D405/14

CPC classification number: C07D401/04 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

Abstract: The present invention provides an aromatic ring compound having a melanin-concentrating hormone receptor antagonistic action and useful as an agent for the prophylaxis or treatment of obesity and the like. The present invention relates to a compound represented by the formula wherein each symbol as defined in the specification, or a salt thereof.

Abstract translation: 本发明提供具有黑色素浓缩激素受体拮抗作用的芳香环化合物，可用作预防或治疗肥胖症等的药剂。 本发明涉及由下式表示的化合物或其盐，其中每个符号如本说明书中所定义。