公开(公告)号：US20170197903A1

公开(公告)日：2017-07-13

申请号：US15502063

申请日：2015-08-06

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Yasutaka Hoashi

IPC: C07C69/34 ,  C11C3/00

CPC classification number: C07C69/34 ,  A61K9/08 ,  A61K9/107 ,  A61K9/127 ,  A61K31/7105 ,  A61K31/713 ,  A61K47/18 ,  A61K48/00 ,  C07C229/12 ,  C11C3/003 ,  C12N15/113 ,  C12N2310/14 ,  C12N2320/32

Abstract: The present invention provides a technology which enables introduction of an active ingredient (e.g. nucleic acids) into various cells with a high efficiency, and compounds used therefor. The present invention provides a compound represented by the formula: [wherein, each symbol is as defined in the present description] or a salt thereof.

公开(公告)号：US12091410B2

公开(公告)日：2024-09-17

申请号：US17413473

申请日：2019-12-11

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Yuichi Kajita ,  Yuhei Miyanohana ,  Tatsuki Koike ,  Yasutaka Hoashi ,  Yasushi Hattori ,  Norihito Tokunaga ,  Tsuneo Oda ,  Tohru Miyazaki ,  Dilhumar Uyghur ,  Yoshiteru Ito ,  Kohei Takeuchi ,  Keisuke Imamura ,  Takahiro Sugimoto ,  Koichiro Fukuda ,  Yasuhisa Kohara ,  Rei Okamoto ,  Taiichi Ohra ,  Naoki Miyamoto ,  Yoshito Terao ,  Masanori Kawasaki

IPC: C07D471/04 ,  C07D215/38 ,  C07D231/56 ,  C07D277/64 ,  C07D401/14

CPC classification number: C07D471/04 ,  C07D215/38 ,  C07D231/56 ,  C07D277/64 ,  C07D401/14

Abstract: The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.
A compound represented by the formula (I):




wherein each symbol is as described in the description, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.

公开(公告)号：US12071434B2

公开(公告)日：2024-08-27

申请号：US17413469

申请日：2019-12-11

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Yuhei Miyanohana ,  Yuichi Kajita ,  Tatsuki Koike ,  Yasutaka Hoashi ,  Yasushi Hattori ,  Norihito Tokunaga ,  Tsuneo Oda ,  Tohru Miyazaki ,  Dilhumar Uyghur ,  Yoshiteru Ito ,  Kohei Takeuchi ,  Keisuke Imamura ,  Takahiro Sugimoto ,  Koichiro Fukuda ,  Yasuhisa Kohara ,  Rei Okamoto ,  Taiichi Ohra ,  Naoki Miyamoto ,  Jun Chiba ,  Yoshito Terao ,  Masanori Kawasaki

IPC: C07D455/02 ,  A61P25/26 ,  C07D217/24 ,  C07D237/32 ,  C07D239/90 ,  C07D401/06 ,  C07D401/10 ,  C07D403/10 ,  C07D417/06 ,  C07D471/04 ,  C07D498/04

CPC classification number: C07D455/02 ,  A61P25/26 ,  C07D217/24 ,  C07D237/32 ,  C07D239/90 ,  C07D401/06 ,  C07D401/10 ,  C07D403/10 ,  C07D417/06 ,  C07D471/04 ,  C07D498/04 ,  C07B2200/05

Abstract: The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.
A compound represented by the formula (I):




wherein each symbol is as described in the description, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.

公开(公告)号：US11987586B1

公开(公告)日：2024-05-21

申请号：US18497602

申请日：2023-10-30

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Yasushi Hattori ,  Marilena Pira ,  Yoshiteru Ito ,  Kohei Takeuchi ,  Eiji Kimura ,  Norihito Tokunaga ,  Shuhei Ikeda ,  Martin Alexander Pawliczek ,  Noriyuki Tezuka ,  Yasutaka Hoashi ,  Yuhei Miyanohana ,  Yuichi Kajita ,  Tatsuki Koike

IPC: C07D487/04 ,  A61P25/00 ,  C07D413/04 ,  C07D519/00

CPC classification number: C07D487/04 ,  A61P25/00 ,  C07D413/04 ,  C07D519/00

Abstract: The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.
A compound represented by the formula (I):




wherein each symbol is as described in the specification, or a salt thereof, is useful as an agent for the prophylaxis or treatment of narcolepsy.

公开(公告)号：US11655241B2

公开(公告)日：2023-05-23

申请号：US16973320

申请日：2019-06-27

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Tsuneo Oda ,  Yoshiteru Ito ,  Tohru Miyazaki ,  Kohei Takeuchi ,  Norihito Tokunaga ,  Yasutaka Hoashi ,  Yasushi Hattori ,  Keisuke Imamura ,  Yuichi Kajita ,  Yuhei Miyanohana ,  Takahiro Sugimoto ,  Tatsuki Koike ,  Dilhumar Uyghur

IPC: C07D405/12 ,  C07D207/14 ,  C07D211/56 ,  C07D401/06 ,  C07D401/14 ,  C07D403/06 ,  C07D405/06 ,  C07D405/14 ,  C07D417/06 ,  C07D417/14

CPC classification number: C07D405/12 ,  C07D207/14 ,  C07D211/56 ,  C07D401/06 ,  C07D401/14 ,  C07D403/06 ,  C07D405/06 ,  C07D405/14 ,  C07D417/06 ,  C07D417/14

Abstract: The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.
A compound represented by the formula (I):




wherein each symbol is as described in the specification, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.

公开(公告)号：US10584097B2

公开(公告)日：2020-03-10

申请号：US16577449

申请日：2019-09-20

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Yuichi Kajita ,  Yuhei Miyanohana ,  Tatsuki Koike ,  Kohei Takeuchi ,  Yoshiteru Ito ,  Norihito Tokunaga ,  Takahiro Sugimoto ,  Tohru Miyazaki ,  Tsuneo Oda ,  Yasutaka Hoashi ,  Yasushi Hattori ,  Keisuke Imamura

IPC: C07D211/56 ,  C07D405/06 ,  C07D205/04 ,  C07D207/14 ,  C07D401/06 ,  C07D401/10 ,  C07D401/14 ,  C07D403/06 ,  C07D405/10 ,  C07D405/12 ,  C07D413/06 ,  C07D417/06 ,  C07D417/14 ,  C07D211/36 ,  A61P25/00

Abstract: The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.A compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof, is useful as an agent for the prophylaxis or treatment of narcolepsy.

公开(公告)号：US10252974B2

公开(公告)日：2019-04-09

申请号：US15502063

申请日：2015-08-06

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Yasutaka Hoashi

IPC: C07C69/00 ,  C07C229/00 ,  A61K31/00 ,  A61K47/00 ,  C11C3/00 ,  C07C69/34 ,  A61K47/18 ,  A61K48/00 ,  A61K31/7105 ,  A61K31/713 ,  C07C229/12 ,  A61K9/08 ,  C12N15/113 ,  A61K9/107 ,  A61K9/127

Abstract: The present invention provides a technology which enables introduction of an active ingredient (e.g. nucleic acids) into various cells with a high efficiency, and compounds used therefor. The present invention provides a compound represented by the formula: [wherein, each symbol is as defined in the present description] or a salt thereof.

公开(公告)号：US20140350260A1

公开(公告)日：2014-11-27

申请号：US14454993

申请日：2014-08-08

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Tatsuki KOIKE ,  Minoru Nakamura ,  Yoshihide Tomata ,  Takafumi Takai ,  Yasutaka Hoashi ,  Yuichi Kajita ,  Tetsuya Tsukamoto ,  Makoto Kamata

IPC: C07D471/04

CPC classification number: C07D471/04

Abstract: The present invention provides a heterocycle derivative having a superior amyloid β production inhibitory activity and/or a superior γ-secretase modulation activity, and use thereof. A compound represented by the formula (I): wherein each symbol is as defined in the present specification, or a salt thereof.

Abstract translation: 本发明提供具有优异淀粉样蛋白的杂环衍生物; 生产抑制活性和/或优异的γ-分泌酶调节活性及其用途。 由式（I）表示的化合物或其盐，其中每个符号如本说明书中所定义。