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公开(公告)号：US11440883B2
公开(公告)日：2022-09-13
申请号：US16811426
申请日：2020-03-06
发明人： Yuichi Kajita , Yuhei Miyanohana , Tatsuki Koike , Kohei Takeuchi , Yoshiteru Ito , Norihito Tokunaga , Takahiro Sugimoto , Tohru Miyazaki , Tsuneo Oda , Yasutaka Hoashi , Yasushi Hattori , Keisuke Imamura
IPC分类号： C07D211/56 , C07D211/36 , C07D405/06 , A61P25/26 , C07D409/10 , A61P25/00 , C07D205/04 , C07D207/14 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/06 , C07D405/10 , C07D405/12 , C07D413/06 , C07D417/06 , C07D417/14
摘要： The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.
A compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof, is useful as an agent for the prophylaxis or treatment of narcolepsy.-
公开(公告)号：US11319286B2
公开(公告)日：2022-05-03
申请号：US16635408
申请日：2018-08-02
发明人： Tatsuhiko Fujimoto , Kentaro Rikimaru , Koichiro Fukuda , Hiromichi Sugimoto , Takahiro Matsumoto , Yuichi Kajita , Satoshi Mikami , Yuhei Miyanohana , Tatsuki Koike , Masaki Daini , Masaki Ogino , Kohei Takeuchi , Tohru Miyazaki , Yoshiteru Ito , Norihito Tokunaga , Takahiro Sugimoto , Tsuneo Oda , Yasutaka Hoashi , Yasushi Hattori , Keisuke Imamura
IPC分类号： C07D207/14 , C07D401/14 , C07D403/06 , A61P25/28
摘要： The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.
A compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof, has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.-
公开(公告)号：US09920047B2
公开(公告)日：2018-03-20
申请号：US15270863
申请日：2016-09-20
发明人： Shigemitsu Matsumoto , Yasushi Hattori , Masashi Toyofuku , Shinji Morimoto , Masaki Daini , Takuto Kojima , Tomohiro Kaku , Mitsuhiro Ito
IPC分类号： C07D417/14 , C07D417/12 , C07D409/12 , C07D307/79 , C07D407/12 , C07D213/82 , C07D333/38 , C07D413/14 , C07D231/14 , C07D333/40 , C07D285/135 , C07D231/12 , C07D277/56 , C07D409/14 , C07D413/12 , C07D307/81 , C07D285/08
CPC分类号： C07D417/14 , C07D213/82 , C07D231/12 , C07D231/14 , C07D277/56 , C07D285/08 , C07D285/135 , C07D307/79 , C07D307/81 , C07D333/38 , C07D333/40 , C07D407/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12
摘要： The present invention provides a compound having a lysine-specific demethylase-1 inhibitory action, and useful as a medicament such as a prophylactic or therapeutic agent for schizophrenia, developmental disorders, particularly diseases having intellectual disability (e.g., autistic spectrum disorders, Rett syndrome, Down's syndrome, Kabuki syndrome, fragile X syndrome, Kleefstra syndrome, neurofibromatosis type 1, Noonan syndrome, tuberous sclerosis), neurodegenerative diseases (e.g., Alzheimer's disease, Parkinson's disease, spinocerebellar degeneration (e.g., dentatorubural pallidoluysian atrophy) and Huntington's disease), epilepsy (e.g., Dravet syndrome) or drug dependence, and the like. A compound represented by the formula wherein each symbol is as defined in the present specification, or a salt thereof.
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公开(公告)号：US09751885B2
公开(公告)日：2017-09-05
申请号：US14435085
申请日：2013-10-11
发明人： Naoki Tomita , Daisuke Tomita , Yusuke Tominari , Shinichi Imamura , Shinji Morimoto , Takuto Kojima , Masashi Toyofuku , Yasushi Hattori , Tomohiro Kaku , Mitsuhiro Ito
IPC分类号： C07D487/04 , C07C255/58 , C07C255/60 , C07D231/40 , C07C317/40 , C07C237/30 , C07C237/38 , C07C237/40 , C07C255/29 , A61K45/06 , C07D309/14 , C07D319/18 , C07D413/12 , C07D241/12 , C07D417/12 , C07D261/14 , C07D207/12 , C07D285/135 , C07D211/58 , C07D295/135 , C07D213/40 , C07D207/46 , C07D213/36 , C07D223/12 , C07D231/38 , C07D241/18 , C07D265/36 , C07D277/38 , C07D333/20 , C07D405/12 , C07D471/04 , C07D513/04
CPC分类号： C07D487/04 , A61K45/06 , C07C237/30 , C07C237/38 , C07C237/40 , C07C255/29 , C07C255/58 , C07C255/60 , C07C317/40 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D207/12 , C07D207/46 , C07D211/58 , C07D213/36 , C07D213/40 , C07D223/12 , C07D231/38 , C07D231/40 , C07D241/12 , C07D241/18 , C07D261/14 , C07D265/36 , C07D277/38 , C07D285/135 , C07D295/135 , C07D309/14 , C07D319/18 , C07D333/20 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D513/04
摘要： The present invention provides a compound having a lysine specific demethylase 1 inhibitory action, and useful as a medicament such as a prophylactic or therapeutic agent for schizophrenia, Alzheimer's disease, Parkinson's disease or Huntington's disease, and the like. The present invention relates to a compound represented by the formula wherein A is a hydrocarbon group optionally having substituent(s), or a heterocyclic group optionally having substituent(s); B is a benzene ring optionally having further substituent(s); R1, R2 and R3 are each independently a hydrogen atom, a hydrocarbon group optionally having substituent(s), or a heterocyclic group optionally having substituent(s); A and R1 are optionally bonded to each other to form, together with the adjacent nitrogen atom, a cyclic group optionally having substituent(s); and R2 and R3 are optionally bonded to each other to form, together with the adjacent nitrogen atom, a cyclic group optionally having substituent(s), or a salt thereof.
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公开(公告)号：US12077522B2
公开(公告)日：2024-09-03
申请号：US17256330
申请日：2019-06-27
发明人： Tatsuhiko Fujimoto , Koichiro Fukuda , Hiromichi Sugimoto , Kentaro Rikimaru , Yoshihiro Banno , Takahiro Matsumoto , Norihito Tokunaga , Yoshihide Tomata , Yuji Ishichi , Shogo Marui , Tsuneo Oda , Tohru Miyazaki , Yasutaka Hoashi , Yasushi Hattori , Yuichi Kajita , Yuhei Miyanohana , Tatsuki Koike
IPC分类号： C07D401/14 , C07D211/56 , C07D405/14
CPC分类号： C07D401/14 , C07D211/56 , C07D405/14
摘要： The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.
A compound represented by the formula (I):
wherein each symbol is as described in the specification, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.-
公开(公告)号：US11028048B2
公开(公告)日：2021-06-08
申请号：US16777273
申请日：2020-01-30
发明人： Yasushi Hattori , Yuhei Miyanohana , Yuichi Kajita , Tatsuki Koike , Yasutaka Hoashi , Norihito Tokunaga , Alexander Martin Pawliczek , Tsuneo Oda , Tohru Miyazaki , Marilena Pira , Javier Miguelez-Ramos
IPC分类号： C07D207/14 , C07D407/08 , C07D417/06
摘要： The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.
A compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.-
公开(公告)号：US09718814B2
公开(公告)日：2017-08-01
申请号：US15203522
申请日：2016-07-06
发明人： Shigemitsu Matsumoto , Yasushi Hattori , Masashi Toyofuku , Shinji Morimoto , Takuto Kojima , Tomohiro Kaku , Mitsuhiro Ito
IPC分类号： C07D417/12 , C07D417/14 , C07D213/82 , C07D333/38 , C07D285/135 , C07D409/14 , C07D231/12 , C07D413/14 , C07D277/56 , C07D409/12 , C07D307/79 , C07D407/12 , C07D231/14 , C07D333/40 , C07D285/08 , C07D413/12 , C07D307/81
CPC分类号： C07D417/14 , C07D213/82 , C07D231/12 , C07D231/14 , C07D277/56 , C07D285/08 , C07D285/135 , C07D307/79 , C07D307/81 , C07D333/38 , C07D333/40 , C07D407/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12
摘要： The present invention provides a compound having a lysine-specific demethylase-1 inhibitory action, and useful as a medicament such as a prophylactic or therapeutic agent for schizophrenia, developmental disorders, particularly diseases having intellectual disability (e.g., autistic spectrum disorders, Rett syndrome, Down's syndrome, Kabuki syndrome, fragile X syndrome, Kleefstra syndrome, neurofibromatosis type 1, Noonan syndrome, tuberous sclerosis), neurodegenerative diseases (e.g., Alzheimer's disease, Parkinson's disease, spinocerebellar degeneration (e.g., dentatorubural pallidoluysian atrophy) and Huntington's disease), epilepsy (e.g., Dravet syndrome) or drug dependence, and the like. A compound represented by the formula wherein each symbol is as defined in the present specification, or a salt thereof.
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公开(公告)号：US09487511B2
公开(公告)日：2016-11-08
申请号：US14682695
申请日：2015-04-09
发明人： Shigemitsu Matsumoto , Yasushi Hattori , Masashi Toyofuku , Shinji Morimoto , Masaki Daini , Takuto Kojima , Tomohiro Kaku , Mitsuhiro Ito
IPC分类号： C07D333/40 , C07D333/38 , C07D407/12 , C07D409/12 , C07D417/14 , C07D417/12 , C07D307/79 , C07D213/82 , C07D413/14 , C07D231/14 , C07D285/08 , C07D285/135
CPC分类号： C07D417/14 , C07D213/82 , C07D231/12 , C07D231/14 , C07D277/56 , C07D285/08 , C07D285/135 , C07D307/79 , C07D307/81 , C07D333/38 , C07D333/40 , C07D407/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12
摘要： The present invention provides a compound having a lysine-specific demethylase-1 inhibitory action, and useful as a medicament such as a prophylactic or therapeutic agent for schizophrenia, developmental disorders, particularly diseases having intellectual disability (e.g., autistic spectrum disorders, Rett syndrome, Down's syndrome, Kabuki syndrome, fragile X syndrome, Kleefstra syndrome, neurofibromatosis type 1, Noonan syndrome, tuberous sclerosis), neurodegenerative diseases (e.g., Alzheimer's disease, Parkinson's disease, spinocerebellar degeneration (e.g., dentatorubural pallidoluysian atrophy) and Huntington's disease), epilepsy (e.g., Dravet syndrome) or drug dependence, and the like. A compound represented by the formula wherein each symbol is as defined in the present specification, or a salt thereof.
摘要翻译： 本发明提供具有赖氨酸特异性脱甲基酶-1抑制作用的化合物，可用作精神分裂症，发育障碍，特别是具有智力障碍的疾病（例如自闭症谱系，Rett综合征， 唐氏综合征，歌舞伎综合征，脆性X综合征，克莱斯特综合征，1型神经纤维瘤病，Noonan综合征，结节性硬化症），神经变性疾病（如阿尔茨海默氏病，帕金森病，脊髓小脑变性（例如，牙周性苍白球萎缩症）和亨廷顿疾病）），癫痫 （例如，Dravet综合征）或药物依赖性等。 由下式表示的化合物，其中每个符号如本说明书中所定义，或其盐。
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公开(公告)号：US20200247747A1
公开(公告)日：2020-08-06
申请号：US16777273
申请日：2020-01-30
发明人： Yasushi Hattori , Yuhei Miyanohana , Yuichi Kajita , Tatsuki Koike , Yasutaka Hoashi , Norihito Tokunaga , Alexander Martin Pawliczek , Tsuneo Oda , Tohru Miyazaki , Yoshiteru Ito , Kohei Takeuchi , Keisuke Imamura , Takahiro Sugimoto
IPC分类号： C07D207/14 , C07D417/06 , C07D407/08
摘要： The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.A compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.
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公开(公告)号：US10428023B2
公开(公告)日：2019-10-01
申请号：US16052967
申请日：2018-08-02
发明人： Yuichi Kajita , Yuhei Miyanohana , Tatsuki Koike , Kohei Takeuchi , Yoshiteru Ito , Norihito Tokunaga , Takahiro Sugimoto , Tohru Miyazaki , Tsuneo Oda , Yasutaka Hoashi , Yasushi Hattori , Keisuke Imamura
IPC分类号： C07D211/56 , A61P25/00 , C07D205/04 , C07D207/14 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/06 , C07D405/10 , C07D405/12 , C07D413/06 , C07D417/06 , C07D417/14 , C07D405/06 , C07D211/36
摘要： The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.A compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof, is useful as an agent for the prophylaxis or treatment of narcolepsy.
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