公开(公告)号：US10744477B2

公开(公告)日：2020-08-18

申请号：US15960319

申请日：2018-04-23

Applicant: TWIST BIOSCIENCE CORPORATION

Inventor： William Banyai ,  Bill James Peck ,  Andres Fernandez ,  Siyuan Chen ,  Pierre Indermuhle ,  Eugene P. Marsh

IPC: B01J19/00 ,  C12N15/10 ,  B01L3/00

Abstract: Devices and methods for de novo synthesis of large and highly accurate libraries of oligonucleic acids are provided herein. Devices include structures having a main channel and microchannels, where the microchannels have a high surface area to volume ratio. Devices disclosed herein provide for de novo synthesis of oligonucleic acids having a low error rate.

公开(公告)号：US09895673B2

公开(公告)日：2018-02-20

申请号：US15365826

申请日：2016-11-30

Applicant: TWIST BIOSCIENCE CORPORATION

Inventor： Bill James Peck ,  Pierre Indermuhle ,  Eugene P. Marsh ,  Andres Fernandez ,  David Stern

IPC: C40B50/18 ,  B01J19/00 ,  C12N15/10

CPC classification number: B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00432 ,  B01J2219/00441 ,  B01J2219/00596 ,  B01J2219/00608 ,  B01J2219/00693 ,  B01J2219/00711 ,  B01J2219/00722

Abstract: Compositions, devices, methods and systems are provided for differential functionalization of a surface of a structure to support biopolymer synthesis. Provided herein are processes which include use of lamps, lasers, and/or microcontact printing to add functional groups to surfaces for the efficient and uniform synthesis of oligonucleic acids.

公开(公告)号：US10987648B2

公开(公告)日：2021-04-27

申请号：US16384678

申请日：2019-04-15

Applicant: Twist Bioscience Corporation

Inventor： Bill James Peck ,  Pierre Indermuhle ,  Eugene P. Marsh ,  Andres Fernandez ,  David Stern

IPC: B01J19/00

Abstract: Compositions, devices, methods and systems are provided for differential functionalization of a surface of a structure to support biopolymer synthesis. Provided herein are processes which include use of lamps, lasers, and/or microcontact printing to add functional groups to surfaces for the efficient and uniform synthesis of oligonucleic acids.

公开(公告)号：US20160229884A1

公开(公告)日：2016-08-11

申请号：US15015059

申请日：2016-02-03

Applicant: TWIST BIOSCIENCE CORPORATION

Inventor： Pierre F. Indermuhle ,  Eugene P. Marsh ,  Andres Fernandez ,  William Banyai ,  Bill J. Peck

IPC: C07H21/04 ,  C12P19/34 ,  C23C16/455 ,  C07H1/00

Abstract: Methods and devices are provided herein for surfaces for de novo nucleic acid synthesis which provide for low error rates. In addition, methods and devices are provided herein for increased nucleic acid mass yield resulting from de novo nucleic acid synthesis.

Abstract translation: 本文提供了提供低错误率的从头核酸合成的表面的方法和装置。 此外，本文提供了用于增加从头核酸合成得到的核酸质量产量的方法和装置。