摘要:
This invention provides novel 4-oxoquinolizine compounds and their uses for a series of broad-spectrum antibiotics having no cross-resistance to existing or emerging classes of antibiotics. In addition the novel 4-oxoquinolizine compounds are useful against CDC Category A and B pathogens The invention also provides pharmaceutical compositions comprising certain 4-oxoquinolizines in combination with subinhibitory concentrations of polymyxin B against clinical isolates which are resistant to quinolones, carbapenems and other antimicrobial agents.
摘要:
A system for delivering a surgical staple can include various components. The system may include an elongate body with a proximal end, a distal end, and a plurality of delivery platforms disposed adjacent the distal end. A sheath can move relative to the elongate body from a first position in which the distal end of the sheath is disposed distally of a distal-most distal delivery platform to a second position in which the distal end of the sheath is disposed proximally of at least one delivery platform. A plurality of intravascular tacks can be within the system with each disposed about a corresponding delivery platform.
摘要:
This invention relates to a kit and methods adapted for use in a vehicle glove compartment box, which provides assistance in various vehicular scenarios related to traffic tickets, DWIs, car wrecks, avoiding repossessions, and using lemon laws. The kit includes a container, camera, and booklet and is small enough to fit conveniently inside a vehicle glove box. The booklet contains sequential step-by-step instructions to assist the user with the vehicular scenarios and is written in a simple and easy-to-read format that does not require a legal dictionary to decipher. In simpler terms, the present invention provides common sense tips to help protect one's legal rights.
摘要:
A plaque tack device for treating atherosclerotic occlusive disease is formed as a thin, annular band made of thin, flexible wire formed in a mesh structure having a plurality of barbs on its outer periphery. It has a width that is small relative to its diameter, to minimize the amount of foreign structure placed in the blood vessel. One or more tacks may be applied in positions along a plaque accumulation site as needed to stabilize the site and/or hold pieces of plaque out of the way of blood flow. The barbs of the tack may be pressed into the plaque and/or blood vessel walls by balloon expansion. Related methods of deployment and delivery devices are provided for insertion of the plaque tack in a compressed state into the blood vessel and expanding it back to its annular shape for holding plaque against the blood vessel walls.
摘要:
A plaque tack device for treating atherosclerotic occlusive disease is formed as a thin, annular band of durable, flexible material having a plurality of barbs or anchoring points on its outer periphery for preventing it from being dislodged. The plaque tack may be used with a balloon angioplasty procedure or as a de novo treatment for blood vessel blockage to reopen the vessel lumen for desired blood flow. It has a width that is small relative to its diameter, to minimize the amount of foreign structure placed in the blood vessel. One or more tacks may be applied in positions along a plaque accumulation site as needed to stabilize the site and/or hold pieces of plaque out of the way of blood flow. The barbs of the tack may be pressed into the plaque and/or blood vessel walls by balloon expansion. Related methods of deployment and delivery devices are provided for insertion of the plaque tack in a compressed state into the blood vessel and expanding it back to its annular shape for holding plaque against the blood vessel walls.
摘要:
Disclosed is a device for dispensing a fluid, in particular a carbonated beverage, from a storage chamber of a container towards the outside via at least one closeable discharge port, comprising a pressure reservoir which is separated from the storage chamber and in which a pressurized propellant is accommodated, and which can be connected to the storage chamber via a pressure regulation mechanism. The pressure regulation mechanism includes an axially moveable regulating element that is impinged upon by means of a spring in the direction of an open position in which propellant is discharged from the pressure reservoir into the storage chamber. The ambient pressure to which the container is exposed acts upon the regulating element in the direction of the open position, and the internal pressure inside the storage chamber of the container acts upon the regulating element in the direction of the closed position.
摘要:
A tack device for holding plaque against blood vessel walls in treating atherosclerotic occlusive disease is formed as a thin, annular band of durable, flexible material having a plurality of barbs or anchoring points on its outer annular periphery. The annular band has a length in the axial direction of the blood vessel walls that is about equal to or less than its diameter as installed in the blood vessel. In a preferred embodiment, the tack device is formed as a compressible metallic mesh band having outer barbs on outer sides of the mesh structure. Another embodiment may have a plurality of compressible mesh bands may be formed spaced apart coaxially from each other and connected by longitudinally extending bridge members. A preferred method is to perform angioplasty with a drug eluting balloon as a first step, and if there is any dissection to the blood vessel caused by the balloon angioplasty, one or more tack devices may be installed to tack down the dissected area of the blood vessel surface, in order to avoid the need to install a stent and thereby maintain a ‘stent-free’ environment.
摘要:
A method of optimising real cellular, wireless communication networks comprising the steps of providing location-referenced values of subscriber traffic for area elements; transmitting a reference signal of constant transmission power; providing a cell-referenced value of the power received from the reference signal; providing a model of the communication network having an original model network configuration, and iteratively optimising the model network configuration by accumulating and weighting the subscriber traffic values of the area elements and by locally adjusting the model network configuration, to provide an optimised model network configuration.
摘要:
A device and method for intravascular treatment of atherosclerotic plaque prior to balloon angioplasty which microperforates the plaque with small sharp spikes acting as serrations for forming cleavage lines or planes in the plaque. The spikes may also be used to transport medication into the plaque. The plaque preparation treatment enables subsequent angioplasty to be performed at low balloon pressures of about 4 atmospheres or less, reduces dissections, and avoids injury to the arterial wall. The subsequent angioplasty may be performed with a drug-eluting balloon (DEB) or drug-coated balloon (DCB). The pre-angioplasty perforation procedure enables more drug to be absorbed during DEB or DCB angioplasty, and makes the need for a stent less likely. Alternatively, any local incidence of plaque dissection after balloon angioplasty may be treated by applying a thin, ring-shaped tack at the dissection site only, rather than applying a stent over the overall plaque site.
摘要:
Implantable cardiac stimulator, with chamber stimulation unit connectable to left/right ventricular stimulation electrode to generate/deliver chamber stimulation pulses for stimulation of ventricle; ventricular sensing unit (VSU) to detect respective chamber contraction and deliver ventricular sensing signal when chamber contraction detected; optional atrial stimulation unit, connectable to atrial stimulation electrode to generate atrial stimulation pulses to stimulate atrium; atrial sensing unit, to detect atrial contraction, deliver atrial sensing signal indicating respective atrial event; tachycardia detection unit, connected to VSU to detect and categorize ventricular/supraventricular tachycardia; treatment control unit (TCU), triggers chamber stimulation unit to deliver antitachycardiac stimulation (ATP); analyzer unit, connected to atrial sensing unit and TCU. Analyzes atrial events from sensing unit before/during/after delivering antitachycardiac stimulation for atrial rhythm pattern during ventricular ATP by comparison atrial rhythm pattern immediately before ATP and to trigger TCU as function of ATP response signal representing comparison result for selection of the following antitachycardiac treatment.