公开(公告)号：US20160090446A1

公开(公告)日：2016-03-31

申请号：US14962619

申请日：2015-12-08

Applicant: IMRA of America, Inc. ,  The Regents of the University of Michigan

Inventor： Duxin Sun ,  Hongwei Chen ,  Wei Qian ,  Yong Che ,  Masayuki Ito ,  Hayley Paholak ,  Kanokwan Sansanaphongpricha

IPC: C08G65/48

CPC classification number: C08G65/48 ,  A61K41/0052 ,  A61K47/50 ,  A61K47/60 ,  A61K49/0065 ,  C08G65/3344

Abstract: The present invention relates to methods, compositions, and kits for generating conjugated gold nanoparticles. In certain embodiments, the present invention provides methods of generating unsaturated conjugated gold nanoparticles by mixing naked gold nanoparticles with a first type of attachment molecules at a molar ratio such that the attachment molecules attach to the naked gold particles at a density level below the saturation level of the naked gold particles (e.g., at a saturation level of 1-99%). In some embodiments, a second type of attachment molecules (e.g., with the opposite charge as the first type of attachment molecules) are mixed with the unsaturated conjugated gold nanoparticles to generate double-conjugated gold nanoparticles (e.g., that are zwitterionic).

Abstract translation: 本发明涉及用于产生共轭金纳米颗粒的方法，组合物和试剂盒。 在某些实施方案中，本发明提供了通过将裸金纳米颗粒与第一类型附着分子以摩尔比混合以使得附着分子以低于饱和水平的密度水平附着于裸金颗粒的方式来产生不饱和共轭金纳米颗粒的方法 的裸金粒子（例如，在1-99％的饱和度水平）。 在一些实施方案中，将第二类型的附着分子（例如，具有相反电荷作为第一类型的附着分子）与不饱和共轭金纳米颗粒混合以产生双共轭金纳米颗粒（例如，两性离子）。

公开(公告)号：US20160058702A1

公开(公告)日：2016-03-03

申请号：US14838618

申请日：2015-08-28

Applicant: The Regents of the University of Michigan

Inventor： Kanokwan Sansanaphongpricha ,  Hongwei Chen ,  Duxin Sun

IPC: A61K9/107 ,  A61K47/34 ,  A61K31/704

CPC classification number: A61K9/107 ,  A61K9/0019 ,  A61K9/5138 ,  A61K9/5146 ,  A61K31/00 ,  A61K31/704 ,  A61K47/34

Abstract: The present invention provides compositions, systems, and methods employing cleavable polymeric micelles. For example, provided herein are compositions comprising micelles that contain a hydrophobic agent (e.g., metal nanoparticles and/or therapeutic agent), where the micelles are formed from a plurality of amphiphilic polymer molecules that comprise a hydrophilic polymer and a hydrophobic polymer, where the hydrophobic polymer comprises a cleavable Furan-Maleimide adduct. Also provided herein are methods of administering such compositions to a subject and treating a localized area of the subject with a device that emits heat, NIR light, and/or alternating magnetic current such that at least some of the micelles inside the subject near the localized area are disrupted (e.g., releasing a therapeutic agent).

Abstract translation: 本发明提供了使用可切割聚合胶束的组合物，体系和方法。 例如，本文提供了包含含有疏水剂（例如，金属纳米颗粒和/或治疗剂）的胶束的组合物，其中胶束由包含亲水性聚合物和疏水性聚合物的多个两亲聚合物分子形成，其中 疏水性聚合物包含可切割的呋喃 - 马来酰亚胺加合物。 本文还提供了将这种组合物施用于受试者并用发射热，NIR光和/或交替磁流的装置治疗受试者的局部区域的方法，使得受试者内的至少一些胶束接近局部 区域被破坏（例如释放治疗剂）。

公开(公告)号：US12226491B2

公开(公告)日：2025-02-18

申请号：US17232751

申请日：2021-04-16

Applicant: The Regents of the University of Michigan

Inventor： Duxin Sun ,  Ryan Clauson ,  Hongwei Chen ,  Chengyi Li ,  Wei Gao ,  Luke Bugada ,  Fei Wen ,  Brett Hill ,  Syed Monem Rizvi

IPC: A61K47/69 ,  A61K9/16 ,  A61K38/19 ,  A61K39/00 ,  A61K39/295 ,  A61K39/39 ,  A61K45/06 ,  A61K47/02 ,  A61K47/64 ,  A61P35/00

Abstract: The present invention provides, in some embodiments, methods, compositions, systems, and kits comprising nano-satellite complexes comprising: a core nanoparticle complex comprising a biocompatible coating surrounding a nanoparticle core; 3-25 satellite particles attached to, or absorbed to, said biocompatible coating; a plurality of antigenic peptides conjugated to, or absorbed to, said satellite particles; and at least one additional property. In other embodiments, provided herein are nano-satellite complexes comprising: a core nanoparticle complex comprising a biocompatible coating surrounding a nanoparticle core; a plurality of satellite particles attached to, or absorbed to, said biocompatible coating; a plurality of antigenic peptides conjugated to, or absorbed to, said satellite particles; and a plurality of LIGHT (TNFSF14) peptides conjugated to, or absorbed to, said satellite particles. In some embodiments, administration of the nanosatellite complexes to a subject with cancer achieves long-term cancer remission (e.g., when combined with an immune checkpoint inhibitor, such as αPD1).

公开(公告)号：US20240139336A1

公开(公告)日：2024-05-02

申请号：US18296642

申请日：2023-04-06

Applicant: The Regents of the University of Michigan

Inventor： Yu Lei ,  Yee Sun Tan ,  Kanokwan Sansanaphongpricha ,  Duxin Sun ,  Hongwei Chen ,  Hongxiang Hu

IPC: A61K47/69 ,  A61K39/00 ,  A61K39/02 ,  A61K39/118 ,  A61K39/385 ,  A61K47/64 ,  A61P35/00

CPC classification number: A61K47/6929 ,  A61K39/0003 ,  A61K39/0011 ,  A61K39/02 ,  A61K39/118 ,  A61K39/385 ,  A61K47/643 ,  A61K47/646 ,  A61K47/6923 ,  A61P35/00 ,  A61K2039/55561 ,  A61K2039/572 ,  A61K2039/60 ,  A61K2039/622 ,  B82Y5/00

Abstract: The present invention provides methods, compositions, systems, and kits comprising nano-satellite complexes and/or serum albumin carrier complexes, which are used for modulating antigen-specific immune response (e.g., enhancing anti-tumor immunity). In certain embodiments, the nano-satellite complexes comprise: a) a core nanoparticle complex comprising a biocompatible coating surrounding a nanoparticle core; b) at least one satellite particle attached to, or absorbed to, the biocompatible coating; and c) an antigenic component conjugated to, or absorbed to, the at least one satellite particle component. In certain embodiments, the complexes further comprise: d) a type I interferon agonist agent. In some embodiments, the serum albumin complexes comprise: a) at least part of a serum albumin protein, b) an antigenic component conjugated to the carrier protein, and c) a type I interferon agonist agent.

公开(公告)号：US20210346478A1

公开(公告)日：2021-11-11

申请号：US17232751

申请日：2021-04-16

Applicant: The Regents of the University of Michigan

Inventor： Duxin Sun ,  Ryan Clauson ,  Hongwei Chen ,  Chengyi Li ,  Wei Gao ,  Luke Bugada ,  Fei Wen ,  Brett Hill ,  Syed Monem Rizvi

IPC: A61K39/00 ,  A61K47/02 ,  A61K9/16 ,  A61K38/19 ,  A61K47/69 ,  A61K47/64 ,  A61K45/06 ,  A61K39/295 ,  A61P35/00 ,  A61K39/39

Abstract: The present invention provides, in some embodiments, methods, compositions, systems, and kits comprising nano-satellite complexes comprising: a core nanoparticle complex comprising a biocompatible coating surrounding a nanoparticle core; 3-25 satellite particles attached to, or absorbed to, said biocompatible coating; a plurality of antigenic peptides conjugated to, or absorbed to, said satellite particles; and at least one additional property. In other embodiments, provided herein are nano-satellite complexes comprising: a core nanoparticle complex comprising a biocompatible coating surrounding a nanoparticle core; a plurality of satellite particles attached to, or absorbed to, said biocompatible coating; a plurality of antigenic peptides conjugated to, or absorbed to, said satellite particles; and a plurality of LIGHT (TNFSF14) peptides conjugated to, or absorbed to, said satellite particles. In some embodiments, administration of the nanosatellite complexes to a subject with cancer achieves long-term cancer remission (e.g., when combined with an immune checkpoint inhibitor, such as αPD1).

公开(公告)号：US09533045B2

公开(公告)日：2017-01-03

申请号：US14457650

申请日：2014-08-12

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Hongwei Chen ,  Duxin Sun

IPC: A61K41/00 ,  A61K33/26 ,  A61N5/06

CPC classification number: A61K41/0052 ,  A61K33/26 ,  A61N5/062 ,  A61N2005/0659 ,  A61N2005/0662

Abstract: The present invention provides methods, systems, and devices for performing photothermal therapy (e.g., to treat cancer) using photothermal nanoparticles with a biocompatible coating surrounding a highly crystallized Fe3O4 core. In certain embodiments, the highly crystallized Fe3O4 core of the photothermal nanoparticles has an X-ray diffraction (XRD) pattern where the brightest diffraction ring is from the 440 plane. In some embodiments, the photothermal therapy is conducted with a device configured to emit electromagnetic radiation in the wavelengths between about 650 nm and 1000 nm, wherein the device further comprises a visible light source that allows a user to determine where the electromagnetic radiation is contacting a subject.

Abstract translation: 本发明提供了使用具有围绕高度结晶的Fe 3 O 4核心的生物相容性涂层的光热纳米颗粒进行光热治疗（例如治疗癌症）的方法，系统和装置。 在某些实施方案中，光热纳米颗粒的高度结晶的Fe 3 O 4核心具有X射线衍射（XRD）图案，其中最亮的衍射环来自440平面。 在一些实施例中，光热疗法是用配置成发射大约650nm和1000nm之间的波长的电磁辐射的装置进行的，其中所述装置还包括允许用户确定电磁辐射在哪里接触的可见光源 学科。

公开(公告)号：US20140296551A1

公开(公告)日：2014-10-02

申请号：US14212594

申请日：2014-03-14

Applicant: The Regents of the University of Michigan ,  IMRA of America, Inc,

Inventor： Duxin Sun ,  Hongwei Chen ,  Wei Qian ,  Yong Che ,  Masayuki Ito ,  Hayley Paholak ,  Kanokwan Sansanaphongpricha

IPC: C08G65/48

CPC classification number: C08G65/48 ,  A61K41/0052 ,  A61K47/50 ,  A61K47/60 ,  A61K49/0065 ,  C08G65/3344

Abstract: The present invention relates to methods, compositions, and kits for generating conjugated gold nanoparticles. In certain embodiments, the present invention provides methods of generating unsaturated conjugated gold nanoparticles by mixing naked gold nanoparticles with a first type of attachment molecules at a molar ratio such that the attachment molecules attach to the naked gold particles at a density level below the saturation level of the naked gold particles (e.g., at a saturation level of 1-99%). In some embodiments, a second type of attachment molecules (e.g., with the opposite charge as the first type of attachment molecules) are mixed with the unsaturated conjugated gold nanoparticles to generate double-conjugated gold nanoparticles (e.g., that are zwitterionic)

Abstract translation: 本发明涉及用于产生共轭金纳米颗粒的方法，组合物和试剂盒。 在某些实施方案中，本发明提供了通过将裸金纳米颗粒与第一类型附着分子以摩尔比混合以使得附着分子以低于饱和水平的密度水平附着于裸金颗粒的方式来产生不饱和共轭金纳米颗粒的方法 的裸金粒子（例如，在1-99％的饱和度水平）。 在一些实施方案中，将第二类型的附着分子（例如，具有相反电荷作为第一类型的附着分子）与不饱和共轭金纳米颗粒混合以产生双共轭金纳米颗粒（例如，两性离子）