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    CORE-SATELLITE NANOCOMPOSITES FOR MRI AND PHOTOTHERMAL THERAPY
    2.
    发明申请
    CORE-SATELLITE NANOCOMPOSITES FOR MRI AND PHOTOTHERMAL THERAPY 审中-公开

    公开(公告)号：US20200164094A1

    公开(公告)日：2020-05-28

    申请号：US16694715

    申请日：2019-11-25

    Applicant: The Regents of the University of Michigan

    Inventor： Hongwei Chen ,  Duxin Sun

    IPC: A61K49/18 ,  A61K41/00 ,  G01R33/56 ,  G01R33/48

    Abstract: The present invention provides methods, compositions, systems, and kits comprising core-satellite nanocomposites useful for photothermal and/or MRI applications (e.g., tumor treatment and/or imaging). In certain embodiments, the core-satellite nanocomposites comprise: i) a core nanoparticle complex comprising a biocompatible coating surrounding a nanoparticle core, and ii) at least one satellite component attached to, or absorbed to, the biocompatible coating. In some embodiments, the nanoparticle core and satellite component are composed of near-infrared photothermal agent material and/or MRI contrast agent material. In further embodiments, the satellite component is additionally or alternatively composed of near-infrared optical dye material.

    Conjugated gold nanoparticles
    3.
    发明授权
    Conjugated gold nanoparticles 有权
    共轭金纳米颗粒

    公开(公告)号：US09234078B2

    公开(公告)日：2016-01-12

    申请号：US14212594

    申请日：2014-03-14

    Applicant: The Regents of the University of Michigan ,  IMRA of America, Inc.

    Inventor： Duxin Sun ,  Hongwei Chen ,  Wei Qian ,  Yong Che ,  Masayuki Ito ,  Hayley Paholak ,  Kanokwan Sansanaphongpricha

    IPC: C08G65/48 ,  A61K47/48 ,  C08G65/334 ,  A61K41/00 ,  A61K49/00

    CPC classification number: C08G65/48 ,  A61K41/0052 ,  A61K47/50 ,  A61K47/60 ,  A61K49/0065 ,  C08G65/3344

    Abstract: The present invention relates to methods, compositions, and kits for generating conjugated gold nanoparticles. In certain embodiments, the present invention provides methods of generating unsaturated conjugated gold nanoparticles by mixing naked gold nanoparticles with a first type of attachment molecules at a molar ratio such that the attachment molecules attach to the naked gold particles at a density level below the saturation level of the naked gold particles (e.g., at a saturation level of 1-99%). In some embodiments, a second type of attachment molecules (e.g., with the opposite charge as the first type of attachment molecules) are mixed with the unsaturated conjugated gold nanoparticles to generate double-conjugated gold nanoparticles (e.g., that are zwitterionic).

    Abstract translation: 本发明涉及用于产生共轭金纳米颗粒的方法，组合物和试剂盒。 在某些实施方案中，本发明提供了通过将裸金纳米颗粒与第一类型附着分子以摩尔比混合以使得附着分子以低于饱和水平的密度水平附着于裸金颗粒的方式来产生不饱和共轭金纳米颗粒的方法 的裸金粒子（例如，在1-99％的饱和度水平）。 在一些实施方案中，将第二类型的附着分子（例如，具有相反电荷作为第一类型的附着分子）与不饱和共轭金纳米颗粒混合以产生双共轭金纳米颗粒（例如，两性离子）。

    PHOTOTHERMAL THERAPY USING MAGNETIC NANOPARTICLES
    4.
    发明申请
    PHOTOTHERMAL THERAPY USING MAGNETIC NANOPARTICLES 有权
    使用磁性纳米粒子的光热疗法

    公开(公告)号：US20150051534A1

    公开(公告)日：2015-02-19

    申请号：US14457650

    申请日：2014-08-12

    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

    Inventor： Hongwei Chen ,  Duxin Sun

    IPC: A61K41/00 ,  A61K33/26 ,  A61N5/06

    CPC classification number: A61K41/0052 ,  A61K33/26 ,  A61N5/062 ,  A61N2005/0659 ,  A61N2005/0662

    Abstract: The present invention provides methods, systems, and devices for performing photothermal therapy (e.g., to treat cancer) using photothermal nanoparticles with a biocompatible coating surrounding a highly crystallized Fe3O4 core. In certain embodiments, the highly crystallized Fe3O4 core of the photothermal nanoparticles has an X-ray diffraction (XRD) pattern where the brightest diffraction ring is from the 440 plane. In some embodiments, the photothermal therapy is conducted with a device configured to emit electromagnetic radiation in the wavelengths between about 650 nm and 1000 nm, wherein the device further comprises a visible light source that allows a user to determine where the electromagnetic radiation is contacting a subject.

    Abstract translation: 本发明提供了使用具有围绕高度结晶的Fe 3 O 4核心的生物相容性涂层的光热纳米颗粒进行光热治疗（例如治疗癌症）的方法，系统和装置。 在某些实施方案中，光热纳米颗粒的高度结晶的Fe 3 O 4核心具有X射线衍射（XRD）图案，其中最亮的衍射环来自440平面。 在一些实施例中，光热疗法是用配置成发射大约650nm和1000nm之间的波长的电磁辐射的装置进行的，其中所述装置还包括可见光源，其允许用户确定电磁辐射在哪里接触 学科。

    Core-satellite nanocomposites for MRI and photothermal therapy
    6.
    发明授权
    Core-satellite nanocomposites for MRI and photothermal therapy 有权

    公开(公告)号：US10898595B2

    公开(公告)日：2021-01-26

    申请号：US16694715

    申请日：2019-11-25

    Applicant: The Regents of the University of Michigan

    Inventor： Hongwei Chen ,  Duxin Sun

    IPC: A61B5/05 ,  A61K49/18 ,  A61K41/00 ,  G01R33/56 ,  G01R33/48 ,  A61N5/06 ,  A61B5/00 ,  A61B5/055

    Abstract: The present invention provides methods, compositions, systems, and kits comprising core-satellite nanocomposites useful for photothermal and/or MRI applications (e.g., tumor treatment and/or imaging). In certain embodiments, the core-satellite nanocomposites comprise: i) a core nanoparticle complex comprising a biocompatible coating surrounding a nanoparticle core, and ii) at least one satellite component attached to, or absorbed to, the biocompatible coating. In some embodiments, the nanoparticle core and satellite component are composed of near-infrared photothermal agent material and/or MRI contrast agent material. In further embodiments, the satellite component is additionally or alternatively composed of near-infrared optical dye material.

    CLEAVABLE POLYMERIC MICELLES
    8.
    发明申请
    CLEAVABLE POLYMERIC MICELLES 审中-公开

    公开(公告)号：US20180140550A1

    公开(公告)日：2018-05-24

    申请号：US15873400

    申请日：2018-01-17

    Applicant: The Regents of the University of Michigan

    Inventor： Kanokwan Sansanaphongpricha ,  Hongwei Chen ,  Duxin Sun

    IPC: A61K9/107 ,  A61K47/34 ,  A61K31/00 ,  A61K31/704

    CPC classification number: A61K9/107 ,  A61K9/0019 ,  A61K9/5138 ,  A61K9/5146 ,  A61K31/00 ,  A61K31/704 ,  A61K47/34

    Abstract: The present invention provides compositions, systems, and methods employing cleavable polymeric micelles. For example, provided herein are compositions comprising micelles that contain a hydrophobic agent (e.g., metal nanoparticles and/or therapeutic agent), where the micelles are formed from a plurality of amphiphilic polymer molecules that comprise a hydrophilic polymer and a hydrophobic polymer, where the hydrophobic polymer comprises a cleavable Furan-Maleimide adduct. Also provided herein are methods of administering such compositions to a subject and treating a localized area of the subject with a device that emits heat, NIR light, and/or alternating magnetic current such that at least some of the micelles inside the subject near the localized area are disrupted (e.g., releasing a therapeutic agent).

    CORE-SATELLITE NANOCOMPOSITES FOR MRI AND PHOTOTHERMAL THERAPY
    9.
    发明申请
    CORE-SATELLITE NANOCOMPOSITES FOR MRI AND PHOTOTHERMAL THERAPY 审中-公开
    用于MRI和光热治疗的核心 - 卫星纳米复合体

    公开(公告)号：US20150065858A1

    公开(公告)日：2015-03-05

    申请号：US14476408

    申请日：2014-09-03

    Applicant: The Regents of the University of Michigan

    Inventor： Hongwei Chen ,  Duxin Sun

    IPC: A61K49/18 ,  A61K33/26 ,  A61B5/00 ,  G01R33/56 ,  G01R33/48 ,  A61K41/00 ,  A61N5/06

    CPC classification number: A61K49/1824 ,  A61B5/0035 ,  A61B5/0075 ,  A61B5/055 ,  A61K41/0052 ,  A61K49/1827 ,  A61K49/183 ,  A61K49/1833 ,  A61K49/1851 ,  A61N5/062 ,  A61N2005/0659 ,  G01R33/4808 ,  G01R33/5601

    Abstract: The present invention provides methods, compositions, systems, and kits comprising core-satellite nanocomposites useful for photothermal and/or MRI applications (e.g., tumor treatment and/or imaging). In certain embodiments, the core-satellite nanocomposites comprise: i) a core nanoparticle complex comprising a biocompatible coating surrounding a nanoparticle core, and ii) at least one satellite component attached to, or absorbed to, the biocompatible coating. In some embodiments, the nanoparticle core and satellite component are composed of near-infrared photothermal agent material and/or MRI contrast agent material. In further embodiments, the satellite component is additionally or alternatively composed of near-infrared optical dye material.

    Abstract translation: 本发明提供包含可用于光热和/或MRI应用（例如肿瘤治疗和/或成像）的核心 - 卫星纳米复合材料的方法，组合物，系统和试剂盒。 在某些实施方案中，核心 - 卫星纳米复合材料包括：i）核心纳米颗粒复合物，其包含围绕纳米颗粒核心的生物相容性涂层，以及ii）附着于生物相容性涂层或吸收生物相容性涂层的至少一种卫星组分。 在一些实施例中，纳米颗粒核心和卫星部件由近红外光热剂材料和/或MRI造影剂材料组成。 在另外的实施例中，卫星组件另外地或替代地由近红外光学染料材料组成。

    Conjugated gold nanoparticles
    10.
    发明授权
    Conjugated gold nanoparticles 有权
    共轭金纳米颗粒

    公开(公告)号：US09587071B2

    公开(公告)日：2017-03-07

    申请号：US14962619

    申请日：2015-12-08

    Applicant: The Regents of the University of Michigan ,  IMRA of America, Inc.

    Inventor： Duxin Sun ,  Hongwei Chen ,  Wei Qian ,  Yong Che ,  Masayuki Ito ,  Hayley Paholak ,  Kanokwan Sansanaphongpricha

    IPC: C08G65/48 ,  A61K47/48 ,  C08G65/334 ,  A61K41/00 ,  A61K49/00

    CPC classification number: C08G65/48 ,  A61K41/0052 ,  A61K47/50 ,  A61K47/60 ,  A61K49/0065 ,  C08G65/3344

    Abstract: The present invention relates to methods, compositions, and kits for generating conjugated gold nanoparticles. In certain embodiments, the present invention provides methods of generating unsaturated conjugated gold nanoparticles by mixing naked gold nanoparticles with a first type of attachment molecules at a molar ratio such that the attachment molecules attach to the naked gold particles at a density level below the saturation level of the naked gold particles (e.g., at a saturation level of 1-99%). In some embodiments, a second type of attachment molecules (e.g., with the opposite charge as the first type of attachment molecules) are mixed with the unsaturated conjugated gold nanoparticles to generate double-conjugated gold nanoparticles (e.g., that are zwitterionic).

    Abstract translation: 本发明涉及用于产生共轭金纳米颗粒的方法，组合物和试剂盒。 在某些实施方案中，本发明提供了通过将裸金纳米颗粒与第一类型附着分子以摩尔比混合以使得附着分子以低于饱和水平的密度水平附着于裸金颗粒的方式来产生不饱和共轭金纳米颗粒的方法 的裸金粒子（例如，在1-99％的饱和度水平）。 在一些实施方案中，将第二类型的附着分子（例如，具有相反电荷作为第一类型的附着分子）与不饱和共轭金纳米颗粒混合以产生双共轭金纳米颗粒（例如，两性离子）。

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