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11.发明授权公开(公告)号：US11407851B2
公开(公告)日：2022-08-09
申请号：US16465555
申请日：2017-12-01
Applicant: The Texas A&M University System
Inventor： Landon D. Nash , Kendal P. Ezell
Abstract: An embodiment includes a system comprising: an iodine containing thermoset open-cell shape memory polymer (SMP) foam that is x-ray visible; wherein (a) the SMP foam is configured to expand from a compressed secondary state to an expanded primary state in response to thermal stimulus, (b) the SMP foam is a poly(urethane-urea-amide). Other embodiments are described herein.
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公开(公告)号：US11369720B2
公开(公告)日：2022-06-28
申请号：US16777190
申请日：2020-01-30
Applicant: The Texas A&M University System
Inventor： Rachael Muschalek , Keith Hearon , Landon D. Nash , Duncan J. Maitland
Abstract: An embodiment includes a system comprising: a substrate of a medical device; an un-foamed polyurethane coating directly contacting the substrate and fixedly attached to the substrate; a thermoset polyurethane shape memory polymer (SMP) foam, having first and second states, which directly contacts the polyurethane coating and fixedly attaches to the polyurethane coating; wherein the polyurethane coating fixedly attaches the SMP foam to the substrate. Other embodiments are described herein.
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公开(公告)号：US10548608B2
公开(公告)日：2020-02-04
申请号：US15579217
申请日：2016-06-07
Inventor： Anthony J. Boyle , Keith Hearon , Duncan J. Maitland , Landon D. Nash , Thomas S. Wilson
Abstract: An embodiment of the invention is a shape memory polymer (SMP) foam designed to recover its original shape through exposure to a solvent. Thermo-responsive SMPs are polymers designed to maintain a programmed secondary shape until heated above their transition temperature, upon which the polymer recovers its original, or primary, shape. The thermo-responsive SMP foam is programmed to its secondary shape prior to use, typically compression of the foam to a small volume, and remains in this programmed shape until exposed to a selected solvent such as dimethyl sulfoxide or ethyl alcohol. Upon exposure to the solvent, the transition temperature of the SMP foam decreases below the temperature of the environment and the SMP foam actuates to its primary shape. The SMP foam is tailored to actuate upon exposure to specific solvents while minimizing or preventing actuation when exposed to water or other solvents. This selective solvent actuation can be used to increase working time of a SMP foam device, that is, the time allowed for use of a device without undesired actuation, while maintaining functional SMP actuation. Solvent actuated SMP foams can be used in various applications including, but not limited to, treatment of aneurysms and arterio-venous malformations, tissue engineering, and wound healing.
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14.发明申请公开(公告)号：US20200017625A1
公开(公告)日：2020-01-16
申请号：US16465555
申请日：2017-12-01
Applicant: The Texas A&M University System
Inventor： Landon D. Nash , Kendal P. Ezell
Abstract: An embodiment includes a system comprising: an iodine containing thermoset open-cell shape memory polymer (SMP) foam that is x-ray visible; wherein (a) the SMP foam is configured to expand from a compressed secondary state to an expanded primary state in response to thermal stimulus, (b) the SMP foam is a poly(urethane-urea-amide). Other embodiments are described herein.
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15.发明申请公开(公告)号：US20180177508A1
公开(公告)日：2018-06-28
申请号：US15579217
申请日：2016-06-07
Inventor： Anthony J. Boyle , Keith Hearon , Duncan J. Maitland , Landon D. Nash , Thomas S. Wilson
CPC classification number: A61B17/12181 , A61B17/12031 , A61B17/12113 , A61B17/1219 , A61B2017/00871 , A61B2017/00938 , A61B2017/00964 , A61L31/06 , A61L31/14 , A61L31/146 , A61L2400/16 , A61L2430/36 , C08L75/04
Abstract: An embodiment of the invention is a shape memory polymer (SMP) foam designed to recover its original shape through exposure to a solvent. Thermo-responsive SMPs are polymers designed to maintain a programmed secondary shape until heated above their transition temperature, upon which the polymer recovers its original, or primary, shape. The thermo-responsive SMP foam is programmed to its secondary shape prior to use, typically compression of the foam to a small volume, and remains in this programmed shape until exposed to a selected solvent such as dimethyl sulfoxide or ethyl alcohol. Upon exposure to the solvent, the transition temperature of the SMP foam decreases below the temperature of the environment and the SMP foam actuates to its primary shape. The SMP foam is tailored to actuate upon exposure to specific solvents while minimizing or preventing actuation when exposed to water or other solvents. This selective solvent actuation can be used to increase working time of a SMP foam device, that is, the time allowed for use of a device without undesired actuation, while maintaining functional SMP actuation. Solvent actuated SMP foams can be used in various applications including, but not limited to, treatment of aneurysms and arterio-venous malformations, tissue engineering, and wound healing.
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Patent Agency Ranking
公开(公告)号：US20230312804A1
公开(公告)日：2023-10-05
申请号：US18177834
申请日：2023-03-03
Inventor： Grace Fletcher , Landon D. Nash , Kendal Ezell , Duncan J. Maitland
CPC classification number: C08G18/3206 , C08G18/14 , C08G18/3271 , C08G18/341 , C08G18/5018 , C08G18/73 , C08G18/755 , C08G18/757 , C08G18/758 , C08K5/03 , C08G2101/00
Abstract: An embodiment includes a polymer composition comprising a thermoplastic polymer that: (a) is bonded to iodine, (b) includes a vinyl group, and (c) includes urethane linkages. Other embodiments are described herein.
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公开(公告)号：US20230250212A1
公开(公告)日：2023-08-10
申请号：US18189277
申请日：2023-03-24
Inventor： Keith Hearon , Landon D. Nash , Thomas Wilson , Duncan J. Maitland , Mark A. Wierzbicki
CPC classification number: C08G18/3206 , C08G18/6715 , C08G18/758 , C08G18/3212 , C08L81/02 , C08L75/16 , C08L75/04 , C08G18/675 , C08G18/73 , B29K2105/04
Abstract: An embodiment includes a platform shape memory polymer system. Such an embodiment exhibits a blend of tunable, high performance mechanical attributes in combination with advanced processing capabilities and good biocompatibility. A post-polymerization crosslinking synthetic approach is employed that combines polyurethane and thiol-ene synthetic processes. Other embodiments are described herein.
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公开(公告)号：US11613603B2
公开(公告)日：2023-03-28
申请号：US16924819
申请日：2020-07-09
Inventor： Keith Hearon , Landon D. Nash , Thomas Wilson , Duncan J. Maitland , Mark A. Wierzbicki
Abstract: An embodiment includes a platform shape memory polymer system. Such an embodiment exhibits a blend of tunable, high performance mechanical attributes in combination with advanced processing capabilities and good biocompatibility. A post-polymerization crosslinking synthetic approach is employed that combines polyurethane and thiol-ene synthetic processes. Other embodiments are described herein.
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公开(公告)号：US11576679B2
公开(公告)日：2023-02-14
申请号：US16319931
申请日：2017-07-28
Applicant: The Texas A&M University System
Inventor： Duncan J. Maitland , Mark A. Wierzbicki , Landon D. Nash , Wonjun Hwang
Abstract: An embodiment includes a system comprising: a catheter; an optic fiber having a long axis and a short axis that is orthogonal to the long axis; first and second radiopaque elements coupled to the optic fiber; a first wire coupled to the optic fiber and extending from the first radiopaque element to the second radiopaque element; a fluid; wherein (a)(i) the first wire wraps at least partially around an exterior surface of the optic fiber; (a)(ii) an outer diameter of the first wire and an outer diameter of the optic fiber are collectively less than an inner diameter of the catheter, and (a)(iii) the first wire is configured to center the optic fiber within the catheter within a plane orthogonal to the long axis.
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20.发明申请公开(公告)号：US20220403091A1
公开(公告)日：2022-12-22
申请号：US17881695
申请日：2022-08-05
Applicant: The Texas A&M University System
Inventor： Landon D. Nash , Kendal P. Ezell
Abstract: An embodiment includes a system comprising: an iodine containing thermoset open-cell shape memory polymer (SMP) foam that is x-ray visible; wherein (a) the SMP foam is configured to expand from a compressed secondary state to an expanded primary state in response to thermal stimulus, (b) the SMP foam is a poly(urethane-urea-amide). Other embodiments are described herein.
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