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公开(公告)号：US11786591B2
公开(公告)日：2023-10-17
申请号：US17334505
申请日：2021-05-28
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , Institute for Research in Biomedicine
发明人： Peter Kwong , Michael Gordon Joyce , Baoshan Zhang , Yongping Yang , Peter Collins , Ursula Buchholz , Davide Corti , Antonio Lanzavecchia , Guillaume Stewart-Jones
IPC分类号： C07K14/005 , A61K39/155 , A61K39/39 , A61K48/00 , C07K14/135
CPC分类号： A61K39/155 , A61K39/39 , A61K48/00 , C07K14/005 , C07K14/135 , C07K2319/70 , C07K2319/73 , C12N2760/18322 , C12N2760/18334 , C12N2760/18522 , C12N2760/18534
摘要： Metapneumovirus (MPV) F proteins stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the MPV F proteins and/or nucleic acid molecules can be used to generate an immune response to MPV in a subject. In additional embodiments, the therapeutically effective amount of the MPV F ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing MPV infection.
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12.发明授权公开(公告)号：US11732011B2
公开(公告)日：2023-08-22
申请号：US17523174
申请日：2021-11-10
发明人： Neil P. King , David Baker , Brooke Fiala , Lance Joseph Stewart , Laurent Perez , Antonio Lanzavecchia , Jessica Marcandalli
IPC分类号： C12N7/00 , C12N1/15 , C12N15/45 , A61K39/12 , A61K39/155 , C07K14/005 , A61P31/14 , B82Y5/00 , A61K39/00
CPC分类号： C07K14/005 , A61K39/12 , A61P31/14 , B82Y5/00 , C12N7/00 , A61K2039/575 , C07K2319/735 , C12N2760/18022 , C12N2760/18322 , C12N2760/18522
摘要： Disclosed herein are nanostructures and their use, where the nanostructures include (a) a plurality of first assemblies, each first assembly comprising a plurality of identical first polypeptides; (b) a plurality of second assemblies, each second assembly comprising a plurality of identical second polypeptides, wherein the second polypeptide differs from the first polypeptide; wherein the plurality of first assemblies non-covalently interact with the plurality of second assemblies to form a nanostructures; and wherein the nanostructure displays multiple copies of one or more paramyxovirus and/or pneumovirus F proteins or antigenic fragments thereof, on an exterior of the nanostructure.
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公开(公告)号：US20220024987A1
公开(公告)日：2022-01-27
申请号：US17378587
申请日：2021-07-16
申请人： The United States of America, as represented by the Secretary, Department of Health and Human , Institute for Research in Biomedicine
发明人： Baoshan Zhang , Guillaume Stewart-Jones , John Mascola , Kai Xu , Gwo-Yu Chuang , Li Ou , Peter Kwong , Yaroslav Tsybovsky , Wing-Pui Kong , Aliaksandr Druz , Davide Corti , Antonio Lanzavecchia
IPC分类号： C07K14/005 , A61K39/155 , A61P31/14 , C12N7/00
摘要： Embodiments of a recombinant human Parainfluenza Virus (hPIV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also disclosed are nucleic acids encoding the hPIV F ectodomain trimer and methods of producing the hPIV F ectodomain trimer. Methods for inducing an immune response in a subject are also disclosed. In some embodiments, the method can be a method for treating or inhibiting a hPIV infection in a subject by administering a effective amount of the recombinant hPIV F ectodomain trimer to the subject.
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公开(公告)号：US20210009661A1
公开(公告)日：2021-01-14
申请号：US16912886
申请日：2020-06-26
IPC分类号： C07K16/10
摘要： This disclosure relates to binding agents with specificity for HIV and to methods for using the same to treat, pre-vent and/or ameliorate HIV infection and/or AIDS.
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公开(公告)号：US10730933B2
公开(公告)日：2020-08-04
申请号：US15780821
申请日：2016-12-05
摘要： This disclosure relates to binding agents with specificity for HIV and to methods for using the same to treat, prevent and/or ameliorate HIV infection and/or AIDS.
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公开(公告)号：US10420834B2
公开(公告)日：2019-09-24
申请号：US15539640
申请日：2015-12-24
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , Institute for Research in Biomedicine
发明人： Peter Kwong , Michael Gordon Joyce , Baoshan Zhang , Yongping Yang , Peter Collins , Ursula Buchholz , Davide Corti , Antonio Lanzavecchia , Guillaume Stewart-Jones
IPC分类号： A61K39/155 , C07K14/005 , A61K39/39 , A61K48/00 , C07K14/135
摘要： Metapneumovirus (MPV) F proteins stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the MPV F proteins and/or nucleic acid molecules can be used to generate an immune response to MPV in a subject. In additional embodiments, the therapeutically effective amount of the MPV F ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing MPV infection.
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公开(公告)号：US20180186897A1
公开(公告)日：2018-07-05
申请号：US15738828
申请日：2016-06-24
发明人： Antonio Lanzavecchia , Roger Geiger , Luca Piccoli
IPC分类号： C07K16/44 , A61P33/06 , C07K14/705 , G01N33/569
CPC分类号： C07K16/44 , A61K39/015 , A61P33/06 , C07K14/70503 , C07K14/70596 , C07K16/28 , C07K2317/21 , C07K2317/30 , C07K2319/33 , G01N33/569 , G01N33/56905 , G01N2333/445 , G01N2800/26 , Y02A50/412 , Y02A50/58
摘要： The present invention provides a pharmaceutical composition, for example a vaccine, which comprises a RIFIN, which is able to bind to a mutated LAIR-1 fragment, which broadly binds to erythrocytes infected with Plasmodium falciparum. Such a RIFIN may be useful in the prevention and/or treatment of malaria.
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公开(公告)号：US09725502B2
公开(公告)日：2017-08-08
申请号：US15284799
申请日：2016-10-04
IPC分类号： A61K38/00 , C07K14/005 , C07K16/08 , A61K39/00
CPC分类号： C07K16/088 , A01D34/63 , A01D34/71 , A01D2101/00 , A61K38/00 , A61K39/00 , A61K39/42 , A61K2039/505 , A61K2039/507 , C07K14/005 , C07K2317/21 , C07K2317/34 , C07K2317/41 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C12N2710/16122
摘要： The invention relates to neutralizing antibodies, and antibody fragments thereof, having high potency in neutralizing hCMV, wherein said antibodies and antibody fragments are specific for one, or a combination of two or more, hCMV gene UL products. The invention also relates to immortalized B cells that produce, and to epitopes that bind to, such antibodies and antibody fragments. In addition, the invention relates to the use of the antibodies, antibody fragments, and epitopes in screening methods as well as in the diagnosis, prevention, and therapy of disease.
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公开(公告)号：US09611316B2
公开(公告)日：2017-04-04
申请号：US14938438
申请日：2015-11-11
IPC分类号： A61K39/42 , C07K14/005 , A61K38/00 , C07K16/08 , C07K5/09
CPC分类号： C07K16/088 , A61K38/00 , A61K39/42 , C07K5/0815 , C07K14/005 , C07K2316/96 , C07K2317/21 , C07K2317/32 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： The invention relates to neutralizing antibodies and antibody fragments having high potency in neutralizing hCMV, wherein said antibodies and antibody fragments are specific for a combination of hCMV proteins UL130 and UL131A, or for a combination of hCMV proteins UL128, UL130 and UL131A. The invention relates also to immortalized B cells that produce, and to epitopes that bind to, such antibodies and antibody fragments. In addition, the invention relates to the use of the antibodies, antibody fragments, and epitopes in screening methods as well as in the diagnosis and therapy of disease.
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公开(公告)号：US20240101609A1
公开(公告)日：2024-03-28
申请号：US18537448
申请日：2023-12-12
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic , Institute for Research in Biomedicine
发明人： Baoshan Zhang , Guillaume Stewart-Jones , Tongqing Zhou , John Mascola , Kai Xu , Yongping Yang , Paul Thomas , Gwo-Yu Chuang , Li Ou , Peter Kwong , Yaroslav Tsybovsky , Wing-Pui Kong , Aliaksandr Druz , Davide Corti , Antonio Lanzavecchia
IPC分类号： C07K14/005 , A61K39/155 , A61P31/14 , C12N7/00
CPC分类号： C07K14/005 , A61K39/155 , A61P31/14 , C12N7/00 , C07K2319/50 , C12N2760/18634 , C12N2760/18734
摘要： Embodiments of a recombinant human Parainfluenza Virus (hPIV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also disclosed are nucleic acids encoding the hPIV F ectodomain trimer and methods of producing the hPIV F ectodomain trimer. Methods for inducing an immune response in a subject are also disclosed. In some embodiments, the method can be a method for treating or inhibiting a hPIV infection in a subject by administering a effective amount of the recombinant hPIV F ectodomain trimer to the subject.
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