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公开(公告)号：US11027007B2
公开(公告)日：2021-06-08
申请号：US16578748
申请日：2019-09-23
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , Institute for Research in Biomedicine
发明人： Peter Kwong , Michael Gordon Joyce , Baoshan Zhang , Yongping Yang , Peter Collins , Ursula Buchholz , Davide Corti , Antonio Lanzavecchia , Guillaume Stewart-Jones
IPC分类号： A61K39/155 , C07K14/115 , A61K39/39 , C07K14/005 , A61K48/00 , C07K14/135
摘要： Metapneumovirus (MPV) F proteins stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the MPV F proteins and/or nucleic acid molecules can be used to generate an immune response to MPV in a subject. In additional embodiments, the therapeutically effective amount of the MPV F ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing MPV infection.
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公开(公告)号：US11786591B2
公开(公告)日：2023-10-17
申请号：US17334505
申请日：2021-05-28
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , Institute for Research in Biomedicine
发明人： Peter Kwong , Michael Gordon Joyce , Baoshan Zhang , Yongping Yang , Peter Collins , Ursula Buchholz , Davide Corti , Antonio Lanzavecchia , Guillaume Stewart-Jones
IPC分类号： C07K14/005 , A61K39/155 , A61K39/39 , A61K48/00 , C07K14/135
CPC分类号： A61K39/155 , A61K39/39 , A61K48/00 , C07K14/005 , C07K14/135 , C07K2319/70 , C07K2319/73 , C12N2760/18322 , C12N2760/18334 , C12N2760/18522 , C12N2760/18534
摘要： Metapneumovirus (MPV) F proteins stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the MPV F proteins and/or nucleic acid molecules can be used to generate an immune response to MPV in a subject. In additional embodiments, the therapeutically effective amount of the MPV F ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing MPV infection.
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公开(公告)号：US10420834B2
公开(公告)日：2019-09-24
申请号：US15539640
申请日：2015-12-24
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , Institute for Research in Biomedicine
发明人： Peter Kwong , Michael Gordon Joyce , Baoshan Zhang , Yongping Yang , Peter Collins , Ursula Buchholz , Davide Corti , Antonio Lanzavecchia , Guillaume Stewart-Jones
IPC分类号： A61K39/155 , C07K14/005 , A61K39/39 , A61K48/00 , C07K14/135
摘要： Metapneumovirus (MPV) F proteins stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the MPV F proteins and/or nucleic acid molecules can be used to generate an immune response to MPV in a subject. In additional embodiments, the therapeutically effective amount of the MPV F ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing MPV infection.
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公开(公告)号：US11136356B2
公开(公告)日：2021-10-05
申请号：US16756777
申请日：2018-10-16
发明人： Peter Kwong , John Mascola , Gwo-Yu Chuang , Hui Geng , Yongping Yang , Cheng Cheng , Jeffrey Boyington , Yen-Ting Lai
摘要： Immunogens comprising a recombinant HIV-1 Env ectodomain trimer stabilized in a prefusion closed conformation and methods of their use and production are disclosed. In several embodiments, the immunogen can be used to elicit an immune response to HIV-1 in a subject.
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公开(公告)号：US10035844B2
公开(公告)日：2018-07-31
申请号：US15612846
申请日：2017-06-02
发明人： Peter D. Kwong , Gary J. Nabel , Rebecca S. Rudicell , John Mascola , Mark Connors , Ivelin Georgiev , Jiang Zhu , Young Do Kwon , Tongqing Zhou , Yongping Yang , Baoshan Zhang , Gwo-Yu Chuang , Xueling Wu , Zhi-yong Yang , Wei Shi
IPC分类号： C07K16/10 , G01N33/569 , A61K39/42 , A61K45/06
CPC分类号： C07K16/1063 , A61K39/42 , A61K45/06 , A61K2039/505 , C07K2317/21 , C07K2317/41 , C07K2317/565 , C07K2317/567 , C07K2317/72 , C07K2317/76 , C07K2317/92 , G01N33/56983 , G01N33/56988
摘要： Monoclonal neutralizing antibodies that specifically bind to HIV-1 gp120 and antigen binding fragments of these antibodies are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV infection is disclosed.
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6.发明授权公开(公告)号：US10961283B2
公开(公告)日：2021-03-30
申请号：US16312166
申请日：2017-06-27
发明人： Peter Kwong , Ivelin Georgiev , Michael Gordon Joyce , Masaru Kanekiyo , Aliaksandr Druz , Ulrich Baxa , Joseph Van Galen , Cheng Cheng , John Mascola , Yaroslav Tsybovsky , Yongping Yang , Barney Graham , Syed Mohammad Moin , Jeffrey Boyington
IPC分类号： C07K14/11 , A61K39/21 , C12N7/00 , C07K14/08 , C07K14/16 , C07K14/165 , C07K14/435 , A61K39/00
摘要： Disclosed are recombinant insect ferritin nanoparticles that can be used to display two different trimeric antigens at an equal ratio. Also disclosed are nucleic acids encoding the recombinant insect ferritin nanoparticles and methods of producing the recombinant insect ferritin nanoparticles. Methods for eliciting an immune response in a subject are also provided.
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公开(公告)号：US10047148B2
公开(公告)日：2018-08-14
申请号：US15699902
申请日：2017-09-08
发明人： Mark Connors , Jinghe Huang , Leo B. Laub , Peter Kwong , Gary Nabel , John R. Mascola , Baoshan Zhang , Rebecca S. Rudicell , Ivelin Georgiev , Yongping Yang , Jiang Zhu , Gilad Ofek
IPC分类号： A61K39/395 , C07K16/00 , A61K39/42 , C07K16/10 , A61K39/00 , G01N33/569 , A61K45/06 , A61K49/00
摘要： Monoclonal neutralizing antibodies are disclosed that specifically bind to the HIV-1 gp41 membrane-proximal external region (MPER). Also disclosed are compositions including the disclosed antibodies that specifically bind gp41, nucleic acids encoding these antibodies, expression vectors including the nucleic acids, and isolated host cells that express the nucleic acids. The antibodies and compositions disclosed herein can be used for detecting the presence of HIV-1 in a biological sample, or detecting an HIV-1 infection or diagnosing AIDS in a subject. In additional, the broad neutralization breadth of the disclosed antibodies makes them ideal for treating a subject with an HIV infection. Thus, disclosed are methods of treating and/or preventing HIV infection.
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公开(公告)号：US10858400B2
公开(公告)日：2020-12-08
申请号：US15633578
申请日：2017-06-26
发明人： Peter Kwong , Barney Graham , Jason McLellan , Man Chen , Baoshan Zhang , Tongqing Zhou , Michael Gordon Joyce , Yongping Yang
IPC分类号： C07K14/005
摘要： Disclosed are immunogens including a recombinant RSV F protein stabilized in a prefusion conformation. Also disclosed are nucleic acids encoding the immunogens and methods of producing the immunogens. Methods for generating an immune response in a subject are also disclosed. In some embodiments, the method is a method for treating or preventing a RSV infection in a subject by administering a therapeutically effective amount of the immunogen to the subject.
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公开(公告)号：US20180319846A1
公开(公告)日：2018-11-08
申请号：US16025858
申请日：2018-07-02
申请人： The United States of America,as represented by the Secretary,Department of Health and Human Services
发明人： Peter D. Kwong , Barney S. Graham , Jason S. McLellan , Jeffrey Boyington , Lei Chen , Man Chen , Gwo-Yu Chuang , Ivelin Stefanov Georgiev , Jason Gorman , Michael Gordon Joyce , Masaru Kanekiyo , Gilad Ofek , Marie Pancera , Mallika Sastry , Cinque Soto , Sanjay Srivatsan , Guillaume Stewart-Jones , Yongping Yang , Baoshan Zhang , Tongqing Zhou
IPC分类号： C07K14/005 , A61K39/155 , C12N7/00 , A61K39/12 , G01N33/564 , A61K39/00
CPC分类号： C07K14/005 , A61K39/12 , A61K39/155 , A61K2039/5252 , A61K2039/5254 , A61K2039/53 , A61K2039/543 , A61K2039/55505 , A61K2039/55561 , A61K2039/55566 , C07K2319/21 , C07K2319/22 , C07K2319/50 , C07K2319/70 , C07K2319/735 , C12N7/00 , C12N2710/10343 , C12N2760/18522 , C12N2760/18534 , G01N33/564
摘要： Disclosed are Respiratory Syncytial Virus (RSV) antigens including a recombinant RSV F protein stabilized in a prefusion conformation. Also disclosed are nucleic acids encoding the antigens and methods of producing the antigens. Methods for generating an immune response in a subject are also disclosed. In some embodiments, the method is a method for treating or preventing a RSV infection in a subject by administering a therapeutically effective amount of the antigen to the subject.
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公开(公告)号：US09783595B2
公开(公告)日：2017-10-10
申请号：US15226744
申请日：2016-08-02
发明人： Mark Connors , Jinghe Huang , Leo B. Laub , Peter Kwong , Gary Nabel , John R. Mascola , Baoshan Zhang , Rebecca S. Rudicell , Ivelin Georgiev , Yongping Yang , Jiang Zhu , Gilad Ofek
CPC分类号： C07K16/1063 , A61K39/42 , A61K45/06 , A61K49/0004 , A61K2039/505 , C07K16/00 , C07K16/1045 , C07K2317/14 , C07K2317/21 , C07K2317/31 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , G01N33/56972 , G01N33/56983 , G01N33/56988 , G01N2333/161
摘要： Monoclonal neutralizing antibodies are disclosed that specifically bind to the HIV-1 gp41 membrane-proximal external region (MPER). Also disclosed are compositions including the disclosed antibodies that specifically bind gp41, nucleic acids encoding these antibodies, expression vectors including the nucleic acids, and isolated host cells that express the nucleic acids. The antibodies and compositions disclosed herein can be used for detecting the presence of HIV-1 in a biological sample, or detecting an HIV-1 infection or diagnosing AIDS in a subject. In additional, the broad neutralization breadth of the disclosed antibodies makes them ideal for treating a subject with an HIV infection. Thus, disclosed are methods of treating and/or preventing HIV infection.
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