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公开(公告)号：US09458141B2
公开(公告)日：2016-10-04
申请号：US14869318
申请日：2015-09-29
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , Forschungsverbund Berlin E.V.
发明人： Marvin C. Gershengorn , Susanne Neumann , Bruce M. Raaka , Craig J. Thomas , James Inglese , Noel T. Southall , Steven Titus , Wei Zheng , Wenwei Huang , Gerd Krause , Gunnar Kleinau
IPC分类号： A61K51/00 , C07D239/88 , C07D217/24 , A61K31/47 , A61P35/00 , A61K31/167 , A61K31/517 , C07C233/01 , C07D405/06 , C07D239/91 , C07D401/06 , C07D405/14 , C07D487/04 , A61K49/00
CPC分类号： C07D405/06 , A61K31/517 , A61K49/0004 , A61K51/00 , C07D239/91 , C07D401/06 , C07D405/14 , C07D487/04
摘要： Disclosed are oxo-hydroquinazolines that are useful as selective TSHR agonists. The compounds may be used for detecting or treating thyroid cancer, or treating a bone degenerative disorder.
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公开(公告)号：US11878004B2
公开(公告)日：2024-01-23
申请号：US17809353
申请日：2022-06-28
申请人： FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC. , The United States of America, as represented by the Secretary, Department of Health and Human Services , THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
发明人： Hengli Tang , Emily M. Lee , Wei Zheng , Ruili Huang , Miao Xu , Wenwei Huang , Khalida Shamim , Guoli Ming , Hongjun Song
IPC分类号： A61K31/4162 , A61P31/14 , A61K31/4184 , A61K31/245 , A61K31/433 , A61K31/4535 , A61K31/517 , A61K31/4741 , A61K31/554 , A61K31/422 , A61K31/4709 , A61K31/336 , A61K31/427 , A61K31/506 , A61K31/519 , A61K31/352 , A61K31/165
CPC分类号： A61K31/4184 , A61K31/165 , A61K31/245 , A61K31/336 , A61K31/352 , A61K31/4162 , A61K31/422 , A61K31/427 , A61K31/433 , A61K31/4535 , A61K31/4709 , A61K31/4741 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/554 , A61P31/14
摘要： The present invention concerns the use of compounds and compositions for the treatment or prevention of Flavivirus infections, such as dengue virus infections and Zika virus infections. Aspects of the invention include methods for treating or preventing Flavivirus virus infection, such as dengue virus and Zika virus infection, by administering a compound or composition of the invention, to a subject in need thereof; methods for inhibiting Flavivirus infections, such as dengue virus and Zika virus infections, in a cell in vitro or in vivo; pharmaceutical compositions; packaged dosage formulations; and kits useful for treating or preventing Flavivirus infections, such as dengue virus and Zika virus infections.
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公开(公告)号：US11779570B2
公开(公告)日：2023-10-10
申请号：US17809345
申请日：2022-06-28
申请人： FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC. , The United States of America, as represented by the Secretary, Department of Health and Human Services , THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
发明人： Hengli Tang , Emily M. Lee , Wei Zheng , Ruili Huang , Miao Xu , Wenwei Huang , Khalida Shamim , Guoli Ming , Hongjun Song
IPC分类号： A61K31/4162 , A61P31/14 , A61K31/4184 , A61K31/245 , A61K31/433 , A61K31/4535 , A61K31/517 , A61K31/4741 , A61K31/554 , A61K31/422 , A61K31/4709 , A61K31/336 , A61K31/427 , A61K31/506 , A61K31/519 , A61K31/352 , A61K31/165
CPC分类号： A61K31/4184 , A61K31/165 , A61K31/245 , A61K31/336 , A61K31/352 , A61K31/4162 , A61K31/422 , A61K31/427 , A61K31/433 , A61K31/4535 , A61K31/4709 , A61K31/4741 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/554 , A61P31/14
摘要： The present invention concerns the use of compounds and compositions for the treatment or prevention of Flavivirus infections, such as dengue virus infections and Zika virus infections. Aspects of the invention include methods for treating or preventing Flavivirus virus infection, such as dengue virus and Zika virus infection, by administering a compound or composition of the invention, to a subject in need thereof; methods for inhibiting Flavivirus infections, such as dengue virus and Zika virus infections, in a cell in vitro or in vivo; pharmaceutical compositions; packaged dosage formulations; and kits useful for treating or preventing Flavivirus infections, such as dengue virus and Zika virus infections.
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公开(公告)号：US11207315B2
公开(公告)日：2021-12-28
申请号：US16718343
申请日：2019-12-18
申请人： FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC. , THE JOHNS HOPKINS UNIVERSITY , The United States of America, as represented by the Secretary, Department of Health and Human Services
发明人： Hengli Tang , Emily M. Lee , Anil Mathew Tharappel , Hongjun Song , Guo-Li Ming , Wei Zheng , Miao Xu , Shu Yang , Ruili Huang , Wenwei Huang , Khalida Shamim , Hao Li
IPC分类号： A61K31/4745 , A61K45/06 , A61P31/14
摘要： The present invention concerns the use of emetine compounds for the treatment or prevention of Flavivirus infections, such as dengue virus infections. Aspects of the invention include methods for treating or preventing Flavivirus virus infection, such as dengue virus infection, by administering an emetine compound such as emetine or cephaeline, or a combination of two or more emetine compounds, to a subject in need thereof; methods for inhibiting Flavivirus infections such as dengue virus infections in a cell in vitro or in vivo; pharmaceutical compositions; packaged dosage formulations; and kits for treating or preventing Flavivirus infections, such dengue virus infections.
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公开(公告)号：US11026947B2
公开(公告)日：2021-06-08
申请号：US16608489
申请日：2018-04-26
申请人： The Brigham and Women's Hospital, Inc. , The United States of America, As Represented By The Secretary, Department Of Health And Human Services
发明人： Paul B. Yu , Wenwei Huang , Philip Edward Sanderson , Jian-Kang Jiang , Khalida Shamim , Wei Zheng , Xiuli Huang , Gregory Tawa , Arthur Lee , Asaf Alimardanov , Junfeng Huang
IPC分类号： A61K31/519 , A61K31/5377 , A61K31/551 , A61P19/08 , A61K31/675 , A61K45/06 , C07D487/04 , C07D519/00 , C07F9/6561
摘要： The present invention provides small-molecule inhibitors of BMP signaling and compositions and methods for inhibiting BMP signaling. These compounds and compositions may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation. These compounds and compositions may also be used to treat subjects with Sjögren's syndrome, or diffuse intrinsic pontine glioma (DIPG).
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公开(公告)号：US10202367B2
公开(公告)日：2019-02-12
申请号：US15317864
申请日：2015-06-12
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , University of Kansas
发明人： Tsanyang Liang , Zongyi Hu , Juan Jose Marugan , Noel Terrence Southall , Shanshan He , Xin Hu , Jingbo Xiao , Marc Ferrer , Wei Zheng , Kevin J. Frankowski , Frank J. Schoenen , Kelin Li
IPC分类号： C07D413/14 , A61K31/4545 , C07D417/14 , C07D471/08 , A61K31/496 , A61K31/5377 , C07D413/06 , A61K31/4178 , A61K31/454 , A61K31/7056 , A61K31/7068 , A61K38/07 , A61K38/13 , A61K38/21
摘要： Disclosed are compounds of formula (I), formula (II), and formula (III): wherein Ar, R1, A, and X are as defined in the specification. These compounds are antiviral agents and are contemplated for use in the treatment of viral infections, for example, hepatitis C. These compounds are also contemplated for use in treating or preventing cancers.
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公开(公告)号：US09296729B2
公开(公告)日：2016-03-29
申请号：US14243821
申请日：2014-04-02
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , Forschungsverbund Berlin E.V.
发明人： Marvin C. Gershengorn , Susanne Neumann , Bruce M. Raaka , Craig J. Thomas , James Inglese , Noel T. Southall , Steven Titus , Wenwei Huang , Gerd Krause , Gunnar Kleinau , Wei Zheng
IPC分类号： C07D405/06 , C07D239/91 , A61K49/00 , A61K51/00 , C07D401/06 , C07D405/14 , C07D487/04 , A61K31/517
CPC分类号： C07D405/06 , A61K31/517 , A61K49/0004 , A61K51/00 , C07D239/91 , C07D401/06 , C07D405/14 , C07D487/04
摘要： Disclosed are oxo-hydroquinazolines that are useful as selective TSHR agonists. The compounds may be used for detecting or treating thyroid cancer, or treating a bone degenerative disorder.
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公开(公告)号：US11903929B2
公开(公告)日：2024-02-20
申请号：US17809327
申请日：2022-06-28
申请人： FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC. , The United States of America, as represented by the Secretary, Department of Health and Human Services , THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
发明人： Hengli Tang , Emily M. Lee , Wei Zheng , Ruili Huang , Miao Xu , Wenwei Huang , Khalida Shamim , Guoli Ming , Hongjun Song
IPC分类号： A61K31/4162 , A61P31/14 , A61K31/4184 , A61K31/245 , A61K31/433 , A61K31/4535 , A61K31/517 , A61K31/4741 , A61K31/554 , A61K31/422 , A61K31/4709 , A61K31/336 , A61K31/427 , A61K31/506 , A61K31/519 , A61K31/352 , A61K31/165
CPC分类号： A61K31/4184 , A61K31/165 , A61K31/245 , A61K31/336 , A61K31/352 , A61K31/4162 , A61K31/422 , A61K31/427 , A61K31/433 , A61K31/4535 , A61K31/4709 , A61K31/4741 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/554 , A61P31/14
摘要： The present invention concerns the use of compounds and compositions for the treatment or prevention of Flavivirus infections, such as dengue virus infections and Zika virus infections. Aspects of the invention include methods for treating or preventing Flavivirus virus infection, such as dengue virus and Zika virus infection, by administering a compound or composition of the invention, to a subject in need thereof; methods for inhibiting Flavivirus infections, such as dengue virus and Zika virus infections, in a cell in vitro or in vivo; pharmaceutical compositions; packaged dosage formulations; and kits useful for treating or preventing Flavivirus infections, such as dengue virus and Zika virus infections.
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公开(公告)号：US11850236B2
公开(公告)日：2023-12-26
申请号：US17809339
申请日：2022-06-28
申请人： FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC. , The United States of America, as represented by the Secretary, Department of Health and Human Services , THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
发明人： Hengli Tang , Emily M. Lee , Wei Zheng , Ruili Huang , Miao Xu , Wenwei Huang , Khalida Shamim , Guoli Ming , Hongjun Song
IPC分类号： A61K31/4162 , A61P31/14 , A61K31/4184 , A61K31/245 , A61K31/433 , A61K31/4535 , A61K31/517 , A61K31/4741 , A61K31/554 , A61K31/422 , A61K31/4709 , A61K31/336 , A61K31/427 , A61K31/506 , A61K31/519 , A61K31/352 , A61K31/165
CPC分类号： A61K31/4184 , A61K31/165 , A61K31/245 , A61K31/336 , A61K31/352 , A61K31/4162 , A61K31/422 , A61K31/427 , A61K31/433 , A61K31/4535 , A61K31/4709 , A61K31/4741 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/554 , A61P31/14
摘要： The present invention concerns the use of compounds and compositions for the treatment or prevention of Flavivirus infections, such as dengue virus infections and Zika virus infections. Aspects of the invention include methods for treating or preventing Flavivirus virus infection, such as dengue virus and Zika virus infection, by administering a compound or composition of the invention, to a subject in need thereof; methods for inhibiting Flavivirus infections, such as dengue virus and Zika virus infections, in a cell in vitro or in vivo; pharmaceutical compositions; packaged dosage formulations; and kits useful for treating or preventing Flavivirus infections, such as dengue virus and Zika virus infections.
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公开(公告)号：US11654147B2
公开(公告)日：2023-05-23
申请号：US17340589
申请日：2021-06-07
申请人： The Brigham and Women's Hospital, Inc. , The United States of America, as Represented by the Secretary, Department of Health and Human Services
发明人： Paul B. Yu , Wenwei Huang , Philip Edward Sanderson , Jian-Kang Jiang , Khalida Shamim , Wei Zheng , Xiuli Huang , Gregory Tawa , Arthur Lee , Asaf Alimardanov , Junfeng Huang
IPC分类号： A61K31/519 , A61P19/08 , A61K31/5377 , A61K31/551 , A61K31/675 , A61K45/06 , C07D487/04 , C07D519/00 , C07F9/6561
CPC分类号： A61K31/519 , A61K31/5377 , A61K31/551 , A61K31/675 , A61K45/06 , A61P19/08 , C07D487/04 , C07D519/00 , C07F9/6561
摘要： The present invention provides small-molecule inhibitors of BMP signaling and compositions and methods for inhibiting BMP signaling. These compounds and compositions may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation. These compounds and compositions may also be used to treat subjects with Sjögren's syndrome, or diffuse intrinsic pontine glioma (DIPG).
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