公开(公告)号：US4565623A

公开(公告)日：1986-01-21

申请号：US642502

申请日：1984-08-20

Applicant: Thomas A. Davis

Inventor： Thomas A. Davis

IPC: C10G21/00 ,  C10C3/08

CPC classification number: C10G21/003

Abstract: This invention deals with a method for deasphalting heavy oils by mixing the oil with a completely miscible solvent at a low treat ratio and then subjecting the resulting one phase mixture to a gaseous antisolvent, such as carbon dioxide, to separate the mixture into two phases. The upper phase contains the majority of the miscible solvent and the product oil containing a significantly lower CCN then did the feedstock.

Abstract translation: 本发明涉及一种通过以低处理比将油与完全混溶的溶剂混合，然后使得到的一相混合物进行气态反溶剂如二氧化碳，将混合物分离成两相，从而使重油脱沥青的方法。 上层含有大部分可混溶的溶剂，含有显着较低的CCN的产品油然后进行原料处理。

公开(公告)号：US4388358A

公开(公告)日：1983-06-14

申请号：US296018

申请日：1981-08-25

Applicant: Thomas A. Davis ,  Donald R. Cowsar

Inventor： Thomas A. Davis ,  Donald R. Cowsar

IPC: A61G5/02 ,  A47C7/00 ,  A47C7/46 ,  A61F5/01 ,  A61G5/00 ,  B29C44/12 ,  B29C67/20 ,  B65D81/02 ,  C09J163/00 ,  B32B1/06 ,  B32B3/18 ,  B32B3/26

CPC classification number: B29C67/207 ,  A47C27/086 ,  A61F5/01 ,  B29C44/1204 ,  B29L2031/753 ,  B29L2031/771 ,  Y10S264/07 ,  Y10S5/913 ,  Y10T428/233 ,  Y10T428/239 ,  Y10T428/249953 ,  Y10T428/249985 ,  Y10T428/249992 ,  Y10T428/25 ,  Y10T428/254

Abstract: A rigid, shaped, mass support system, such as support or seating appliances for disabled or handicapped persons, is provided by charging a flexible container (2) made of elastic polymeric film with a uniform mixture of rigid particles of a mesh size relatively small compared to the size of the system and a curable adhesive polymeric binder material. The charged container (2) and its contents are molded to adapt to or fit the shape of the mass, such as the contour of that portion of the body to be supported, and evacuated to remove volatiles and fix the shape of the contents of the container. The adhesive binder is then cured to solidify the molded contents of the container to form a composite, from which the polymeric film can be stripped away, after which an adhesive paint is applied to seal and protect the surface.

Abstract translation: 通过将由弹性聚合物膜制成的柔性容器（2）与网格尺寸相对较小的刚性颗粒的均匀混合物相比较，来提供用于残疾人或残疾人的支撑或座椅装置的刚性，成形的质量支撑系统 到系统的尺寸和可固化的粘合剂聚合物粘合剂材料。 被充填的容器（2）及其内容物被模制以适应或适配质量的形状，例如待支撑的身体的那部分的轮廓，并抽真空以除去挥发物并固定其中的内容物的形状 容器。 然后将粘合剂粘合剂固化以固化容器的模制内容物以形成复合材料，从中可以剥离聚合物膜，之后施加粘合剂涂料以密封和保护表面。

公开(公告)号：US10726943B2

公开(公告)日：2020-07-28

申请号：US13083090

申请日：2011-04-08

Applicant: Alexander Stojadinovic ,  Eric Elster ,  Doug K. Tadaki ,  John S. Eberhardt, III ,  Trevor Brown ,  Thomas A. Davis ,  Jonathan Forsberg ,  Jason Hawksworth

Inventor： Alexander Stojadinovic ,  Eric Elster ,  Doug K. Tadaki ,  John S. Eberhardt, III ,  Trevor Brown ,  Thomas A. Davis ,  Jonathan Forsberg ,  Jason Hawksworth

IPC: G01N33/48 ,  G16B40/00 ,  G16B50/00 ,  G16B25/00

Abstract: An embodiment of the invention provides a method for determining a patient-specific probability of disease. The method collects clinical parameters from a plurality of patients to create a training database. A fully unsupervised Bayesian Belief Network model is created using data from the training database; and, the fully unsupervised Bayesian Belief Network is validated. Clinical parameters are collected from an individual patient; and, such clinical parameters are input into the fully unsupervised Bayesian Belief Network model via a graphical user interface. The patient-specific probability of the healing rate of an acute traumatic wound is output from the fully unsupervised Bayesian Belief Network model and sent to the graphical user interface for use by a clinician in pre-operative planning. The fully unsupervised Bayesian Belief Network model is updated using the clinical parameters from the individual patient and the patient-specific probability of the healing rate of an acute traumatic wound.

公开(公告)号：US20150258144A1

公开(公告)日：2015-09-17

申请号：US14210701

申请日：2014-03-14

Applicant: Thomas A. Davis ,  Khairul Anam ,  Eric A. Elster ,  Douglas K. Tadaki

Inventor： Thomas A. Davis ,  Khairul Anam ,  Eric A. Elster ,  Douglas K. Tadaki

IPC: A61K35/28 ,  A61K45/06

CPC classification number: A61K35/28 ,  A61K31/255 ,  A61K39/001 ,  A61K45/06 ,  A61K2035/122 ,  C12N5/0605 ,  C12N5/0667 ,  C12N5/0668

Abstract: A method inducing chimerism and allograft tolerance by co-infusion of stein/progenitor-like cells and donor cells, wherein the donor cells can be bone marrow cells. The method also comprises the conditioning comprising depletion of CD4+ and CD8+ T-cells and administration of low doses of anti-neoplastic drugs. The inventive method comprises an aspect wherein allograft tolerance is induced without systemically suppressing the immune system.

Abstract translation: 一种诱导嵌合体和同种异体移植耐受性的方法，通过共同输注stein /祖细胞样细胞和供体细胞，其中供体细胞可以是骨髓细胞。 该方法还包括调节，其包括消耗CD4 +和CD8 + T细胞并施用低剂量的抗肿瘤药物。 本发明的方法包括诱导同种异体移植耐受而不系统地抑制免疫系统的方面。

公开(公告)号：US20110289036A1

公开(公告)日：2011-11-24

申请号：US13083184

申请日：2011-04-08

Applicant: Alexander Stojadinovic ,  Eric A. Elster ,  Doug K. Tadaki ,  John S. Eberhardt, III ,  Trevor Brown ,  Thomas A. Davis ,  Jonathan Forsberg ,  Jason Hawksworth ,  Roslyn Mannon

Inventor： Alexander Stojadinovic ,  Eric A. Elster ,  Doug K. Tadaki ,  John S. Eberhardt, III ,  Trevor Brown ,  Thomas A. Davis ,  Jonathan Forsberg ,  Jason Hawksworth ,  Roslyn Mannon

IPC: G06N5/00 ,  G06F17/00

CPC classification number: G06F19/24 ,  G06F19/20 ,  G06F19/28

Abstract: An embodiment of the invention provides a method for determining a patient-specific probability of transplant glomerulopathy. The method collects clinical parameters from a plurality of patients to create a training database. A fully unsupervised Bayesian Belief Network model is created using data from the training database; and, the fully unsupervised Bayesian Belief Network is validated. Clinical parameters are collected from an individual patient; and, such clinical parameters are input into the fully unsupervised Bayesian Belief Network model via a graphical user interface. The patient-specific probability of transplant glomerulopathy is output from the fully unsupervised Bayesian Belief Network model and sent to the graphical user interface for use by a clinician in pre-operative planning. The fully unsupervised Bayesian Belief Network model is updated using the clinical parameters from the individual patient and the patient-specific probability of transplant glomerulopathy.

Abstract translation: 本发明的实施例提供了一种用于确定移植肾小球病的患者特异性概率的方法。 该方法从多个患者收集临床参数以创建训练数据库。 使用培训数据库中的数据创建完全无监督的贝叶斯信念网络模型; 并且，完全无监督的贝叶斯信仰网络得到验证。 从个体患者收集临床参数; 并且通过图形用户界面将这样的临床参数输入到完全无监督的贝叶斯信仰网络模型中。 移植肾小球病的患者特异性概率是从完全无监督的贝叶斯信念网络模型输出的，并发送到图形用户界面，供临床医生在术前规划中使用。 使用来自个体患者的临床参数和患者特异性移植肾小球病概率来更新完全无监督的贝叶斯信念网络模型。

公开(公告)号：US20110091426A1

公开(公告)日：2011-04-21

申请号：US10628886

申请日：2003-07-29

Applicant: John P. Chute ,  Abba A. Saini ,  Dennis J. Chute ,  Thomas A. Davis

Inventor： John P. Chute ,  Abba A. Saini ,  Dennis J. Chute ,  Thomas A. Davis

IPC: A61K35/28 ,  A61P43/00

CPC classification number: C12N5/0647 ,  A61K2035/124 ,  C12N2501/125 ,  C12N2501/22 ,  C12N2501/23 ,  C12N2501/26 ,  C12N2502/28

Abstract: A novel co-culture system using human brain endothelial cells (HUBEC) which promotes the expansion of human CD34+CD38− cells consistent with the PMVEC system is disclosed. HUBEC were isolated from cadaveric donors, passed in primary culture, cloned and found to be Von Willebrand Factor positive. Cultivation of purified bone marrow CD34+ cells on HUBEC monolayers supplemented with GM-CSF+IL-3+IL-6+SCF+flt-3 ligand caused a 14.5-fold increase in total cells, an 6.6-fold increase in CD34+ cells, and, most remarkably, a 440-fold increase in CD34+CD38− cells after 7 days. Further, CFU-GM production increased 15.1-fold, BFU-E increased 8-fold, and CFU-Mix increased 5.2-fold. Optimal generation was dependent upon the continued presence of exogenous supplied cytokines. In comparison, identically treated stroma-free suspension cultures supported a 10.2-fold expansion of total cells, a 3-fold increase in CD34+ cells and maintained the CD34+CD38− cell pool after 7 days of culture. Moreover, we found that non-brain human endothelial cells isolated from the same donors supported neither the expansion nor the maintenance of human CD34+CD38− cells. Although few steady state CD34+CD38− cells give rise to visible colony-forming cells in methylcellulose cultures, our FACS based cell cycle and sorting experiments demonstrated the activation of a highly clonogenic CD34+CD38− population (24% cloning efficiency) during ex-vivo culture on cytokine treated HUBEC. These results suggest that bone marrow CD34+CD38− cells require a stromal cell microenvironment for optimal expansion and that ex-vivo expanded CD34+CD38− cells generated in the HUBEC culture system appear to retain some degree of primitive “stemness”.

Abstract translation: 公开了一种使用人脑内皮细胞（HUBEC）的新型共培养系统，其促进与PMVEC系统一致的人CD34 + CD38细胞的扩增。 HUBEC从尸体供体中分离出来，通过原代培养，克隆并发现是Von Willebrand因子阳性。 在补充有GM-CSF + IL-3 + IL-6 + SCF + flt-3配体的HUBEC单层上培养纯化的骨髓CD34 +细胞导致总细胞增加14.5倍，CD34 +细胞增加6.6倍， ，最显着的是7天后CD34 + CD38细胞增加了440倍。 此外，CFU-GM生产增加了15.1倍，BFU-E增加了8倍，CFU-Mix增加了5.2倍。 最佳产生取决于外源性供体细胞因子的持续存在。 相比之下，相同处理的无基质悬浮培养物支持总细胞的10.2倍扩增，CD34 +细胞增加3倍，并在培养7天后维持CD34 + CD38细胞池。 此外，我们发现从同一供体分离的非脑内皮细胞既不支持扩增也不维持人类CD34 + CD38细胞。 尽管很少的稳态CD34 + CD38-细胞在甲基纤维素培养物中产生可见的集落形成细胞，但是我们的基于FACS的细胞周期和分选实验证明了在前体细胞周期中高度克隆CD34 + CD38-群体的活化（24％克隆效率） 细胞因子治疗HUBEC的体内培养。 这些结果表明，骨髓CD34 + CD38-细胞需要基质细胞微环境进行最佳扩增，并且在HUBEC培养系统中产生的离体扩增的CD34 + CD38-细胞似乎保留了一定程度的原始“干性”。

公开(公告)号：US5049233A

公开(公告)日：1991-09-17

申请号：US519396

申请日：1990-07-06

Applicant: Thomas A. Davis

Inventor： Thomas A. Davis

IPC: C01D1/38 ,  C01F7/14 ,  C23F1/46

CPC classification number: C01F7/14 ,  C01D1/38 ,  C23F1/46

Abstract: A method for the recovery and recycling of sodium hydroxide from the waste solution of aluminum etching operations. The method utilizes a dialysis membrane column or stack to initially remove sodium hydroxide from the waste solution and return it to the etch tank base solution sufficiently concentrated to carry on the basic etching operation. The method permits the recovery of salable quantities of aluminum hydroxide.

Abstract translation: 从铝蚀刻操作的废溶液中回收和再循环氢氧化钠的方法。 该方法利用透析膜柱或叠层来首先从废溶液中除去氢氧化钠并将其返回到足够浓缩的蚀刻槽底溶液中以进行基本蚀刻操作。 该方法允许回收可销售量的氢氧化铝。

公开(公告)号：US4707257A

公开(公告)日：1987-11-17

申请号：US868649

申请日：1986-05-29

Applicant: Thomas A. Davis ,  Kurt Bozenmayer ,  Donald J. Butterworth

Inventor： Thomas A. Davis ,  Kurt Bozenmayer ,  Donald J. Butterworth

IPC: B01D24/14 ,  B01D24/46 ,  B01D23/24

CPC classification number: B01D24/4631 ,  B01D24/14 ,  B01D2201/087

Abstract: An air/water distributor underdrain assembly for providing a uniform distribution and metering of backwash air and/or water through a filter bed. The distributor assembly includes a distributor member which defines a distributor chamber for receipt of backwash air and/or water thereinto. A plurality of first and second spaced apart openings extend through the distributor member. A shroud extends downwardly into the distributor chamber from each of the first openings in fluid communication with an intermediate portion of the distributor chamber for directing backwash water therethrough. Backwash air collected in a gas compartment formed in an upper portion of the distributor chamber is directed through the second openings.

Abstract translation: 一个空气/水分配器底盘组件，用于通过过滤床提供反冲洗空气和/或水的均匀分布和计量。 分配器组件包括分配器构件，其限定用于接收反冲洗空气和/或水的分配器室。 多个第一和第二间隔开的开口延伸穿过分配器构件。 护罩从与分配器室的中间部分流体连通的每个第一开口向下延伸到分配器室中，用于引导反冲洗水通过。 收集在形成在分配器室的上部的气室中的回洗空气被引导通过第二开口。

公开(公告)号：US4536283A

公开(公告)日：1985-08-20

申请号：US642501

申请日：1984-08-20

Applicant: Thomas A. Davis

Inventor： Thomas A. Davis

IPC: C10C3/08 ,  C10G21/00 ,  C10G21/02 ,  C10G21/28 ,  C10C3/00

CPC classification number: C10G21/28 ,  C10C3/08 ,  C10G21/003 ,  C10G21/02

Abstract: The present invention relates to a process for the recovery of hydrocarbon oils from other heavier oils such as vacuum residua and, more particularly, to an improved process for deasphalting petroleum oils containing those asphalts. In one aspect of the invention, the process treats a solvent which has contacted the heavy oil with a gaseous antisolvent to separate effectively and usually without distillation, the solvent from the extracted oil. The deasphalted oil product typically will have low metals contaminants and enhanced MCR. Utilities or energy requirements for the process may be improved over prior art processes.

Abstract translation: 本发明涉及一种从其它较重油中回收烃油的方法，例如真空残渣，更具体地说，涉及一种用于沥青含有这些沥青的石油的改进方法。 在本发明的一个方面，该方法处理已经与重油接触的溶剂与气态反溶剂有效分离并且通常没有蒸馏，从提取的油中除去溶剂。 脱沥青油产品通常将具有低金属污染物和增强的MCR。 与现有技术方法相比，该方法的实用或能量需求可以得到改善。

公开(公告)号：US4451101A

公开(公告)日：1984-05-29

申请号：US390619

申请日：1982-06-21

Applicant: Thomas A. Davis

Inventor： Thomas A. Davis

IPC: H01R13/447 ,  H05K5/03

CPC classification number: H01R13/447

Abstract: A combination cover plate and safety guard plate to be interfaced with a conventional electrical wall receptacle to prevent a child of tender years from gaining unauthorized access to the receptacle and sustaining serious injury from an electric shock as a consequence of an accidental contact with a current carrying wire. The cover plate is adapted to receive one or more of the electrical receptacles, so that the power can be supplied therefrom to an electrical appliance, or the like. The cover plate and safety guard plate are pivotably interconnected with one another at first ends thereof. Each of the second ends of the cover plate and safety guard plate includes respective spring-biased retaining means by which the cover and safety guard plates can be releaseably connected together. Accordingly, the safety guard plate may be rotated towards the cover plate and secured in a position across the face thereof, whereby to cover the receptacles and prevent unauthorized access thereto. The safety guard plate may be rotated away from the cover plate by exerting sufficient force against the bias of a spring, whereby to permit the disconnection of the respective retaining means. The spring is selected so that the force required to disconnect the respective retaining means is greater than that which a child of tender years is capable of exerting.

Abstract translation: 组合盖板和安全防护板，与传统的电气壁插座接口，以防止招标年龄的孩子因为与当前携带的意外接触而导致未经授权的进入容器并导致严重的电击伤害 线。 盖板适于容纳一个或多个电插座，使得电力可从其提供给电器等。 盖板和安全保护板在其第一端处彼此可枢转地互连。 盖板和安全保护板的每个第二端包括相应的弹簧偏置保持装置，通过该保持装置可以将盖和安全保护板可释放地连接在一起。 因此，安全保护板可以朝向盖板旋转并固定在横过其表面的位置，从而覆盖插座并防止未经授权的访问。 通过施加足够的力抵抗弹簧的偏压，安全保护板可以从盖板旋转离开，从而允许相应的保持装置断开。 选择弹簧使得断开相应保持装置所需的力大于投标年龄的孩子能够施加的力。