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    Recovery of regenerant electrolyte
    2.
    发明授权
    Recovery of regenerant electrolyte 有权

    公开(公告)号：US09776137B2

    公开(公告)日：2017-10-03

    申请号：US12617250

    申请日：2009-11-12

    申请人： Thomas A. Davis

    发明人： Thomas A. Davis

    IPC分类号： B01D61/44 ,  B01D61/02

    CPC分类号： B01D61/44 ,  B01D61/025 ,  B01D2311/2623 ,  Y10T428/31504 ,  Y10T428/31725

    摘要： Methods, systems and compositions for recovery of regenerant ions from spent regenerant solution by utilization of electrodialysis are provided. For example, in certain aspects methods for separating spent regenerant using an electrodialysis system comprising selective membranes are described. Furthermore, the invention provides methods for treating a friable solid ion-removal material to prevent fragmentation during regeneration.

    Clinical Decision Model
    4.
    发明申请
    Clinical Decision Model 审中-公开
    临床决策模型

    公开(公告)号：US20110289035A1

    公开(公告)日：2011-11-24

    申请号：US13083090

    申请日：2011-04-08

    申请人： Alexander Stojadinovic ,  Eric Elster ,  Doug K. Tadaki ,  John S. Eberhardt, III ,  Trevor Brown ,  Thomas A. Davis ,  Jonathan Forsberg ,  Jason Hawksworth

    发明人： Alexander Stojadinovic ,  Eric Elster ,  Doug K. Tadaki ,  John S. Eberhardt, III ,  Trevor Brown ,  Thomas A. Davis ,  Jonathan Forsberg ,  Jason Hawksworth

    IPC分类号： G06N5/00 ,  G06F17/00

    CPC分类号： G16B40/00 ,  G16B25/00 ,  G16B50/00

    摘要： An embodiment of the invention provides a method for determining a patient-specific probability of disease. The method collects clinical parameters from a plurality of patients to create a training database. A fully unsupervised Bayesian Belief Network model is created using data from the training database; and, the fully unsupervised Bayesian Belief Network is validated. Clinical parameters are collected from an individual patient; and, such clinical parameters are input into the fully unsupervised Bayesian Belief Network model via a graphical user interface. The patient-specific probability of the healing rate of an acute traumatic wound is output from the fully unsupervised Bayesian Belief Network model and sent to the graphical user interface for use by a clinician in pre-operative planning. The fully unsupervised Bayesian Belief Network model is updated using the clinical parameters from the individual patient and the patient-specific probability of the healing rate of an acute traumatic wound.

    摘要翻译： 本发明的实施例提供了一种用于确定患者特异性疾病概率的方法。 该方法从多个患者收集临床参数以创建训练数据库。 使用培训数据库中的数据创建完全无监督的贝叶斯信念网络模型; 并且，完全无监督的贝叶斯信仰网络得到验证。 从个体患者收集临床参数; 并且通过图形用户界面将这样的临床参数输入到完全无监督的贝叶斯信仰网络模型中。 急性创伤性伤口的愈合率的患者特异性概率是从完全无监督的贝叶斯信念网络模型输出的，并发送到图形用户界面，供临床医生在术前规划中使用。 完全无监督的贝叶斯信仰网络模型使用来自个体患者的临床参数和急性创伤性伤口愈合速率的患者特异性概率进行更新。

    Water desalination process and apparatus
    5.
    发明授权
    Water desalination process and apparatus 有权
    水脱盐工艺及设备

    公开(公告)号：US07459088B2

    公开(公告)日：2008-12-02

    申请号：US11225852

    申请日：2005-09-13

    申请人： Thomas A. Davis

    发明人： Thomas A. Davis

    IPC分类号： B01D61/44 ,  B01D61/42 ,  B01D61/02 ,  B01D61/46

    CPC分类号： B01D61/44 ,  B01D61/022 ,  B01D61/025 ,  B01D61/027 ,  B01D61/422 ,  B01D61/445 ,  B01D61/48 ,  B01D61/52 ,  B01D61/58 ,  C01D3/06 ,  C01F11/46 ,  C02F1/441 ,  C02F1/469 ,  C02F1/4693 ,  C02F1/5236 ,  C02F5/00 ,  C02F2101/103 ,  C02F2103/08 ,  Y02A20/131 ,  Y02A20/134

    摘要： A process and system for purifying water is disclosed. For example, in one embodiment, the process may be used to remove a divalent salt, such as calcium sulfate, from a water source in order to prevent the divalent salt from precipitating during the process. The water source, for instance, may be fed to an ion separating device, such as an electrodialysis device. In the electrodialysis device, an ion exchange takes place between the divalent salt and another salt, such as a monovalent salt to produce two concentrated salt streams that contain salts having greater solubility in water than the divalent salt. In one embodiment, the two salt streams that are produced may then be combined to precipitate the divalent salt in a controlled manner. During the process, various other components contained within the water feed stream may also be removed from the stream and converted into useful products. In one particular embodiment, the process is configured to receive a byproduct stream from a reverse osmosis process.

    摘要翻译： 公开了一种用于净化水的方法和系统。 例如，在一个实施方案中，该方法可用于从水源除去二价盐，例如硫酸钙，以防止二价盐在该过程中沉淀。 例如，水源可以被供给到离子分离装置，例如电渗析装置。 在电渗析装置中，在二价盐和另一种盐如一价盐之间进行离子交换，以产生两种浓缩盐流，其含有比二价盐更好的在水中的溶解度的盐。 在一个实施方案中，然后可以将所生产的两种盐流以受控的方式组合以沉淀二价盐。 在该过程中，包含在水进料流内的各种其它组分也可以从流中除去并转化成有用的产物。 在一个具体实施方案中，该方法被配置为从反渗透过程接收副产物流。

    Human brain endothelial cells and growth medium and method for expansion of primitive CD34+CD38-bone marrow stem cells
    6.
    发明授权
    Human brain endothelial cells and growth medium and method for expansion of primitive CD34+CD38-bone marrow stem cells 失效
    人脑内皮细胞和生长培养基以及扩增原始CD34 + CD38-骨髓干细胞的方法

    公开(公告)号：US06642049B1

    公开(公告)日：2003-11-04

    申请号：US09452855

    申请日：1999-12-03

    申请人： John P. Chute ,  Abha A. Saini ,  Dennis J. Chute ,  Thomas A. Davis

    发明人： John P. Chute ,  Abha A. Saini ,  Dennis J. Chute ,  Thomas A. Davis

    IPC分类号： C12N500

    CPC分类号： C12N5/0647 ,  A61K2035/124 ,  C12N2501/125 ,  C12N2501/22 ,  C12N2501/23 ,  C12N2501/26 ,  C12N2502/28

    摘要： A novel co-culture system using human brain endothelial cells (HUBEC) which promotes the expansion of human CD34+CD38− cells consistent with the PMVEC system is disclosed. HUBEC were isolated from cadaveric donors, passed in primary culture, cloned and found to be Von Willebrand Factor positive. Cultivation of purified bone marrow CD34+ cells on HUBEC monolayers supplemented with GM-CSF+IL-3+IL-6+SCF+flt-3 ligand caused a 14.5-fold increase in total cells, an 6.6-fold increase in CD34+ cells, and, most remarkably, a 440-fold increase in CD34+CD38− cells after 7 days. Further, CFU-GM production increased 15.1-fold, BFU-E increased 8-fold, and CFU-Mix increased 5.2-fold. Optimal generation was dependent upon the continued presence of exogenous supplied cytokines. Moreover, we found that non-brain human endothelial cells isolated from the same donors supported neither the expansion nor the maintenance of human CD34+CD38− cells.

    摘要翻译： 公开了一种使用人类脑内皮细胞（HUBEC）的新型共培养系统，其促进与PMVEC系统一致的人CD34 + CD38 +细胞的扩增。 HUBEC从尸体供体中分离出来，通过原代培养，克隆并发现是Von Willebrand因子阳性。 在补充有GM-CSF + IL-3 + IL-6 + SCF + flt-3配体的HUBEC单层上培养纯化的骨髓CD34 +细胞导致总细胞增加14.5倍，CD34增加6.6倍 + +细胞，最显着地是7天后CD34 + CD38 +细胞增加440倍。 此外，CFU-GM生产增加了15.1倍，BFU-E增加了8倍，CFU-Mix增加了5.2倍。 最佳产生取决于外源性供体细胞因子的持续存在。 此外，我们发现从相同供体分离的非脑内皮细胞既不支持人CD34 + CD38 +细胞的扩增和维持。

    Method and apparatus for generating acid and base regenerants and the use thereof to regenerate ion-exchange resins
    7.
    发明授权
    Method and apparatus for generating acid and base regenerants and the use thereof to regenerate ion-exchange resins 失效
    用于产生酸和碱再生剂的方法和设备及其用于再生离子交换树脂的用途

    公开(公告)号：US4880513A

    公开(公告)日：1989-11-14

    申请号：US876911

    申请日：1986-06-20

    申请人： Thomas A. Davis ,  Donald J. Butterworth

    发明人： Thomas A. Davis ,  Donald J. Butterworth

    IPC分类号： B01D61/44 ,  B01J49/00 ,  B01J49/02 ,  C02F1/42 ,  C02F1/469

    CPC分类号： B01J49/00 ,  B01D61/445

    摘要： A method and apparatus for generating acid and base regenerant solutions by utilization of a bipolar membrane electrodialysis stack. A mineral-containing salt solution is continuously circulated through the stack to produce a partially demineralized salt solution, an acid solution and a base solution. The acid solution and base solution are continuously circulated through the stack to increase the concentration thereof. The circulating salt solution is controlled to maintain the salt concentration in the range of 2% to 25% and the pH in the range of 8-11. The concentrations of the circulating acid solution and base solution are controlled to maintain the concentrations thereof in the range of 0.2N to 3.0N. The concentrated acid solution and base solution are utilized to regenerate exhausted ion-exchange resins.

    Hemoperfusion device for specific modification or removal of components of whole blood
    8.
    发明授权
    Hemoperfusion device for specific modification or removal of components of whole blood 失效
    用于特异性修饰或去除全​​血组分的血液灌注装置

    公开(公告)号：US4252653A

    公开(公告)日：1981-02-24

    申请号：US936886

    申请日：1978-08-25

    申请人： Lee R. Beck ,  Thomas A. Davis

    发明人： Lee R. Beck ,  Thomas A. Davis

    IPC分类号： A61M1/36 ,  B01D15/08 ,  B01D13/00

    CPC分类号： A61M1/3679 ,  B01D15/08

    摘要： A hemoperfusion device is disclosed for the specific modification or removal of components of whole blood. The device involves a 3-dimensional arrangement of fibers within a housing arranged to provide maximum exposed fiber surface and flow-channel diameter, while also reducing the tortuosity of the flow path. Desired effector molecules are bound to the fibers to allow them to contact the target components of the blood, whereby to remove the target components. Details of the fiber and effector molecules are disclosed and a specific device is described.

    摘要翻译： 公开了用于特异性修饰或去除全​​血组分的血液灌注装置。 该装置涉及在壳体内的纤维的三维布置，其布置成提供最大暴露的纤维表面和流动通道直径，同时还减小了流动路径的弯曲度。 期望的效应分子与纤维结合，使其与血液的目标成分接触，由此除去目标组分。 公开了纤维和效应分子的细节，并描述了具体的装置。

    Electrically regenerated ion exchange system
    9.
    发明授权
    Electrically regenerated ion exchange system 失效
    电再生离子交换系统

    公开(公告)号：US4032452A

    公开(公告)日：1977-06-28

    申请号：US631841

    申请日：1975-11-13

    申请人： Thomas A. Davis

    发明人： Thomas A. Davis

    IPC分类号： B01J47/12 ,  B01J49/00 ,  C08J5/22 ,  B01D57/00

    CPC分类号： B01J49/0052 ,  C08J5/2206 ,  C08J2379/08

    摘要： The electrical efficiency of an electrically regenerated ion exchange system is improved by using elongated ion exchange members having a continuous ion exchange phase that is more conductive in the exhausted form than it is in the regenerated form. Preferably, the system includes anion exchange members that extend through the wall of the demineralization compartment closest to the anode but do not extend through the wall of the demineralization compartment closest to the cathode, and cation exchange members that extend through the wall of the demineralization compartment closest to the cathode but do not extend through the wall of the demineralization compartment closest to the anode.

    摘要翻译： 电再生离子交换系统的电效率通过使用具有连续离子交换相的细长离子交换元件来改善，该离子交换相在排气形式中比在再生形式中更具导电性。 优选地，该系统包括阴离子交换构件，该阴离子交换构件延伸通过最靠近阳极的脱盐处理室的壁，但不延伸通过最靠近阴极的软化室的壁，以及延伸穿过脱盐室的壁的阳离子交换构件 最靠近阴极但不延伸通过最靠近阳极的去矿质隔间的壁。

    Bayesian clinical decision model for determining probability of transplant glomerulopathy
    10.
    发明授权
    Bayesian clinical decision model for determining probability of transplant glomerulopathy 有权
    贝叶斯临床决定模型，用于确定移植肾小球病的概率

    公开(公告)号：US08510245B2

    公开(公告)日：2013-08-13

    申请号：US13083184

    申请日：2011-04-08

    申请人： Alexander Stojadinovic ,  Eric A. Elster ,  Doug K. Tadaki ,  John S. Eberhardt, III ,  Trevor Brown ,  Thomas A. Davis ,  Jonathan Forsberg ,  Jason Hawksworth ,  Roslyn Mannon

    发明人： Alexander Stojadinovic ,  Eric A. Elster ,  Doug K. Tadaki ,  John S. Eberhardt, III ,  Trevor Brown ,  Thomas A. Davis ,  Jonathan Forsberg ,  Jason Hawksworth ,  Roslyn Mannon

    IPC分类号： G06N5/00

    CPC分类号： G06F19/24 ,  G06F19/20 ,  G06F19/28

    摘要： An embodiment of the invention provides a method for determining a patient-specific probability of transplant glomerulopathy. The method collects clinical parameters from a plurality of patients to create a training database. A fully unsupervised Bayesian Belief Network model is created using data from the training database; and, the fully unsupervised Bayesian Belief Network is validated. Clinical parameters are collected from an individual patient; and, such clinical parameters are input into the fully unsupervised Bayesian Belief Network model via a graphical user interface. The patient-specific probability of transplant glomerulopathy is output from the fully unsupervised Bayesian Belief Network model and sent to the graphical user interface for use by a clinician in pre-operative planning. The fully unsupervised Bayesian Belief Network model is updated using the clinical parameters from the individual patient and the patient-specific probability of transplant glomerulopathy.

    摘要翻译： 本发明的实施例提供了一种用于确定移植肾小球病的患者特异性概率的方法。 该方法从多个患者收集临床参数以创建训练数据库。 使用培训数据库中的数据创建完全无监督的贝叶斯信念网络模型; 并且，完全无监督的贝叶斯信仰网络得到验证。 从个体患者收集临床参数; 并且通过图形用户界面将这样的临床参数输入到完全无监督的贝叶斯信仰网络模型中。 移植肾小球病的患者特异性概率是从完全无监督的贝叶斯信念网络模型输出的，并发送到图形用户界面，供临床医生在术前规划中使用。 使用来自个体患者的临床参数和患者特异性移植肾小球病概率来更新完全无监督的贝叶斯信念网络模型。