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32 条记录 (耗时 0.032 秒)

    Indirect measurement of tissue analytes through tissue properties
    13.
    发明授权
    Indirect measurement of tissue analytes through tissue properties 失效
    通过组织特性间接测量组织分析物

    公开(公告)号：US07039446B2

    公开(公告)日：2006-05-02

    申请号：US10349573

    申请日：2003-01-22

    申请人： Timothy L. Ruchti ,  Thomas B. Blank ,  Alexander D. Lorenz ,  Stephen L. Monfre ,  Kevin H. Hazen ,  Suresh N. Thennadil

    发明人： Timothy L. Ruchti ,  Thomas B. Blank ,  Alexander D. Lorenz ,  Stephen L. Monfre ,  Kevin H. Hazen ,  Suresh N. Thennadil

    IPC分类号： A61B5/00

    CPC分类号： A61B5/1455 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/14532 ,  A61B5/1495 ,  A61B2560/0223 ,  G01N21/274 ,  G01N21/31 ,  G01N21/33 ,  G01N21/359 ,  G01N21/65 ,  G01N2021/3595

    摘要： Methods and system for noninvasive determination of tissue analytes utilize tissue properties as reflected in key features of an analytical signal to improve measurement accuracy and precision. Physiological conditions such as changes in water distribution among tissue compartments lead to complex alterations in the measured analytical signal of skin, leading to a biased noninvasive analyte measurement. Changes in the tissue properties are detected by identifying key features in the analytical signal responsive to physiological variations. Conditions not conducive to the noninvasive measurement are detected. Noninvasive measurements that are biased by physiological changes in tissue are compensated. In an alternate embodiment, the analyte is measured indirectly based on natural physiological response of tissue to changes in analyte concentration. A system capable of such measurements is provided.

    摘要翻译： 非侵入性测定组织分析物的方法和系统利用分析信号的关键特征反映的组织性质来提高测量精度和精度。 生理条件如组织间隔水分配变化导致测量的皮肤分析信号的复杂变化，导致偏向的非侵入性分析物测量。 通过识别响应于生理变化的分析信号中的关键特征来检测组织性质的变化。 检测到不利于非侵入性测量的条件。 由组织中生理变化偏向的无创测量得到补偿。 在替代实施方案中，基于组织对分析物浓度变化的天然生理反应间接测量分析物。 提供能够进行这种测量的系统。

    Method and apparatus for minimizing spectral effects attributable to tissue state variations during NIR-based non-invasive blood analyte determination
    14.
    发明授权
    Method and apparatus for minimizing spectral effects attributable to tissue state variations during NIR-based non-invasive blood analyte determination 有权
    用于最小化归因于基于NIR的非侵入性血液分析物测定期间的组织状态变化的光谱效应的方法和装置

    公开(公告)号：US06640117B2

    公开(公告)日：2003-10-28

    申请号：US09955531

    申请日：2001-09-17

    申请人： Marcy R. Makarewicz ,  Mutua Mattu ,  Thomas B. Blank ,  Stephen L. Monfre ,  Timothy L. Ruchti

    发明人： Marcy R. Makarewicz ,  Mutua Mattu ,  Thomas B. Blank ,  Stephen L. Monfre ,  Timothy L. Ruchti

    IPC分类号： A61B500

    CPC分类号： A61B5/1495 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/1491

    摘要： A method and apparatus for minimizing confounding effects in a noninvasive in-vivo spectral measurement caused by fluctuations in tissue state monitors a selected tissue state parameter spectroscopically and maintains the selected parameter within a target range, at which spectral effects attributable to the changes in the selected parameter are minimized. The invention includes both active and passive control. A preferred embodiment of the invention provides a method and apparatus for minimizing the confounding effects in near IR spectral measurements attributable to shifts in skin temperature at a tissue measurement site. Spectroscopic monitoring of skin temperature at the measurement site provides near-instantaneous temperature readings by eliminating thermal time constants. A thermistor positioned at the measurement site provides active control. The spectrometer and the temperature control device are incorporated into a single instrument for noninvasive measurement of blood glucose concentration.

    摘要翻译： 用于最小化由组织状态的波动引起的非侵入性体内光谱测量中的混杂效应的方法和装置通过光谱方式监测所选择的组织状态参数，并将所选择的参数保持在目标范围内，在该范围内，归因于所选择的变化的光谱效应 参数最小化。 本发明包括主动和被动控制。 本发明的一个优选实施例提供了一种方法和装置，用于最小化归因于组织测量部位的皮肤温度变化的近红外光谱测量中的混杂效应。 光谱监测测量点的皮肤温度通过消除热时间常数提供近乎瞬时的温度读数。 位于测量位置的热敏电阻提供主动控制。 光谱仪和温度控制装置被并入单个仪器中用于非侵入性测量血糖浓度。

    Use of targeted glycemic profiles in the calibration of a noninvasive blood glucose monitor
    15.
    发明授权
    Use of targeted glycemic profiles in the calibration of a noninvasive blood glucose monitor 失效

    公开(公告)号：US06487429B2

    公开(公告)日：2002-11-26

    申请号：US09766872

    申请日：2001-01-18

    申请人： Linda Hockersmith ,  Thomas B. Blank ,  Stephen L. Monfre ,  Timothy L. Ruchti

    发明人： Linda Hockersmith ,  Thomas B. Blank ,  Stephen L. Monfre ,  Timothy L. Ruchti

    IPC分类号： A61B500

    CPC分类号： A61B5/14532

    摘要： A method of calibrating a non-invasive blood glucose measurement instrument to a diabetic test subject employs targeted glycemic profiles in anti-correlated pairs. During calibration, reference blood glucose determinations are made using conventional invasive sampling methods. Concurrently, noninvasive spectral measurements are made using the noninvasive glucose monitor. Through controlled oral ingestion by the subject of calculated amounts of carbohydrate, the subject's blood glucose level is manipulated to mimic the patterns of the targeted profiles. During a first visit, a first profile of a pair is induced; during a second visit the inverse of the first profile is induced. The targeted profiles produce reference blood glucose values in which correlation to sampling factors is reduced or eliminated, thus the resulting calibration is correlated to glucose, and not to other analytes, sampling factors or environmental factors. A formula is provided for calculating the required amount of carbohydrate to ingest to induce a targeted glycemic profile in a test subject.

    METHOD OF SCREENING FOR DISORDERS OF GLUCOSE METABOLISM
    17.
    发明申请
    METHOD OF SCREENING FOR DISORDERS OF GLUCOSE METABOLISM 审中-公开
    葡萄糖代谢障碍筛查方法

    公开(公告)号：US20090098587A1

    公开(公告)日：2009-04-16

    申请号：US12099740

    申请日：2008-04-08

    申请人： Donald Hetzel ,  Stephen L. Monfre ,  Kevin H. Hazen ,  Timothy L. Ruchti ,  Thomas B. Blank ,  Linda Hockersmith ,  Andrew Cone

    发明人： Donald Hetzel ,  Stephen L. Monfre ,  Kevin H. Hazen ,  Timothy L. Ruchti ,  Thomas B. Blank ,  Linda Hockersmith ,  Andrew Cone

    IPC分类号： C12Q1/54

    CPC分类号： C12Q1/54 ,  A61B5/14532 ,  A61B5/7264 ,  G01N33/66 ,  G01N2800/042 ,  G16H50/20 ,  G16H50/70

    摘要： A method of screening for disorders of glucose metabolism such as impaired glucose tolerance and diabetes allows prevention, or early detection and treatment of diabetic complications such as cardiovascular disease, retinopathy, and other disorders of the major organs and systems. A mathematical algorithm evaluates the shape of a subject's glucose profile and classifies the profile into one of several predefined clusters, each cluster corresponding either to a normal condition or one of several abnormal conditions. The series of blood glucose values making up the glucose tolerance curve may be measured using any glucose analyzer including: invasive, minimally invasive and noninvasive types. The method is executed on a processing device programmed to perform the steps of the method. Depending on the outcome of the screening, a subject may be provided with additional information concerning their condition and/or counseled to consult further with their health care provider.

    摘要翻译： 筛选葡萄糖代谢紊乱如葡萄糖耐量异常和糖尿病的方法允许预防或早期检测和治疗糖尿病并发症如心血管疾病，视网膜病变和主要器官和系统的其他病症。 数学算法评估受试者的葡萄糖谱的形状并将轮廓分类为几个预定义的簇之一，每个簇对应于正常条件或几个异常条件之一。 构成葡萄糖耐量曲线的一系列血糖值可以使用任何葡萄糖分析仪来测量，包括：侵入性，微创和非侵入性类型。 该方法在被编程为执行该方法的步骤的处理装置上执行。 根据筛查结果，可以向受试者提供有关其病情的信息和/或咨询，以进一步咨询其医护人员。

    Method and apparatus for control of skin perfusion for indirect glucose measurement
    18.
    发明授权
    Method and apparatus for control of skin perfusion for indirect glucose measurement 失效
    用于控制间接葡萄糖测量的皮肤灌注的方法和装置

    公开(公告)号：US07509153B2

    公开(公告)日：2009-03-24

    申请号：US10384049

    申请日：2003-03-07

    申请人： Thomas B. Blank ,  Timothy L. Ruchti ,  Mutua Mattu ,  Marcy Makarewicz ,  Stephen L. Monfre ,  Alexander D. Lorenz

    发明人： Thomas B. Blank ,  Timothy L. Ruchti ,  Mutua Mattu ,  Marcy Makarewicz ,  Stephen L. Monfre ,  Alexander D. Lorenz

    IPC分类号： A61B5/1455

    CPC分类号： A61B5/1455 ,  A61B5/14532 ,  A61B5/1491 ,  A61B5/1495 ,  A61B2560/0223 ,  G01N21/31 ,  G01N21/33 ,  G01N21/359 ,  G01N21/65 ,  G01N2021/3595

    摘要： A method and apparatus for noninvasive glucose measurement measures glucose indirectly from the natural response of tissue to variations in analyte concentration. The indirect measurement method utilizes factors affected by or correlated with the concentration of glucose, such as refractive index, electrolyte distribution or tissue scattering. Measurement reliability is greatly improved by stabilizing optical properties of the tissue at the measurement site, thus blood perfusion rates at the sample site are regulated. Perfusion is monitored and stabilized by spectroscopically measuring a control parameter, such as skin temperature, that directly affects perfusion. The control parameter is maintained in a range about a set point, thus stabilizing perfusion. Skin temperature is controlled using a variety of means, including the use of active heating and cooling elements, passive devices, such as thermal wraps, and through the use of a heated coupling medium having favorable heat transfer properties.

    摘要翻译： 用于非侵入性葡萄糖测量的方法和装置从组织的自然反应间接测量葡萄糖对分析物浓度的变化。 间接测量方法利用受葡萄糖浓度影响或与葡萄糖浓度相关的因素，如折射率，电解质分布或组织散射。 通过稳定测量部位的组织的光学特性，可以大大提高测量可靠性，从而调节样品位置的血液灌注速率。 通过光谱测量直接影响灌注的控制参数（如皮肤温度）来监测和稳定灌注。 控制参数保持在设定点的范围内，从而稳定灌注。 使用各种手段控制皮肤温度，包括使用主动加热和冷却元件，无源器件，例如热封，以及通过使用具有良好传热特性的加热耦合介质。