公开(公告)号：US07206623B2

公开(公告)日：2007-04-17

申请号：US10170921

申请日：2002-06-12

申请人： Thomas B. Blank ,  George Acosta ,  Mutua Mattu ,  Marcy Makarewicz ,  Stephen L. Monfre ,  Alexander D. Lorenz ,  Timothy L. Ruchti

发明人： Thomas B. Blank ,  George Acosta ,  Mutua Mattu ,  Marcy Makarewicz ,  Stephen L. Monfre ,  Alexander D. Lorenz ,  Timothy L. Ruchti

IPC分类号： A61B5/00

CPC分类号： A61B5/0059 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/01 ,  A61B5/061 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/6824 ,  A61B5/6833 ,  A61B5/6843 ,  A61B2560/0233 ,  A61B2562/12 ,  A61B2562/146

摘要： An optical sampling interface system minimizes and compensates error resulting from sampling variations and measurement site state fluctuations. Components include: An optical probe placement guide having an aperture wherein the optical probe is received, facilitates repeatable placement accuracy on surface of a tissue measurement site with minimal, repeatable disturbance to surface tissue. The aperture creates a tissue meniscus that minimizes interference due to surface irregularities and controls variation in tissue volume sampled; an occlusive element placed over the tissue meniscus isolates the meniscus from environmental fluctuations, stabilizing hydration at the site and thus, surface tension; an optical coupling medium eliminates air gaps between skin surface and optical probe; a bias correction element applies a bias correction to spectral measurements, and associated analyte measurements. When the guide is replaced, a new bias correction is determined for measurements done with the new placement. Separate components of system can be individually deployed.

公开(公告)号：US07606608B2

公开(公告)日：2009-10-20

申请号：US11008001

申请日：2004-12-08

申请人： Thomas B. Blank ,  George Acosta ,  Mutua Mattu ,  Marcy Makarewicz ,  Stephen L. Monfre ,  Alexander D. Lorenz ,  Timothy L. Ruchti ,  Kevin H. Hazen ,  Donovan D. Berry ,  Roxanne E. Abul-Haj

发明人： Thomas B. Blank ,  George Acosta ,  Mutua Mattu ,  Marcy Makarewicz ,  Stephen L. Monfre ,  Alexander D. Lorenz ,  Timothy L. Ruchti ,  Kevin H. Hazen ,  Donovan D. Berry ,  Roxanne E. Abul-Haj

IPC分类号： A61B5/1455

CPC分类号： G01N21/359 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/6833

摘要： An optical sampling interface system is disclosed that minimizes and compensates for errors that result from sampling variations and measurement site state fluctuations. Embodiments of the invention use a guide that does at least one of, induce the formation of a tissue meniscus, minimize interference due to surface irregularities, control variation in the volume of tissue sampled, use a two-part guide system, use a guide that controls rotation of a sample probe and allows z-axis movement of the probe, use a separate base module and sample module in conjunction with a guide, and use a guide that controls rotation. Optional components include an occlusive element and a coupling fluid.

摘要翻译： 公开了一种光学采样接口系统，其最小化并补偿由采样变化和测量位置状态波动引起的误差。 本发明的实施例使用至少一个引导组织弯液面的形成的引导件，使由于表面不规则性引起的干扰最小化，控制组织体积的变化，使用两部分引导系统，使用指导 控制样品探针的旋转并允许探针的z轴移动，使用独立的基本模块和样品模块与导轨结合使用，并使用控制旋转的指南。 可选组件包括闭塞元件和耦合流体。

公开(公告)号：US07233816B2

公开(公告)日：2007-06-19

申请号：US10917802

申请日：2004-08-12

申请人： Thomas B. Blank ,  George Acosta ,  Mutua Mattu ,  Marcy Makarewicz ,  Stephen L. Monfre ,  Alexander D. Lorenz ,  Timothy L. Ruchti

发明人： Thomas B. Blank ,  George Acosta ,  Mutua Mattu ,  Marcy Makarewicz ,  Stephen L. Monfre ,  Alexander D. Lorenz ,  Timothy L. Ruchti

IPC分类号： A61B5/00

CPC分类号： A61B5/0059 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/01 ,  A61B5/061 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/6824 ,  A61B5/6833 ,  A61B5/6843 ,  A61B2560/0233 ,  A61B2562/12 ,  A61B2562/146

摘要： An optical sampling interface system minimizes and compensates error resulting from sampling variations and measurement site state fluctuations. Components include: An optical probe placement guide having an aperture wherein the optical probe is received, facilitates repeatable placement accuracy on surface of a tissue measurement site with minimal, repeatable disturbance to surface tissue. The aperture creates a tissue meniscus that minimizes interference due to surface irregularities and controls variation in tissue volume sampled; an occlusive element placed over the tissue meniscus isolates the meniscus from environmental fluctuations, stabilizing hydration at the site and thus, surface tension; an optical coupling medium eliminates air gaps between skin surface and optical probe; a bias correction element applies a bias correction to spectral measurements, and associated analyte measurements. When the guide is replaced, a new bias correction is determined for measurements done with the new placement. Separate components of system can be individually deployed.

公开(公告)号：US06839584B2

公开(公告)日：2005-01-04

申请号：US09954856

申请日：2001-09-17

申请人： Marcy Makarewicz ,  Mutua Mattu ,  Thomas B. Blank ,  George Acosta ,  Edward Handy ,  William Hay ,  Timothy Stippick ,  Benjamin Richie

发明人： Marcy Makarewicz ,  Mutua Mattu ,  Thomas B. Blank ,  George Acosta ,  Edward Handy ,  William Hay ,  Timothy Stippick ,  Benjamin Richie

IPC分类号： A61B20060101 ,  A61B5/00

CPC分类号： A61B5/14532 ,  A61B5/061 ,  A61B5/1459 ,  A61B5/6824 ,  A61B2562/146

摘要： An apparatus and method for reproducibly interfacing a living tissue sample to the measurement probe of a spectrometer instrument in-situ minimizes spectral interference related to sampling variations. A minimal contact subject interface includes supports replaceably mounted on a base. An optical coupling means, such as a fiber optic probe, contacts the measurement site through a probe aperture in the base. During use, a subject rests an extremity on the support elements, so that the extremity is reproducibly positioned and supported in relation to the optical coupling means. The supports have a small contact area, minimizing contact with the skin at the measurement site. The interface module is adjustable to fit any subject.By reproducibly positioning and supporting the body appendage using minimal contact supports, spectral interference due to variations in placement, applied pressure, and temperature transients secondary to contact with the interface module are greatly minimized.

摘要翻译： 将生物组织样本可再现地将光谱仪器的测量探针接地的设备和方法原位最小化与采样变化相关的光谱干扰。 最小接触主体界面包括可替换地安装在基座上的支撑件。 诸如光纤探针的光学耦合装置通过基座中的探针孔接触测量部位。 在使用期间，被摄体将支撑元件的末端置于支撑元件上，使得末端相对于光耦合装置可再现地定位和支撑。 支架具有很小的接触面积，使测量点与皮肤接触最小化。 接口模块是可调整的，适合任何物体。通过使用最小的接触支持可重复地定位和支撑身体附件，由于与接口模块接触的位置变化，施加的压力和温度瞬变引起的频谱干扰大大降低。

公开(公告)号：US06415167B1

公开(公告)日：2002-07-02

申请号：US09563782

申请日：2000-05-02

申请人： Thomas B. Blank ,  George Acosta ,  Mutua Mattu ,  Stephen L. Monfre

发明人： Thomas B. Blank ,  George Acosta ,  Mutua Mattu ,  Stephen L. Monfre

IPC分类号： A61B500

CPC分类号： A61B5/0059 ,  A61B5/061 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/6824 ,  A61B2562/12 ,  A61B2562/146

摘要： A fiber optic probe placement guide minimizes sampling errors during optical sampling of a tissue measurement site by allowing repeatable placement of the fiber optic probe at a targeted tissue measurement site. A mount, contoured to conform to the shape of the tissue measurement site, typically the arm of a human subject, contains an aperture for receiving a fiber optic probe. A temperature probe on the contact surface of the guide allows for monitoring of surface temperature within the vicinity of the tissue measurement site. Crosshair slots in the mount align with corresponding crosshairs at the tissue measurement site. The fiber optic probe placement guide is affixed to the tissue measurement site by means of adhesive tape or fastenable straps. Guideposts on the external surface of the mount are received by corresponding receptacles on a subject interface bearing the fiber optic probe to facilitate alignment of the fiber optic probe with the aperture.

摘要翻译： 光纤探针放置导向器通过允许将光纤探针重复放置在目标组织测量部位来最小化组织测量部位的光学采样期间的采样误差。 通常是组织测量部位的形状，通常是人体受试者的臂的形状的安装件包含用于接收光纤探针的孔。 引导件的接触表面上的温度探头允许监测组织测量部位附近的表面温度。 安装座上的十字准线槽与组织测量部位的相应十字准线对齐。 光纤探针放置导板通过胶带或可固定带固定在组织测量部位。 安装座外表面上的导轨由承载光纤探头的主体接口上的​​相应插座接收，以便光纤探头与孔径对准。

公开(公告)号：US07299080B2

公开(公告)日：2007-11-20

申请号：US10820322

申请日：2004-04-07

申请人： George Acosta ,  James R. Henderson ,  N. Alan Abul-Haj ,  Timothy L. Ruchti ,  Stephen L. Monfre ,  Thomas B. Blank ,  Kevin H. Hazen

发明人： George Acosta ,  James R. Henderson ,  N. Alan Abul-Haj ,  Timothy L. Ruchti ,  Stephen L. Monfre ,  Thomas B. Blank ,  Kevin H. Hazen

IPC分类号： A61B5/00

CPC分类号： A61B5/1455 ,  A61B5/0075 ,  A61B5/1075 ,  A61B5/14532 ,  A61B5/1495 ,  A61B5/441 ,  A61B5/4869 ,  A61B5/4872 ,  A61B5/6824 ,  A61B5/7203 ,  A61B5/726 ,  A61B2560/0233 ,  A61B2562/0233 ,  A61B2562/0242 ,  G01N21/359 ,  G01N21/474 ,  G01N21/49

摘要： A near IR spectrometer-based analyzer attaches continuously or semi-continuously to a human subject and collects spectral measurements for determining a biological parameter in the sampled tissue, such as glucose concentration. The analyzer includes an optical system optimized to target the cutaneous layer of the sampled tissue so that interference from the adipose layer is minimized. The optical system includes at least one optical probe. Spacing between optical paths and detection fibers of each probe and between probes is optimized to minimize sampling of the adipose subcutaneous layer and to maximize collection of light backscattered from the cutaneous layer. Penetration depth is optimized by limiting range of distances between paths and detection fibers. Minimizing sampling of the adipose layer greatly reduces interference contributed by the fat band in the sample spectrum, increasing signal-to-noise ratio. Providing multiple probes also minimizes interference in the sample spectrum due to placement errors.

摘要翻译： 基于近红外光谱仪的分析仪连续或半连续地连接到人类受试者并且收集用于确定采样组织中的生物学参数（诸如葡萄糖浓度）的光谱测量。 该分析仪包括优化的靶向采样组织的皮肤层的光学系统，使得来自脂肪层的干扰最小化。 光学系统包括至少一个光学探针。 针对每个探针和探针之间的光路和检测纤维之间的间距进行优化，以最小化脂肪皮下层的取样，并最大限度地收集从皮肤层反射的光。 穿透深度通过限制路径和检测光纤之间的距离范围进行优化。 最小化脂肪层的取样大大减少了样品谱中脂肪带所造成的干扰，提高了信噪比。 提供多个探针也可以最小化由于放置误差而导致的样品光谱干扰。

公开(公告)号：US20050203359A1

公开(公告)日：2005-09-15

申请号：US11008001

申请日：2004-12-08

申请人： Thomas Blank ,  George Acosta ,  Mutua Mattu ,  Marcy Makarewicz ,  Stephen Monfre ,  Alexander Lorenz ,  Timothy Ruchti ,  Kevin Hazen ,  Donovan Berry ,  Roxanne Abul-Haj

发明人： Thomas Blank ,  George Acosta ,  Mutua Mattu ,  Marcy Makarewicz ,  Stephen Monfre ,  Alexander Lorenz ,  Timothy Ruchti ,  Kevin Hazen ,  Donovan Berry ,  Roxanne Abul-Haj

IPC分类号： A61B5/00 ,  G01N21/35

CPC分类号： G01N21/359 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/6833

摘要： An optical sampling interface system is disclosed that minimizes and compensates for errors that result from sampling variations and measurement site state fluctuations. Embodiments of the invention use a guide that does at least one of, induce the formation of a tissue meniscus, minimize interference due to surface irregularities, control variation in the volume of tissue sampled, use a two-part guide system, use a guide that controls rotation of a sample probe and allows z-axis movement of the probe, use a separate base module and sample module in conjunction with a guide, and use a guide that controls rotation. Optional components include an occlusive element and a coupling fluid.

摘要翻译： 公开了一种光学采样接口系统，其最小化并补偿由采样变化和测量位置状态波动引起的误差。 本发明的实施例使用至少一个引导组织弯液面的形成的引导件，使由于表面不规则性引起的干扰最小化，控制组织体积的变化，使用两部分引导系统，使用指导 控制样品探针的旋转并允许探针的z轴移动，使用独立的基本模块和样品模块与导轨结合使用，并使用控制旋转的指南。 可选组件包括闭塞元件和耦合流体。

公开(公告)号：US20050049466A1

公开(公告)日：2005-03-03

申请号：US10917802

申请日：2004-08-12

申请人： Thomas Blank ,  George Acosta ,  Mutua Mattu ,  Marcy Makarewicz ,  Stephen Monfre ,  Alexander Lorenz ,  Timothy Ruchti

发明人： Thomas Blank ,  George Acosta ,  Mutua Mattu ,  Marcy Makarewicz ,  Stephen Monfre ,  Alexander Lorenz ,  Timothy Ruchti

IPC分类号： A61B5/01 ,  A61B20060101 ,  A61B1/00 ,  A61B5/00 ,  A61B5/0205 ,  A61B5/145 ,  A61B5/1455 ,  A61K9/00 ,  G01N21/01 ,  G01N21/35

CPC分类号： A61B5/0059 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/01 ,  A61B5/061 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/6824 ,  A61B5/6833 ,  A61B5/6843 ,  A61B2560/0233 ,  A61B2562/12 ,  A61B2562/146

摘要： An optical sampling interface system minimizes and compensates error resulting from sampling variations and measurement site state fluctuations. Components include: An optical probe placement guide having an aperture wherein the optical probe is received, facilitates repeatable placement accuracy on surface of a tissue measurement site with minimal, repeatable disturbance to surface tissue. The aperture creates a tissue meniscus that minimizes interference due to surface irregularities and controls variation in tissue volume sampled; an occlusive element placed over the tissue meniscus isolates the meniscus from environmental fluctuations, stabilizing hydration at the site and thus, surface tension; an optical coupling medium eliminates air gaps between skin surface and optical probe; a bias correction element applies a bias correction to spectral measurements, and associated analyte measurements. When the guide is replaced, a new bias correction is determined for measurements done with the new placement. Separate components of system can be individually deployed.

摘要翻译： 光采样接口系统最小化并补偿由采样变化和测量位置状态波动引起的误差。 组件包括：具有孔的光学探针放置引导件，其中接收光学探针，在组织测量位置的表面上促进对表面组织具有最小的，可重复的干扰的可重复放置精度。 孔径产生组织弯月面，其最小化由于表面不规则性引起的干扰并控制采集的组织体积的变化; 放置在组织半月板上方的闭塞元件将半月板与环境波动隔离，稳定了现场的水化，从而表现出张力; 光学耦合介质消除皮肤表面和光学探针之间的气隙; 偏置校正元件对光谱测量和相关的分析物测量应用偏差校正。 当导向器被更换时，新的偏置校正被确定用于新放置的测量。 可以单独部署系统的单独组件。

公开(公告)号：US20070060805A9

公开(公告)日：2007-03-15

申请号：US10917802

申请日：2004-08-12

申请人： Thomas Blank ,  George Acosta ,  Mutua Mattu ,  Marcy Makarewicz ,  Stephen Monfre ,  Alexander Lorenz ,  Timothy Ruchti

发明人： Thomas Blank ,  George Acosta ,  Mutua Mattu ,  Marcy Makarewicz ,  Stephen Monfre ,  Alexander Lorenz ,  Timothy Ruchti

IPC分类号： A61B5/00

CPC分类号： A61B5/0059 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/01 ,  A61B5/061 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/6824 ,  A61B5/6833 ,  A61B5/6843 ,  A61B2560/0233 ,  A61B2562/12 ,  A61B2562/146

摘要： An optical sampling interface system minimizes and compensates error resulting from sampling variations and measurement site state fluctuations. Components include: An optical probe placement guide having an aperture wherein the optical probe is received, facilitates repeatable placement accuracy on surface of a tissue measurement site with minimal, repeatable disturbance to surface tissue. The aperture creates a tissue meniscus that minimizes interference due to surface irregularities and controls variation in tissue volume sampled; an occlusive element placed over the tissue meniscus isolates the meniscus from environmental fluctuations, stabilizing hydration at the site and thus, surface tension; an optical coupling medium eliminates air gaps between skin surface and optical probe; a bias correction element applies a bias correction to spectral measurements, and associated analyte measurements. When the guide is replaced, a new bias correction is determined for measurements done with the new placement. Separate components of system can be individually deployed.

摘要翻译： 光采样接口系统最小化并补偿由采样变化和测量位置状态波动引起的误差。 组件包括：具有孔的光学探针放置引导件，其中接收光学探针，在组织测量位置的表面上促进对表面组织具有最小的，可重复的干扰的可重复放置精度。 孔径产生组织弯月面，其最小化由于表面不规则性引起的干扰并控制采集的组织体积的变化; 放置在组织半月板上方的闭塞元件将半月板与环境波动隔离，稳定了现场的水化，从而表现出张力; 光学耦合介质消除皮肤表面和光学探针之间的气隙; 偏置校正元件对光谱测量和相关的分析物测量应用偏差校正。 当导向器被更换时，新的偏置校正被确定用于新放置的测量。 可以单独部署系统的单独组件。

公开(公告)号：US07333843B2

公开(公告)日：2008-02-19

申请号：US10824459

申请日：2004-04-13

申请人： Stephen L. Monfre ,  George Acosta ,  Thomas B. Blank ,  Kevin H. Hazen

发明人： Stephen L. Monfre ,  George Acosta ,  Thomas B. Blank ,  Kevin H. Hazen

IPC分类号： A61B5/00

CPC分类号： A61B5/6841 ,  A61B5/14532 ,  A61B5/1455 ,  G01N21/359 ,  G01N21/474

摘要： A placement guide apparatus with an improved hydration inducing plug used in coupling a noninvasive analyzer to a sampling site to determine analyte in the human body is disclosed. The hydration inducing plug includes at least one fluoropolymer that may be used as a coupling agent. The guide apparatus may further include an automated or semi-automated coupling fluid delivery system. Use of either of these couplers mitigates issues associated with related technology and enhances noninvasive analyte measurements, such as a near-IR diffuse reflectance based noninvasive glucose concentration analyzer.

摘要翻译： 公开了一种具有改进的水合诱导塞的放置引导装置，其用于将非侵入性分析器耦合到取样部位以确定人体中的分析物。 水合诱导塞包括至少一种可用作偶联剂的含氟聚合物。 引导装置还可以包括自动化或半自动化耦合流体输送系统。 使用这些耦合剂中的任一种可减轻与相关技术相关的问题，并增强非侵入性分析物测量，例如基于近红外漫反射的非侵入性葡萄糖浓度分析仪。