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    Method for implanting prosthetic valves
    11.
    发明申请
    Method for implanting prosthetic valves 审中-公开
    植入人工瓣膜的方法

    公开(公告)号：US20060259128A1

    公开(公告)日：2006-11-16

    申请号：US11404439

    申请日：2006-04-14

    申请人： Dusan Pavcnik ,  Brian Case ,  Ram Paul ,  Jacob Flagle

    发明人： Dusan Pavcnik ,  Brian Case ,  Ram Paul ,  Jacob Flagle

    IPC分类号： A61F2/06

    CPC分类号： A61F2/2412 ,  A61F2/2427 ,  A61F2/2475 ,  A61F2250/0002 ,  A61F2250/0096

    摘要： Methods for implanting a prosthetic valve in a body vessel having a fluid flow therethrough are provided. One method includes identifying a position of an existing valve and determining a factor affecting fluid flow in at least one of a first direction and a second direction at the existing valve. The method includes selecting the implantation position for a prosthetic valve at a distance away from the existing valve position in consideration of the factor. The method further includes providing the prosthetic valve for delivery to the implantation position, delivering and implanting the prosthetic valve at the position. The prosthetic valve includes at least one flexible member movable between a first position that permits fluid flow in the first direction and the second position that substantially prevents fluid flow in a second direction.

    摘要翻译： 提供了将人造瓣植入具有流体流体的体内容器中的方法。 一种方法包括识别现有阀的位置并且确定影响现有阀处的第一方向和第二方向中的至少一个中的流体流动的因素。 该方法包括考虑到该因素，在离开现有阀位置的距离处选择假体瓣膜的植入位置。 该方法还包括提供用于输送到植入位置的人造瓣膜，将该假体瓣膜输送和植入该位置。 假体瓣膜包括至少一个柔性构件，其可在第一位置和第二位置之间移动，所述第一位置允许流体在第一方向上流动，而第二位置基本上防止流体沿第二方向流动。

    Inverting occlusion devices, methods, and systems
    12.
    发明申请
    Inverting occlusion devices, methods, and systems 有权
    反相闭塞装置，方法和系统

    公开(公告)号：US20060149309A1

    公开(公告)日：2006-07-06

    申请号：US11322145

    申请日：2005-12-29

    申请人： Ram Paul ,  Brian Case ,  Jacob Flagle

    发明人： Ram Paul ,  Brian Case ,  Jacob Flagle

    IPC分类号： A61M29/02

    CPC分类号： A61B17/00008 ,  A61B17/12022 ,  A61B17/12109 ,  A61B17/12136 ,  A61B17/12181 ,  A61B2017/1205

    摘要： Described are devices, methods and systems useful for achieving occlusion of vascular vessels. Percutaneous procedures can be used to occlude and obliterate the greater saphenous vein, for example in the treatment of varicose vein condition caused by venous reflux. Certain embodiments encompass the percutaneous delivery of an occlusion device inverted within a cannula, its deployment and filling, so as to occlude or obliterate a portion of a vascular vessel.

    摘要翻译： 描述了用于实现血管血管阻塞的装置，方法和系统。 经皮手术可用于闭塞和闭塞较大的隐静脉，例如用于治疗由静脉回流引起的静脉曲张病变。 某些实施方案包括在插管内反转的闭塞装置的经皮递送，其展开和填充，以封闭或消除血管容器的一部分。

    Methods and systems for modifying vascular valves
    13.
    发明申请
    Methods and systems for modifying vascular valves 有权
    改变血管瓣膜的方法和系统

    公开(公告)号：US20060136045A1

    公开(公告)日：2006-06-22

    申请号：US11260360

    申请日：2005-10-27

    申请人： Jacob Flagle ,  Brian Case

    发明人： Jacob Flagle ,  Brian Case

    IPC分类号： A61F2/06

    CPC分类号： A61B17/00234 ,  A61B17/00491 ,  A61B17/064 ,  A61B17/122 ,  A61B18/1492 ,  A61B2017/00783 ,  A61F2/06 ,  A61F2/2475 ,  Y10S623/904

    摘要： Described are methods and systems for modifying vascular valves in order to reduce retrograde blood flow through the valves. Preferred methods include connecting vascular valve leaflets with at least one remodelable material, such that the valve leaflets become fused by the ingrowth of the patient's native tissue. Preferred remodelable materials include collagenous extracellular matrix material, such as small intestine submucosa.

    摘要翻译： 描述了用于修改血管瓣膜以减少通过瓣膜的逆行血流量的方法和系统。 优选的方法包括将血管瓣叶与至少一种可重塑材料连接，使得瓣膜小叶通过患者的天然组织的向内生长而变得熔化。 优选的可重塑材料包括胶原细胞外基质材料，例如小肠粘膜下层。

    METHODS OF TREATING VENOUS VALVE RELATED CONDITIONS WITH A FLOW-MODIFYING IMPLANTABLE MEDICAL DEVICE
    14.
    发明申请
    METHODS OF TREATING VENOUS VALVE RELATED CONDITIONS WITH A FLOW-MODIFYING IMPLANTABLE MEDICAL DEVICE 审中-公开
    用流动修改植入式医疗装置处理通气阀相关条件的方法

    公开(公告)号：US20080051879A1

    公开(公告)日：2008-02-28

    申请号：US11844003

    申请日：2007-08-23

    申请人： Brian Case ,  Gary Shirley ,  Ram Paul ,  Jacob Flagle

    发明人： Brian Case ,  Gary Shirley ,  Ram Paul ,  Jacob Flagle

    IPC分类号： A61F2/06

    CPC分类号： A61F2/2475 ,  A61F2/07 ,  A61F2002/068

    摘要： Implantable medical devices adapted to modify fluid flow within a body vessel are provided herein. The medical devices may include a fluid flow restricting channel configured to reduce longitudinal fluid flow in a retrograde direction or in an antegrade direction. Preferably, the medical devices are flow-modifying devices that reduce fluid flow through the medical device to a greater extent in a retrograde direction than in an antegrade direction. Methods of treatment comprising the step of implanting a flow-modifying medical device within a body vessel are also provided. Flow-modifying devices are useful, for example, in treating venous valve related conditions.

    摘要翻译： 本文提供了适于改变体内容器内的流体流动的植入式医疗装置。 医疗装置可以包括流体流动限制通道，该流体流动限制通道构造成减小沿逆行方向或顺行方向的纵向流体流动。 优选地，医疗装置是流动改变装置，其减少流体通过医疗装置的流体在逆行方向上比在顺行方向上更大程度地流动。 还提供了包括在身体容器内植入流动改变医疗装置的步骤的治疗方法。 流动改变装置例如在治疗静脉瓣相关病症中是有用的。

    Prosthetic valve devices and methods of making such devices
    17.
    发明申请
    Prosthetic valve devices and methods of making such devices 有权
    假体瓣膜装置及其制造方法

    公开(公告)号：US20050027348A1

    公开(公告)日：2005-02-03

    申请号：US10909153

    申请日：2004-07-30

    申请人： Brian Case ,  Jacob Flagle

    发明人： Brian Case ,  Jacob Flagle

    IPC分类号： A61F2/06 ,  A61F2/24 ,  A61F2/90

    CPC分类号： A61F2/2412 ,  A61F2/2415 ,  A61F2/2418 ,  A61F2/2475 ,  A61F2220/0075

    摘要： Prosthetic valve devices for implantation in body vessels, and methods of making same, are provided. The device has a main body with first and second ends and defining a lumen, with the second end being inverted into the lumen. A valve is disposed at the second end. In multiple valve devices, valves are disposed at the first and second ends, and individually may be inverted into the lumen. The prosthetic valve devices may further include a support structure such as a stent. Methods of making a prosthetic valve device include providing a main body having first and second ends and defining a lumen, forming a valve at the second end, and inverting the second end into the lumen. Methods may further comprise forming multiple valves and may also include attaching a support structure.

    摘要翻译： 提供用于植入体内血管的假体瓣膜装置及其制造方法。 该装置具有主体，其具有第一和第二端并且限定内腔，其中第二端被倒置成内腔。 阀设置在第二端。 在多个阀装置中，阀设置在第一和第二端处，并且可以单独地倒置到内腔中。 假体瓣膜装置还可以包括诸如支架的支撑结构。 制造假体瓣膜装置的方法包括提供具有第一端和第二端并限定内腔的主体，在第二端形成阀，并将第二端翻转成内腔。 方法还可以包括形成多个阀并且还可以包括附接支撑结构。

    Implantable support frame with electrolytically removable material
    18.
    发明申请
    Implantable support frame with electrolytically removable material 审中-公开
    具有电解可移除材料的可植入支架

    公开(公告)号：US20070067022A1

    公开(公告)日：2007-03-22

    申请号：US11511008

    申请日：2006-08-28

    申请人： Brian Case ,  Jacob Flagle

    发明人： Brian Case ,  Jacob Flagle

    IPC分类号： A61F2/06 ,  A61F2/82

    CPC分类号： A61F2/2418 ,  A61F2/2436 ,  A61F2/2475 ,  A61F2220/0016 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2250/0031

    摘要： Endoluminally implantable medical devices having an electrolytically removable portion are provided, as well as methods pertaining to the same. The electrolytically removable portion can be dissolved within a body vessel after implantation of the medical device, by application of an electrical current from an electrode on a catheter inside the body vessel or by induction of an electrical current within the removable region. Electrolytic dissolution of the removable portion can alter the mechanical strength of the implanted frame within the body vessel. Medical devices can be an endovascular valve comprising a frame and one or more valve members adapted to regulate fluid flow in a body vessel, such as a vein.

    摘要翻译： 提供了具有电解可移除部分的可植入植入式医疗装置以及与之相关的方法。 电解移除部分可以在植入医疗装置之后溶解在体内容器中，通过将电流从电极施加到体内容器内的导管上或通过在可移除区域内感应电流来溶解。 可移除部分的电解溶解可以改变植入框架在体内容器内的机械强度。 医疗装置可以是血管内瓣膜，其包括框架和一个或多个阀构件，其适于调节诸如静脉的体容器中的流体流动。