公开(公告)号：US08507205B2

公开(公告)日：2013-08-13

申请号：US13100395

申请日：2011-05-04

申请人： Malek Faham ,  Thomas Willis

发明人： Malek Faham ,  Thomas Willis

IPC分类号： C12Q1/68 ,  C12P19/34

CPC分类号： C12Q1/6886 ,  C12N15/1072 ,  C12Q1/6809 ,  C12Q1/6827 ,  C12Q1/6869 ,  C12Q1/6881 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/16 ,  Y02A90/26

摘要： The invention provides a method of making measurements on individual cells of a population, particularly cells that have identifying nucleic acid sequences, such as lymphoid cells. In one aspect, the invention provides a method of making multiparameter measurements on individual cells of such a population by carrying out a polymerase cycling assembly (PCA) reaction to link their identifying nucleic acid sequences to other cellular nucleic acids of interest. The fusion products of such PCA reaction are then sequenced and tabulated to generate multiparameter data for cells of the population.

摘要翻译： 本发明提供了对群体的单个细胞进行测量的方法，特别是具有鉴定核酸序列的细胞，例如淋巴样细胞。 一方面，本发明提供了一种通过进行聚合酶循环组件（PCA）反应以将其鉴定的核酸序列与感兴趣的其它细胞核酸连接的方法来对这样的群体的个体细胞进行多参数测量。 然后对这种PCA反应的融合产物进行测序并列表，以产生群体细胞的多参数数据。

公开(公告)号：US20110207134A1

公开(公告)日：2011-08-25

申请号：US13100365

申请日：2011-05-04

申请人： Malek Faham ,  Thomas Willis

发明人： Malek Faham ,  Thomas Willis

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q1/6874 ,  C12Q1/6881 ,  C12Q1/6883 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/16

摘要： There is a need for improved methods for determining the diagnosis and prognosis of patients with conditions, including autoimmune disease and cancer, especially lymphoid neoplasms, such as lymphomas and leukemias. Provided herein are methods for using DNA sequencing to identify personalized, or patient-specific biomarkers in patients with lymphoid neoplasms, autoimmune disease and other conditions. Identified biomarkers can be used to determine and/or monitor the disease state for a subject with an associated lymphoid disorder or autoimmune disease or other condition. In particular, the invention provides a sensitive method for monitoring lymphoid neoplasms that undergo clonal evolutions without the need to development alternative assays for the evolved or mutated clones serving as patient-specific biomarkers.

摘要翻译： 需要一种改进的方法来确定包括自身免疫性疾病和癌症在内的患者的诊断和预后，特别是淋巴瘤和白血病等淋巴样肿瘤。 本文提供了使用DNA测序鉴定患有淋巴样肿瘤，自身免疫疾病和其他病症的个体化或患者特异性生物标志物的方法。 识别的生物标志物可以用于确定和/或监测具有相关淋巴样病症或自身免疫疾病或其他病症的受试者的疾病状态。 特别地，本发明提供了用于监测经历克隆进化的淋巴样肿瘤的敏感方法，而不需要用作用作患者特异性生物标志物的进化或突变克隆的替代性测定。

公开(公告)号：US20060209056A1

公开(公告)日：2006-09-21

申请号：US11027105

申请日：2004-12-30

申请人： Thomas Willis ,  Samson Huang

发明人： Thomas Willis ,  Samson Huang

IPC分类号： G09G5/00

CPC分类号： G09G3/3611 ,  G09G3/001 ,  G09G3/2081

摘要： In some embodiments, a drive circuit may be coupled to a pixel element, wherein the drive circuit is configured to provide at least three different signal levels to the pixel element. Other embodiments are disclosed and claimed.

摘要翻译： 在一些实施例中，驱动电路可以耦合到像素元件，其中驱动电路被配置为向像素元件提供至少三个不同的信号电平。 公开和要求保护其他实施例。

公开(公告)号：US20060066605A1

公开(公告)日：2006-03-30

申请号：US11273437

申请日：2005-11-14

申请人： Thomas Willis

发明人： Thomas Willis

IPC分类号： G09G5/00

CPC分类号： G09G3/3688 ,  G09G3/2014 ,  G09G3/3406 ,  G09G2300/0408 ,  G09G2310/0235

摘要： A first pixel of a pixel array of a microdisplay is driven with a first pulse having a duration determined on the basis of a value loaded into a counter. A second pixel of the pixel array is driven with a second pulse having a duration determined on the basis of (a) the value loaded into the counter and (b) a value stored in a register.

公开(公告)号：US20130005584A1

公开(公告)日：2013-01-03

申请号：US13459701

申请日：2012-04-30

申请人： Malek Faham ,  Thomas Willis

发明人： Malek Faham ,  Thomas Willis

IPC分类号： C40B20/00

CPC分类号： C12Q1/6886 ,  C12N15/1072 ,  C12Q1/6809 ,  C12Q1/6827 ,  C12Q1/6869 ,  C12Q1/6881 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/16 ,  Y02A90/26

摘要： There is a need for improved methods for determining the diagnosis and prognosis of patients with conditions, including autoimmune disease and cancer. Provided herein are methods for using DNA sequencing to identify personalized biomarkers in patients with autoimmune disease and other conditions. Identified biomarkers can be used to determine the disease state for a subject with an autoimmune disease or other condition.

摘要翻译： 需要改进的方法来确定包括自身免疫性疾病和癌症在内的患者的诊断和预后。 本文提供了使用DNA测序鉴定患有自身免疫疾病和其他病症的个体化生物标志物的方法。 识别的生物标志物可用于确定具有自身免疫疾病或其他病症的受试者的疾病状态。

公开(公告)号：US20110207617A1

公开(公告)日：2011-08-25

申请号：US13100395

申请日：2011-05-04

申请人： Malek Faham ,  Thomas Willis

发明人： Malek Faham ,  Thomas Willis

IPC分类号： C40B30/00

CPC分类号： C12Q1/6886 ,  C12N15/1072 ,  C12Q1/6809 ,  C12Q1/6827 ,  C12Q1/6869 ,  C12Q1/6881 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/16 ,  Y02A90/26

摘要： The invention provides a method of making measurements on individual cells of a population, particularly cells that have identifying nucleic acid sequences, such as lymphoid cells. In one aspect, the invention provides a method of making multiparameter measurements on individual cells of such a population by carrying out a polymerase cycling assembly (PCA) reaction to link their identifying nucleic acid sequences to other cellular nucleic acids of interest. The fusion products of such PCA reaction are then sequenced and tabulated to generate multiparameter data for cells of the population.

摘要翻译： 本发明提供了对群体的单个细胞进行测量的方法，特别是具有鉴定核酸序列的细胞，例如淋巴样细胞。 一方面，本发明提供了一种通过进行聚合酶循环组件（PCA）反应以将其鉴定的核酸序列与感兴趣的其它细胞核酸连接的方法来对这样的群体的个体细胞进行多参数测量。 然后对这种PCA反应的融合产物进行测序并列表，以产生群体细胞的多参数数据。

公开(公告)号：US20060158405A1

公开(公告)日：2006-07-20

申请号：US11037619

申请日：2005-01-18

申请人： Thomas Willis

发明人： Thomas Willis

IPC分类号： G09G3/34

CPC分类号： G09G3/2037 ,  G09G2310/0235 ,  H04N9/3114 ,  H04N9/3123

摘要： In a spatial light modulator, a frame may be broken up into a plurality of colors. A given frame may include at least a first portion and a second portion. During the first portion of the frame, more significant bits of the data for a given pixel may be displayed and during a second portion of the frame, less significant bits may be disclosed. In some embodiments, the frame may be broken into two color subframes for each color, but in other embodiments, more than two such subframes may be utilized. In one embodiment, the frame may be broken into red, blue, and green and each color may be displayed at least twice, such that more significant bits are displayed first and less significant bits are displayed thereafter.

摘要翻译： 在空间光调制器中，帧可以被分解为多种颜色。 给定的框架可以包括至少第一部分和第二部分。 在帧的第一部分期间，可以显示给定像素的数据的更高有效位，并且在帧的第二部分期间，可以公开较不重要的位。 在一些实施例中，对于每种颜色，帧可以被分成两个颜色的子帧，但是在其他实施例中，可以利用多于两个这样的子帧。 在一个实施例中，帧可以被分成红色，蓝色和绿色，并且每个颜色可以显示至少两次，使得首先显示更高有效位，此后显示较低有效位。

公开(公告)号：US20060101227A1

公开(公告)日：2006-05-11

申请号：US11316788

申请日：2005-12-22

申请人： Thomas Willis ,  Achmed Zahir

发明人： Thomas Willis ,  Achmed Zahir

IPC分类号： G06F12/10

CPC分类号： G06F12/1027

摘要： A sharing mechanism is herein disclosed for multiple logical processors using a translation lookaside buffer (TLB) to translate virtual addresses, for example into physical addresses. The mechanism supports sharing of TLB entries among logical processors, which may access address spaces in common. The mechanism further supports private TLB entries among logical processors, which for example, may each access a different physical address through identical virtual addresses. The sharing mechanism provides for installation and updating of TLB entries as private entries or as shared entries transparently, without requiring special operating system support or modifications. Through use of the disclosed sharing mechanism, fast and efficient virtual address translation is provided without requiring more expensive functional redundancy.

公开(公告)号：US20060061581A1

公开(公告)日：2006-03-23

申请号：US11273001

申请日：2005-11-14

申请人： Thomas Willis ,  Steven Midford

发明人： Thomas Willis ,  Steven Midford

IPC分类号： G09G5/36

CPC分类号： G09G5/395 ,  G09G2320/103 ,  G09G2330/022

摘要： A method, apparatus, and signal-bearing medium for sending to a display device modified regions of a frame buffer. A frame buffer is divided into the regions, and data in the frame buffer represents pixels on the display device. The frame buffer accumulates writes until the region being written to changes, at which time the region is copied to the display device.

公开(公告)号：US20050195208A1

公开(公告)日：2005-09-08

申请号：US11119664

申请日：2005-05-02

申请人： Thomas Willis ,  Steven Midford

发明人： Thomas Willis ,  Steven Midford

IPC分类号： G06F12/10 ,  G09G5/36 ,  G09G5/37

CPC分类号： G06F12/1027 ,  G06F12/1081 ,  G09G5/36 ,  Y02D10/13

摘要： A method, apparatus, and signal-bearing medium for sending to a display device only those regions of the display screen that change. A frame buffer is divided into tiles, which may be composed of one or more regions, and data in the frame buffer represents pixels on the display screen. When data representing a pixel is modified in the frame buffer, the region or tile associated with the pixel is marked as dirty, and those tiles or regions that are dirty in the frame buffer are written to the display.