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公开(公告)号：US20050281863A1
公开(公告)日：2005-12-22
申请号：US11203931
申请日：2005-08-15
Applicant: Aron Anderson , Laurie Lawin , Byron Shen , Eugene de Juan , Signe Varner , Ralph Chappa
Inventor： Aron Anderson , Laurie Lawin , Byron Shen , Eugene de Juan , Signe Varner , Ralph Chappa
CPC classification number: A61K31/58 , A61F2310/00353 , A61K9/0051
Abstract: The invention provides controlled release bioactive agent delivery devices that include a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension, and a polymeric coated composition in contact with the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent, wherein the first polymer and the second polymer are hydrophobic. The invention also provides methods of delivering a bioactive agent to a patient in a controlled release manner, as well as methods of making controlled release bioactive agent delivery devices.
Abstract translation: 本发明提供控制释放的生物活性剂递送装置，其包括具有延伸方向的本体构件，沿着延伸方向的纵向轴线，以及近端和远端，其中，身体构件的至少一部分偏离 所述聚合物涂覆组合物包括第一聚合物，第二聚合物和生物活性剂，其中所述第一聚合物和所述第二聚合物是疏水性的。 本发明还提供了以受控释放方式将生物活性剂递送至患者的方法，以及制备控制释放的生物活性剂递送装置的方法。
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公开(公告)号：US20070101933A1
公开(公告)日：2007-05-10
申请号：US11539443
申请日：2006-10-06
Applicant: Ralph Chappa
Inventor： Ralph Chappa
IPC: B05B5/025
CPC classification number: B05D1/02 , B05B7/0807 , B05B7/0861 , B05B7/0869 , B05B13/0207 , B05B13/0228 , B05B13/0436 , B05B13/0442 , B05C13/025 , B05D1/002 , Y10S118/11
Abstract: The invention relates to methods and apparatuses that reduce problems encountered during coating of a device, such as a medical device having a cylindrical shape. In an embodiment, the invention includes an apparatus including a bidirectional rotation member. In an embodiment, the invention includes a method with a bidirectional indexing movement. In an embodiment, the invention includes a coating solution supply member having a major axis oriented parallel to a gap between rollers on a coating apparatus. In an embodiment, the invention includes a device retaining member. In an embodiment, the invention includes an air nozzle or an air knife. In an embodiment, the invention includes a method including removing a static charge from a small diameter medical device.
Abstract translation: 本发明涉及减少装置涂覆期间遇到的问题的方法和装置，例如具有圆柱形形状的医疗装置。 在一个实施例中，本发明包括一种包括双向旋转构件的装置。 在一个实施例中，本发明包括具有双向分度运动的方法。 在一个实施方案中，本发明包括具有平行于涂覆设备上的辊之间的间隙定向的长轴的涂布溶液供应构件。 在一个实施例中，本发明包括装置保持构件。 在一个实施例中，本发明包括空气喷嘴或气刀。 在一个实施例中，本发明包括一种包括从小直径医疗装置中去除静电荷的方法。
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公开(公告)号：US20060210701A1
公开(公告)日：2006-09-21
申请号：US11421637
申请日：2006-06-01
Applicant: Ralph Chappa , Steven Porter
Inventor： Ralph Chappa , Steven Porter
CPC classification number: B05D1/002 , A61L31/10 , B05B13/0242 , B05B13/0442 , B05B16/40
Abstract: The invention provides an apparatus for coating a device comprising a coating chamber and a device rotator having at least one device mount wherein the apparatus allows insertion and retraction of the device on the device mount into and out of the coating chamber. In another aspect, the invention provides a method of applying a substantially uniform coating on a device comprising the steps of providing an apparatus for coating a device, mounting the device onto the device mount, purging the coating chamber to reduce humidity in the coating chamber, maintaining a reduced humidity content in the coating chamber, inserting the device into the coating chamber, disposing a coating material on the device and rotating the device mounts about the device axis.
Abstract translation: 本发明提供了一种用于涂覆装置的装置，该装置包括涂覆室和具有至少一个装置安装件的装置旋转器，其中装置允许装置在装置安装件上进出涂层室的插入和缩回。 另一方面，本发明提供了一种在装置上施加基本上均匀的涂层的方法，包括以下步骤：提供用于涂覆装置的装置，将装置安装到装置安装件上，清洗涂布室以减少涂覆室中的湿度， 保持涂布室中的湿度降低，将装置插入涂覆室中，将涂层材料设置在装置上并使装置围绕装置轴线旋转。
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公开(公告)号：US20060134168A1
公开(公告)日：2006-06-22
申请号：US11295167
申请日：2005-12-06
Applicant: Ralph Chappa , Kimberly Lindsoe
Inventor： Ralph Chappa , Kimberly Lindsoe
CPC classification number: A61L31/16 , A61K6/0017 , A61K31/56 , A61L27/34 , A61L27/50 , A61L27/54 , A61L31/10 , A61L31/14 , A61L2300/216 , A61L2300/222 , A61L2300/43 , A61L2300/602 , A61L2300/606 , A61L2300/63 , A61L2420/02 , A61L2420/06
Abstract: The present invention relates to coatings with crystallized active agent(s) and related methods. In an embodiment, the invention includes a method for coating a medical device including selecting a solvent and a polymer, selecting a concentration of an active agent of at least a certain amount of saturation, forming a coating composition having the selected concentration of the active agent, and applying the coating composition to the medical device. In an embodiment, the invention includes an elution control coating disposed on a medical device, the elution control coating including a polymer, and an active agent, wherein the active agent is at least about 80% crystallized within one week of being disposed on the medical device. In an embodiment, the invention includes a method for enhancing the formation of active agent crystals within a coating layer including forming a coating solution and adjusting the concentration of the active agent in the coating solution to reach some percentage of the active agent saturation point. In an embodiment, the invention includes a method of enhancing crystallization of an active agent, the method including forming a coating solution comprising a polymer, an active agent, and a solvent; applying the coating solution to a substrate; and increasing the rate of active agent nucleation within the coating.
Abstract translation: 本发明涉及具有结晶活性剂的涂层和相关方法。 在一个实施方案中，本发明包括用于涂覆医疗装置的方法，包括选择溶剂和聚合物，选择至少一定量饱和度的活性剂的浓度，形成具有选定浓度的活性剂的涂料组合物 ，并将所述涂料组合物施用于所述医疗装置。 在一个实施方案中，本发明包括设置在医疗装置上的洗脱控制涂层，洗脱控制涂层包括聚合物和活性剂，其中活性剂在被放置在医疗上的一周内至少约80％结晶 设备。 在一个实施方案中，本发明包括一种用于增强涂层内活性剂晶体形成的方法，包括形成涂层溶液并调节涂层溶液中活性剂的浓度达到活性剂饱和点的一定百分比。 在一个实施方案中，本发明包括增强活性剂结晶的方法，所述方法包括形成包含聚合物，活性剂和溶剂的包衣溶液; 将涂布溶液涂布到基材上; 并增加涂层内活性剂成核的速率。
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公开(公告)号：US20050287188A1
公开(公告)日：2005-12-29
申请号：US11203981
申请日：2005-08-15
Applicant: Aron Anderson , Laurie Lawin , Byron Shen , Eugene de Juan , Signe Varner , Ralph Chappa
Inventor： Aron Anderson , Laurie Lawin , Byron Shen , Eugene de Juan , Signe Varner , Ralph Chappa
CPC classification number: A61K31/58 , A61F2310/00353 , A61K9/0051
Abstract: The invention provides retrievable devices for sustained delivery of bioactive agent to a site within a patient, the devices including a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension; a cap at the proximal end of the body member; and a polymeric coated composition in contact with a surface of the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent.
Abstract translation: 本发明提供了用于将生物活性剂持续递送到患者内的部位的可回收装置，所述装置包括具有延伸方向的本体构件，沿着延伸方向的纵向轴线，以及近端和远端，其中， 身体构件的至少一部分偏离延伸方向; 在主体构件的近端处的帽; 以及与本体构件的表面接触的聚合物涂覆的组合物，所述聚合物涂覆的组合物包含第一聚合物，第二聚合物和生物活性剂。
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Patent Agency Ranking
公开(公告)号：US20050271706A1
公开(公告)日：2005-12-08
申请号：US11204271
申请日：2005-08-15
Applicant: Aron Anderson , Laurie Lawin , Byron Shen , Eugene Juan , Signe Varner , Ralph Chappa
Inventor： Aron Anderson , Laurie Lawin , Byron Shen , Eugene Juan , Signe Varner , Ralph Chappa
CPC classification number: A61K31/58 , A61F2310/00353 , A61K9/0051
Abstract: The invention provides methods for delivering bioactive agent to an eye, the methods including steps of providing a device at an implantation site within the eye, and maintaining the device at the implantation site to provide a therapeutically effective amount of the bioactive agent to the eye. The device includes a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension. A polymeric coated composition is provided in contact with a surface of the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent. The invention also provides methods of administering a therapeutically effective amount of bioactive agent to a posterior segment of an eye.
Abstract translation: 本发明提供了将生物活性剂递送到眼睛的方法，所述方法包括以下步骤：在眼睛内的植入部位提供装置，并将装置保持在植入部位以向眼睛提供治疗有效量的生物活性剂。 该装置包括具有延伸方向的本体构件，沿着延伸方向的纵向轴线，以及近端和远端，其中主体构件的至少一部分偏离延伸方向。 提供与主体构件的表面接触的聚合物涂覆的组合物，聚合物涂覆的组合物包括第一聚合物，第二聚合物和生物活性剂。 本发明还提供了将治疗有效量的生物活性剂施用于眼后段的方法。
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公开(公告)号：US20080114451A1
公开(公告)日：2008-05-15
申请号：US12016343
申请日：2008-01-18
Applicant: Sean Stucke , Kimberly Lindsoe , Ralph Chappa , Dale Swan
Inventor： Sean Stucke , Kimberly Lindsoe , Ralph Chappa , Dale Swan
CPC classification number: A61L31/16 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/258 , A61L2300/404 , A61L2300/406 , A61L2300/606 , C08L71/02
Abstract: A coating composition, in both its uncrosslinked and crosslinked forms, for use in increasing the static friction of a surface of a delivery system comprising a medical device having a surface in contact with the surface of a delivery component, the static friction of the surface being increased in an amount sufficient to substantially maintain the position of the medical device on the delivery component against forces asserted on the delivery system as it navigates through a vessel of the body. The delivery system may comprise a balloon catheter as the delivery component and a stent as the medical device. A composition includes a polyether monomer, such as an alkoxy poly(alkylene glycol), a carboxylic acid-containing monomer, such as (meth)acrylic acid, optionally a photoderivatized monomer, and a hydrophilic monomer such as (meth)acrylamide.
Abstract translation: 一种涂料组合物，以其未交联和交联的形式，用于增加递送系统的表面的静摩擦力，其包括具有与输送组分表面接触的表面的医疗装置，表面的静摩擦力 增加的量足以基本上保持医疗装置在输送部件上的位置，抵抗在输送系统导航通过身体的血管时所断言的力。 输送系统可以包括作为输送部件的气囊导管和作为医疗装置的支架。 组合物包括聚醚单体，例如烷氧基聚（亚烷基二醇），含羧酸的单体，例如（甲基）丙烯酸，任选的光衍生单体和亲水性单体如（甲基）丙烯酰胺。
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18.发明申请Combination Degradable and Non-Degradable Matrices for Active Agent Delivery 有权用于活性剂递送的组合可降解和不可降解矩阵公开(公告)号：US20080020045A1
公开(公告)日：2008-01-24
申请号：US11770316
申请日：2007-06-28
Applicant: Ralph Chappa , Robert Hergenrother , Paula Bushendorf , Joram Slager
Inventor： Ralph Chappa , Robert Hergenrother , Paula Bushendorf , Joram Slager
IPC: A61K47/30 , A61K38/02 , A61K9/00 , A61K39/395
CPC classification number: A61L27/58 , A61L27/48 , A61L27/54 , A61L2300/252 , A61L2300/256 , A61L2300/604 , C08L23/0853 , C08L23/0869 , C08L33/08 , C08L71/02 , C08L2201/06 , C08L2666/22
Abstract: The present invention relates to relates to combination degradable and non-degradable matrices and related methods. In an embodiment, the invention includes an active agent delivery matrix including a degradable polymer network, a non-degradable polymer network, the non-degradable polymer network interspersed within the degradable polymer network, and an active agent. In an embodiment, the invention includes an active agent elution control matrix including a degradable polymer; and a non-degradable polymer interspersed with the degradable polymer. In an embodiment, the invention includes a method of making an active agent delivery matrix including mixing a degradable polymer with a first solvent to form a degradable polymer solution; mixing a non-degradable polymer with a second solvent to form a non-degradable polymer solution; and simultaneously depositing the degradable polymer solution and the non-degradable polymer solution onto a substrate.
Abstract translation: 本发明涉及可降解和不可降解的基质和相关方法。 在一个实施方案中，本发明包括活性剂递送基质，其包括可降解聚合物网络，不可降解聚合物网络，散布在可降解聚合物网络内的不可降解聚合物网络和活性剂。 在一个实施方案中，本发明包括包含可降解聚合物的活性剂洗脱控制基质; 和散布有可降解聚合物的不可降解聚合物。 在一个实施方案中，本发明包括制备活性剂递送基质的方法，包括将可降解聚合物与第一溶剂混合以形成可降解的聚合物溶液; 将不可降解的聚合物与第二溶剂混合以形成不可降解的聚合物溶液; 同时将可降解聚合物溶液和不可降解聚合物溶液沉积在基材上。
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公开(公告)号：US20060216324A1
公开(公告)日：2006-09-28
申请号：US11440524
申请日：2006-05-25
Applicant: Sean Stucke , Ralph Chappa , Joseph Chinn , Aron Anderson
Inventor： Sean Stucke , Ralph Chappa , Joseph Chinn , Aron Anderson
CPC classification number: A61L31/16 , A61L27/34 , A61L27/54 , A61L31/10 , A61L33/0011 , A61L2300/406 , A61L2300/416 , A61L2300/42 , A61L2300/608 , C08L33/10 , C08L29/04 , C08L39/06
Abstract: The invention provides methods and compositions for providing biocompatible surfaces to medical articles. In particular the invention provides biocompatible coatings with heparin activity. In some aspects, the biocompatible coatings of the invention are able to release a bioactive agent. The coatings can be formed using biostable or biodegradable polymeric material and photoreactive groups. The invention also provides methods for improving the quality of bioactive agent-containing coatings by performing pre-irradiation of biocompatible coating compositions.
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公开(公告)号：US20060088653A1
公开(公告)日：2006-04-27
申请号：US10976193
申请日：2004-10-27
Applicant: Ralph Chappa
Inventor： Ralph Chappa
CPC classification number: B05B13/0228
Abstract: The invention relates to methods and apparatuses that reduce problems encountered during coating of a device, such as a medical device having a cylindrical shape. In an embodiment, the invention includes an apparatus including a bi-directional rotation member. In an embodiment, the invention includes a method with a bi-directional indexing movement. In an embodiment, the invention includes a coating solution supply member having a major axis oriented parallel to a gap between rollers on a coating apparatus. In an embodiment, the invention includes a device retaining member. In an embodiment, the invention includes an air nozzle or an air knife. In an embodiment, the invention includes a method including removing a static charge from a small diameter medical device.
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