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公开(公告)号：US20070292596A1
公开(公告)日：2007-12-20
申请号：US11846955
申请日：2007-08-29
Applicant: Ralph Chappa , Sean Stucke , Richard Amos , Terrence Everson , Stephen Chudzik , Dale Swan , Peter Duquette
Inventor： Ralph Chappa , Sean Stucke , Richard Amos , Terrence Everson , Stephen Chudzik , Dale Swan , Peter Duquette
CPC classification number: B82Y30/00 , A61L27/34 , C09D4/00 , Y10S522/904 , Y10T428/249991 , Y10T428/249992 , C08F220/56 , C08F220/54
Abstract: A grafting reagent and related method of using the reagent to form a polymeric layer on a support surface, and particularly a porous support surface, in a manner that provides and/or preserves desired properties (such as porosity) of the surface. The reagent and method can be used to provide a thin, conformable, uniform, uncrosslinked coating having desired properties onto the surface of a preformed, and particularly a porous, polymeric substrate. The method includes the steps of a) providing a porous support surface, b) providing a nonpolymeric grafting reagent comprising a photoinitator group, c) providing one or more polymerizable monomers adapted to be contacted with the surface, in the presence of the grafting reagent, and to be polymerized upon activation of the photoinitiator; and d) applying the grafting reagent and monomer(s) to the surface in a manner, and under conditions, suitable to coat the surface with the grafting reagent and to cause the polymerization of monomers to the surface upon activation of the grafting reagent.
Abstract translation: 以提供和/或保留表面的所需性质（例如孔隙率）的方式使用试剂在支撑表面上，特别是多孔载体表面上形成聚合物层的接枝试剂和相关方法。 试剂和方法可用于提供具有所需性质的薄的，一致的，均匀的未交联的涂层，其具有预先形成的，特别是多孔的聚合物基材的表面。 该方法包括以下步骤：a）提供多孔载体表面，b）提供包含光引发剂基团的非聚合物接枝剂，c）在接枝剂存在下，提供适于与表面接触的一种或多种可聚合单体， 并在激活光引发剂时聚合; 和d）以接枝试剂的方式和条件下将接枝试剂和单体施用于表面，并且在接枝试剂活化时使单体聚合成表面。
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公开(公告)号：US20060165872A1
公开(公告)日：2006-07-27
申请号：US11388478
申请日：2006-03-24
Applicant: Ralph Chappa , Mark Carlson
Inventor： Ralph Chappa , Mark Carlson
CPC classification number: B05B7/0807 , B05B7/0861 , B05B7/0869 , B05B13/0207 , B05B13/0228 , B05B13/0436 , B05B13/0442 , B05D1/002 , B05D1/02
Abstract: A method for coating a rollable device including a device rotator having a pair of rollers and spray nozzle is described. The spray nozzle produces a spray of coating material that is directed towards a gap that is between the rollers of the pair. The majority of any spray not deposited on the rollable device during a coating process passes through the gap between the rollers.
Abstract translation: 描述了一种包括具有一对辊和喷嘴的装置旋转器的可卷绕装置的方法。 喷嘴产生喷涂的涂料，该喷涂材料指向一对间的间隙。 在涂布过程中，大部分没有沉积在可滚动装置上的喷雾通过辊之间的间隙。
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公开(公告)号：US20050196424A1
公开(公告)日：2005-09-08
申请号：US11102465
申请日：2005-04-08
Applicant: Ralph Chappa
Inventor： Ralph Chappa
CPC classification number: A61L31/10 , A61F9/0017 , A61K9/0051 , A61K31/58 , C08L31/04 , C08L33/10
Abstract: Embodiments of the invention include coated medical devices that can elute one or more bioactive agents within the body, and methods for producing the same. In an embodiment, the invention includes a method of forming a coated medical device including depositing a coated composition onto a medical device having a roughened segment and a smooth segment. In an embodiment, the invention includes a method of forming a coated implantable medical device including depositing a coated composition onto a medical device having a body segment and a piercing segment. In an embodiment, the invention includes a medical device, a coated composition provided on the substrate surface, the composition including a bioactive agent and a polymer. The medical device includes an uncoated component wherein the edge of the coated composition is within 0.5 mm of the uncoated component. In an embodiment, the invention includes a method for disposing a coated composition on a medical device with an ultrasonically atomized spray stream including moving a spray stream in a pattern having a plurality of transverse sweeps and a plurality of longitudinal movements.
Abstract translation: 本发明的实施方案包括可以洗脱身体内的一种或多种生物活性剂的涂覆的医疗装置及其制备方法。 在一个实施方案中，本发明包括形成涂覆的医疗装置的方法，包括将涂覆的组合物沉积在具有粗糙部分和平滑部分的医疗装置上。 在一个实施方案中，本发明包括形成涂覆的可植入医疗装置的方法，包括将涂覆的组合物沉积到具有身体部分和刺穿部分的医疗装置上。 在一个实施方案中，本发明包括医疗装置，设置在基材表面上的涂布组合物，所述组合物包含生物活性剂和聚合物。 医疗装置包括未涂覆的组分，其中涂覆组合物的边缘在未涂覆组分的0.5mm以内。 在一个实施方案中，本发明包括用超声波雾化喷雾流将医用装置上的涂覆组合物设置为包括使具有多个横向扫描和多个纵向移动的图案移动喷雾流的方法。
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公开(公告)号：US20050158449A1
公开(公告)日：2005-07-21
申请号：US10976348
申请日：2004-10-27
Applicant: Ralph Chappa
Inventor： Ralph Chappa
CPC classification number: B05D1/02 , B05B7/0807 , B05B7/0861 , B05B7/0869 , B05B13/0207 , B05B13/0228 , B05B13/0436 , B05B13/0442 , B05C13/025 , B05D1/002 , Y10S118/11
Abstract: The invention relates to methods and apparatuses that reduce problems encountered during coating of a device, such as a medical device having a cylindrical shape. In an embodiment, the invention includes an apparatus including a bi-directional rotation member. In an embodiment, the invention includes a method with a bi-directional indexing movement. In an embodiment, the invention includes a coating solution supply member having a major axis oriented parallel to a gap between rollers on a coating apparatus. In an embodiment, the invention includes a device retaining member. In an embodiment, the invention includes an air nozzle or an air knife. In an embodiment, the invention includes a method including removing a static charge from a small diameter medical device.
Abstract translation: 本发明涉及减少装置涂覆期间遇到的问题的方法和装置，例如具有圆柱形形状的医疗装置。 在一个实施例中，本发明包括一种包括双向旋转构件的装置。 在一个实施例中，本发明包括具有双向分度运动的方法。 在一个实施方案中，本发明包括具有平行于涂覆设备上的辊之间的间隙定向的长轴的涂布溶液供应构件。 在一个实施例中，本发明包括装置保持构件。 在一个实施例中，本发明包括空气喷嘴或气刀。 在一个实施例中，本发明包括一种包括从小直径医疗装置中去除静电荷的方法。
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5.发明申请Devices, articles, coatings, and methods for controlled active agent release 审中-公开用于控制活性剂释放的装置，制品，涂料和方法公开(公告)号：US20050281858A1
公开(公告)日：2005-12-22
申请号：US11156245
申请日：2005-06-17
Applicant: Tim Kloke , Ralph Chappa
Inventor： Tim Kloke , Ralph Chappa
CPC classification number: A61L27/40 , A61L27/34 , A61L27/54 , A61L31/10 , A61L31/12 , A61L31/16 , A61L2300/608 , A61L2420/08
Abstract: The present invention relates to multi-layer coatings and device, articles, and methods regarding the same, for controlled active agent release. Embodiments of the present invention include devices, articles, coatings, and methods relating to an composition including an active agent, a first layer disposed on the composition, and a second layer disposed on the first layer, wherein the second layer is configured to provide controlled release of the active agent through the second layer and the second layer has release characteristics that are distinct from the first layer.
Abstract translation: 本发明涉及用于受控活性剂释放的多层涂层及其相关的装置，制品和方法。 本发明的实施方案包括与包含活性剂的组合物，设置在组合物上的第一层和设置在第一层上的第二层相关的装置，制品，涂层和方法，其中第二层被配置为提供受控的 活性剂通过第二层和第二层的释放具有与第一层不同的释放特性。
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Patent Agency Ranking
公开(公告)号：US20050260246A1
公开(公告)日：2005-11-24
申请号：US11123835
申请日：2005-05-06
Applicant: Stephen Chudzik , Aron Anderson , Ralph Chappa , Timothy Kloke , Laurie Lawin , Klaus Wormuth
Inventor： Stephen Chudzik , Aron Anderson , Ralph Chappa , Timothy Kloke , Laurie Lawin , Klaus Wormuth
CPC classification number: A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/602 , A61L2300/606 , C08L33/06
Abstract: A coating composition for use in coating implantable medical devices to improve their ability to release bioactive agents in vivo. The coating composition is particularly adapted for use with devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a mixture of a first polymer component such as poly(butyl methacrylate) and a second polymer component such as poly(ethylene-co-vinyl acetate).
Abstract translation: 用于涂覆可植入医疗装置以提高其在体内释放生物活性剂的能力的涂料组合物。 涂料组合物特别适用于在其输送和/或使用过程（例如支架和导管）中经历显着弯曲和/或膨胀的装置。 组合物包括与第一聚合物组分如聚（甲基丙烯酸丁酯）和第二聚合物组分如聚（乙烯 - 共 - 乙酸乙烯酯）的混合物的组合的生物活性剂。
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公开(公告)号：US20050244453A1
公开(公告)日：2005-11-03
申请号：US11090655
申请日：2005-03-25
Applicant: Sean Stucke , Ralph Chappa , Joseph Chinn , Aron Anderson
Inventor： Sean Stucke , Ralph Chappa , Joseph Chinn , Aron Anderson
CPC classification number: A61L31/16 , A61L27/34 , A61L27/54 , A61L31/10 , A61L33/0011 , A61L2300/406 , A61L2300/416 , A61L2300/42 , A61L2300/608 , C08L33/10 , C08L29/04 , C08L39/06
Abstract: The invention provides methods and compositions for providing biocompatible surfaces to medical articles. In particular the invention provides biocompatible coatings with heparin activity. In some aspects, the biocompatible coatings of the invention are able to release a bioactive agent. The coatings can be formed using biostable or biodegradable polymeric material and photoreactive groups. The invention also provides methods for improving the quality of bioactive agent-containing coatings by performing pre-irradiation of biocompatible coating compositions.
Abstract translation: 本发明提供了用于向医疗制品提供生物相容性表面的方法和组合物。 特别地，本发明提供具有肝素活性的生物相容性涂层。 在一些方面，本发明的生物相容性涂层能够释放生物活性剂。 可以使用生物稳定或可生物降解的聚合物材料和光反应性基团形成涂层。 本发明还提供了通过进行生物相容性涂料组合物的预辐射来提高含生物活性剂的涂层的质量的方法。
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公开(公告)号：US20050170427A1
公开(公告)日：2005-08-04
申请号：US11101271
申请日：2005-04-06
Applicant: Ralph Chappa , Sheau-Ping Hu , Dale Swan , Melvin Swanson , Patrick Guire
Inventor： Ralph Chappa , Sheau-Ping Hu , Dale Swan , Melvin Swanson , Patrick Guire
IPC: G01N33/53 , C07B61/00 , C07C45/63 , C07C235/84 , C07C323/42 , C07H21/00 , C12M1/00 , C12N15/09 , C12Q1/68 , C12Q1/6834 , C40B40/06 , C40B60/14 , G01N1/28 , G01N21/78 , G01N33/566 , G01N37/00 , C07H21/04 , C12M1/34
CPC classification number: B82Y30/00 , B01J2219/00317 , B01J2219/00531 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00635 , B01J2219/00637 , B01J2219/00659 , B01J2219/00677 , B01J2219/00711 , B01J2219/00716 , B01J2219/00722 , C07B2200/11 , C07C45/63 , C07C235/84 , C07C323/42 , C07H21/00 , C12Q1/6834 , C40B40/06 , C40B60/14 , C07C49/813
Abstract: Method and reagent composition for covalent attachment of target molecules, such as nucleic acids, onto the surface of a substrate. The reagent composition includes groups capable of covalently binding to the target molecule. Optionally, the composition can contain photoreactive groups for use in attaching the reagent composition to the surface. The reagent composition can be used to provide activated slides for use in preparing microarrays of nucleic acids.
Abstract translation: 用于将目标分子（例如核酸）共价连接到基底表面上的方法和试剂组合物。 试剂组合物包括能够共价结合靶分子的基团。 任选地，组合物可以含有用于将试剂组合物附着到表面上的光反应性基团。 试剂组合物可用于提供用于制备核酸微阵列的活性载玻片。
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公开(公告)号：US20060067968A1
公开(公告)日：2006-03-30
申请号：US11281845
申请日：2005-11-17
Applicant: Stephen Chudzik , Aron Anderson , Ralph Chappa , Timothy Kloke
Inventor： Stephen Chudzik , Aron Anderson , Ralph Chappa , Timothy Kloke
CPC classification number: A61L31/16 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/602 , A61L2300/606 , C08L33/06
Abstract: A coating composition for use in coating implantable medical devices to improve their ability to release bioactive agents in vivo. The coating composition is particularly adapted for use with devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a mixture of a first polymer component such as poly(butyl methacrylate) and a second polymer component such as poly(ethylene-co-vinyl acetate).
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公开(公告)号：US20060057277A1
公开(公告)日：2006-03-16
申请号：US11223811
申请日：2005-09-09
Applicant: Ralph Chappa
Inventor： Ralph Chappa
CPC classification number: A61L27/54 , A61L27/34 , A61L31/10 , A61L31/16 , A61L2300/602
Abstract: The present invention relates to methods, devices, and coatings, wherein active agent release is determined by deposition rate of a coating or material. In an embodiment, the invention includes a method for coating a medical device, including identifying active agent elution rates for a coating composition applied to substrates at a plurality of coating deposition rates, selecting one of the coating deposition rates, and applying the coating composition to the medical device at the selected deposition rate. In an embodiment, the invention includes a combination including a medical device and a composition for coating the surface of a medical device with an active agent in a manner that permits the coated surface to release the active agent over time when implanted in vivo.
Abstract translation: 本发明涉及方法，装置和涂层，其中通过涂层或材料的沉积速率确定活性剂释放。 在一个实施方案中，本发明包括用于涂覆医疗装置的方法，包括鉴定以多种涂布沉积速率施加到基材上的涂料组合物的活性剂洗脱速率，选择一种涂布沉积速率，以及将涂料组合物施用于 医疗器械以选定的沉积速率。 在一个实施方案中，本发明包括一种组合，其包括医疗装置和用于用活性剂涂覆医疗装置的表面的组合物，使得当植入体内时涂覆表面随时间推移释放活性剂。
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