公开(公告)号：US07687513B1

公开(公告)日：2010-03-30

申请号：US11254782

申请日：2005-10-21

申请人： Mark Muldoon ,  Joan F. Brennecke ,  Edward J. Maginn ,  Eric F. V. Scriven ,  Colin H. McAteer ,  Ramiah Murugan

发明人： Mark Muldoon ,  Joan F. Brennecke ,  Edward J. Maginn ,  Eric F. V. Scriven ,  Colin H. McAteer ,  Ramiah Murugan

IPC分类号： A01N43/40 ,  A61K31/435

CPC分类号： A61K31/435 ,  C07D213/20 ,  C07D213/74 ,  C07D213/80 ,  C07D401/04 ,  C10M133/40 ,  C10M171/00 ,  C10M2201/081 ,  C10M2201/082 ,  C10M2201/087 ,  C10M2207/122 ,  C10M2215/16 ,  C10M2215/221 ,  C10M2219/04 ,  C10M2219/042 ,  C10N2220/04 ,  C10N2230/08 ,  C10N2230/72 ,  C10N2240/10 ,  C10N2240/14

摘要： Disclosed herein are aminopyridinium cations and compositions containing these cations. Piperidino pyridinium cations and compositions containing these cations are also described. Ionic compositions, particularly liquid ionic compositions that contain the aminopyridinium cation or piperidino pyridinium cation are also described. Methods of enhancing the thermal stability of a compound, particularly an ionic compound, using the aminopyridinium or piperidino pyridinium cations, are also presented. Compositions having an expanded liquidus range of from about −73° C. to about 444° C. are also described. Solvents, heat transfer fluids, and lubricants having improved thermal stability characteristics and an expanded and improved liquidus range are also disclosed.

摘要翻译： 本文公开了氨基吡啶鎓阳离子和含有这些阳离子的组合物。 还描述了哌啶子基吡啶鎓阳离子和含有这些阳离子的组合物。 还描述了离子组合物，特别是含有氨基吡啶鎓阳离子或哌啶子基吡啶鎓阳离子的液体离子组合物。 还提出了使用氨基吡啶鎓或哌啶子基吡啶鎓阳离子增强化合物，特别是离子化合物的热稳定性的方法。 还描述了具有约-73℃至约444℃的扩大液相线范围的组合物。 还公开了具有改进的热稳定性特征和膨胀和改善的液相线范围的溶剂，传热流体和润滑剂。

公开(公告)号：US06958400B2

公开(公告)日：2005-10-25

申请号：US10425504

申请日：2003-04-29

申请人： Marudai Balasubramanian ,  Joel R. Calvin ,  Eric F. V. Scriven ,  Charles R. Hopper ,  Ramiah Murugan ,  L. Mark Huckstep

发明人： Marudai Balasubramanian ,  Joel R. Calvin ,  Eric F. V. Scriven ,  Charles R. Hopper ,  Ramiah Murugan ,  L. Mark Huckstep

IPC分类号： C07D213/74 ,  B01J31/02 ,  B01J35/02 ,  B01J37/00 ,  C07D213/73 ,  C07D213/84 ,  C07D213/02

CPC分类号： C07D213/73 ,  B01J31/0237 ,  B01J31/0244 ,  B01J35/023 ,  B01J37/0063 ,  B01J2231/4205 ,  C07D213/74 ,  C07D213/84

摘要： Processes for preparing a 4-(secondary or tertiary)aminopyridine are provided. The processes comprise reacting a 4-substituted pyridine base having a leaving group as the 4-substituent, with an activating agent so as to form a corresponding 1,4-substituted pyridine; reacting the 1,4-substituted pyridine with a primary or secondary amine to substitute an amino group at the 4-position, and thereby form a corresponding 1-substituted-4-(secondary or tertiary) aminopyridine, wherein the reacting is conducted in a substitution reaction medium essentially free from strong base; and treating the 1-substituted-4-aminopyridine compound to remove the 1-substituent and thereby form a product medium including the 4-(secondary or tertiary) amino-pyridine.

摘要翻译： 提供了制备4-（仲或叔）氨基吡啶的方法。 该方法包括使具有离去基团的4-取代吡啶碱作为4-取代基与活化剂反应，形成相应的1,4-取代的吡啶; 使1,4-取代的吡啶与伯胺或仲胺反应以代替4-位氨基，从而形成相应的1-取代-4-（仲或叔）氨基吡啶，其中反应在 取代反应介质基本上不含强碱; 并处理1-取代-4-氨基吡啶化合物以除去1-取代基，从而形成包含4-（仲或叔）氨基 - 吡啶的产物介质。

公开(公告)号：US6046336A

公开(公告)日：2000-04-04

申请号：US127542

申请日：1998-07-31

申请人： Joe W. Curtis ,  Charles R. Hopper ,  Ramiah Murugan ,  L. Mark Huckstep ,  Marudai Balasubramanian ,  Joel R. Calvin ,  Eric F. V. Scriven

发明人： Joe W. Curtis ,  Charles R. Hopper ,  Ramiah Murugan ,  L. Mark Huckstep ,  Marudai Balasubramanian ,  Joel R. Calvin ,  Eric F. V. Scriven

IPC分类号： C07D213/74 ,  B01J31/02 ,  B01J35/02 ,  B01J37/00 ,  C07D213/73 ,  C07D213/84 ,  C07D213/02

CPC分类号： C07D213/73 ,  B01J31/0237 ,  B01J31/0244 ,  B01J35/023 ,  B01J37/0063 ,  C07D213/74 ,  C07D213/84 ,  B01J2231/4205

摘要： Described are preferred processes for producing extrusion-granulated supernucleophilic 4-amino-substituted pyridine catalysts, and granular products obtainable therefrom. Also described are preferred activation-substitution-deactivation processes for producing 4-aminopyridine compounds, which involve the use of acrylic acid or acrylamide or analogs thereof for activation, and substitution steps conducted under mild basic conditions in an excess of the amine reagent for 4-substitution. Such processes provide improved reacted masses which are more readily processed to recover the products in pure, heat-stable form. Further, described are processes for preparing 4-substituted-pyridines via pyridine betaines.

摘要翻译： 描述了用于生产挤出造粒的超亲核4-氨基取代的吡啶催化剂的优选方法和可从其获得的颗粒产物。 还描述了用于生产4-氨基吡啶化合物的优选的活化取代失活方法，其涉及使用丙烯酸或丙烯酰胺或其类似物进行活化，以及在温和的碱性条件下在过量的胺试剂中进行4-取代 - 代换。 这些方法提供改进的反应物质，其更容易加工以以纯的，热稳定的形式回收产物。 此外，描述了通过吡啶甜菜碱制备4-取代吡啶的方法。

公开(公告)号：US5824756A

公开(公告)日：1998-10-20

申请号：US615309

申请日：1996-08-02

申请人： Eric F. V. Scriven ,  James R. Stout ,  Ramiah Murugan ,  James G. Keay

发明人： Eric F. V. Scriven ,  James R. Stout ,  Ramiah Murugan ,  James G. Keay

IPC分类号： C08F2/06 ,  C08F2/10 ,  C08F8/00 ,  C08F26/06

CPC分类号： C08F26/06 ,  C08F8/06 ,  C08F8/44 ,  C08F2800/10 ,  C08F2800/20

摘要： Described are preferred processes for producing linear polyvinylpyridines. The processes involve the use of hydrogen peroxide to initiate polymerization of vinylpyridine monomers in an aqueous solvent. Processes of the invention provide good reaction rates and conversions, and are particularly advantageous in achieving control of the M.sub.w 's of the final product polymers.

摘要翻译： PCT No.PCT / US94 / 12150 Sec。 371日期：1996年8月2日 102（e）日期1996年8月2日PCT 1994年10月25日PCT PCT。 公开号WO95 / 11926 日期1995年5月4日描述了制备直链聚乙烯吡啶的优选方法。 该方法涉及使用过氧化氢引发乙烯基吡啶单体在水性溶剂中的聚合。 本发明的方法提供良好的反应速率和转化率，并且在实现对最终产物聚合物的Mw的控制方面特别有利。

公开(公告)号：US4968806A

公开(公告)日：1990-11-06

申请号：US352980

申请日：1989-05-17

申请人： Donald W. McQuigg ,  Edward E. Sowers ,  Gerald L. Goe ,  Eric F. V. Scriven

发明人： Donald W. McQuigg ,  Edward E. Sowers ,  Gerald L. Goe ,  Eric F. V. Scriven

IPC分类号： B01J31/06 ,  C07D213/74 ,  C08F12/00 ,  C08F12/26 ,  C08F26/06 ,  C08F212/14 ,  C08F226/06

CPC分类号： C07D213/74 ,  C08F12/26

摘要： A cross-linked polymer-supported 4-(N-benzyl-N-methylamino) pyridine material and process for its preparation in high yield and having effective physical and catalytic properties. The polymer-supported catalyst is characterized by the suspension copolymerization of an organic phase containing the corresponding vinyl-substituted pyridine monomer, a styrene monomer, and a suitable cross-linking agent and free radical-generating catalyst in the presence of an aqueous phase containing a cellulose ether derivative as the stabilizing agent. A purified acid salt of the vinyl-substituted pyridine monomer useful in polymerizations and stable for storage as either a solid or an aqueous solution.

公开(公告)号：US06391995B1

公开(公告)日：2002-05-21

申请号：US09781095

申请日：2001-02-09

申请人： Ramiah Murugan ,  Eric F. V. Scriven ,  James R. Stout ,  Stephanie Syler Metrick

发明人： Ramiah Murugan ,  Eric F. V. Scriven ,  James R. Stout ,  Stephanie Syler Metrick

IPC分类号： C08F12606

摘要： Described are preferred processes for preparing quaternary amine polymers of good color, comprising preparing a free base amine polymer by polymerizing a free base amine monomer in the presence of a water-soluble azo initiator, and subjecting the resultant polymer to quaternization conditions. Also described are unique, water-soluble quaternary amine polymers obtainable by such processes, and dye complexing polymer blends useful in the manufacture of detergents.

公开(公告)号：US5932736A

公开(公告)日：1999-08-03

申请号：US56681

申请日：1998-04-07

申请人： Ramiah Murugan ,  Eric F. V. Scriven

发明人： Ramiah Murugan ,  Eric F. V. Scriven

IPC分类号： C07D213/61 ,  C07D213/80 ,  C07D215/04 ,  C07D239/36 ,  C07D239/38 ,  C07D213/06 ,  C07D213/08 ,  C07D213/09

CPC分类号： C07D213/80 ,  C07D213/61 ,  C07D215/04 ,  C07D239/36 ,  C07D239/38

摘要： Described are preferred processes for preparing heterocycles having one or more nitrogen and/or oxygen heteroatoms, utilizing a 1,3-dihalopropene as an effective 3-carbon fragment. Preferred processes yield pyridines, quinolines, oxazoles, pyrimidines and pyrazoles, depending upon the other reactant or reactants utilized with the 1,3-dihalopropene.

公开(公告)号：US5541331A

公开(公告)日：1996-07-30

申请号：US482965

申请日：1995-06-15

申请人： Ramiah Murugan ,  Gerald L. Goe ,  Eric F. V. Scriven

发明人： Ramiah Murugan ,  Gerald L. Goe ,  Eric F. V. Scriven

IPC分类号： C07D211/22 ,  C07D213/30 ,  C07D213/28

CPC分类号： C07D213/30 ,  C07D211/22

摘要： Disclosed are preferred processes for producing .alpha.-2-pyridyl.alpha.-aryl carbinol or .alpha.-4-pyridyl .alpha.-aryl carbinol compounds.

摘要翻译： 公开了制备α-2-吡啶基α-芳基甲醇或α-4-吡啶基α-芳基甲醇化合物的优选方法。

公开(公告)号：US5424436A

公开(公告)日：1995-06-13

申请号：US118494

申请日：1993-09-08

申请人： Gerald L. Goe ,  James G. Keay ,  Eric F. V. Scriven ,  Michael L. Prunier ,  Steven J. Quimby

发明人： Gerald L. Goe ,  James G. Keay ,  Eric F. V. Scriven ,  Michael L. Prunier ,  Steven J. Quimby

IPC分类号： C07D213/38 ,  C07D213/48 ,  C07D213/53 ,  C07D213/24

CPC分类号： C07D213/53 ,  C07D213/38 ,  C07D213/48

摘要： Imines are synthesized by the hydrogenation of pyridinecarbonitriles with amines in the presence of a rhodium-loaded catalyst. The resulting imines are stable and may be transiminated and then hydrogenated to form selected secondary amine products or may be hydrolyzed to aldehydes.Further, a very useful class of unsymmetrical secondary amines represented by the formula RCH.sub.2 NHAr (in which R is not aliphatic and Ar is aromatic and not attached to R), which has heretofore been accessible only with some difficulty, can be synthesized by processes herein disclosed utilizing the reductive intermolecular coupling of nitriles and primary aromatic amines.

摘要翻译： 在负载铑的催化剂的存在下，吡啶羰腈与胺的氢化合成了亚胺。 所得的亚胺是稳定的并且可以被过渡化，然后氢化形成选择的仲胺产物，或者可以水解成醛。 此外，由式RCH2NHAr（其中R不是脂族且Ar是芳族且不连接到R）表示的非常有用的一类非对称仲胺，其迄今为止只有一些困难才可以获得，可以通过本文公开的方法合成 利用腈和伯芳基胺的还原分子间偶联。

公开(公告)号：US5147954A

公开(公告)日：1992-09-15

申请号：US609393

申请日：1990-11-05

申请人： Donald W. McQuigg ,  Edward E. Sowers ,  Gerald L. Goe ,  Eric F. V. Scriven ,  James G. Keay

发明人： Donald W. McQuigg ,  Edward E. Sowers ,  Gerald L. Goe ,  Eric F. V. Scriven ,  James G. Keay

IPC分类号： C07D213/74 ,  C08F12/26

CPC分类号： C07D213/74 ,  C08F12/26

摘要： A cross-linked polymer-supported 4-(N-benzyl-N-methylamino) pyridine material and process for its preparation in high yield and having effective physical and catalytic properties. The polymer-supported catalyst is characterized by the suspension copolymerization of an organic phase containing the corresponding vinyl-substituted pyridine monomer, a styrene monomer, and a suitable cross-linking agent and free radical-generating catalyst in the presence of an aqueous phase containing a cellulose ether derivative as the stabilizing agent. A purified acid salt of the vinyl-substituted pyridine monomer useful in polymerizations and stable for storage as either a solid or an aqueous solution.

摘要翻译： 交联聚合物负载的4-（N-苄基-N-甲基氨基）吡啶材料及其高产率制备并具有有效物理和催化性能的方法。 聚合物负载的催化剂的特征在于在含有相应的乙烯基取代的吡啶单体，苯乙烯单体和合适的交联剂和产生自由基的催化剂的有机相的悬浮共聚， 纤维素醚衍生物作为稳定剂。 乙烯基取代的吡啶单体的纯化酸盐可用于聚合并稳定存储为固体或水溶液。