公开(公告)号：US11234998B2

公开(公告)日：2022-02-01

申请号：US16821459

申请日：2020-03-17

申请人： Tricol Biomedical, Inc.

发明人： Simon McCarthy ,  Barbara McGrath ,  Sam Kuhn ,  Jess Kimball ,  Michael Stolten ,  Amanda Bennett

IPC分类号： A61K31/722 ,  A61K9/70 ,  A61K47/12 ,  A61K9/16 ,  A61K9/19

摘要： The present invention comprises chitosan materials and methods of using carbonic acid for aqueous solubilization of neutralized or pre-treated chitosan gels and provides, among other things, substantially acid salt free composition native final forms without requiring subsequent acid salt elution. The invention includes chitosan-based solid and semi-solid material forms, optionally reinforced with chitosan fibers, such as powders, fibers, films, matrices, sponges, implants, scaffolds, fillers, and hydrogels. Native final forms are produced from chitosan powder solubilized in an aqueous acidic solution, processed to form a high pH hydrated chitosan gel precipitate material that is then neutralized by water washing and re-solubilized substantially to chitosan solution using carbonic acid. Chitosan materials can be mixed in solution with one or more of other hydrophilic polymers to create compositional heterogeneity and pharmaceutical agents to achieve controlled release of the agent(s) from the final forms at the site of application.

公开(公告)号：US20180263634A1

公开(公告)日：2018-09-20

申请号：US15925352

申请日：2018-03-19

申请人： Tricol Biomedical, Inc.

发明人： Matthew Hoskins ,  Alysha Wold ,  Stephanie Wiegman ,  Bill Shields ,  Simona Buergi ,  Simon McCarthy ,  Cole Gannett ,  Ervelyn Winata

IPC分类号： A61B17/132 ,  A61B17/135 ,  A61B17/12

CPC分类号： A61B17/1325 ,  A61B17/135 ,  A61B2017/12004

摘要： The present invention relates to a compressive band and hemostatic dressing system and related methods of use to provide rapid, non-occlusive bleeding control, arterial injury treatment, and injury protection comfortably and reliably after vascular access procedures. The present invention may comprise some or all of the following elements: a positioner assembly, a compressive cushion component, a compression plate, a strap with a flexible hinge assembly, and a hemostatic dressing. In a preferred embodiment, the systems and methods are applied to treat and ameliorate vascular injury in a transradial percutaneous access procedure and protect against underlying vascular injury; however, the systems and methods described herein may be applied to any vascular access procedure including arm or leg vascular approaches such as the femoral, brachial, dorsalis pedis or tibial blood vessels in arterial or venous line or sheath removal or trocar removal, and in hemodialysis.

公开(公告)号：US20180214160A1

公开(公告)日：2018-08-02

申请号：US15542626

申请日：2016-01-08

申请人： Tricol Biomedical, Inc.

发明人： Matthew Hoskins ,  Alysha Wold ,  Stephanie Wiegman ,  Bill Shields ,  Simona Buergi ,  Simon McCarthy ,  Cole Gannett ,  Ervelyn Winata

IPC分类号： A61B17/132 ,  A61B17/135

CPC分类号： A61B17/1325 ,  A61B17/135 ,  A61B2017/12004

摘要： The present invention relates to a compressive band and hemostatic dressing system and related methods of use to provide rapid, non-occlusive bleeding control, arterial injury treatment, and injury protection comfortably and reliably after vascular access procedures. The present invention may comprise some or all of the following elements: a positioner assembly, a compressive cushion component, a compression plate, a strap with a flexible hinge assembly, and a hemostatic dressing. In a preferred embodiment, the systems and methods are applied to treat and ameliorate vascular injury in a transradial percutaneous access procedure and protect against underlying vascular injury; however, the systems and methods described herein may be applied to any vascular access procedure including arm or leg vascular approaches such as the femoral, brachial, dorsalis pedis or tibial blood vessels in arterial or venous line or sheath removal or trocar removal, and in hemodialysis.

公开(公告)号：US20180110897A1

公开(公告)日：2018-04-26

申请号：US15565388

申请日：2016-04-11

申请人： Tricol Biomedical, Inc.

发明人： Maggie Bush ,  Sam Kuhn ,  Simon McCarthy

IPC分类号： A61L24/08 ,  A61L24/00

CPC分类号： A61L24/08 ,  A61K9/06 ,  A61K31/155 ,  A61K31/785 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/36 ,  A61L24/0031 ,  A61L24/0042 ,  A61L2400/04 ,  C08L5/08 ,  C08L1/284

摘要： An aqueous chitosan gel system of novel non-scarring, non-interfering, transparent, stable, solubilized chitosan that controls bleeding is described herein. The aqueous chitosan gel system can comprise water, chitosan, an acid, a plasticizer, a rheology modifying agent, an antioxidant stabilizer, an alcohol, and a multi-valent salt. Additional components of the aqueous chitosan gel system can comprise a bifunctional organic acid, a tnfunctional organic acid, a multi-functional organic acid, a phosphoric acid, a polyphosphoric acid and a salt.

公开(公告)号：US09925210B2

公开(公告)日：2018-03-27

申请号：US14614316

申请日：2015-02-04

申请人： Tricol Biomedical, Inc.

发明人： Simon McCarthy ,  Barbara McGrath ,  Sam Kuhn ,  Jess Kimball ,  Michael Stolten ,  Amanda Bennett

IPC分类号： A61K31/722 ,  A61K9/19 ,  A61K9/16 ,  A61K47/12 ,  A61K9/70

CPC分类号： A61K31/722 ,  A61K9/1652 ,  A61K9/1694 ,  A61K9/19 ,  A61K9/70 ,  A61K47/12

摘要： The present invention comprises chitosan materials and methods of using carbonic acid for aqueous solubilization of neutralized or pre-treated chitosan gels and provides, among other things, substantially acid salt free composition native final forms without requiring subsequent acid salt elution. The invention includes chitosan-based solid and semi-solid material forms, optionally reinforced with chitosan fibers, such as powders, fibers, films, matrices, sponges, implants, scaffolds, fillers, and hydrogels. Native final forms are produced from chitosan powder solubilized in an aqueous acidic solution, processed to form a high pH hydrated chitosan gel precipitate material that is then neutralized by water washing and re-solubilized substantially to chitosan solution using carbonic acid. Chitosan materials can be mixed in solution with one or more of other hydrophilic polymers to create compositional heterogeneity and pharmaceutical agents to achieve controlled release of the agent(s) from the final forms at the site of application.

公开(公告)号：US20170119934A1

公开(公告)日：2017-05-04

申请号：US15371010

申请日：2016-12-06

申请人： Tricol Biomedical, Inc.

发明人： Barbara McGrath ,  Simon McCarthy ,  Sam Kuhn ,  Alysha Wold ,  Michael Stolten ,  Amanda Bennett

IPC分类号： A61L27/58 ,  C08L89/06 ,  G01N33/50 ,  C08L5/08 ,  C08B37/08 ,  A61L27/26

CPC分类号： A61L27/58 ,  A61K9/0024 ,  A61K47/36 ,  A61K49/0008 ,  A61L27/20 ,  A61L27/26 ,  A61L2400/04 ,  C08B37/003 ,  C08L5/08 ,  C08L89/06 ,  C08L2201/06 ,  G01N33/5014 ,  G01N33/6869 ,  G01N2333/545 ,  G01N2400/28

摘要： The invention relates to biocompatible, bioabsorbable derivatized non-crosslinked chitosan compositions optionally crosslinked to gelatin/collagen by 1-ethyl-3-[3-dimethylaminopropyl] carbodiimide hydrochloride (EDC) for biomedical use and methods of making and testing such compositions, including a modified acute systemic toxicity test. The compositions comprise derivatized chitosan reacetylated to a degree of N-deacetylation (DDA) of between about 15% and 40%. The compositions are typically bioabsorbed in about 90 days or less and can be made to bioabsorb at differing rates of speed. The compositions are initially soluble in aqueous solution below pH 6.5. The compositions have an acid content that can be adjusted between about 0% (w/w) and about 8% (w/w) to customize the composition for uses that require and/or tolerate differing levels of cytotoxicity, adhesion, composition cohesion, and cell infiltration into the composition.