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公开(公告)号：US4938759A
公开(公告)日：1990-07-03
申请号：US903002
申请日：1986-09-02
申请人： David J. Enscore , Eun S. Lee , Su I. Yum
发明人： David J. Enscore , Eun S. Lee , Su I. Yum
CPC分类号： A61K9/7053 , A61K9/7084 , A61K9/7092
摘要： A transdermal delivery device having a release-rate controlling-adhesive is disclosed having improved delivery characteristics. The device employs a polyisobutylene/mineral oil adhesive formulation and an ethylene/viny acetate (EVA) drug reservoir formulation. The device is useful in delivering a wide variety of transdermally administrable drugs, particularly those which are moderately soluble in mineral oil. Preferred embodiments deliver timolol base and atropine base from an EVA (40% VA) reservoir formulation.
摘要翻译： 公开了具有释放速率控制粘合剂的透皮递送装置，具有改进的输送特性。 该装置采用聚异丁烯/矿物油粘合剂配方和乙烯/乙酸乙烯酯（EVA）药物储库配方。 该装置可用于递送多种透皮给药药物，特别是适用于矿物油的药物。 优选实施方案从EVA（40％VA）储存剂配方递送噻吗洛尔碱和阿托品碱。
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12.发明授权Interstitial fluid methods and devices for determination of an analyte in the body 有权用于测定体内分析物的组织液方法和装置公开(公告)号：US06251083B1
公开(公告)日：2001-06-26
申请号：US09391002
申请日：1999-09-07
申请人： Su I. Yum , Jeffrey N. Roe , Joel S. Douglas
发明人： Su I. Yum , Jeffrey N. Roe , Joel S. Douglas
IPC分类号： A61B500
CPC分类号： A61B5/14514 , A61B5/14532
摘要： Devices and methods for utilizing dry chemistry dye indicator systems for body fluid analysis, such as glucose level provided by incorporating a porous membrane in a disposable patch. The devices also provide for microtitration of fluid samples in fixed volumetric openings containing indicator reagent. The devices provided are low cost due to efficient manufacturing methods provided.
摘要翻译： 用于使用干化学染料指示剂系统进行体液分析的装置和方法，例如通过将多孔膜并入一次性贴片而提供的葡萄糖水平。 该装置还提供含有指示剂试剂的固定体积开口中的液体样品的微量滴定。 所提供的装置由于提供的有效制造方法而成本低。
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公开(公告)号：US5344656A
公开(公告)日：1994-09-06
申请号：US78540
申请日：1993-06-16
CPC分类号： A61K9/7084 , A61K31/46
摘要： Rate controlled transdermal delivery devices are disclosed which utilize an in-line adhesive to maintain the device on the skin and deliver an agent which is a solvent or a plasticizer for the in-line adhesive. The initial equilibrated concentration of the agent in the agent reservoir and the adhesive is below saturation, and the reservoir comprises the agent dissolved in a solvent with respect to which the rate controlling element of the device is substantially impermeable. In preferred embodiments the initial loading of the agent in reservoir is sufficient to prevent the activity of the agent in the reservoir from decreasing by more than about 50% and preferably no more than about 25% during the predetermined period of administration; and the thicknesses of the adhesive, rate controlling membrane and reservoir layers are selected so that at least 50% and preferably at least 75% initial equilibrated agent loading is in the reservoir layer. The devices are usable to deliver agents which are liquid at body temperatures such as benztropine, secoverine, nicotine, arecoline, polyethylene glycol monolaurate, glycerol monolaurate, glycerol monooleate and ethanol, for example.
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公开(公告)号：US4969871A
公开(公告)日：1990-11-13
申请号：US311906
申请日：1989-02-15
申请人： Felix Theeuwes , Su I. Yum
发明人： Felix Theeuwes , Su I. Yum
IPC分类号： A61M5/14
CPC分类号： A61M5/1407
摘要： A drug formulation chamber for an intravenous administration set is provided. The intravenous administration set includes a container of an IV fluid, a drip chamber, a drug formulation chamber, and an adapter-needle assembly. The drug formulation chamber has a fluid inlet and a fluid outlet for maintaining a flow of IV fluid through the chamber. A portion of the chamber wall is comprised of a window material which allows the drug to diffuse therethrough but which prevents convective loss of the IV fluid. A flow distributor is provided within the chamber for distributing the flow of IV fluid along the interior surface of the window. A transdermal-type drug delivery device is adhered to the exterior surface of the window. Drug is delivered by the delivery device through the window and into the flowing IV fluid. The device delivers drug into the IV fluid at a rate that is independent of the flow rate of IV fluid through the formulation chamber. The rate of drug delivery from the device into the IV fluid is controlled by either the window itself or by a membrane layer in the drug delivery device. A plurality of drug delivery devices may be adhered to the window to deliver a plurality of drugs or to deliver a single drug at a higher dosage rate. A similar window may be placed in an IV bag to deliver a drug into the IV fluid therein.
摘要翻译： 提供了用于静脉内给药组的药物制剂室。 静脉内给药组包括IV液体的容器，滴液室，药物制剂室和适配器 - 针组件。 药物制剂室具有流体入口和流体出口，用于维持IV流体流过腔室的流动。 室壁的一部分由允许药物扩散通过但防止IV流体的对流损失的窗口材料构成。 在室内提供流动分配器，用于沿着窗口的内表面分配IV流体流。 透皮型药物输送装置粘附在窗户的外表面上。 药物由输送装置通过窗口输送到流动的IV流体中。 该装置以与通过制剂室的IV流体的流速无关的速率将药物递送到IV流体中。 从装置向IV流体的药物递送速率由窗口本身或药物递送装置中的膜层控制。 多个药物递送装置可以粘附到窗户以递送多种药物或以更高的剂量率递送单一药物。 类似的窗口可以放置在IV袋中以将药物递送到其中的IV流体中。
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公开(公告)号：US4938748A
公开(公告)日：1990-07-03
申请号：US239563
申请日：1988-09-01
申请人： Su I. Yum , Felix Theeuwes
发明人： Su I. Yum , Felix Theeuwes
CPC分类号： A61F5/441
摘要： A patient-care apparatus comprising a container for receiving a biological fluid, and a delivery device on the outside of the container, which device comprises a biocide that is released to the container for preventing the multiplication of and/or eliminating the presence of unwanted pathogens in the container.
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公开(公告)号：US5633008A
公开(公告)日：1997-05-27
申请号：US105262
申请日：1993-08-12
申请人： James L. Osborne , Melinda K. Nelson , David J. Enscore , Su I. Yum , Robert M. Gale , Donna D. Causey
发明人： James L. Osborne , Melinda K. Nelson , David J. Enscore , Su I. Yum , Robert M. Gale , Donna D. Causey
IPC分类号： A61K9/70 , A61K31/465 , A61F13/00
CPC分类号： A61K9/7084 , A61K31/465 , A61K9/7053 , A61K9/7069 , Y10S514/813
摘要： A method of administering nicotine transdermally in which a nicotine patch, capable of administering nicotine for at least 16 hours at rates that are efficacious in smoking cessation therapy, is applied in the morning upon waking and removed prior to sleep. This method is effective even though nicotine is not essential during sleep and many smokers experience morning craving.
摘要翻译： 一种经皮给药尼古丁的方法，其中可以在睡眠前醒来并在睡眠前去除能够以有效戒烟治疗的速率给尼古丁至少16小时的尼古丁贴片。 即使尼古丁在睡眠中不是必需的，许多吸烟者也经历早晨的渴望，这种方法是有效的。
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公开(公告)号：US5540665A
公开(公告)日：1996-07-30
申请号：US189473
申请日：1994-01-31
申请人： Stanley A. Mercado , Mark M. McPhee , Avtar S. Nat , Su I. Yum , Scott A. Bura
发明人： Stanley A. Mercado , Mark M. McPhee , Avtar S. Nat , Su I. Yum , Scott A. Bura
CPC分类号： C06D5/10 , A61M5/14526 , C06D5/00
摘要： The present invention provides a gas generating engine for driving a beneficial agent dispensing device. The engine comprising (a) a solid composition comprising an acidic compound or a basic compound, or a combination thereof, and (b) a means for maintaining substantially constant the surface area of the solid composition exposed to a reservoir fluid comprising water, or water and an acidic compound, or water and a basic compound, wherein in operation, the solid composition is exposed to the reservoir fluid which dissolves the solid composition and causes it to generate a gas, the gas being a driving fluid to dispense a beneficial agent. The present invention further provides a fluid driven dispensing device for delivering an agent into an environment of use, the device be driven by the gas generating engine.
摘要翻译： 本发明提供一种用于驱动有益剂分配装置的气体发生发动机。 所述发动机包括（a）包含酸性化合物或碱性化合物或其组合的固体组合物，和（b）用于使暴露于包含水或水的储液器的固体组合物的表面积基本上恒定的装置 和酸性化合物，或水和碱性化合物，其中在操作中，固体组合物暴露于溶解固体组合物并使其产生气体的储层流体，气体是用于分配有益剂的驱动流体。 本发明还提供一种用于将试剂输送到使用环境中的流体驱动分配装置，该装置由气体发生引擎驱动。
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公开(公告)号：US5508039A
公开(公告)日：1996-04-16
申请号：US211786
申请日：1994-06-13
CPC分类号： A61K9/7084 , A61K31/40 , A61K47/14 , A61K9/0014
摘要： The present invention is directed to the transdermal administration of melatonin together with a suitable permeation enhancer. The invention includes a transdermal drug delivery device (10) comprising a matrix (12) adapted to be placed in melatonin- and permeation enhancer-transmitting relation with the skin site (18). The matrix (12) contains sufficient amounts of a permeation enhancer and of melatonin, in combination, to continuously administer to the skin (18) for a predetermined period of time the melatonin to provide an effective therapeutic result. The invention is also directed to a method for the transdermal administration of a therapeutically effective amount of melatonin together with a skin permeation-enhancing amount of a suitable permeation enhancer. The invention further includes methods for time- and rate-patterned transdermal delivery of melatonin to simulate the natural circadian rhythmic profile of melatonin in mammals.
摘要翻译： PCT No.PCT / US92 / 08919 Sec。 371日期1994年6月13日 102（e）日期1994年6月13日PCT提交于1992年10月16日PCT出版社 出版物WO93 / 07870 日期：1993年04月29日。本发明涉及褪黑激素与合适的渗透促进剂的透皮给药。 本发明包括透皮药物递送装置（10），其包括适于与皮肤部位（18）放置在与褪黑激素和渗透增强剂 - 传递关系中的基质（12）。 基质（12）含有足够量的渗透促进剂和褪黑激素组合，以连续给予皮肤（18）一段预定的时间，以提供有效的治疗结果。 本发明还涉及一种用于透皮施用治疗有效量的褪黑激素以及皮肤渗透增强量的合适的渗透增强剂的方法。 本发明还包括用于对褪黑激素进行时间和速率图案化的透皮递送以模拟哺乳动物中褪黑激素的天然昼夜节律谱的方法。
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公开(公告)号：US5364630A
公开(公告)日：1994-11-15
申请号：US80280
申请日：1993-06-21
IPC分类号： A61K9/70 , A61K31/465 , A61F13/00
CPC分类号： A61K31/465 , A61K9/7084
摘要： Rate controlled transdermal nicotine delivery systems are disclosed which utilize an in-line adhesive to maintain the systems on the skin. The initial equilibrated concentration of nicotine in the nicotine reservoir and the adhesive is below saturation, preferably at a thermodynamic activity no greater than 0.50, and the reservoir comprises the nicotine dissolved in a material with respect to which the rate controlling element of the device is substantially impermeable. In preferred embodiments the initial loading of nicotine in the reservoir is sufficient to prevent the activity of the nicotine in the reservoir from decreasing by more than about 75% and preferably no more than about 25% during the predetermined period of administration; and the thickness of the adhesive, rate controlling membrane and reservoir layers are selected so that at least 50% and, preferably at least 75% of the initial equilibrated nicotine loading is in the reservoir layer.
摘要翻译： 公开了速率控制的透皮尼古丁递送系统，其利用直列粘合剂将系统保持在皮肤上。 尼古丁储存器和粘合剂中尼古丁的初始平衡浓度低于饱和度，优选在不大于0.50的热力学活性下，并且储存器包含溶解在该装置的速率控制元件基本相当于的材料中的尼古丁 不渗透 在优选的实施方案中，储存器中尼古丁的初始加载量足以防止储存器中的尼古丁的活性在给定的给药期间减少超过约75％，优选不超过约25％; 并且选择粘合剂，速率控制膜和储存层的厚度，使得初始平衡的尼古丁负载的至少50％，优选至少75％在储层中。
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公开(公告)号：US5045059A
公开(公告)日：1991-09-03
申请号：US568457
申请日：1990-08-15
申请人： Felix Theeuwes , Su I. Yum
发明人： Felix Theeuwes , Su I. Yum
IPC分类号： A61M5/14
CPC分类号： A61M5/1407
摘要： A drug formulation chamber for an intravenous administration set is provided. The intravenous administration set includes a container of an IV fluid, a drip chamber, a drug formulation chamber, and an adapter-needle assembly. The drug formulation chamber has a fluid inlet and a fluid outlet for maintaining a flow of IV fluid through the chamber. A portion of the chamber wall is comprised of a window material which allows the drug to diffuse therethrough but which prevents convective loss of the IV fluid. A flow distributor is provided within the chamber for distributing the flow of IV fluid along the interior surface of the window. A transdermal-type drug delivery device is adhered to the exterior surface of the window. Drug is delivered by the delivery device through the window and into the flowing IV fluid. The device delivers drug into the IV fluid at a rate that is independent of the flow rate of IV fluid through the formulation chamber. The rate of drug delivery from the device into the IV fluid is controlled by either the window itself or by a membrane layer in the drug delivery device. A plurality of drug delivery devices may be adhered to the window to deliver a plurality of drugs or to deliver a single drug at a higher dosage rate. A similar window may be placed in an IV bag to deliver a drug into the IV fluid therein.
摘要翻译： 提供了用于静脉内给药组的药物制剂室。 静脉内给药组包括IV液体的容器，滴液室，药物制剂室和适配器 - 针组件。 药物制剂室具有流体入口和流体出口，用于维持IV流体流过腔室的流动。 室壁的一部分由允许药物扩散通过但防止IV流体的对流损失的窗口材料构成。 在室内提供流动分配器，用于沿着窗口的内表面分配IV流体流。 透皮型药物输送装置粘附在窗户的外表面上。 药物由输送装置通过窗口输送到流动的IV流体中。 该装置以与通过制剂室的IV流体的流速无关的速率将药物递送到IV流体中。 从装置向IV流体的药物递送速率由窗口本身或药物递送装置中的膜层控制。 多个药物递送装置可以粘附到窗户以递送多种药物或以更高的剂量率递送单一药物。 类似的窗口可以放置在IV袋中以将药物递送到其中的IV流体中。
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