公开(公告)号：US20210047688A1

公开(公告)日：2021-02-18

申请号：US17089876

申请日：2020-11-05

Applicant: Ultima Genomics, Inc.

Inventor： Gilad ALMOGY ,  Kristopher BARBEE ,  Nathan BECKETT

IPC: C12Q1/6874 ,  C12Q1/6809 ,  C12Q1/6825 ,  B01J19/00 ,  B01L3/00

Abstract: Provided are methods for biological sample processing and analysis. A method can comprise providing a substrate configured to rotate. The substrate can comprise an array having immobilized thereto a biological analyte. A solution comprising a plurality of probes may be directed, via centrifugal force, across the substrate during rotation of the substrate, to couple at least one of the plurality of probes with the biological analyte. A detector can be configured to detect a signal from the at least one probe coupled to the biological analyte, thereby analyzing the biological analyte.

公开(公告)号：US20250012778A1

公开(公告)日：2025-01-09

申请号：US18776046

申请日：2024-07-17

Applicant: Ultima Genomics, Inc.

Inventor： Kristopher BARBEE ,  Nathan BECKETT ,  Denis PRISTINSKI ,  Derek SCHULTE ,  Avishai BARTOV ,  Jamie SULLIVAN ,  Dumitru BRINZA ,  Abizar LAKDAWALLA ,  Steven MENCHEN ,  Gilad ALMOGY ,  Mark PRATT

IPC: G01N33/49 ,  G01N1/02 ,  G01N1/22 ,  G01Q10/04

Abstract: Provided are systems and methods for analyte detection and analysis. A system can comprise an open substrate configured to rotate. The open substrate can comprise an array of immobilized analytes. A solution comprising a plurality of probes may be directed, via centrifugal force, across the array during rotation of the substrate, to couple at least one of the plurality of probes with at least one of the analytes to form a bound probe. A detector can be configured to detect a signal from the bound probe via continuous rotational area scanning of the substrate.

公开(公告)号：US20220162696A1

公开(公告)日：2022-05-26

申请号：US17543521

申请日：2021-12-06

Applicant: Ultima Genomics, Inc.

Inventor： Nathan BECKETT ,  Gilad ALMOGY ,  Nathan CASWELL ,  Jacob A. WOLF ,  Kristopher BARBEE ,  Denis PRISTINSKI ,  Mark PRATT ,  Gene POLOVY ,  Osip SCHWARTZ ,  Stephanie KUBECKA ,  Steven MENCHEN ,  Joseph ANTHONY ,  Jose Martin SOSA ,  Phillip You Fai LEE

IPC: C12Q1/6874 ,  G01N35/10

Abstract: Provided are systems and methods for analyte detection and analysis. A system can comprise an open substrate. The open substrate may be configured to rotate or otherwise move. The open substrate can comprise an array of individually addressable locations, with analytes immobilized thereto. The substrate may be spatially indexed to identify nucleic acid molecules from one or more sources, and/or sequences thereof, with the respective one or more sources. A solution comprising a plurality of probes may be directed across the array to couple at least one of the plurality of probes with at least one of the analytes to form a bound probe. A detector can be configured to detect a signal from the bound probe via scanning of the substrate while minimizing temperature fluctuations of the substrate or optical aberrations caused by bubbles.

公开(公告)号：US20200371329A1

公开(公告)日：2020-11-26

申请号：US16677115

申请日：2019-11-07

Applicant: Ultima Genomics, Inc.

Inventor： Gilad ALMOGY ,  Nathan BECKETT ,  Nathan CASWELL ,  Jacob A. WOLF ,  Gene POLOVY ,  Denis PRISTINSKI

IPC: G02B21/00 ,  G01N33/00 ,  G01N1/28

Abstract: Provided are systems and methods for analyte detection and analysis. A system can comprise an open substrate. The open substrate may be configured to rotate or otherwise move. The open substrate can comprise an array of individually addressable locations, with analytes immobilized thereto. The substrate may be spatially indexed to identify nucleic acid molecules from one or more sources, and/or sequences thereof, with the respective one or more sources. A solution comprising a plurality of probes may be directed across the array to couple at least one of the plurality of probes with at least one of the analytes to form a bound probe. A detector can be configured to detect a signal from the bound probe via scanning of the substrate while minimizing temperature fluctuations of the substrate or optical aberrations caused by bubbles.

公开(公告)号：US20190271039A1

公开(公告)日：2019-09-05

申请号：US16416889

申请日：2019-05-20

Applicant: Ultima Genomics, Inc.

Inventor： Gilad ALMOGY ,  Kristopher BARBEE ,  Nathan BECKETT

IPC: C12Q1/6874 ,  G01N33/543 ,  C12Q1/6809 ,  B01L3/00 ,  B01J19/00 ,  C12Q1/6825

Abstract: Provided are methods for biological sample processing and analysis. A method can comprise providing a substrate configured to rotate. The substrate can comprise an array having immobilized thereto a biological analyte. A solution comprising a plurality of probes may be directed, via centrifugal force, across the substrate during rotation of the substrate, to couple at least one of the plurality of probes with the biological analyte. A detector can be configured to detect a signal from the at least one probe coupled to the biological analyte, thereby analyzing the biological analyte.

公开(公告)号：US20190271038A1

公开(公告)日：2019-09-05

申请号：US16416856

申请日：2019-05-20

Applicant: Ultima Genomics, Inc.

Inventor： Gilad ALMOGY ,  Kristopher BARBEE ,  Nathan BECKETT

IPC: C12Q1/6874 ,  G01N33/543 ,  C12Q1/6809 ,  B01L3/00 ,  B01J19/00 ,  C12Q1/6825

Abstract: Provided are methods for biological sample processing and analysis. A method can comprise providing a substrate configured to rotate. The substrate can comprise an array having immobilized thereto a biological analyte. A solution comprising a plurality of probes may be directed, via centrifugal force, across the substrate during rotation of the substrate, to couple at least one of the plurality of probes with the biological analyte. A detector can be configured to detect a signal from the at least one probe coupled to the biological analyte, thereby analyzing the biological analyte.

公开(公告)号：US20190153520A1

公开(公告)日：2019-05-23

申请号：US15974543

申请日：2018-05-08

Applicant: Ultima Genomics, Inc.

Inventor： Kristopher BARBEE ,  Nathan BECKETT ,  Denis PRISTINSKI ,  Derek SCHULTE ,  Avishai BARTOV ,  Jamie SULLIVAN ,  Dumitru BRINZA ,  Abizar LAKDAWALLA ,  Steven MENCHEN ,  Gilad ALMOGY ,  Mark PRATT

IPC: C12Q1/6825 ,  B01L3/00

Abstract: Provided are systems and methods for analyte detection and analysis. A system can comprise an open substrate configured to rotate. The open substrate can comprise an array of immobilized analytes. A solution comprising a plurality of probes may be directed, via centrifugal force, across the array during rotation of the substrate, to couple at least one of the plurality of probes with at least one of the analytes to form a bound probe. A detector can be configured to detect a signal from the bound probe via continuous rotational area scanning of the substrate.

公开(公告)号：US20250091050A1

公开(公告)日：2025-03-20

申请号：US18898149

申请日：2024-09-26

Applicant: ULTIMA GENOMICS, INC.

Inventor： Nathan BECKETT ,  Nathan CASWELL ,  Stephanie KUBECKA ,  Jacob A. WOLF ,  Michael DARCY, JR. ,  Patrick D. KINNEY ,  Theo NIKIFOROV ,  Michael John KENNEDY ,  Armando REIMER ,  Reshef ELISHA ,  Arunika MAKAM ,  Joseph RICKWALDER ,  Evan HANING

IPC: B01L7/00

Abstract: Provided herein are systems, and methods configured to optimize a system for sequencing one or more nucleic acid samples.

公开(公告)号：US20240027425A1

公开(公告)日：2024-01-25

申请号：US18224378

申请日：2023-07-20

Applicant: Ultima Genomics, Inc.

Inventor： Kristopher BARBEE ,  Nathan BECKETT ,  Denis PRISTINSKI ,  Derek SCHULTE ,  Avishai BARTOV ,  Jamie SULLIVAN ,  Dumitru BRINZA ,  Abizar LAKDAWALLA ,  Steven MENCHEN ,  Gilad ALMOGY ,  Mark PRATT

IPC: G01N33/49 ,  G01N1/02 ,  G01Q10/04

CPC classification number: G01N33/492 ,  G01N1/02 ,  G01Q10/04 ,  G01N2001/2291

Abstract: Provided are systems and methods for analyte detection and analysis. A system can comprise an open substrate configured to rotate. The open substrate can comprise an array of immobilized analytes. A solution comprising a plurality of probes may be directed, via centrifugal force, across the array during rotation of the substrate, to couple at least one of the plurality of probes with at least one of the analytes to form a bound probe. A detector can be configured to detect a signal from the bound probe via continuous rotational area scanning of the substrate.

公开(公告)号：US20230279487A1

公开(公告)日：2023-09-07

申请号：US18124481

申请日：2023-03-21

Applicant: Ultima Genomics, Inc.

Inventor： Gilad ALMOGY ,  Nathan BECKETT ,  Mark PRATT ,  Anatoly A. SURDUTOVICH ,  Nathan CASWELL ,  Patrick D. KINNEY

IPC: C12Q1/6869 ,  B01L3/00 ,  G01N35/10

CPC classification number: C12Q1/6869 ,  B01L3/5085 ,  G01N35/1002 ,  B01L2200/16 ,  B01L2300/023

Abstract: Provided herein methods, systems, and apparatus for high throughput sequencing, such as at an industrial scale. A sequencing system and/or apparatus may comprise one or more stations that can be operated in parallel and/or independent of one or more other stations.