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公开(公告)号：US10030006B2
公开(公告)日：2018-07-24
申请号：US15035610
申请日：2014-11-11
Applicant: University of Kansas
Inventor： Brian S. J. Blagg , Huiping Zhao
IPC: C07D405/12 , C07D405/14 , C07D413/12 , A61K31/352 , A61K31/4025 , A61K31/453 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D311/16 , G16H50/50
Abstract: Compounds of the formulas: wherein: R1-R4, X1, Y1, and A are as defined herein are provided. Pharmaceutical compositions of the compounds are also provided. In some aspects, these compounds are are useful for the treatment of a disease or disorder. In some embodiments, the disease or disorder is a proliferative disease such as cancer.
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公开(公告)号：US20150057240A1
公开(公告)日：2015-02-26
申请号：US14377616
申请日：2013-02-08
Applicant: University of Kansas
Inventor： Brian S. J. Blagg , Bhaskar Reddy Kusuma , Teather Sundstrom
IPC: C07H15/203 , C07C211/17
CPC classification number: C07H15/207 , C07C211/17 , C07H15/203
Abstract: Hsp90 C-terminal inhibitors and pharmaceutical compositions containing such compounds are provided. The compounds of the disclosure are useful for the treatment and/or prevention of neurodegenerative disorders such as diabetic peripheral neuropathy.
Abstract translation: 提供Hsp90 C末端抑制剂和含有这些化合物的药物组合物。 本公开的化合物可用于治疗和/或预防神经变性疾病如糖尿病性周围神经病变。
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公开(公告)号：US11028041B2
公开(公告)日：2021-06-08
申请号：US16640897
申请日：2018-08-23
Applicant: University of Kansas
Inventor： Brian S. J. Blagg , Vincent Matthew Crowley
IPC: C07C69/94 , A61P35/04 , C07C229/52 , C07D213/55 , C07D213/643 , C07C69/76 , A61K31/216 , A61K31/44 , A61P27/02
Abstract: The present technology provides compounds selective for the Grp94 isoform, as well as compositions including such compounds, that are useful for treatment of multiple myeloma, melanoma, lung cancer, hepatocellular carcinoma, breast cancer, prostate cancer, and/or glaucoma. Methods using the compounds are also provided.
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Patent Agency Ranking
公开(公告)号：US12024536B2
公开(公告)日：2024-07-02
申请号：US17863135
申请日：2022-07-12
Applicant: UNIVERSITY OF KANSAS
Inventor： Brian S. J. Blagg , Bhaskar Reddy Kusuma , Teather Sundstrom
IPC: C07H15/207 , C07C211/17 , C07H15/203
CPC classification number: C07H15/207 , C07C211/17 , C07H15/203
Abstract: Hsp90 C-terminal inhibitors and pharmaceutical compositions containing such compounds are provided. The compounds of the disclosure are useful for the treatment and/or prevention of neurodegenerative disorders such as diabetic peripheral neuropathy.
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公开(公告)号：US11939291B2
公开(公告)日：2024-03-26
申请号：US17226359
申请日：2021-04-09
Applicant: University of Kansas , University of South Florida
Inventor： Sanket Jaiprakash Mishra , Brian S. J. Blagg , Chad Anthony Dickey
IPC: C07D207/325 , A61P27/06 , A61P35/00 , C07C13/18 , C07D213/62 , C07D401/06
CPC classification number: C07D207/325 , A61P27/06 , A61P35/00 , C07C13/18 , C07D213/62 , C07D401/06
Abstract: The present technology provides compounds according to Formula I or Formula III as well as compositions including such compounds useful for the treatment of metastatic cancer and/or glaucoma.
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公开(公告)号：US10590157B2
公开(公告)日：2020-03-17
申请号：US16018401
申请日：2018-06-26
Applicant: UNIVERSITY OF KANSAS
Inventor： Brian S. J. Blagg , Bhaskar Reddy Kusuma , Teather Sundstrom
IPC: C07H15/207 , C07H15/203 , C07C211/17
Abstract: Hsp90 C-terminal inhibitors and pharmaceutical compositions containing such compounds are provided. The compounds of the disclosure are useful for the treatment and/or prevention of neurodegenerative disorders such as diabetic peripheral neuropathy.
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公开(公告)号：US09994556B2
公开(公告)日：2018-06-12
申请号：US15318351
申请日：2015-06-12
Applicant: THE UNIVERSITY OF KANSAS
Inventor： Jinbo Zhao , Huiping Zhao , Brian S. J. Blagg
IPC: C07D405/14 , C07D401/12
CPC classification number: C07D405/14 , C07D401/12
Abstract: Provided herein are compounds of the formulas: which are 90-kDa heat shock protein inhibitors. Pharmaceutical compositions of the compounds are also provided. In some aspects, these compounds may be used for the treatment of diseases, including cancer, e.g., cancers of the breast, the prostate, and the head & neck.
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公开(公告)号：US09422320B2
公开(公告)日：2016-08-23
申请号：US14377616
申请日：2013-02-08
Applicant: University of Kansas
Inventor： Brian S. J. Blagg , Bhaskar Reddy Kusuma , Teather Sundstrom
IPC: C07C211/17 , C07H15/203
CPC classification number: C07H15/207 , C07C211/17 , C07H15/203
Abstract: Hsp90 C-terminal inhibitors and pharmaceutical compositions containing such compounds are provided. The compounds of the disclosure are useful for the treatment and/or prevention of neurodegenerative disorders such as diabetic peripheral neuropathy.
Abstract translation: 提供Hsp90 C末端抑制剂和含有这些化合物的药物组合物。 本公开的化合物可用于治疗和/或预防神经变性疾病如糖尿病性周围神经病变。
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