公开(公告)号：US10143384B2

公开(公告)日：2018-12-04

申请号：US14677905

申请日：2015-04-02

Applicant: University of Virginia Patent Foundation

Inventor： Xiao Chen ,  Frederick H. Epstein ,  Yang Yang ,  Michael Salerno ,  Craig H. Meyer

IPC: G01V3/00 ,  A61B5/02 ,  A61B5/055 ,  G01R33/561 ,  G01R33/48 ,  G01R33/54 ,  G01R33/56 ,  A61B5/00

Abstract: Some aspects of the present disclosure relate to accelerated imaging using variable-density sampling and compressed sensing with parallel imaging. In one embodiment, a method includes acquiring magnetic resonance data associated with a physiological activity in an area of interest of a subject. The acquiring includes performing accelerated variable-density sampling with phase-contrast displacement encoding. The method also includes reconstructing, from the acquired magnetic resonance data, images corresponding to the physiological activity in the area of interest. The reconstructing includes performing parallel imaging and compressed sensing.

公开(公告)号：US20180306880A1

公开(公告)日：2018-10-25

申请号：US15959913

申请日：2018-04-23

Applicant: University of Virginia Patent Foundation

Inventor： Michael Salerno ,  Yang Yang

IPC: G01R33/483 ,  G01R33/48 ,  G01R33/561 ,  G01R33/58 ,  G01R33/56 ,  A61B5/055

CPC classification number: G01R33/4835 ,  A61B5/055 ,  A61B5/7257 ,  A61B5/7285 ,  G01R33/4824 ,  G01R33/5601 ,  G01R33/5605 ,  G01R33/5611 ,  G01R33/56341 ,  G01R33/583

Abstract: Systems and methods for simultaneous multi-slice imaging. In one embodiment, a method for magnetic resonance imaging of a region of interest of a subject includes simultaneously exciting multiple, different slice locations corresponding to a region of interest of a subject using a radio-frequency (rf) pulse, for obtaining multiple slices. The excitation phase is modulated between acquisitions using a phase cycling scheme configured to create signal cancellation of all but one slice of the multiple excited slices from the different slice locations. The method also includes applying an imaging pulse sequence using a spiral k-space trajectory to acquire image data from the multiple slices, for an image or series of images of the region of interest; and reconstructing, from the multiple slices, images of the region of interest, wherein the reconstructing recovers unaliased images from the different slice locations.

公开(公告)号：US09953439B2

公开(公告)日：2018-04-24

申请号：US14952859

申请日：2015-11-25

Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATION

Inventor： Michael Salerno ,  Craig H. Meyer ,  Xiao Chen ,  Yang Yang ,  Frederick H. Epstein ,  Christopher M. Kramer

IPC: G06K9/00 ,  G06T11/00 ,  A61B5/055 ,  A61B5/00 ,  A61B5/026 ,  G01R33/48 ,  G01R33/56 ,  G01R33/561 ,  G01R33/563

CPC classification number: G06T11/003 ,  A61B5/0044 ,  A61B5/0263 ,  A61B5/055 ,  G01R33/4826 ,  G01R33/5601 ,  G01R33/5611 ,  G01R33/56366

Abstract: Some aspects of the present disclosure relate to systems and methods for three-dimensional spiral perfusion imaging. In one embodiment, a method for perfusion imaging of a subject includes acquiring perfusion imaging data associated with the heart of a subject. The acquiring includes applying an imaging pulse sequence with a three-dimensional stack-of-spirals trajectory. The method also includes reconstructing perfusion images from the acquired perfusion imaging data. The reconstructing includes parallel imaging and motion-guided compressed sensing. The method also includes determining, from the reconstructed perfusion images, absolute perfusion values based on time-intensity relationships to quantify myocardial blood flow of the heart of the subject, and generating a quantitative volumetric perfusion flow map based on the determined absolute perfusion values.

公开(公告)号：US20170076449A1

公开(公告)日：2017-03-16

申请号：US15267371

申请日：2016-09-16

Applicant: University of Virginia Patent Foundation

Inventor： Kelvin Chow ,  Yang Yang ,  Michael Salerno

IPC: G06T7/00

CPC classification number: G06T7/38 ,  G06T2207/10088 ,  G06T2207/30048

Abstract: In one aspect, the disclosed technology relates to a method which, in one example embodiment, includes acquiring magnetic resonance imaging data for a plurality of images of the heart of a subject during free breathing of the subject. The method also includes generating an additional plurality of images with high tissue-blood contrast over the region of interest, and selecting a subset of images from the plurality of images, based upon a pre-determined quality metric of image similarity, to be used for non-rigid image registration. The method also includes aligning the subset of images by non-rigid image registration using a combination of the plurality of images and the additional plurality of images, and creating a parametric map from the aligned images.

Abstract translation: 一方面，所公开的技术涉及在一个示例性实施例中包括在受试者的自由呼吸期间获取对象的心脏的多个图像的磁共振成像数据的方法。 该方法还包括在感兴趣区域上产生具有高组织 - 血液对比度的附加多个图像，以及基于图像相似度的预定质量度量从多个图像中选择图像的子集，以用于 非刚性图像注册。 该方法还包括使用多个图像和附加多个图像的组合通过非刚性图像配准来对齐图像子集，以及从对准的图像创建参数图。

公开(公告)号：US09224210B2

公开(公告)日：2015-12-29

申请号：US14174748

申请日：2014-02-06

Applicant: University of Virginia Patent Foundation

Inventor： Frederick H Epstein ,  Xiao Chen ,  Yang Yang ,  Michael Salerno

IPC: G06T7/20 ,  G06T7/00 ,  G06K9/62 ,  G01R33/565 ,  G01R33/563 ,  G01R33/56 ,  G01R33/561

CPC classification number: G06T7/20 ,  G01R33/5608 ,  G01R33/561 ,  G01R33/56308 ,  G01R33/56509 ,  G06K9/6218 ,  G06K2209/05 ,  G06T7/0012 ,  G06T2207/10096 ,  G06T2207/30048

Abstract: Some aspects of the present disclosure relate to systems and methods for accelerated dynamic magnetic resonance imaging (MRI). In an example embodiment, a method includes acquiring undersampled MRI data corresponding to a set of images associated with an area of interest of a subject, and separating an image of the set of images into image regions. The method also includes performing motion tracking for each of the image regions, grouping the motion-tracked image regions into clusters, and applying a sparsity transform to the clusters, to form sparsity-exploited, transformed image regions. The method further includes forming a set of merged images from the plurality of sparsity-exploited, transformed image regions, and updating the set of merged images based on data fidelity, to form an updated set of estimated images.

Abstract translation: 本公开的一些方面涉及用于加速动态磁共振成像（MRI）的系统和方法。 在示例性实施例中，一种方法包括获取对应于与被摄体感兴趣的区域相关联的一组图像的欠采样的MRI数据，以及将该组图像分离成图像区域。 该方法还包括对每个图像区域执行运动跟踪，将运动跟踪的图像区域分组成群集，以及将稀疏变换应用于群集，以形成稀疏性利用的变换图像区域。 所述方法还包括从所述多个经稀疏利用的变换的图像区域形成一组合并的图像，以及基于数据保真度来更新所合并的图像集合，以形成更新的估计图像集。