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    Systems and Methods for Three-Dimensional Spiral Perfusion Imaging
    2.
    发明申请
    Systems and Methods for Three-Dimensional Spiral Perfusion Imaging 有权
    三维螺旋灌注成像系统与方法

    公开(公告)号：US20160148378A1

    公开(公告)日：2016-05-26

    申请号：US14952859

    申请日：2015-11-25

    Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATION

    Inventor： Michael Salerno ,  Craig H. Meyer ,  Xiao Chen ,  Yang Yang ,  Frederick H. Epstein ,  Christopher M. Kramer

    IPC: G06T7/00 ,  G06T15/08 ,  G06T11/00 ,  G06T7/20

    CPC classification number: G06T11/003 ,  A61B5/0044 ,  A61B5/0263 ,  A61B5/055 ,  G01R33/4826 ,  G01R33/5601 ,  G01R33/5611 ,  G01R33/56366

    Abstract: Some aspects of the present disclosure relate to systems and methods for three-dimensional spiral perfusion imaging. In one embodiment, a method for perfusion imaging of a subject includes acquiring perfusion imaging data associated with the heart of a subject. The acquiring includes applying an imaging pulse sequence with a three-dimensional stack-of-spirals trajectory. The method also includes reconstructing perfusion images from the acquired perfusion imaging data. The reconstructing includes parallel imaging and motion-guided compressed sensing. The method also includes determining, from the reconstructed perfusion images, absolute perfusion values based on time-intensity relationships to quantify myocardial blood flow of the heart of the subject, and generating a quantitative volumetric perfusion flow map based on the determined absolute perfusion values.

    Abstract translation: 本公开的一些方面涉及用于三维螺旋灌注成像的系统和方法。 在一个实施例中，用于对象的灌注成像的方法包括获取与受试者的心脏相关联的灌注成像数据。 该采集包括应用具有三维叠加螺旋轨迹的成像脉冲序列。 该方法还包括从获取的灌注成像数据重建灌注图像。 重建包括并行成像和运动引导压缩感测。 该方法还包括根据重建的灌注图像确定基于时间 - 强度关系的绝对灌注值，以量化受试者心脏的心肌血流量，以及基于确定的绝对灌注值产生定量体积灌注流程图。

    Multiband spiral cardiac MRI with non-cartesian reconstruction methods
    4.
    发明授权
    Multiband spiral cardiac MRI with non-cartesian reconstruction methods 有权

    公开(公告)号：US11320506B2

    公开(公告)日：2022-05-03

    申请号：US16843869

    申请日：2020-04-08

    Applicant: University of Virginia Patent Foundation

    Inventor： Changyu Sun ,  Frederick H. Epstein ,  Yang Yang ,  Xiaoying Cai ,  Michael Salerno ,  Craig H. Meyer ,  Daniel Stuart Weller

    IPC: G01R33/48 ,  G01R33/36 ,  G01R33/567 ,  G06T7/262 ,  G01R33/58

    Abstract: A computerized method of reconstructing acquired magnetic resonance image (MRI) data to produce a series of output images includes acquiring a multiband k-space data set from a plurality of multiband slices of spiral MRI data; simultaneously acquiring a single band k-space data set comprising respective single band spiral image slices that are each associated with a respective one of the multiband slices in the multiband k-space data set; using the single band k-space data set, for each individual multiband slice, calculating a respective calibration kernel to apply to the multi-band k-space data set for each individual multiband slice; separating each individual multiband slice from the multiband k space data set by phase demodulating the multi-band k-space data using multiband phase demodulation operators corresponding to the individual multiband slice and convolving phase demodulated multi-band k-space data with a selected convolution operator to form a gridded set of the multi-band k-space data corresponding to the individual multiband slice.

    Cardiac and Respiratory Self-Gated Motion-Corrected Free-Breathing Spiral Cine Imaging
    5.
    发明申请
    Cardiac and Respiratory Self-Gated Motion-Corrected Free-Breathing Spiral Cine Imaging 审中-公开

    公开(公告)号：US20190154785A1

    公开(公告)日：2019-05-23

    申请号：US16195424

    申请日：2018-11-19

    Applicant: University of Virginia Patent Foundation

    Inventor： Ruixi Zhou ,  Yang Yang ,  Michael Salerno

    IPC: G01R33/563 ,  G01R33/567 ,  A61B5/055

    Abstract: In some aspects, the present disclosure relates to free-breathing cine imaging of an area of interest of a subject. In one embodiment, a method includes acquiring, during free breathing of the subject, magnetic resonance imaging data corresponding to an area of interest of a subject that comprises the heart, wherein the acquiring comprises applying a pulse sequence with a spiral trajectory. The method also includes performing cardiac self-gating using a self-gating signal extracted from a central region of k-space, and performing respiratory motion correction to compensate for changes in the heart position during respiratory motion, wherein the motion correction comprises rigid or non-rigid registration to determine corrective displacements. The method also includes performing image reconstruction to produce cine images of the area of interest over a plurality of heart-beats.

    Systems and methods for reducing respiratory-induced motion artifacts for accelerated imaging
    7.
    发明授权
    Systems and methods for reducing respiratory-induced motion artifacts for accelerated imaging 有权

    公开(公告)号：US10849561B2

    公开(公告)日：2020-12-01

    申请号：US15331292

    申请日：2016-10-21

    Applicant: University of Virginia Patent Foundation

    Inventor： Wei Huang ,  Yang Yang ,  Xiao Chen ,  Michael Salerno

    IPC: A61B5/00 ,  A61B5/055 ,  G01R33/565 ,  A61B5/113 ,  G01R33/561

    Abstract: In some aspects, the disclosed technology relates to reducing respiratory-induced motion artifacts for accelerated imaging. In one embodiment, magnetic resonance data may be acquired for an area of a subject containing the heart. The acquired data may include motion-corrupted data due to respiration of the subject. From the acquired data, an image may be independently reconstructed for each of a plurality of time frames, with each time frame corresponding to one of a plurality of heartbeats. A region containing the heart of the subject may be automatically detected in the reconstructed images, and rigid motion registration may be performed on the region of the reconstructed images containing the heart. Based on the rigid motion registration, a linear phase shift for motion correction may be determined. The linear phase shift may be applied to the motion-corrupted data to produce linear phase-shifted data, and a k-t image reconstruction may be performed on the linear phase-shifted data to produce motion-corrected images.

    Free-breathing parameter mapping with high-contrast image registration
    8.
    发明授权
    Free-breathing parameter mapping with high-contrast image registration 有权

    公开(公告)号：US10198810B2

    公开(公告)日：2019-02-05

    申请号：US15267371

    申请日：2016-09-16

    Applicant: University of Virginia Patent Foundation

    Inventor： Kelvin Chow ,  Yang Yang ,  Michael Salerno

    IPC: G06T7/00

    Abstract: In one aspect, the disclosed technology relates to a method which, in one example embodiment, includes acquiring magnetic resonance imaging data for a plurality of images of the heart of a subject during free breathing of the subject. The method also includes generating an additional plurality of images with high tissue-blood contrast over the region of interest, and selecting a subset of images from the plurality of images, based upon a pre-determined quality metric of image similarity, to be used for non-rigid image registration. The method also includes aligning the subset of images by non-rigid image registration using a combination of the plurality of images and the additional plurality of images, and creating a parametric map from the aligned images.

    SYSTEMS AND METHODS FOR REDUCING RESPIRATORY-INDUCED MOTION ARTIFACTS FOR ACCELERATED IMAGING
    9.
    发明申请
    SYSTEMS AND METHODS FOR REDUCING RESPIRATORY-INDUCED MOTION ARTIFACTS FOR ACCELERATED IMAGING 审中-公开

    公开(公告)号：US20170112449A1

    公开(公告)日：2017-04-27

    申请号：US15331292

    申请日：2016-10-21

    Applicant: University of Virginia Patent Foundation

    Inventor： Wei Huang ,  Yang Yang ,  Xiao Chen ,  Michael Salerno

    IPC: A61B5/00 ,  G01R33/565 ,  G01R33/561 ,  A61B5/055 ,  G06T7/00

    CPC classification number: A61B5/7207 ,  A61B5/0044 ,  A61B5/055 ,  A61B5/113 ,  G01R33/5611 ,  G01R33/56509

    Abstract: In some aspects, the disclosed technology relates to reducing respiratory-induced motion artifacts for accelerated imaging. In one embodiment, magnetic resonance data may be acquired for an area of a subject containing the heart. The acquired data may include motion-corrupted data due to respiration of the subject. From the acquired data, an image may be independently reconstructed for each of a plurality of time frames, with each time frame corresponding to one of a plurality of heartbeats. A region containing the heart of the subject may be automatically detected in the reconstructed images, and rigid motion registration may be performed on the region of the reconstructed images containing the heart. Based on the rigid motion registration, a linear phase shift for motion correction may be determined. The linear phase shift may be applied to the motion-corrupted data to produce linear phase-shifted data, and a k-t image reconstruction may be performed on the linear phase-shifted data to produce motion-corrected images.

    Systems and methods for simultaneous multi-slice imaging
    10.
    发明授权
    Systems and methods for simultaneous multi-slice imaging 有权

    公开(公告)号：US10753994B2

    公开(公告)日：2020-08-25

    申请号：US15959913

    申请日：2018-04-23

    Applicant: University of Virginia Patent Foundation

    Inventor： Michael Salerno ,  Yang Yang

    IPC: G01R33/483 ,  A61B5/055 ,  G01R33/58 ,  G01R33/48 ,  G01R33/561 ,  A61B5/00 ,  G01R33/56 ,  G01R33/563

    Abstract: Systems and methods for simultaneous multi-slice imaging. In one embodiment, a method for magnetic resonance imaging of a region of interest of a subject includes simultaneously exciting multiple, different slice locations corresponding to a region of interest of a subject using a radio-frequency (rf) pulse, for obtaining multiple slices. The excitation phase is modulated between acquisitions using a phase cycling scheme configured to create signal cancellation of all but one slice of the multiple excited slices from the different slice locations. The method also includes applying an imaging pulse sequence using a spiral k-space trajectory to acquire image data from the multiple slices, for an image or series of images of the region of interest; and reconstructing, from the multiple slices, images of the region of interest, wherein the reconstructing recovers unaliased images from the different slice locations.

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