公开(公告)号：US20250035636A1

公开(公告)日：2025-01-30

申请号：US18911931

申请日：2024-10-10

Applicant: University of Washington through its Center for Commercialization

Inventor： Daniel T. Chiu ,  Changfeng Wu ,  Xuanjun Zhang ,  Jiangbo Yu ,  Fangmao Ye

IPC: G01N33/58 ,  B82Y15/00 ,  B82Y30/00 ,  B82Y40/00 ,  C08G61/12 ,  C08J3/11 ,  C09K11/02 ,  C09K11/06 ,  H10K85/10

Abstract: The present invention provides, among other aspects, stabilized chromophoric nanoparticles. In certain embodiments, the chromophoric nanoparticles provided herein are rationally functionalized with a pre-determined number of functional groups. In certain embodiments, the stable chromophoric nanoparticles provided herein are modified with a low density of functional groups. In yet other embodiments, the chromophoric nanoparticles provided herein are conjugated to one or more molecules. Also provided herein are methods for making rationally functionalized chromophoric nanoparticles.

公开(公告)号：US11697713B2

公开(公告)日：2023-07-11

申请号：US16138732

申请日：2018-09-21

Applicant: University of Washington through its Center for Commercialization

Inventor： Daniel T. Chiu ,  Changfeng Wu ,  Yu Rong ,  Yong Zhang ,  Yi-Che Wu ,  Yang-Hsiang Chan ,  Xuanjun Zhang ,  Jiangbo Yu ,  Wei Sun

IPC: A61K47/32 ,  C08G77/00 ,  C08G77/398 ,  C08G75/32 ,  G01N33/58 ,  A61K49/00 ,  C09B69/10 ,  H10K85/10 ,  C08G79/00 ,  B82Y40/00 ,  B82Y30/00 ,  G01N21/64 ,  H10K50/11

CPC classification number: C08G75/32 ,  A61K49/0019 ,  A61K49/0067 ,  C08G79/00 ,  C09B69/105 ,  G01N33/582 ,  G01N33/587 ,  H10K85/10 ,  H10K85/113 ,  H10K85/115 ,  H10K85/151 ,  B82Y30/00 ,  B82Y40/00 ,  G01N2021/6439 ,  H10K50/11

Abstract: Polymers, monomers, chromophoric polymer dots and related methods are provided. Highly fluorescent chromophoric polymer dots with narrow-band emissions are provided. Methods for synthesizing the chromophoric polymers, preparation methods for forming the chromophoric polymer dots, and biological applications using the unique properties of narrow-band emissions are also provided.

公开(公告)号：US11249073B2

公开(公告)日：2022-02-15

申请号：US14434200

申请日：2013-10-08

Applicant: University of Washington through its Center for Commercialization

Inventor： Daniel T. Chiu ,  Wei Sun ,  Jiangbo Yu ,  Changfeng Wu

IPC: G01N33/52 ,  C12N5/09 ,  C09K11/06 ,  C12N13/00

Abstract: The present disclosure provides metal-containing (MC) semiconducting (SC) Pdots (MC-SC-Pdots) with beneficial functionalities in both cellular imaging and manipulation, among other applications. The Pdots comprise at least one nanoparticle comprising at least one metal, and a semiconducting polymer associated with the nanoparticle.

公开(公告)号：US10150841B2

公开(公告)日：2018-12-11

申请号：US14366863

申请日：2012-12-27

Applicant: University of Washington through its Center for Commercialization

Inventor： Daniel T. Chiu ,  Changfeng Wu ,  Yu Rong ,  Yong Zhang ,  Yi-Che Wu ,  Yang-Hsiang Chan ,  Xuanjun Zhang ,  Jiangbo Yu ,  Wei Sun

IPC: C08G75/32 ,  C08G79/00 ,  G01N33/58 ,  H01L51/00 ,  A61K49/00 ,  C09B69/10 ,  G01N21/64 ,  H01L51/50 ,  B82Y40/00 ,  B82Y30/00

Abstract: Polymers, monomers, chromophoric polymer dots and related methods are provided. Highly fluorescent chromophoric polymer dots with narrow-band emissions are provided. Methods for synthesizing the chromophoric polymers, preparation methods for forming the chromophoric polymer dots, and biological applications using the unique properties of narrow-band emissions are also provided.

公开(公告)号：US20140350183A1

公开(公告)日：2014-11-27

申请号：US14366863

申请日：2012-12-27

Applicant: University of Washington through its Center for Commercialization

Inventor： Daniel T. Chiu ,  Changfeng Wu ,  Yu Rong ,  Yong Zhang ,  Yi-Che Wu ,  Yang-Hsiang Chan ,  Xuanjun Zhang ,  Jiangbo Yu ,  Wei Sun

IPC: C08G75/32 ,  H01L51/00 ,  G01N33/58 ,  C08G79/00

CPC classification number: C08G75/32 ,  A61K49/0019 ,  A61K49/0067 ,  B82Y30/00 ,  B82Y40/00 ,  C08G79/00 ,  C09B69/105 ,  G01N33/582 ,  G01N33/587 ,  G01N2021/6439 ,  H01L51/0034 ,  H01L51/0036 ,  H01L51/0039 ,  H01L51/0043 ,  H01L51/5012

Abstract: Polymers, monomers, chromophoric polymer dots and related methods are provided. Highly fluorescent chromophoric polymer dots with narrow-band emissions are provided. Methods for synthesizing the chromophoric polymers, preparation methods for forming the chromophoric polymer dots, and biological applications using the unique properties of narrow-band emissions are also provided.

Abstract translation: 提供聚合物，单体，发色聚合物点和相关方法。 提供了具有窄带辐射的高度荧光发色聚合物点。 还提供了合成发色聚合物的方法，形成发色聚合物点的制备方法和使用窄带发射的独特性质的生物应用。

公开(公告)号：US10768180B2

公开(公告)日：2020-09-08

申请号：US16041569

申请日：2018-07-20

Applicant: University of Washington through its Center for Commercialization

Inventor： Daniel T. Chiu ,  Yuhui Jin ,  Fangmao Ye ,  Changfeng Wu ,  Yang-Hsiang Chan

IPC: G01N33/58 ,  H01L51/00 ,  B82Y40/00 ,  A61K49/00 ,  H01L51/50 ,  B82Y15/00 ,  B82Y5/00

Abstract: Polymer nanoparticles and related methods are provided. The polymer particles can include polymer dots having a coating including a polyelectrolyte polymer. Methods of making and using the polymer nanoparticles are also provided.

公开(公告)号：US10514381B2

公开(公告)日：2019-12-24

申请号：US14774971

申请日：2014-03-14

Applicant: University of Washington through its Center for Commercialization

Inventor： Daniel T. Chiu ,  Wei Sun ,  Jiangbo Yu ,  Changfeng Wu ,  Fangmao Ye

IPC: G01N33/58 ,  C09K11/02 ,  G01N33/543 ,  C08G61/02 ,  C08G73/00 ,  C08G75/32 ,  G01N33/533

Abstract: Lyophilized chromophoric polymer dot compositions are provided. Also disclosed are methods of making and using the lyophilized compositions, methods of dispersing the lyophilized compositions in aqueous solutions and kits supplying the compositions.

公开(公告)号：US09810693B2

公开(公告)日：2017-11-07

申请号：US13865942

申请日：2013-04-18

Applicant: University of Washington Through its Center for Commercialization

Inventor： Daniel T. Chiu ,  Changfeng Wu ,  Xuanjun Zhang ,  Jiangbo Yu ,  Fangmao Ye

IPC: G01N33/58 ,  C09K11/06 ,  B82Y30/00 ,  B82Y40/00 ,  H01L51/00 ,  B82Y15/00 ,  C08G61/12 ,  C08J3/11 ,  C09K11/02

CPC classification number: G01N33/588 ,  B82Y15/00 ,  B82Y30/00 ,  B82Y40/00 ,  C08G61/126 ,  C08G2261/12 ,  C08G2261/1426 ,  C08G2261/228 ,  C08G2261/3142 ,  C08G2261/3246 ,  C08G2261/522 ,  C08G2261/54 ,  C08G2261/72 ,  C08G2261/94 ,  C08J3/11 ,  C08J2327/22 ,  C09K11/025 ,  C09K11/06 ,  C09K2211/1425 ,  H01L51/0039

Abstract: The present invention provides, among other aspects, stabilized chromophoric nanoparticles. In certain embodiments, the chromophoric nanoparticles provided herein are rationally functionalized with a pre-determined number of functional groups. In certain embodiments, the stable chromophoric nanoparticles provided herein are modified with a low density of functional groups. In yet other embodiments, the chromophoric nanoparticles provided herein are conjugated to one or more molecules. Also provided herein are methods for making rationally functionalized chromophoric nanoparticles.

公开(公告)号：US20160341737A1

公开(公告)日：2016-11-24

申请号：US15167513

申请日：2016-05-27

Applicant: University of Washington through its Center for Commercialization

Inventor： Daniel T. Chiu ,  Changfeng Wu ,  Xuanjun Zhang ,  Jiangbo Yu ,  Fangmao Ye

IPC: G01N33/58 ,  C09K11/06 ,  C09K11/02 ,  C08J3/11 ,  C08G61/12

Abstract: The present invention provides, among other aspects, stabilized chromophoric nanoparticles. In certain embodiments, the chromophoric nanoparticles provided herein are rationally functionalized with a pre-determined number of functional groups. In certain embodiments, the stable chromophoric nanoparticles provided herein are modified with a low density of functional groups. In yet other embodiments, the chromophoric nanoparticles provided herein are conjugated to one or more molecules. Also provided herein are methods for making rationally functionalized chromophoric nanoparticles.

公开(公告)号：US20150037259A1

公开(公告)日：2015-02-05

申请号：US14373835

申请日：2013-02-01

Applicant: University of Washington through its Center for Commercialization

Inventor： Daniel T. Chiu ,  Yuhui Jin ,  Fangmao Ye ,  Changfeng Wu ,  Yang-Hsiang Chan

IPC: G01N33/58 ,  A61K49/00

CPC classification number: G01N33/588 ,  A61K49/0065 ,  B82Y5/00 ,  B82Y15/00 ,  B82Y40/00 ,  H01L51/0036 ,  H01L51/0039 ,  H01L51/0043 ,  H01L51/5012

Abstract: Polymer nanoparticles and related methods include polymer dots having a coating including a polyelectrolyte polymer. The polymer dots can have a polyelectrolyte coating that can improve colloidal stability of the particles as compared to polymer dots not having the coating. A method of preparing a population of nanoparticles. The methods can include, e.g., providing the population of nanoparticles having a condensed semiconducting polymer; and combining, in a first aqueous solution comprising polyelectrolytes, the population of nanoparticles having the condensed semiconducting polymer to form a population of nanoparticles having a polyelectrolyte coating surrounding the condensed semiconducting polymer of each of the nanoparticles in the population. The methods can include a step of forming the condensed semiconducting polymer using nanoprecipitation or miniemulsion techniques. The polyelectrolyte coating can completely surround the condensed semiconducting polymer.

Abstract translation: 聚合物纳米粒子和相关方法包括具有包括聚电解质聚合物的涂层的聚合物点。 与不具有涂层的聚合物点相比，聚合物点可以具有可以改善颗粒的胶体稳定性的聚电解质涂层。 一种制备纳米颗粒群体的方法。 所述方法可以包括例如提供具有冷凝的半导体聚合物的纳米颗粒群; 并且在包含聚电解质的第一水溶液中混合具有所述缩合的半导体聚合物的纳米颗粒群以形成纳米颗粒群，所述纳米颗粒群包含围绕群体中每个纳米颗粒的缩合半导体聚合物的聚电解质涂层。 该方法可以包括使用纳米沉淀或微乳液技术形成冷凝的半导体聚合物的步骤。 聚电解质涂层可以完全包围冷凝的半导体聚合物。