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公开(公告)号：US20230408526A1
公开(公告)日：2023-12-21
申请号：US18058458
申请日：2022-11-23
发明人： Daniel T. Chiu , Changfeng Wu , Xuanjun Zhang , Jiangbo Yu , Fangmao Ye
IPC分类号： G01N33/58 , B82Y30/00 , B82Y40/00 , B82Y15/00 , H10K85/10 , C09K11/06 , C08G61/12 , C08J3/11 , C09K11/02
CPC分类号： G01N33/588 , C09K2211/1425 , B82Y40/00 , B82Y15/00 , H10K85/115 , C09K11/06 , C08G61/126 , C08J3/11 , C09K11/025 , C08G2261/12 , C08G2261/1426 , C08G2261/228 , C08G2261/3142 , C08G2261/3246 , C08G2261/522 , C08G2261/54 , C08G2261/72 , C08G2261/94 , C08J2327/22 , B82Y30/00
摘要： The present invention provides, among other aspects, stabilized chromophoric nanoparticles. In certain embodiments, the chromophoric nanoparticles provided herein are rationally functionalized with a pre-determined number of functional groups. In certain embodiments, the stable chromophoric nanoparticles provided herein are modified with a low density of functional groups. In yet other embodiments, the chromophoric nanoparticles provided herein are conjugated to one or more molecules. Also provided herein are methods for making rationally functionalized chromophoric nanoparticles.
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公开(公告)号：US11674964B2
公开(公告)日：2023-06-13
申请号：US17538447
申请日：2021-11-30
发明人： Daniel T. Chiu , Changfeng Wu , Jiangbo Yu
CPC分类号： G01N33/58 , C09K11/02 , C09K11/06 , G01N21/6408 , G01N21/6428 , G01N33/582 , G01N33/587 , G01N33/588 , C09K2211/1007 , C09K2211/1011 , C09K2211/1044 , C09K2211/1416 , C09K2211/182 , G01N2021/6417 , G01N2021/6439 , G01N2021/6441 , G01N2201/12
摘要： The present disclosure provides encoded chromophoric polymer particles that are capable of, for example, optical and/or biomolecular encoding of analytes. The present disclosure also provides suspensions comprising a plurality of encoded chromophoric polymer particles. The present disclosure also provides methods of using the encoded chromophoric polymer particles and systems for performing multiplex analysis with encoded chromophoric polymer particles.
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公开(公告)号：US11585818B2
公开(公告)日：2023-02-21
申请号：US16989491
申请日：2020-08-10
发明人： Daniel T. Chiu , Changfeng Wu , Xuanjun Zhang , Jiangbo Yu , Fangmao Ye
IPC分类号： C09K11/02 , G01N33/58 , B82Y30/00 , B82Y40/00 , B82Y15/00 , C09K11/06 , H01L51/00 , C08G61/12 , C08J3/11
摘要： The present invention provides, among other aspects, stabilized chromophoric nanoparticles. In certain embodiments, the chromophoric nanoparticles provided herein are rationally functionalized with a pre-determined number of functional groups. In certain embodiments, the stable chromophoric nanoparticles provided herein are modified with a low density of functional groups. In yet other embodiments, the chromophoric nanoparticles provided herein are conjugated to one or more molecules. Also provided herein are methods for making rationally functionalized chromophoric nanoparticles.
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公开(公告)号：US10983130B2
公开(公告)日：2021-04-20
申请号：US14904269
申请日：2014-07-11
发明人： Daniel Chiu , Yong Zhang , Jiangbo Yu , Yu Rong
摘要： This disclosure provides semiconducting polymer dots (Pdots) for use in a wide variety of applications. In particular, this disclosure provides Pdots that are halogenated, including fluorinated Pdots. This disclosure also provides methods for synthesizing Pdots and methods for using Pdots, such as for biological imaging.
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公开(公告)号：US10444243B2
公开(公告)日：2019-10-15
申请号：US15100056
申请日：2014-11-25
发明人： Daniel T. Chiu , Changfeng Wu , Jiangbo Yu
摘要： The present disclosure provides encoded chromophoric polymer particles that are capable of, for example, optical and/or biomolecular encoding of analytes. The present disclosure also provides suspensions comprising a plurality of encoded chromophoric polymer particles. The present disclosure also provides methods of using the encoded chromophoric polymer particles and systems for performing multiplex analysis with encoded chromophoric polymer particles.
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公开(公告)号：US11697713B2
公开(公告)日：2023-07-11
申请号：US16138732
申请日：2018-09-21
发明人： Daniel T. Chiu , Changfeng Wu , Yu Rong , Yong Zhang , Yi-Che Wu , Yang-Hsiang Chan , Xuanjun Zhang , Jiangbo Yu , Wei Sun
IPC分类号： A61K47/32 , C08G77/00 , C08G77/398 , C08G75/32 , G01N33/58 , A61K49/00 , C09B69/10 , H10K85/10 , C08G79/00 , B82Y40/00 , B82Y30/00 , G01N21/64 , H10K50/11
CPC分类号： C08G75/32 , A61K49/0019 , A61K49/0067 , C08G79/00 , C09B69/105 , G01N33/582 , G01N33/587 , H10K85/10 , H10K85/113 , H10K85/115 , H10K85/151 , B82Y30/00 , B82Y40/00 , G01N2021/6439 , H10K50/11
摘要： Polymers, monomers, chromophoric polymer dots and related methods are provided. Highly fluorescent chromophoric polymer dots with narrow-band emissions are provided. Methods for synthesizing the chromophoric polymers, preparation methods for forming the chromophoric polymer dots, and biological applications using the unique properties of narrow-band emissions are also provided.
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公开(公告)号：US11249073B2
公开(公告)日：2022-02-15
申请号：US14434200
申请日：2013-10-08
发明人： Daniel T. Chiu , Wei Sun , Jiangbo Yu , Changfeng Wu
摘要： The present disclosure provides metal-containing (MC) semiconducting (SC) Pdots (MC-SC-Pdots) with beneficial functionalities in both cellular imaging and manipulation, among other applications. The Pdots comprise at least one nanoparticle comprising at least one metal, and a semiconducting polymer associated with the nanoparticle.
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公开(公告)号：US10150841B2
公开(公告)日：2018-12-11
申请号：US14366863
申请日：2012-12-27
发明人： Daniel T. Chiu , Changfeng Wu , Yu Rong , Yong Zhang , Yi-Che Wu , Yang-Hsiang Chan , Xuanjun Zhang , Jiangbo Yu , Wei Sun
IPC分类号： C08G75/32 , C08G79/00 , G01N33/58 , H01L51/00 , A61K49/00 , C09B69/10 , G01N21/64 , H01L51/50 , B82Y40/00 , B82Y30/00
摘要： Polymers, monomers, chromophoric polymer dots and related methods are provided. Highly fluorescent chromophoric polymer dots with narrow-band emissions are provided. Methods for synthesizing the chromophoric polymers, preparation methods for forming the chromophoric polymer dots, and biological applications using the unique properties of narrow-band emissions are also provided.
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公开(公告)号：US20140350183A1
公开(公告)日：2014-11-27
申请号：US14366863
申请日：2012-12-27
发明人： Daniel T. Chiu , Changfeng Wu , Yu Rong , Yong Zhang , Yi-Che Wu , Yang-Hsiang Chan , Xuanjun Zhang , Jiangbo Yu , Wei Sun
CPC分类号： C08G75/32 , A61K49/0019 , A61K49/0067 , B82Y30/00 , B82Y40/00 , C08G79/00 , C09B69/105 , G01N33/582 , G01N33/587 , G01N2021/6439 , H01L51/0034 , H01L51/0036 , H01L51/0039 , H01L51/0043 , H01L51/5012
摘要： Polymers, monomers, chromophoric polymer dots and related methods are provided. Highly fluorescent chromophoric polymer dots with narrow-band emissions are provided. Methods for synthesizing the chromophoric polymers, preparation methods for forming the chromophoric polymer dots, and biological applications using the unique properties of narrow-band emissions are also provided.
摘要翻译： 提供聚合物，单体，发色聚合物点和相关方法。 提供了具有窄带辐射的高度荧光发色聚合物点。 还提供了合成发色聚合物的方法，形成发色聚合物点的制备方法和使用窄带发射的独特性质的生物应用。
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公开(公告)号：US10514381B2
公开(公告)日：2019-12-24
申请号：US14774971
申请日：2014-03-14
发明人： Daniel T. Chiu , Wei Sun , Jiangbo Yu , Changfeng Wu , Fangmao Ye
IPC分类号： G01N33/58 , C09K11/02 , G01N33/543 , C08G61/02 , C08G73/00 , C08G75/32 , G01N33/533
摘要： Lyophilized chromophoric polymer dot compositions are provided. Also disclosed are methods of making and using the lyophilized compositions, methods of dispersing the lyophilized compositions in aqueous solutions and kits supplying the compositions.
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