公开(公告)号：US20150012055A1

公开(公告)日：2015-01-08

申请号：US14446500

申请日：2014-07-30

Applicant: Valencia Technologies Corporation

Inventor： Jeffrey H. Greiner ,  David K. L. Peterson ,  Chuladatta Thenuwara

IPC: A61N1/05 ,  A61N1/375 ,  A61N1/36

CPC classification number: A61N1/0504 ,  A61H39/002 ,  A61H2201/5005 ,  A61H2201/5035 ,  A61H2201/5038 ,  A61H2201/5097 ,  A61N1/3605 ,  A61N1/36117 ,  A61N1/36125 ,  A61N1/36175 ,  A61N1/37205 ,  A61N1/3756 ,  A61N1/3758 ,  A61N1/3782 ,  Y10S128/907

Abstract: Disclosed is an implantable, coin-sized, self-contained, leadless electroacupuncture (EA) device having at least two electrode contacts attached to the surface of its housing. The electrodes include a central cathode electrode on a bottom side of the housing, and a circumferential anode electrode that surrounds the cathode electrode. In one embodiment, the anode annular electrode is a ring electrode placed around the perimeter edge of the coin-shaped housing. The EA device is adapted to be implanted through a very small incision, e.g., less than about 2-3 cm in length, directly adjacent to a selected acupuncture site known to moderate or affect a hypertension condition of a patient. Appropriate power management circuitry within the device allows a primary battery having a relatively high internal impedance to be used without causing unacceptable dips in battery voltage when the instantaneous battery current surges. Stimulation pulses are generated during a stimulation session that has a duration of T3 minutes and which is applied every T4 minutes. The duty cycle, or ratio of T3 to T4, is very low, not greater than 0.05. This low duty cycle, along with careful power management, allows the EA device to perform its intended function for several years.

Abstract translation: 公开了一种植入式，硬币大小的独立的无引线电针（EA）装置，其具有附接到其壳体表面的至少两个电极触点。 电极包括在壳体的底侧上的中央阴极电极和围绕阴极电极的周向阳极电极。 在一个实施例中，阳极环形电极是围绕硬币形壳体的周边边缘放置的环形电极。 EA装置适于通过非常小的切口植入，例如长度小于约2-3厘米，直接与已知中度或影响患者高血压状况的所选择的针灸部位相邻。 器件内的合适的电源管理电路允许使用具有相对较高的内部阻抗的一次电池，而不会在瞬间电池电流骤升时导致电池电压的不可接受的下降。 在刺激会话期间产生刺激脉冲，持续时间为T3分钟，每T4分钟应用一次。 T3到T4的占空比或比例很低，不大于0.05。 这个低占空比，以及仔细的电源管理，允许EA设备执行其预期功能几年。

公开(公告)号：US20140214113A1

公开(公告)日：2014-07-31

申请号：US13796314

申请日：2013-03-12

Applicant: Valencia Technologies Corporation

Inventor： Jeffrey H. Greiner ,  David K. L. Peterson ,  Chuladatta Thenuwara ,  Stacy O. Greiner

IPC: A61H39/00 ,  H05K13/04

CPC classification number: A61H39/002 ,  A61N1/36067 ,  A61N1/36096 ,  A61N1/36107 ,  A61N1/36114 ,  A61N1/36117 ,  A61N1/36125 ,  A61N1/36175 ,  A61N1/37205 ,  A61N1/3756 ,  A61N1/3758 ,  A61N1/3782 ,  H01L2224/48091 ,  Y10T29/49002 ,  H01L2924/00014

Abstract: An implantable electroacupuncture device (IEAD) treats a medical condition of a patient through application of electroacupuncture (EA) stimulation pulses applied at a target tissue location, such as an acupoint. The IEAD comprises an implantable, coin-sized, self-contained, leadless electroacupuncture device having at least two electrodes attached to an outside surface of its housing. The device generates EA stimulation pulses in accordance with a specified stimulation regimen. Power management circuitry within the device allows a primary battery, having a high internal impedance, to be used to power the device. The stimulation regimen generates stimulation pulses during a stimulation session of duration T3 minutes applied every T4 minutes. The duty cycle, or ratio T3/T4, is very low, no greater than 0.05. The low duty cycle and careful power management allow the IEAD to perform its intended function for several years.

Abstract translation: 可植入电针装置（IEAD）通过施加在目标组织位置（例如穴位）上施加的电针（EA）刺激脉冲来治疗患者的医疗状况。 IEAD包括可植入的硬币大小的独立的无引线电针装置，其具有附接到其外壳的外表面的至少两个电极。 该设备根据指定的刺激方案产生EA刺激脉冲。 设备内的电源管理电路允许使用具有高内部阻抗的一次电池为设备供电。 刺激方案在每T4分钟施用持续时间T3分钟的刺激期间产生刺激脉冲。 占空比或比例T3 / T4非常低，不大于0.05。 低占空比和仔细的电源管理允许IEAD执行其预期功能几年。

公开(公告)号：US10940033B2

公开(公告)日：2021-03-09

申请号：US15793905

申请日：2017-10-25

Applicant: Valencia Technologies Corporation

Inventor： Jeffrey H. Greiner ,  David K. L. Peterson ,  Chuladatta Thenuwara ,  Stacy O. Greiner

IPC: A61F5/41 ,  A61H39/00 ,  A61N1/375 ,  A61N1/36 ,  A61N1/372 ,  A61N1/18 ,  A61N1/378

Abstract: An exemplary method treating an erectile dysfunction condition in a patient includes 1) generating, by an electroacupuncture device implanted beneath a skin surface of the patient, stimulation sessions at a duty cycle that is less than 0.05, and 2) applying, by the electroacupuncture device in accordance with the duty cycle, the stimulation sessions to a target tissue location within the patient by way of an electrode array located within the patient at an acupoint corresponding to the target tissue location.

公开(公告)号：US20180200143A1

公开(公告)日：2018-07-19

申请号：US15918781

申请日：2018-03-12

Applicant: Valencia Technologies Corporation

Inventor： Jeffrey H. Greiner ,  David K. L. Peterson ,  Chuladatta Thenuwara ,  Stacy O. Greiner

IPC: A61H39/00 ,  A61N1/378 ,  A61N1/375 ,  A61N1/372 ,  A61F5/00 ,  A61N1/36

CPC classification number: A61H39/002 ,  A61F5/0026 ,  A61H2201/50 ,  A61H2201/5005 ,  A61H2201/5038 ,  A61H2201/5097 ,  A61N1/36085 ,  A61N1/36117 ,  A61N1/36125 ,  A61N1/36153 ,  A61N1/36157 ,  A61N1/36175 ,  A61N1/37205 ,  A61N1/375 ,  A61N1/3756 ,  A61N1/3758 ,  A61N1/3782 ,  Y10T29/49117

Abstract: An exemplary method includes generating, by an electroacupuncture device implanted beneath a skin surface of a patient, stimulation sessions at a duty cycle that is less than 0.05, and applying, by the electroacupuncture device in accordance with the duty cycle, the stimulation sessions to a location within the patient. A primary battery located within the electroacupuncture device and having an internal impedance greater than 5 ohms is configured to provide operating power to pulse generation circuitry within the electroacupuncture device.

公开(公告)号：US20180021566A1

公开(公告)日：2018-01-25

申请号：US15700013

申请日：2017-09-08

Applicant: Valencia Technologies Corporation

Inventor： Jeffrey H. Greiner ,  David K. L. Peterson ,  Chuladatta Thenuwara

IPC: A61N1/05 ,  A61N1/372 ,  A61N1/375 ,  A61N1/36 ,  A61H39/00 ,  A61N1/378

CPC classification number: A61N1/0504 ,  A61H39/002 ,  A61H2201/5005 ,  A61H2201/5035 ,  A61H2201/5038 ,  A61H2201/5097 ,  A61N1/3605 ,  A61N1/36117 ,  A61N1/36125 ,  A61N1/36175 ,  A61N1/37205 ,  A61N1/3756 ,  A61N1/3758 ,  A61N1/3782 ,  Y10S128/907

Abstract: An electroacupuncture device for treating hypertension in a patient includes 1) a housing configured to be implanted beneath a skin surface of the patient at an acupoint corresponding to a target tissue location within the patient, the acupoint comprising at least one of PC5, PC6, ST36, and ST37, 2) a central electrode of a first polarity and centrally located and substantially planar on a first surface of the housing, 3) an annular electrode of a second polarity and that surrounds the central electrode on the first surface of the housing, the annular electrode being spaced apart from the central electrode, and 4) pulse generation circuitry located within the housing and electrically coupled to the annular and central electrodes.

公开(公告)号：US09827421B2

公开(公告)日：2017-11-28

申请号：US14811633

申请日：2015-07-28

Applicant: Valencia Technologies Corporation

Inventor： Jeffrey H. Greiner ,  David K. L. Peterson ,  Chuladatta Thenuwara ,  Stacy Greiner Chambliss

IPC: A61N1/00 ,  A61N1/36 ,  A61N1/05 ,  A61N1/372 ,  A61N1/375 ,  A61N1/378

CPC classification number: A61N1/36071 ,  A61N1/0551 ,  A61N1/36125 ,  A61N1/36175 ,  A61N1/37205 ,  A61N1/37223 ,  A61N1/3756 ,  A61N1/3758 ,  A61N1/3782 ,  H01L2224/48091 ,  Y10T29/49002 ,  H01L2924/00014

Abstract: An exemplary method of treating a chronic low back pain condition in a patient includes 1) generating, by an electroacupuncture device implanted beneath a skin surface of the patient at at least one of acupoints BL22, BL23, BL24, BL25, and BL26 within the patient, stimulation sessions at a duty cycle that is less than 0.05, wherein the duty cycle is a ratio of T3 to T4 and each stimulation session included in the stimulation sessions has a duration of T3 minutes and occurs at a rate of once every T4 minutes, and 2) applying, by the electroacupuncture device, the stimulation sessions to the target tissue location in accordance with the duty cycle.

公开(公告)号：US20170202738A1

公开(公告)日：2017-07-20

申请号：US15421267

申请日：2017-01-31

Applicant: Valencia Technologies Corporation

Inventor： Jeffrey H. Greiner ,  David K. L. Peterson ,  Chuladatta Thenuwara

IPC: A61H39/00 ,  A61N1/375 ,  A61N1/372 ,  A61N1/36

CPC classification number: A61H39/002 ,  A61H39/00 ,  A61H2201/01 ,  A61N1/3606 ,  A61N1/36114 ,  A61N1/36117 ,  A61N1/36125 ,  A61N1/36153 ,  A61N1/36157 ,  A61N1/36175 ,  A61N1/37205 ,  A61N1/37223 ,  A61N1/3756 ,  A61N1/3782 ,  A61N1/3787 ,  Y10T29/49002

Abstract: An exemplary method treating a cardiovascular disease in a patient includes 1) generating, by an electroacupuncture device implanted beneath a skin surface of the patient, stimulation sessions at a duty cycle that is less than 0.05, and 2) applying, by the electroacupuncture device in accordance with the duty cycle, the stimulation sessions to a median nerve of the patient by way of an electrode array located within the patient at an acupoint corresponding to the median nerve.

公开(公告)号：US09566213B2

公开(公告)日：2017-02-14

申请号：US14859098

申请日：2015-09-18

Applicant: Valencia Technologies Corporation

Inventor： Jeffrey H. Greiner ,  David K. L. Peterson ,  Chuladatta Thenuwara ,  Stacy Greiner Chambliss

IPC: A61N1/375 ,  A61H39/00 ,  A61N1/36 ,  A61N1/372 ,  A61F5/00 ,  A61N1/378

CPC classification number: A61H39/002 ,  A61F5/0026 ,  A61H2201/50 ,  A61H2201/5005 ,  A61H2201/5038 ,  A61H2201/5097 ,  A61N1/36085 ,  A61N1/36117 ,  A61N1/36125 ,  A61N1/36153 ,  A61N1/36157 ,  A61N1/36175 ,  A61N1/37205 ,  A61N1/375 ,  A61N1/3756 ,  A61N1/3758 ,  A61N1/3782 ,  Y10T29/49117

Abstract: An exemplary method of treating obesity or dyslipidemia of a patient includes 1) generating, by an electroacupuncture device implanted beneath a skin surface of the patient at an acupoint corresponding to at least one of a saphenous nerve and a peroneal nerve of the patient, stimulation sessions at a duty cycle that is less than 0.05, and 2) applying, by the electroacupuncture device in accordance with the duty cycle, the stimulation sessions to at least one of the saphenous nerve and the peroneal nerve by way of a central electrode and an annular electrode located on a housing of the electroacupuncture device.

Abstract translation: 一种治疗患者肥胖或血脂异常的示例性方法包括：通过植入患者皮肤表面下方的针刺装置产生对应于患者的隐神经和腓神经中的至少一个的穴位，刺激会话 在小于0.05的占空比下，以及2）通过电针装置根据占空比将刺激会话通过中心电极和环形的至少一个隐神经和腓神经施加 电极位于电针装置的壳体上。

公开(公告)号：US09364390B2

公开(公告)日：2016-06-14

申请号：US13736039

申请日：2013-01-07

Applicant: Valencia Technologies Corporation

Inventor： Jeffrey H. Greiner ,  David K. L. Peterson ,  Chuladatta Thenuwara ,  Stacy O. Greiner

IPC: A61N1/375 ,  A61H39/00 ,  A61N1/372 ,  A61N1/00 ,  A61N1/36 ,  A61N1/32 ,  A61N1/378

CPC classification number: A61H39/002 ,  A61H2201/01 ,  A61H2201/5005 ,  A61H2201/5038 ,  A61N1/32 ,  A61N1/36085 ,  A61N1/36089 ,  A61N1/36125 ,  A61N1/36153 ,  A61N1/36157 ,  A61N1/36175 ,  A61N1/37205 ,  A61N1/3756 ,  A61N1/3758 ,  A61N1/3782 ,  Y10T29/49208

Abstract: An implantable electroacupuncture device (IEAD) treats obese conditions of a patient through application of stimulation pulses applied at acupoints SP4, LR8 or ST40, or their underlying nerves saphenous and peroneal. The IEAD comprises an implantable, coin-sized, self-contained, leadless electroacupuncture device having at least two electrodes attached to an outside surface of its housing. The device generates stimulation pulses in accordance with a specified stimulation regimen. Power management circuitry within the device allows a primary battery, having a high internal impedance, to be used to power the device. The stimulation regimen generates stimulation pulses during a stimulation session of duration T3 minutes applied every T4 minutes. The duty cycle, or ratio T3/T4, is very low, no greater than 0.05. The low duty cycle and careful power management allow the IEAD to perform its intended function for several years.

Abstract translation: 可植入电针装置（IEAD）通过施加在穴位SP4，LR8或ST40上施加的刺激脉冲或其潜伏的隐神经和腓神经来治疗患者的肥胖状况。 IEAD包括可植入的硬币大小的独立的无引线电针装置，其具有附接到其外壳的外表面的至少两个电极。 该设备根据指定的刺激方案产生刺激脉冲。 设备内的电源管理电路允许使用具有高内部阻抗的一次电池为设备供电。 刺激方案在每T4分钟施用持续时间T3分钟的刺激期间产生刺激脉冲。 占空比或比例T3 / T4非常低，不大于0.05。 低占空比和仔细的电源管理允许IEAD执行其预期功能几年。

公开(公告)号：US20150321014A1

公开(公告)日：2015-11-12

申请号：US14805336

申请日：2015-07-21

Applicant: Valencia Technologies Corporation

Inventor： David K. L. Peterson ,  Jeffrey H. Greiner

IPC: A61N1/378 ,  A61N1/36 ,  A61N1/375

CPC classification number: A61N1/378 ,  A61H39/002 ,  A61H2201/5005 ,  A61H2201/5035 ,  A61H2201/5038 ,  A61H2201/5097 ,  A61N1/36117 ,  A61N1/36125 ,  A61N1/36175 ,  A61N1/37205 ,  A61N1/3756 ,  A61N1/3758 ,  A61N1/3782

Abstract: An implantable electroacupuncture device (IEAD) treats a specified medical condition of a patient through application of electroacupuncture (EA) stimulation pulses applied substantially at or near a specified acupoint, its underlying nerves, or other target tissue location. The IEAD includes an IEAD housing having an electrode configuration thereon that includes at least two electrodes, and pulse generation circuitry located within the IEAD housing and electrically coupled to the at least two electrodes. The pulse generation circuitry is adapted to deliver stimulation pulses to the patient's body tissue at or near the target tissue location in accordance with a specified stimulation regimen, the stimulation regimen requiring that the stimulation session have a duration of T3 minutes and a rate of occurrence of once every T4 minutes, and wherein a ratio of T3/T4 is no greater than 0.05.

Abstract translation: 可植入电针装置（IEAD）通过施加基本上在特定穴位，其下面的神经或其他目标组织位置处或附近施加的电针（EA）刺激脉冲来治疗患者的指定的医疗状况。 IEAD包括其上具有电极配置的IEAD外壳，其包括至少两个电极，以及位于IEAD外壳内并电耦合到至少两个电极的脉冲发生电路。 脉冲发生电路适于根据指定的刺激方案将刺激脉冲传送到目标组织位置处或附近的患者身体组织，刺激方案要求刺激会话具有T3分钟的持续时间和发生率 每T4分钟一次，其中T3 / T4的比例不大于0.05。