公开(公告)号：US20170216632A1

公开(公告)日：2017-08-03

申请号：US15489396

申请日：2017-04-17

申请人： W. Davis Lee ,  Artur Teymurazyan ,  Mark R. Amato ,  Scott Penfold ,  James P. Bennett

发明人： W. Davis Lee ,  Artur Teymurazyan ,  Mark R. Amato ,  Scott Penfold ,  James P. Bennett

IPC分类号： A61N5/10

CPC分类号： A61N5/1081 ,  A61B6/032 ,  A61B6/037 ,  A61B6/4258 ,  A61B6/5205 ,  A61N5/103 ,  A61N5/1037 ,  A61N5/1039 ,  A61N5/1049 ,  A61N5/1067 ,  A61N5/1069 ,  A61N5/107 ,  A61N5/1077 ,  A61N5/1082 ,  A61N2005/1051 ,  A61N2005/1052 ,  A61N2005/1054 ,  A61N2005/1061 ,  A61N2005/1087 ,  A61N2005/1095 ,  A61N2005/1097 ,  G21K1/093 ,  G21K5/04

摘要： The invention comprises a method and apparatus for directing a positively charged particle beam to a tumor of a patient, comprising the steps of: (1) transporting the positively charged particle beam sequentially from a synchrotron, through a beam transport line, and through a nozzle system toward the tumor, the beam transport line comprising a rotatable beamline section; (2) pre-rotating the positively charged particle beam using a solenoid, the solenoid positioned in the beam transport line between the synchrotron and the rotatable beamline section; and (3) rotating the rotatable beamline section, where the step of pre-rotating maintains a geometric relationship between a radial cross-section of the positively charged particle beam and magnet surfaces in the rotatable beamline section as a function of rotation of the rotatable beamline section, which reduces otherwise changed dispersive forces as the rotatable beamline is positioned in separate areas about the patient.

公开(公告)号：US20170128747A1

公开(公告)日：2017-05-11

申请号：US15413066

申请日：2017-01-23

申请人： James P. Bennett ,  Kyle Schmanke ,  Lauri Reichert ,  Stephen Sledge ,  Nick Ruebel ,  Jillian Reno ,  Edward Ivanov ,  Mark R. Amato ,  Scott Penfold ,  W. Davis Lee

发明人： James P. Bennett ,  Kyle Schmanke ,  Lauri Reichert ,  Stephen Sledge ,  Nick Ruebel ,  Jillian Reno ,  Edward Ivanov ,  Mark R. Amato ,  Scott Penfold ,  W. Davis Lee

IPC分类号： A61N5/10 ,  A61B6/00

CPC分类号： A61N5/1049 ,  A61B6/032 ,  A61B6/4085 ,  A61B6/4258 ,  A61B6/5205 ,  A61B6/5235 ,  A61B6/582 ,  A61N5/1037 ,  A61N5/1067 ,  A61N5/1069 ,  A61N5/107 ,  A61N5/1077 ,  A61N5/1081 ,  A61N5/1082 ,  A61N2005/1051 ,  A61N2005/1054 ,  A61N2005/1061 ,  A61N2005/1087 ,  A61N2005/1095 ,  A61N2005/1097 ,  G21K1/08 ,  G21K5/04

摘要： The invention comprises an X-ray—positively charged particle double/dual exposure imaging apparatus and method of use thereof. Double exposure imaging of a tumor of a patient is performed using detector hardware responsive to both X-rays and positively charged particles. A near-simultaneous double exposure yields enhanced resolution due to the imaging rate versus patient movement, no requirement of a software overlay step of the X-ray based image and the positively charged particle based image, and enhancement of an X-ray image, the enhancement resultant from a differing physical interaction of the positively charged particles with the patient compared to interactions of X-rays and the patient. Further, resolution enhancements utilize individual particle tracking, as measured using detection screens, to determine a probable intra-patient path. Residual energy positively charged particles are optionally used to generate a second or dual image at a secondary detector, such as a detector detecting scintillation resultant from proton absorbance.

公开(公告)号：US20170056688A1

公开(公告)日：2017-03-02

申请号：US15348625

申请日：2016-11-10

申请人： Scott Penfold ,  W. Davis Lee ,  Mark R. Amato

发明人： Scott Penfold ,  W. Davis Lee ,  Mark R. Amato

IPC分类号： A61N5/10

CPC分类号： A61N5/1067 ,  A61B6/032 ,  A61B6/4258 ,  A61B6/5205 ,  A61N5/1037 ,  A61N5/1044 ,  A61N5/1049 ,  A61N5/1069 ,  A61N5/107 ,  A61N5/1077 ,  A61N5/1082 ,  A61N2005/1054 ,  A61N2005/1087 ,  A61N2005/1095 ,  A61N2005/1097 ,  G21K1/08 ,  G21K5/04

摘要： The invention comprises a method and apparatus for probing a tumor of a patient using positively charged particles, comprising the steps of: (1) sequentially delivering sets of varied and known positively charged particles to a patient; (2) after transmission through the patient, sequentially detecting a residual energy of each of the sets of positively charged particles; and (3) determining a water equivalent thickness of a probed path of the patient using a plot of the detector response as a function of residual energy that is fit with a curve. The analyzer relates a half maximum of the fit curve, such as a Gaussian curve, to the water equivalent thickness of the sampled beam path. Repeated measurements as a function of incident angle and/or position of the incident charged particles allows generation of an image of the sample, such as a computed tomography image.

摘要翻译： 本发明包括用于使用带正电荷的微粒探测患者肿瘤的方法和装置，其包括以下步骤：（1）将一系列不同且已知的带正电荷的颗粒顺序递送给患者; （2）通过病人传送后，依次检测各带正电粒子的剩余能量; 和（3）使用与曲线拟合的残余能量的函数的检测器响应的图来确定患者的探测路径的水当量厚度。 分析仪将拟合曲线的半值最大值（例如高斯曲线）与采样光束路径的水当量厚度相关联。 作为入射角度和/或入射带电粒子的位置的函数的重复测量允许产生样本的图像，例如计算机断层摄影图像。

公开(公告)号：US11426609B2

公开(公告)日：2022-08-30

申请号：US17171220

申请日：2021-02-09

申请人： James P. Bennett ,  W. Davis Lee ,  Mark R. Amato

发明人： James P. Bennett ,  W. Davis Lee ,  Mark R. Amato

IPC分类号： A61N5/10 ,  A61B6/03 ,  G21K5/04 ,  G21K1/093 ,  A61B6/00 ,  G21K5/10 ,  G21K1/087

摘要： The invention comprises a method and apparatus for treating a tumor of a patient with charged particles, comprising the step of developing a multi-modality treatment plan, the multi-modality treatment plan directing: (1) use of a first beam type to treat a first volume of the tumor, the first beam type a first mass per particle and (2) use of a second beam type to treat a second volume of the tumor, the second beam type comprising a second mass per particle, where the second mass per particle is at least ten percent different than the first mass per particle and the second volume differs from the first volume. The multi-modality treatment plan is optionally formed by selectively merging treatment plans using the respective particle types or is developed using properties of the multiple particle types.

公开(公告)号：US20210162239A1

公开(公告)日：2021-06-03

申请号：US17171220

申请日：2021-02-09

申请人： James P. Bennett ,  W. Davis Lee ,  Mark R. Amato

发明人： James P. Bennett ,  W. Davis Lee ,  Mark R. Amato

IPC分类号： A61N5/10 ,  A61B6/00 ,  G21K1/093 ,  A61B6/03 ,  G21K5/04 ,  G21K5/10 ,  G21K1/087

摘要： The invention comprises a method and apparatus for treating a tumor of a patient with charged particles, comprising the step of developing a multi-modality treatment plan, the multi-modality treatment plan directing: (1) use of a first beam type to treat a first volume of the tumor, the first beam type a first mass per particle and (2) use of a second beam type to treat a second volume of the tumor, the second beam type comprising a second mass per particle, where the second mass per particle is at least ten percent different than the first mass per particle and the second volume differs from the first volume. The multi-modality treatment plan is optionally formed by selectively merging treatment plans using the respective particle types or is developed using properties of the multiple particle types.

公开(公告)号：US20210025027A1

公开(公告)日：2021-01-28

申请号：US16523974

申请日：2019-07-26

申请人： W. Davis Lee ,  Mark R. Amato

发明人： W. Davis Lee ,  Mark R. Amato

IPC分类号： C22B59/00 ,  C22B5/12

摘要： The invention comprises a method and apparatus for generating a rare earth from a rare earth oxide, comprising the sequential steps of: (1) reducing temperature about the rare earth oxide to less than zero degrees Celsius; (2) reducing pressure to boil off contaminant water in a powder sample of the rare earth oxide at a molecular escape velocity not disturbing the powdered rare earth oxide; and (3) heating the rare earth oxide to greater than 1000° C. in the presence hydrogen gas while optionally: (1) collecting and determining mass of a water product to determine a consumption mass of the starting hydrogen gas in a main reaction process using the equation RE2O3+3H2→2RE+3 H2O, wherein “RE” comprises at a rare earth and (2) injecting replacement hydrogen gas into the main reaction chamber up to the consumption mass.

公开(公告)号：US10556126B2

公开(公告)日：2020-02-11

申请号：US15478927

申请日：2017-04-04

申请人： Mark R. Amato ,  Susan L. Michaud ,  James P. Bennett ,  Jillian Reno ,  W. Davis Lee ,  Nick Ruebel

发明人： Mark R. Amato ,  Susan L. Michaud ,  James P. Bennett ,  Jillian Reno ,  W. Davis Lee ,  Nick Ruebel

IPC分类号： A61N5/10

摘要： The invention comprises a method for generating a procedure for treating a tumor of a patient using positively charged particles, comprising the steps of: (1) providing a set of treatment goal specifications; (2) generating tomographic images of the tumor using a first set of groups of the positively charge particles delivered from a synchrotron; and (3) a computer implemented algorithm automatically generating a tumor radiation treatment plan, of the tumor using the positively charged particles, using the set of treatment goal specifications and the tomographic images. Optionally, the method automatically updates the radiation treatment plan upon: a detected movement of the tumor relative to surrounding patient constituents and/or upon detection of a previously unforeseen intervening object in a treatment beam path.

公开(公告)号：US20180178041A1

公开(公告)日：2018-06-28

申请号：US15892305

申请日：2018-02-08

申请人： W. Davis Lee ,  Mark R. Amato ,  Nick Ruebel ,  Jillian Reno ,  Susan L. Michaud

发明人： W. Davis Lee ,  Mark R. Amato ,  Nick Ruebel ,  Jillian Reno ,  Susan L. Michaud

IPC分类号： A61N5/10 ,  G21K5/04 ,  A61B6/03 ,  G21K1/08 ,  A61B6/00

CPC分类号： A61N5/1081 ,  A61B6/032 ,  A61B6/4258 ,  A61B6/5205 ,  A61N5/1037 ,  A61N5/1049 ,  A61N5/1067 ,  A61N5/1069 ,  A61N5/107 ,  A61N5/1077 ,  A61N5/1082 ,  A61N2005/1051 ,  A61N2005/1054 ,  A61N2005/1061 ,  A61N2005/1087 ,  A61N2005/1095 ,  A61N2005/1097 ,  G21K1/08 ,  G21K5/04

摘要： The invention comprises a fiducial marker—fiducial detector based treatment room position determination/positioning system apparatus and method of use thereof. A set of fiducial markers and fiducial detectors are used to mark/determine relative position of static and/or moveable objects in a treatment room using photons passing from the markers to the detectors. Further, position and orientation of at least one of the objects is calibrated to a reference line, such as a zero-offset beam treatment line passing through an exit nozzle, which yields a relative position of each fiducially marked object in the treatment room. Treatment calculations are subsequently determined using the reference line and/or points thereon. The treatment calculations are optionally and preferably performed without use of an isocenter point, such as a central point about which a treatment room gantry rotates, which eliminates mechanical errors associated with the isocenter point being an isocenter volume in practice.

公开(公告)号：US09981147B2

公开(公告)日：2018-05-29

申请号：US15228626

申请日：2016-08-04

申请人： W. Davis Lee ,  Mark R. Amato ,  James P. Bennett

发明人： W. Davis Lee ,  Mark R. Amato ,  James P. Bennett

IPC分类号： A61N5/00 ,  A61N5/10 ,  G21K5/04 ,  A61B6/03 ,  A61B6/00 ,  G21K1/08

CPC分类号： A61N5/1081 ,  A61B6/032 ,  A61B6/4216 ,  A61B6/4258 ,  A61B6/5205 ,  A61N5/1039 ,  A61N5/1067 ,  A61N5/107 ,  A61N5/1077 ,  A61N5/1082 ,  A61N2005/1054 ,  A61N2005/1087 ,  A61N2005/1095 ,  A61N2005/1097 ,  G21K1/08 ,  G21K5/04

摘要： The invention comprises an apparatus and method of use thereof for extracting ions from an ion source, such as for use in cancer treatment or tomographic imaging. The extraction apparatus uses a triode extraction system, with the ion source and/or first electrode held at a first potential; an extraction electrode held at a second potential; and a gating electrode, positioned between the ion source and the extraction electrode, oscillating and/or alternating between a first suppression potential proximate that of the ion source potential and a second extraction potential between the ion source potential and the extraction electrode potential. Optionally, the ion source comprises an electron cyclotron resonance ion source.

公开(公告)号：US20170348547A1

公开(公告)日：2017-12-07

申请号：US15676900

申请日：2017-08-14

申请人： W. Davis Lee ,  Mark R. Amato

发明人： W. Davis Lee ,  Mark R. Amato

IPC分类号： A61N5/10

CPC分类号： A61N5/1081 ,  A61B6/032 ,  A61B6/4085 ,  A61B6/4258 ,  A61B6/4441 ,  A61B6/5205 ,  A61N5/1037 ,  A61N5/1039 ,  A61N5/1049 ,  A61N5/1067 ,  A61N5/1069 ,  A61N5/107 ,  A61N5/1077 ,  A61N5/1082 ,  A61N2005/1051 ,  A61N2005/1054 ,  A61N2005/1061 ,  A61N2005/1087 ,  A61N2005/1095 ,  A61N2005/1097 ,  G21K1/10 ,  G21K5/04

摘要： The invention comprises a method and apparatus for reducing a kinetic energy of positively charged particles, comprising the steps of: (1) transporting the positively charged particles from an accelerator into an exit nozzle system along a beam line; (2) providing a first chamber of the exit nozzle system, the first chamber comprising: an incident side comprising an incident aperture, an exit side comprising an exit aperture, and a beam path of the positively charged particles from the incident aperture to the exit aperture; (3) filling the beam path in the chamber with a liquid; and (4) using the liquid to reduce the kinetic energy of the positively charged particles. The kinetic energy dissipater is optionally used in combination with a proton therapy cancer treatment system and/or a proton tomography imaging system.