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11.发明授权Orientia tsutsugamushi truncated recombinant outer membrane protein (R47) and (R56) vaccines diagnostics and therapeutics for scrub typhus 有权东方恙虫病截断的重组外膜蛋白（R47）和（R56）疫苗诊断和治疗恙虫病公开(公告)号：US07820395B2
公开(公告)日：2010-10-26
申请号：US11876997
申请日：2007-10-23
申请人： Wei Mei Ching , Hong Ge , Chien-Chung Chao
发明人： Wei Mei Ching , Hong Ge , Chien-Chung Chao
IPC分类号： G01N33/53 , G01N33/554 , G01N33/00
CPC分类号： A61K39/0233 , A61K39/00 , C07K14/195 , C07K16/1246 , G01N33/56911 , G01N2333/29 , G01N2469/10 , G01N2469/20 , Y02A50/403 , Y02A50/59 , Y10S530/825
摘要： A scrub typhus diagnostic method and vaccine using a composition comprising truncated r47 protein and truncated r56 protein is disclosed. Vaccines composed of r56 protein variants are also disclosed. Methods of reducing HIV viral loads using r47 and r56 proteins and antibodies raised against r47 and r56 are also disclosed.
摘要翻译： 公开了使用包含截短的r47蛋白和截短的r56蛋白的组合物的擦伤斑疹伤害诊断方法和疫苗。 还公开了由r56蛋白质变体组成的疫苗。 还公开了使用r47和r56蛋白降低HIV病毒载量的方法和针对r47和r56产生的抗体。
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12.发明授权Cloning and expression of the full length 110 kDa antigen of Orientia tsutsugamushi to be used as a vaccine component against scrub typhus 有权克隆和表达恙虫病东方全长110 kDa的抗原，用作疫苗组分，用于恙虫病公开(公告)号：US07371821B2
公开(公告)日：2008-05-13
申请号：US11108867
申请日：2005-04-19
申请人： Wei-Mei Ching , Chien-Chung Chao
发明人： Wei-Mei Ching , Chien-Chung Chao
CPC分类号： C07K14/29 , A61K38/00 , A61K48/00 , Y10S530/825
摘要： The inventive subject matter relates to a recombinant 110 kDa protein from O. tsutsugamuchi, Karp, Kato and Gilliam strains and for a DNA expression system containing DNA encoding the 110 kDa protein of O. tsutsugamuchi. The invention also relates to the use of these recombinant contructs in a formulation for the induction of a protective immune response against O. tsutsugamuchi invection using. The inventive subject matter also relates to a recombinant 110 kDa O. tsutsugamuchi protein or 110 kDa fragments for the production of antigen for use in immunodiagnosistic asssays for scrub typhus.
摘要翻译： 本发明涉及来自恙虫螨，Karp，Kato和Gilliam菌株的重组110kDa蛋白质，以及含有编码恙虫the the的110kDa蛋白质的DNA的DNA表达系统。 本发明还涉及这些重组构型在制剂中用于诱导针对恙虫病ts疮侵入的保护性免疫应答的用途。 本发明还涉及用于产生抗原的重组110kDa O. tsutsugamami蛋白或110kDa片段，用于免疫诊断性屁股用于恙虫病。
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13.发明申请ORIENTIA TSUTSUGAMUSHI TRUNCATED RECOMBINANT OUTER MEMBRANE PROTEIN (r47) AND (r56) VACCINES DIAGNOSTICS AND THERAPEUTICS FOR SCRUB TYPHUS 有权ORIENTIA TSUTSUGAMUSHI TRUNCATED重组外膜蛋白（r47）和（r56）疫苗诊断和治疗方法公开(公告)号：US20080044806A1
公开(公告)日：2008-02-21
申请号：US11876997
申请日：2007-10-23
申请人： Wei Mei Ching , Hong Ge , Chien-Chung Chao
发明人： Wei Mei Ching , Hong Ge , Chien-Chung Chao
CPC分类号： A61K39/0233 , A61K39/00 , C07K14/195 , C07K16/1246 , G01N33/56911 , G01N2333/29 , G01N2469/10 , G01N2469/20 , Y02A50/403 , Y02A50/59 , Y10S530/825
摘要： A scrub typhus diagnostic method and vaccine using a composition comprising truncated r47 protein and truncated r56 protein is disclosed. Vaccines composed of r56 protein variants are also disclosed. Methods of reducing HIV viral loads using r47 and r56 proteins and antibodies raised against r47 and r56 are also disclosed.
摘要翻译： 公开了使用包含截短的r47蛋白和截短的r56蛋白的组合物的擦伤斑疹伤害诊断方法和疫苗。 还公开了由r56蛋白质变体组成的疫苗。 还公开了使用r47和r56蛋白降低HIV病毒载量的方法和针对r47和r56产生的抗体。
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14.发明授权公开(公告)号：US08287876B2
公开(公告)日：2012-10-16
申请号：US13371578
申请日：2012-02-13
申请人： Wei-Mei Ching , Chien-Chung Chao
发明人： Wei-Mei Ching , Chien-Chung Chao
IPC分类号： A61K39/00
CPC分类号： G01N33/56911 , C07K14/195 , Y02A50/59
摘要： Recombinant chimeric antigens comprising unmodified and modified reactive polypeptide fragments of expressed product of the recombinant 56 kDa proteins of multiple strain of scrub typhus, such as Karp, Kato (Ktr56), Gilliam (Gmr56), and TA763 (TAr56). The invention is useful for detecting prior exposure to a number of strains of scrub typhus, based on the strength of reaction toward the chimeric protein and as a component in vaccine formulations and production of immune globulins for passive prophylaxis and immunity in subjects against heterologous infections.
摘要翻译： 重组嵌合抗原包括多重斑马疹病毒株，如Karp，Kato（Ktr56），Gillam（Gmr56）和TA763（TAr56）的重组56kDa蛋白的表达产物的未修饰和修饰的反应性多肽片段。 基于针对嵌合蛋白的反应强度以及作为疫苗制剂中的组分和免疫球蛋白的产生，本发明可用于检测先前暴露于许多恙虫病菌株的方法，用于针对异源感染的受试者的被动预防和免疫。
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15.发明授权Orientia tsutsugamushi truncated recombinant outer membrane protein (r47) and (r57) vaccines diagnostics and therapeutics for scrub typhus 有权东方恙虫病截断重组外膜蛋白（r47）和（r57）疫苗诊断和治疗恙虫病公开(公告)号：US07306808B2
公开(公告)日：2007-12-11
申请号：US10438345
申请日：2003-05-15
申请人： Wei Mei Ching , Hong Ge , Chien-Chung Chao
发明人： Wei Mei Ching , Hong Ge , Chien-Chung Chao
CPC分类号： A61K39/0233 , A61K39/00 , C07K14/195 , C07K16/1246 , G01N33/56911 , G01N2333/29 , G01N2469/10 , G01N2469/20 , Y02A50/403 , Y02A50/59 , Y10S530/825
摘要： A scrub typhus vaccine comprising truncated r47 protein and truncated r56 protein is disclosed. Vaccines composed of r56 protein variants are also disclosed. Methods of reducing HIV viral loads using r47 and r56 proteins and antibodies raised against r47 and r56 are also disclosed.
摘要翻译： 公开了包含截短的r47蛋白和截短的r56蛋白的擦伤斑疹伤寒疫苗。 还公开了由r56蛋白质变体组成的疫苗。 还公开了使用r47和r56蛋白降低HIV病毒载量的方法和针对r47和r56产生的抗体。
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公开(公告)号：US08142787B2
公开(公告)日：2012-03-27
申请号：US13104059
申请日：2011-05-10
申请人： Wei-Mei Ching , Chien-Chung Chao
发明人： Wei-Mei Ching , Chien-Chung Chao
IPC分类号： A61K39/00
CPC分类号： G01N33/56911 , C07K14/195 , Y02A50/59
摘要： Recombinant chimeric antigens comprising unmodified and modified reactive polypeptide fragments of expressed product of the recombinant 56 kDa proteins of multiple strain of scrub typhus, such as Karp, Kato (Ktr56), Gilliam (Gmr56), and TA763 (TAr56). The invention is useful for detecting prior exposure to a number of strains of scrub typhus, based on the strength of reaction toward the chimeric protein and as a component in vaccine formulations and production of immune globulins for passive prophylaxis and immunity in subjects against heterologous infections.
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17.发明申请公开(公告)号：US20090285857A1
公开(公告)日：2009-11-19
申请号：US12467533
申请日：2009-05-18
申请人： Wei-Mei Ching , Chien-Chung Chao
发明人： Wei-Mei Ching , Chien-Chung Chao
IPC分类号： A61K39/02 , C07K14/195 , G01N33/53 , A61P37/04
CPC分类号： G01N33/56911 , C07K14/195 , Y02A50/59
摘要： Recombinant chimeric antigens comprising unmodified and modified reactive polypeptide fragments of expressed product of the recombinant 56 kDa proteins of multiple strain of scrub typhus, such as Karp, Kato (Ktr56), Gilliam (Gmr56), and TA763 (TAr56). The invention is useful for detecting prior exposure to a number of strains of scrub typhus, based on the strength of reaction toward the chimeric protein and as a component in vaccine formulations and production of immune globulins for passive prophylaxis and immunity in subjects against heterologous infections.
摘要翻译： 重组嵌合抗原包括多重斑马疹病毒株，如Karp，Kato（Ktr56），Gillam（Gmr56）和TA763（TAr56）的重组56kDa蛋白的表达产物的未修饰和修饰的反应性多肽片段。 基于针对嵌合蛋白的反应强度以及作为疫苗制剂中的组分和免疫球蛋白的产生，本发明可用于检测先前暴露于许多恙虫病菌株的方法，用于针对异源感染的受试者的被动预防和免疫。
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公开(公告)号：US20060204430A1
公开(公告)日：2006-09-14
申请号：US11224590
申请日：2005-09-12
申请人： Lawrence Bool , Chien-Chung Chao , Mark Weise , Jurron Bradley
发明人： Lawrence Bool , Chien-Chung Chao , Mark Weise , Jurron Bradley
IPC分类号： C01D3/00
CPC分类号： C10J3/485 , B01J20/20 , C01B32/336 , C10J2300/093 , C10J2300/0959 , C10J2300/0973 , C10J2300/1846
摘要： A gas mixture preheated to high temperatures using an oxy-fuel, an oxygen-enriched air-fuel or an air-fuel burner is used to devolatilize and partially oxidize carbonaceous feedstock, thereby producing an active residual char that can be used in applications utilizing activated carbon. Use of hot gas and ground carbonaceous feedstock allows the equipment to be minimized, thereby allowing the activated carbon to be produced at or near points of use, for example the production of activated char at or near utility boilers for use in the reduction of mercury emissions from flue gas streams.
摘要翻译： 使用氧燃料，富氧空气燃料或空气 - 燃料燃烧器预热至高温的气体混合物用于使含碳原料脱挥发分并部分氧化，从而产生活性残余炭，其可用于利用活化的 碳。 使用热气和粉碎的碳质原料可使设备最小化，从而允许在使用点或附近生产活性炭，例如在用于减少汞排放的公用锅炉附近生产活性炭 来自烟气流。
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19.发明授权Catalytic adsorbents for mercury removal from flue gas and methods of manufacture therefor 有权用于从烟道气中除汞的催化吸附剂及其制造方法公开(公告)号：US08609580B2
公开(公告)日：2013-12-17
申请号：US13219209
申请日：2011-08-26
IPC分类号： B01J20/20
CPC分类号： B01D53/64 , B01D53/8665 , B01D2251/60 , B01D2253/102 , B01D2257/602 , B01J20/046 , B01J20/20 , B01J20/3204 , B01J20/3236
摘要： The present invention provides catalytic adsorbents formed from doping activated carbon with a dispersed halide salt. The catalytic adsorbents provided herein are stable and harmless at room temperature, yet allow for chemical adsorption at elevated temperatures typical of those for flue gas streams. The present invention also provides methods of manufacturing the doped activated carbon adsorbents.
摘要翻译： 本发明提供了通过用分散的卤化物盐掺杂活性炭形成的催化吸附剂。 本文提供的催化吸附剂在室温下是稳定和无害的，但允许在用于烟道气流的典型的高温下进行化学吸附。 本发明还提供了制造掺杂的活性炭吸附剂的方法。
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公开(公告)号：US08328909B2
公开(公告)日：2012-12-11
申请号：US12788565
申请日：2010-05-27
CPC分类号： B01D53/10 , B01D53/8665 , B01D2251/402 , B01D2251/604 , B01D2253/102 , B01D2255/20 , B01D2255/202 , B01D2255/204 , B01D2257/602 , B01J20/0237 , B01J20/0288 , B01J20/041 , B01J20/046 , B01J20/10 , B01J20/20 , B01J20/3078 , B01J20/3204 , B01J20/3236 , B01J2220/42 , B01J2220/4812 , B01J2220/4837 , C04B18/08 , Y02W30/92
摘要： Solid adsorbents, following their use for mercury removal from flue gas, that do not interfere with the ability of air-entraining additives (such as surfactants) to form stable bubbles when added to fly ash containing the adsorbents. The interference is overcome by heating the materials used in the manufacture of the adsorbent so that magnesium hydroxide and/or one or more alkali compounds containing one or more silicate, aluminate, and/or phosphate moiety, added or already present in the materials, binds multivalent cations present in the materials that could otherwise interfere with the surfactant activity.
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