公开(公告)号：US4992598A

公开(公告)日：1991-02-12

申请号：US478072

申请日：1990-02-09

Applicant: Heinz Strutz ,  Werner Mueller

Inventor： Heinz Strutz ,  Werner Mueller

IPC: C07C37/68 ,  C07C37/70 ,  C07C37/82 ,  C07C39/16

CPC classification number: C07C37/70 ,  C07C37/685 ,  C07C37/82 ,  C07C37/84

Abstract: A process for the purificationof 1,1,1-tris(4'-hydroxyphenyl)ethane by washing a crude admixture containing both it and impurities with a saturated solution of 1,1,1-tris(4'-hydroxyphenyl)ethane in water and methanol; and isolating the washed crude admixture from the effluent and dissolving the washed crude admixture in methanol, and adding water and sodium borohydride to the dissolved, washed crude admixture to form a precipitate of 1,1,1-tris(4'-hydroxyphenyl)ethane, and filtering the precipitate to form a resultant purified 1,1,1-tris(4'-hydroxyphenyl)ethane and a filtrate. Another embodiment of the invention provides iteratively repeating the process by washing an additional crude admixture batch with the filtrate from a prior purification.

公开(公告)号：US4158485A

公开(公告)日：1979-06-19

申请号：US885200

申请日：1978-03-10

Applicant: Werner Mueller ,  Christoph Rotter ,  Wolfgang Welsch

Inventor： Werner Mueller ,  Christoph Rotter ,  Wolfgang Welsch

IPC: G02F1/1339 ,  G02F1/13

CPC classification number: G02F1/1339

Abstract: A liquid crystal cell having a chamber for receiving a layer of liquid crystal material which chamber is defined by a pair of plate members joined together adjacent their edges by a substantially continuous glass solder seal characterized by the glass solder seal being provided in the form of one or more glass fibers which are interposed between the plates and fused to form the glass solder seal. To facilitate positioning the one or more glass solder fibers, positioning means are provided on one surface of one of the plates and may be protruberances which are formed either by crystallizing glass solder, or by laser bombardment of the one surface. To facilitate the obtaining of the desired spacing between the plates, each of the glass fibers may have a core which may be either hard glass or a metal such as gold which core is surrounded by a lower melting glass so that during fusion of the fiber, the core remains substantially unmelted. In another embodiment, the glass fibers contain a material, such as being impregnated with CuO, which will absorb infrared radiation so that during the method of forming the cell, the step of heating to fuse the fibers includes subjecting the fibers to infrared radiation after preheating the assembled plates and fibers.

Abstract translation: 一种具有用于接收液晶材料层的室的液晶单元，该室由一对板构件限定，所述一对板构件通过基本上连续的玻璃焊料密封接合在其边缘附近，其特征在于所述玻璃焊料密封件以一个形式提供 或更多的玻璃纤维，其插入在板之间并熔化以形成玻璃焊料密封。 为了便于定位一个或多个玻璃焊料纤维，定位装置设置在一个板的一个表面上，并且可以是通过使玻璃焊料结晶或通过一个表面的激光轰击形成的突起。 为了便于获得板之间的期望间隔，每个玻璃纤维可以具有芯，其可以是硬玻璃或金属，例如金，该芯由下熔融玻璃围绕，使得在纤维融合期间， 核心基本上未熔化。 在另一个实施方案中，玻璃纤维含有诸如被CuO浸渍的材料，其将吸收红外辐射，使得在形成电池的方法期间，加热熔化纤维的步骤包括在预热之后对纤维进行红外辐射 组装板和纤维。

公开(公告)号：US10029011B2

公开(公告)日：2018-07-24

申请号：US13509542

申请日：2010-11-11

Applicant: Annika Hagendorf ,  Gerrit Hauck ,  Werner Mueller ,  Isabell Schoettle ,  Verena Siefke-Henzler ,  Katrin Tertsch

Inventor： Annika Hagendorf ,  Gerrit Hauck ,  Werner Mueller ,  Isabell Schoettle ,  Verena Siefke-Henzler ,  Katrin Tertsch

IPC: A61K38/28 ,  A61P5/50 ,  C07K14/62 ,  A61K33/30 ,  A61K38/00 ,  A61P3/08 ,  A61P3/10 ,  A61K38/26 ,  A61P7/12 ,  C07K14/605 ,  A61K47/10 ,  A61K9/00 ,  A61K47/18

Abstract: A liquid composition comprising a GLP-1 agonist or/and a pharmacologically tolerable salt thereof, an insulin or/and a pharmacologically tolerable salt thereof, and, optionally, at least one pharmaceutically acceptable excipient, wherein the composition comprises methionine, as add-on therapy with metformin where appropriate.

公开(公告)号：US09022560B2

公开(公告)日：2015-05-05

申请号：US13988239

申请日：2011-11-16

Applicant: Wolfgang Becken ,  Gregor Esser ,  Helmut Altheimer ,  Edda Wehner ,  Stephan Trumm ,  Werner Mueller ,  Dietmar Uttenweiler

Inventor： Wolfgang Becken ,  Gregor Esser ,  Helmut Altheimer ,  Edda Wehner ,  Stephan Trumm ,  Werner Mueller ,  Dietmar Uttenweiler

IPC: G02C7/06 ,  G02C7/02

CPC classification number: G02C7/022 ,  G02C7/02 ,  G02C7/024 ,  G02C7/028 ,  G02C7/06 ,  G02C7/061 ,  G02C7/068 ,  G02C2202/20 ,  G02C2202/22

Abstract: A method for producing a series of base lenses, which cover a predetermined power range, wherein each base lens of the series has a base power different from the base powers of the other base lenses of the series, and has at least one diffractive base grating, the method comprising: specifying the base powers of each base lens of the series and calculating the base grating of each base lens of the series so as to minimize the color fringe of the respective base lens with the specified base power in a predetermined region of the spectacle lens.

Abstract translation: 一种用于制造覆盖预定功率范围的一系列基座透镜的方法，其中该系列的每个基底透镜具有与该系列的其它基座透镜的基本功率不同的基本功率，并且具有至少一个衍射基准光栅 该方法包括：指定该系列的每个基础镜头的基本功率，并计算该系列的每个基座镜头的基本光栅，以便在具有指定的基本功率的相应基础镜头的预定区域中使颜色条纹最小化 眼镜镜片。

公开(公告)号：US08757800B2

公开(公告)日：2014-06-24

申请号：US12524315

申请日：2008-01-25

Applicant: Gregor Esser ,  Wolfgang Becken ,  Helmut Altheimer ,  Anne Seidemann ,  Dietmar Uttenweiler ,  Werner Mueller ,  Edda Wehner

Inventor： Gregor Esser ,  Wolfgang Becken ,  Helmut Altheimer ,  Anne Seidemann ,  Dietmar Uttenweiler ,  Werner Mueller ,  Edda Wehner

IPC: G02C7/02

CPC classification number: G02C7/027 ,  G02C7/02 ,  G02C7/028 ,  G02C7/061 ,  G02C2202/22

Abstract: The invention relates to a method, a computer program product and a system for designing or producing a spectacle lens for a spectacle wearer. Said method consists of the following steps: individual user data or application data of the spectacle wearer is obtained; the design concept for the spectacle lens having a plurality of evaluation points is determined; a main beam path through the plurality of evaluation points is determined; a local wavefront is specified for each of the main beams in the surroundings of the respective main beam; optical properties of the spectacle lens are determined on the evaluation points by determining an influence of the spectacle lens on the local wavefronts in the surroundings of the respective evaluation point; and the design concept is evaluated in accordance with the determined optical properties and the individual user data.

Abstract translation: 本发明涉及一种用于眼镜佩戴者的眼镜镜片的设计或制造方法，计算机程序产品和系统。 所述方法包括以下步骤：获得眼镜佩戴者的个人用户数据或应用数据; 确定具有多个评价点的眼镜镜片的设计概念; 确定通过多个评估点的主光束路径; 为相应主光束的周围的每个主光束指定局部波前; 通过确定眼镜镜片对各评估点的周围的局部波前的影响，在评价点上确定眼镜片的光学特性; 并且根据确定的光学性质和各个用户数据来评估设计概念。

公开(公告)号：US08450313B2

公开(公告)日：2013-05-28

申请号：US13477217

申请日：2012-05-22

Applicant: Daniel Hunziker ,  Christian Lerner ,  Werner Mueller ,  Ulrike Obst Sander ,  Philippe Pflieger ,  Pius Waldmeier

Inventor： Daniel Hunziker ,  Christian Lerner ,  Werner Mueller ,  Ulrike Obst Sander ,  Philippe Pflieger ,  Pius Waldmeier

IPC: A61K31/538 ,  C07D265/30 ,  C07D413/10

CPC classification number: C07D413/10 ,  C07C255/54 ,  C07C255/57 ,  C07D213/63 ,  C07D235/26 ,  C07D263/58 ,  C07D265/36 ,  C07D285/14 ,  C07D317/46 ,  C07D317/54 ,  C07D317/60 ,  C07D401/10 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D455/02 ,  C07D498/04

Abstract: The present invention relates to compounds of formula I wherein R1a to R1e, R2, R3 and R5 are as defined in the description and claims and R4 signifies a bicyclic heteroaryl group or a cyanophenyl group, as well as pharmaceutically acceptable salts thereof. The compounds are glucocorticoid receptor antagonists useful for the treatment and/or prevention of diseases such as diabetes, dyslipidemia, obesity, hypertension, cardiovascular diseases, adrenal imbalance or depression.

Abstract translation: 本发明涉及式I化合物，其中R 1a至R 11，R 2，R 3和R 5如说明书和权利要求中所定义，R 4表示双环杂芳基或氰基苯基，以及其药学上可接受的盐。 该化合物是可用于治疗和/或预防糖尿病，血脂异常，肥胖，高血压，心血管疾病，肾上腺不平衡或抑郁症等疾病的糖皮质激素受体拮抗剂。

公开(公告)号：US20120295846A1

公开(公告)日：2012-11-22

申请号：US13509542

申请日：2010-11-11

Applicant: Annika Hagendorf ,  Gerrit Hauck ,  Werner Mueller ,  Isabell Schoettle ,  Verena Siefke-Henzler ,  Katrin Tertsch

Inventor： Annika Hagendorf ,  Gerrit Hauck ,  Werner Mueller ,  Isabell Schoettle ,  Verena Siefke-Henzler ,  Katrin Tertsch

IPC: A61K38/28 ,  A61P3/04 ,  A61P3/10

CPC classification number: A61K47/10 ,  A61K9/0019 ,  A61K38/26 ,  A61K38/28 ,  A61K47/183 ,  C07K14/605 ,  C07K14/62 ,  A61K2300/00

Abstract: A liquid composition comprising a GLP-1 agonist or/and a pharmacologically tolerable salt thereof, an insulin or/and a pharmacologically tolerable salt thereof, and, optionally, at least one pharmaceutically acceptable excipient, wherein the composition comprises methionine, as add-on therapy with metformin where appropriate.

Abstract translation: 一种液体组合物，其包含GLP-1激动剂或/和其药理学上可耐受的盐，胰岛素或/和其药理学上可耐受的盐，以及任选的至少一种药学上可接受的赋形剂，其中所述组合物包含甲硫氨酸，作为附加 酌情用二甲双胍治疗。

公开(公告)号：US08303113B2

公开(公告)日：2012-11-06

申请号：US12524302

申请日：2008-01-25

Applicant: Gregor Esser ,  Helmut Altheimer ,  Wolfgang Becken ,  Robert Bichler ,  Anne Seidemann ,  Martin Zimmerman ,  Werner Mueller ,  Jochen Brosig ,  Dietmar Uttenweiler

Inventor： Gregor Esser ,  Helmut Altheimer ,  Wolfgang Becken ,  Robert Bichler ,  Anne Seidemann ,  Martin Zimmerman ,  Werner Mueller ,  Jochen Brosig ,  Dietmar Uttenweiler

IPC: G02C7/02 ,  G02C7/06

CPC classification number: G02C7/061 ,  G02C7/027 ,  G02C13/005

Abstract: The invention relates to a method for producing a progressive spectacle lens and to a corresponding apparatus, a computer program product, a storage medium and to the use of a progressive spectacle lens. The invention also relates to a method for producing a progressive spectacle lens for correcting defective vision of a spectacle wearer, comprising the following steps: the vertical and/or the horizontal spatial position of a distance reference point and/or a near reference point is specified or determined in accordance with individual data of the spectacle wearer; the spectacle lens is optimized or calculated such that the required dioptric effect of the spectacle lens is obtained in the individually determined distance reference point and/or the near reference point.

Abstract translation: 本发明涉及一种渐进式眼镜镜片的制造方法以及相应的装置，计算机程序产品，存储介质以及逐行眼镜镜片的使用。 本发明还涉及一种用于制造用于矫正眼镜佩戴者的缺陷视力的渐进式眼镜镜片的方法，包括以下步骤：指定距离参考点和/或近参考点的垂直和/或水平空间位置 或根据眼镜佩戴者的个人数据确定; 优化或计算眼镜镜片，使得在单独确定的距离参考点和/或近参考点中获得眼镜镜片的所需度数效果。

公开(公告)号：US20100249124A1

公开(公告)日：2010-09-30

申请号：US12727271

申请日：2010-03-19

Applicant: Daniel Hunziker ,  Christian Lerner ,  Werner Mueller ,  Ulrike Obst Sander ,  Philippe Pflieger ,  Pius Waldmeier

Inventor： Daniel Hunziker ,  Christian Lerner ,  Werner Mueller ,  Ulrike Obst Sander ,  Philippe Pflieger ,  Pius Waldmeier

IPC: A61K31/538 ,  C07D265/36 ,  C07D455/02 ,  A61K31/4375 ,  C07D235/26 ,  A61K31/4184 ,  C07D401/10 ,  A61K31/4439 ,  C07D317/46 ,  A61K31/36 ,  C07D241/14 ,  A61K31/497 ,  C07D263/54 ,  A61K31/423 ,  C07D215/58 ,  A61K31/473 ,  C07C255/50 ,  A61K31/277 ,  C07D285/14 ,  A61K31/433 ,  C07D239/34 ,  C07D413/10 ,  A61P9/00 ,  A61P3/04 ,  A61P25/24 ,  A61P3/10

CPC classification number: C07D413/10 ,  C07C255/54 ,  C07C255/57 ,  C07D213/63 ,  C07D235/26 ,  C07D263/58 ,  C07D265/36 ,  C07D285/14 ,  C07D317/46 ,  C07D317/54 ,  C07D317/60 ,  C07D401/10 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D455/02 ,  C07D498/04

Abstract: The present invention relates to compounds of formula I wherein R1a to R1c, R2, R3 and R5 are as defined in the description and claims and R4 signifies a bicyclic heteroaryl group or a cyanophenyl group, as well as pharmaceutically acceptable salts thereof. The compounds are glucocorticoid receptor antagonists useful for the treatment and/or prevention of diseases such as diabetes, dyslipidemia, obesity, hypertension, cardiovascular diseases, adrenal imbalance or depression.

Abstract translation: 本发明涉及式I化合物，其中R 1a至R 1c，R 2，R 3和R 5如说明书和权利要求书中所定义，R 4表示双环杂芳基或氰基苯基，以及其药学上可接受的盐。 该化合物是可用于治疗和/或预防糖尿病，血脂异常，肥胖，高血压，心血管疾病，肾上腺不平衡或抑郁症等疾病的糖皮质激素受体拮抗剂。

公开(公告)号：US20100198817A1

公开(公告)日：2010-08-05

申请号：US12668711

申请日：2008-07-14

Applicant: Gregor Esser ,  Anne Seidemann ,  Wolfgang Becken ,  Edda Wehner ,  Helmut Altheimer ,  Werner Mueller ,  Dietmar Uttenweiler

Inventor： Gregor Esser ,  Anne Seidemann ,  Wolfgang Becken ,  Edda Wehner ,  Helmut Altheimer ,  Werner Mueller ,  Dietmar Uttenweiler

IPC: G06F17/30

CPC classification number: G02C7/02 ,  G02C2202/22

Abstract: The present invention relates in summary to a method for checking and/or determining user data of a spectacle lens user comprising the steps of:—providing (S1) subjective data of a spectacle lens user, wherein the subjective data comprise at least subjective refraction data;—providing (S2) objective refraction data of the spectacle lens user;—comparing (S3) at least one subset of the subjective refraction data with at least one subset of the objective refraction data and determining a comparison result;—matching (S3) at least the subset of the subjective refraction data to the objective refraction data on the basis of the comparison result under the assumption that the comparison result fulfills at least one predetermined comparison condition, otherwise maintaining at least the subset of the subjective refraction data and/or—providing a message containing the comparison result, and to a further method, a computer program product and two devices for checking and/or determining user data.

Abstract translation: 本发明总结涉及一种用于检查和/或确定眼镜镜片用户的用户数据的方法，包括以下步骤： - 提供（S1）眼镜镜片用户的主观数据，其中主观数据至少包括主观折射数据 提供（S2）眼镜镜片用户的客观折射数据; - 将主观折射数据的至少一个子集与目标折射数据的至少一个子集进行比较（S3）并确定比较结果; - 匹配（S3） 至少基于比较结果的主观折射数据的子主体折射数据到比较结果，假设比较结果满足至少一个预定的比较条件，否则至少保持主观折射数据的子集和/或 - 提供包含比较结果的消息，以及另一方法，计算机程序产品和用于检查和/或确定的两个设备 用户数据。