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26 条记录 (耗时 0.02 秒)

    5-(Optionally substituted phenyl)-6H-1,3,4-thiadiazine-2-amines
    12.
    发明授权
    5-(Optionally substituted phenyl)-6H-1,3,4-thiadiazine-2-amines 失效
    5-（任选取代的苯基）-6H-1,3,4-噻二嗪-2-胺

    公开(公告)号：US4272532A

    公开(公告)日：1981-06-09

    申请号：US71954

    申请日：1979-09-04

    申请人： Winton D. Jones ,  Francis P. Miller

    发明人： Winton D. Jones ,  Francis P. Miller

    IPC分类号： C07D285/16 ,  A61K31/54

    CPC分类号： C07D285/16

    摘要： A method of inducing sedation in a patient comprises administering to a patient in which sedation is desired an amount effective for inducing sedation of a compound of the formula ##STR1## wherein R is H, or C.sub.1-5 or 7 -straight or branched chain alkyl:R.sub.1 is H, C.sub.1-5 or 7 -straight or branched chain alkyl or allyl;R.sub.2 is phenyl or phenyl substituted with F, Cl, Br, NO.sub.2, C.sub.1-5 straight or branched chain alkyl, C.sub.1-5 straight or branched chain alkoxy, 2,4-di-Cl, 2,4-di-F or 2,4-di-Br, with the proviso that when the phenyl group is monosubstituted with F, the F atom is not in the o-position; andR.sub.3 is H or C-1-5 straight or branched chain alkyl, with the proviso that when R.sub.3 is straight or branched chain alkyl, R.sub.2 is unsubstituted phenyl; ora pharmaceutically acceptable acid addition salt thereof.

    摘要翻译： 诱导患者镇静的方法包括向需要镇静的患者施用有效诱导下式化合物镇静的量，其中R为H，或C 1-5或7-直链或支链烷基 R1为H，C1-5或7-直链或支链烷基或烯丙基; R2是苯基或被F，Cl，Br，NO2，C1-5直链或支链烷基，C1-5直链或支链烷氧基，2,4-二Cl，2,4-di-F或2 ，4-二-Br，条件是当苯基被F单取代时，F原子不在o位; 且R 3为H或C 1-5直链或支链烷基，条件是当R 3为直链或支链烷基时，R 2为未取代的苯基; 或其药学上可接受的酸加成盐。

    3-aryl-5-alkylthio-4H-1,2,4-triazoles
    13.
    发明授权
    3-aryl-5-alkylthio-4H-1,2,4-triazoles 失效
    3-芳基-5-烷硫基-4H-1,2,4-三唑

    公开(公告)号：US5260450A

    公开(公告)日：1993-11-09

    申请号：US928256

    申请日：1992-08-11

    申请人： John M. Kane ,  Francis P. Miller

    发明人： John M. Kane ,  Francis P. Miller

    IPC分类号： C07D249/12 ,  C07D401/04 ,  C07D409/04

    CPC分类号： C07D401/04 ,  C07D249/12 ,  C07D409/04

    摘要： This invention relates to novel sulfone and sulfoxide derivatives of 3-aryl-5-alkylthio-4H-1,2,4-triazoles and to the use of 3-aryl-5-alkylthio-, alkylsulfinyl- and alkylsulfonyl-4H-1,2,4-triazoles in the treatment of patients suffering from convulsant seizures.

    摘要翻译： 本发明涉及3-芳基-5-烷硫基-4H-1,2,4-三唑的新型砜和亚砜衍生物以及3-芳基-5-烷硫基 - 烷基亚磺酰基 - 和烷基磺酰基-4H-1的用途， 2,4-三唑治疗患有惊厥发作的患者。