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1.发明授权1,4-Disubstituted-piperidinyl compounds useful as analgesics and muscle relaxants 失效可用作镇痛药和肌肉松弛剂的1,4-二取代哌啶基化合物
公开(公告)号：US4870083A
公开(公告)日：1989-09-26
申请号：US254208
申请日：1988-10-11
IPC分类号： A61K31/445 , A61K31/4465 , A61P25/04 , C07D211/22
CPC分类号： C07D211/22
摘要： The present invention relates to 1,4-disubstituted-piperidinyl compounds and their use as analgesic agents and as muscle relaxants.
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2.发明授权Use of 1,4-disubstituted-piperidinyl compounds for analgesia and muscle relaxation 失效用于麻醉和松弛放松的1,4-二异丁基哌啶化合物的应用
公开(公告)号：US5162342A
公开(公告)日：1992-11-10
申请号：US725704
申请日：1991-07-03
IPC分类号： C07D211/22 , C07D211/32
CPC分类号： C07D211/22 , C07D211/32 , Y10S514/906
摘要： The present invention relates to 1,4-disubstituted-piperidinyl compounds that have utility as analgesics and as muscle relaxants.
摘要翻译： 本发明涉及作为止痛剂和肌肉松弛剂有用的1,4-二取代哌啶基化合物。
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公开(公告)号：US5064838A
公开(公告)日：1991-11-12
申请号：US279900
申请日：1988-12-07
IPC分类号： A61K20060101 , A61K31/00 , A61K31/445 , A61K31/451 , A61P21/00 , A61P21/02 , A61P25/04 , C07D20060101 , C07D211/18 , C07D211/22 , C07D211/32
CPC分类号： C07D211/22 , C07D211/32
摘要： The present invention relates to 1,4-disubstituted-piperidinyl compounds that have utility as analgesics and as muscle relaxants.
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公开(公告)号：US5500433A
公开(公告)日：1996-03-19
申请号：US371063
申请日：1995-01-10
申请人： Albert A. Carr , Richard C. Dage , John E. Koerner , Tung Li , Francis P. Miller , Thaddeus R. Nieduzak , Mark W. Dudley , . Christopher J. Schmidt , Robert A. Frank
发明人： Albert A. Carr , Richard C. Dage , John E. Koerner , Tung Li , Francis P. Miller , Thaddeus R. Nieduzak , Mark W. Dudley , . Christopher J. Schmidt , Robert A. Frank
IPC分类号： C07D211/32 , A61K31/445
CPC分类号： C07D211/32 , Y10S514/81 , Y10S514/811 , Y10S514/812 , Y10S514/813 , Y10S514/821 , Y10S514/822
摘要： The present invention is directed to a new class of piperidinyl medicinal agents which are useful for treating drug abuse.
摘要翻译： 本发明涉及可用于治疗药物滥用的新一类哌啶基药物。
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公开(公告)号：US5292752A
公开(公告)日：1994-03-08
申请号：US847971
申请日：1992-03-05
申请人： Albert A. Carr , Richard C. Dage , John E. Koerner , Tung Li , Francis P. Miller , Thaddeus R. Nieduzak
发明人： Albert A. Carr , Richard C. Dage , John E. Koerner , Tung Li , Francis P. Miller , Thaddeus R. Nieduzak
IPC分类号： C07D211/32 , A61K31/445
CPC分类号： C07D211/32 , Y10S514/81 , Y10S514/811 , Y10S514/812 , Y10S514/813 , Y10S514/821 , Y10S514/822
摘要： The present invention is directed to a new class of piperidinyl medicinal agents which are useful as antithrombotic agents and as serotonin 5HT.sub.2 antagonists.
摘要翻译： 本发明涉及可用作抗血栓形成剂和5-羟色胺5HT 2拮抗剂的新一类哌啶基药物。
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6.发明授权1-piperidinyl alkanoylanyl sulfonamides for treatment of cardiac arrhythmia 失效用于治疗心律失常的1-哌啶基烷酰基烷基磺酰胺
公开(公告)号：US5478846A
公开(公告)日：1995-12-26
申请号：US279623
申请日：1994-07-22
IPC分类号： C07D211/22 , C07D211/32 , A61K31/445 , C07D211/28
CPC分类号： C07D211/22 , C07D211/32
摘要： The present invention is direct to a new class of 1-piperidinyl alkanoarylsulfonamides of the formula I ##STR1## wherein R, X, m, n, and Alk are defined in the specification, and their use as antiarrhythmic agents.
摘要翻译： 本发明直接涉及新一类式I的1-哌啶基烷酰基芳基磺酰胺，其中R，X，m，n和Alk在说明书中定义，以及它们作为抗心律不齐剂的用途。
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7.发明申请Novel Heterocyclic Substituted Carbonyl Derivatives and Their Use as Dopamine D3 Receptor Ligands 失效新型杂环取代羰基衍生物及其作为多巴胺D3受体配体的用途公开(公告)号：US20090247509A1
公开(公告)日：2009-10-01
申请号：US12425731
申请日：2009-04-17
申请人： James A. Hendrix , Horst Hemmerle , Matthias Urmann , Gregory M. Shutske , Joseph T. Strupczewski , Kenneth J. Bordeau , John G. Jurcak , Thaddeus R. Nieduzak , Sharon A. Jackson , Paul Angell , James P. Carey , George Lee , David Fink , Jean-Francois Sabuco , Yulin Chiang , Nicola Collar
发明人： James A. Hendrix , Horst Hemmerle , Matthias Urmann , Gregory M. Shutske , Joseph T. Strupczewski , Kenneth J. Bordeau , John G. Jurcak , Thaddeus R. Nieduzak , Sharon A. Jackson , Paul Angell , James P. Carey , George Lee , David Fink , Jean-Francois Sabuco , Yulin Chiang , Nicola Collar
IPC分类号： A61K31/496 , C07D409/04 , C07D403/04 , C07D401/04 , C07D295/10 , C07D498/04 , C07D413/14 , C07D401/14 , A61K31/497 , A61K31/4965 , A61K31/454 , A61K31/551 , A61K31/4545 , A61K31/453
CPC分类号： A61K31/496 , C07D209/08 , C07D213/74 , C07D215/40 , C07D231/12 , C07D233/56 , C07D239/42 , C07D241/04 , C07D241/20 , C07D249/08 , C07D261/20 , C07D295/14 , C07D295/155 , C07D307/66 , C07D307/68 , C07D317/58 , C07D333/58 , C07D333/66 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/04 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D471/06 , C07D495/04 , C07D498/04
摘要： The invention relates to heterocyclic substituted carbonyl derivatives that display selective binding to dopamine D3 receptors. In another aspect, the invention relates to a method for treating central nervous system disorders associated with the dopamine D3 receptor activity in a patient in need of such treatment comprising administering to the subject a therapeutically effective amount of said compounds for alleviation of such disorder. The central nervous system disorders that may be treated with these compounds include Psychotic Disorders, Substance Dependence, Substance Abuse, Dyskinetic Disorders (e.g. Parkinson's Disease, Parkinsonism, Neuroleptic-Induced Tardive Dyskinesia, Gilles de la Tourette Syndrome and Huntington's Disease), Dementia, Anxiety Disorders, Sleep Disorders, Circadian Rhythm Disorders and Mood Disorders. The subject invention is also directed towards processes for the preparation of the compounds described herein as well as methods for making and using the compounds as imaging agents for dopamine D3 receptors.
摘要翻译： 本发明涉及显示与多巴胺D3受体的选择性结合的杂环取代的羰基衍生物。 另一方面，本发明涉及一种治疗需要这种治疗的患者中与多巴胺D3受体活性相关的中枢神经系统障碍的方法，其包括向受试者施用治疗有效量的所述化合物以减轻这种病症。 可能用这些化合物治疗的中枢神经系统疾病包括心理障碍，物质依赖性，物质滥用，运动障碍（例如帕金森病，帕金森综合征，神经灵敏诱导的迟发性运动障碍，杜氏综合征和亨廷顿疾病），痴呆，焦虑 疾病，睡眠障碍，昼夜节律紊乱和情绪障碍。 本发明还涉及本文所述化合物的制备方法以及制备和使用化合物作为多巴胺D3受体的显像剂的方法。
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