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公开(公告)号：US09279114B2
公开(公告)日：2016-03-08
申请号：US13490559
申请日：2012-06-07
CPC分类号： C12N9/52 , A23J3/346 , A23K20/189 , A23K50/30 , A23K50/60 , A23K50/75 , C11D3/38609 , C11D3/38618
摘要： Proteases derived from Nocardiopsis dassonvillei subsp. dassonvillei DSM 43235, Nocardiopsis prasina DSM 15649, Nocardiopsis prasina (previously alba) DSM 14010 Nocardiopsis sp. DSM 16424, Nocardiopsis alkaliphila DSM 44657 and Nocardiopsis lucentensis DSM 44048, as well as homologous proteases; their recombinant production in various hosts, including transgenic plants and non-human animals, and their use in animal feed and detergents. The proteases are acid-stable, alkali-stable, and/or thermostable.
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公开(公告)号：US20120321746A1
公开(公告)日：2012-12-20
申请号：US13490559
申请日：2012-06-07
IPC分类号： C12N9/52 , C12N15/57 , C12N15/63 , A23K1/165 , C12N5/10 , C12N1/15 , C12N1/19 , C12S3/14 , C12N1/21
CPC分类号： C12N9/52 , A23J3/346 , A23K20/189 , A23K50/30 , A23K50/60 , A23K50/75 , C11D3/38609 , C11D3/38618
摘要： Proteases derived from Nocardiopsis dassonvillei subsp. dassonvillei DSM 43235, Nocardiopsis prasina DSM 15649, Nocardiopsis prasina (previously alba) DSM 14010 Nocardiopsis sp. DSM 16424, Nocardiopsis alkaliphila DSM 44657 and Nocardiopsis lucentensis DSM 44048, as well as homologous proteases; their recombinant production in various hosts, including transgenic plants and non-human animals, and their use in animal feed and detergents. The proteases are acid-stable, alkali-stable, and/or thermostable.
摘要翻译： 衍生自Nocardiopsis dassonvillei subsp。 dassonvillei DSM 43235，Nocardiopsis prasina DSM 15649，Nocardiopsis prasina（以前的alba）DSM 14010 Nocardiopsis sp。 DSM 16424，Nocardiopsis alkaliphila DSM 44657和Nocardiopsis lucentensis DSM 44048以及同源蛋白酶; 其在各种宿主中的重组生产，包括转基因植物和非人类动物，以及它们在动物饲料和洗涤剂中的应用。 蛋白酶是酸稳定的，碱稳定的和/或热稳定的。
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公开(公告)号：US20110158976A1
公开(公告)日：2011-06-30
申请号：US11597273
申请日：2005-05-24
申请人： Allan Svendsen , Svend Kaasgaard , Kim Borch , Morten Fischer , Dan Pettersson , Peter Colin Gregory
发明人： Allan Svendsen , Svend Kaasgaard , Kim Borch , Morten Fischer , Dan Pettersson , Peter Colin Gregory
CPC分类号： A61K38/482 , A61K38/465 , A61K38/47 , A61K2300/00
摘要： The pharmaceutical use of proteases related to a protease derived from Nocardiopsis sp. NRRL 18262 (SEQ ID NO: 1), optionally in combination with a lipase and/or an amylase. Examples of medical indications are: Treatment of digestive disorders, pancreatic exocrine insufficiency (PEI), pancreatitis, cystic fibrosis, diabetes type I, and/or diabetes type II.
摘要翻译： 与来自诺卡氏菌属的蛋白酶有关的蛋白酶的药物用途 NRRL 18262（SEQ ID NO：1），任选与脂肪酶和/或淀粉酶组合。 医学适应症的例子有：消化系统疾病，胰腺外分泌功能不全（PEI），胰腺炎，囊性纤维化，I型糖尿病和/或II型糖尿病的治疗。
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公开(公告)号：US20050058747A1
公开(公告)日：2005-03-17
申请号：US10873593
申请日：2004-06-21
IPC分类号： A23K3/00 , C07H21/04 , C11D3/386 , C12N9/08 , C12N9/52 , C12N9/54 , C12N9/58 , C12N15/57 , C12N15/74
CPC分类号： C12N9/52 , A01K2217/05 , C12N9/58 , C12N2310/111
摘要： The present invention relates to thermostable proteases homologous to proteases derived from Nocardiopsis, and the production thereof by the wild-type, and in recombinant host cells including transgenic plants and non-human transgenic animals. The proteases are effective in animal feed, in particular fish feed, and detergents. The proteases are capable of degrading the soybean Bowman-Birk inhibitor, and other antinutritional factors such as soybean agglutinin and the Kunitz trypsin inhibitor, as well as the isolated soy storage proteins glycinin and beta-conglycinin. Characteristic structural features of relevance for the thermostability of these proteases of peptidase family S2A or S1E are disclosed.
摘要翻译： 本发明涉及与来源于诺卡氏菌属的蛋白酶同源的热稳定蛋白酶，以及野生型的生产，以及包含转基因植物和非人转基因动物的重组宿主细胞。 蛋白酶在动物饲料，特别是鱼饲料和洗涤剂中是有效的。 蛋白酶能够降解大豆Bowman-Birk抑制剂和其他抗营养因子如大豆凝集素和Kunitz胰蛋白酶抑制剂，以及分离的大豆贮存蛋白大豆球蛋白和β-伴大豆球蛋白。 公开了与肽酶家族S2A或S1E的这些蛋白酶的热稳定性相关的特征性结构特征。
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