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公开(公告)号:US09856327B2
公开(公告)日:2018-01-02
申请号:US15186167
申请日:2016-06-17
Applicant: Xencor, Inc.
Inventor: Matthew J. Bernett , Gregory Moore , John Desjarlais , Seung Chu , Rumana Rashid , Umesh Muchhal , Sung-Hyung Lee
CPC classification number: C07K16/468 , A61K2039/505 , C07K16/2809 , C07K16/2866 , C07K16/2887 , C07K16/2896 , C07K16/30 , C07K16/3061 , C07K16/40 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/515 , C07K2317/52 , C07K2317/522 , C07K2317/526 , C07K2317/528 , C07K2317/55 , C07K2317/565 , C07K2317/60 , C07K2317/622 , C07K2317/64 , C07K2317/70 , C07K2317/73 , C07K2317/92 , C07K2317/94
Abstract: The present invention is directed to novel heterodimeric antibodies.
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公开(公告)号:US20160176969A1
公开(公告)日:2016-06-23
申请号:US14952705
申请日:2015-11-25
Applicant: XENCOR, INC.
Inventor: Matthew J. Bernett , Gregory Moore , John Desjarlais , Seung Chu , Sung-Hyung Lee
CPC classification number: C07K16/2815 , A61K2039/505 , C07K16/22 , C07K16/2803 , C07K16/2809 , C07K16/2887 , C07K16/2896 , C07K16/30 , C07K16/40 , C07K16/468 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/522 , C07K2317/55 , C07K2317/60 , C07K2317/622 , C07K2317/73 , C07K2317/90 , C07K2317/94
Abstract: The invention provides bispecific antibodies that co-engage CD8 (preferably bivalently) and a target tumor antigen.
Abstract translation: 本发明提供了共参与CD8(优选二价))和靶肿瘤抗原的双特异性抗体。
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公开(公告)号:US12129309B2
公开(公告)日:2024-10-29
申请号:US17736475
申请日:2022-05-04
Applicant: Xencor, Inc.
Inventor: Matthew Bernett , Gregory Moore , John Desjarlais , Seung Chu , Rumana Rashid , Umesh Muchhal
CPC classification number: C07K16/40 , C07K16/18 , C07K16/2809 , C07K16/2896 , C07K16/3061 , A61K2039/505 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/64 , C07K2317/73 , C07K2317/92
Abstract: The present invention is directed to heterodimeric antibodies that bind CD3 and CD38.
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公开(公告)号:US11945880B2
公开(公告)日:2024-04-02
申请号:US17542342
申请日:2021-12-03
Applicant: Xencor, Inc.
Inventor: Matthew J. Bernett , Gregory Moore , John Desjarlais , Seung Chu , Rumana Rashid , Umesh Muchhal , Sung-Hyung Lee
CPC classification number: C07K16/468 , C07K16/2809 , C07K16/2866 , C07K16/2887 , C07K16/2896 , C07K16/30 , C07K16/3061 , C07K16/40 , A61K2039/505 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/515 , C07K2317/52 , C07K2317/522 , C07K2317/526 , C07K2317/528 , C07K2317/55 , C07K2317/565 , C07K2317/60 , C07K2317/622 , C07K2317/64 , C07K2317/70 , C07K2317/73 , C07K2317/92 , C07K2317/94
Abstract: The present invention is directed to novel heterodimeric antibodies.
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公开(公告)号:US11840579B2
公开(公告)日:2023-12-12
申请号:US17086213
申请日:2020-10-30
Applicant: Xencor, Inc.
Inventor: Matthew Bernett , Seung Chu , Gregory Moore , John Desjarlais
CPC classification number: C07K16/468 , C07K16/2809 , C07K16/2896 , C07K16/30 , C07K2317/24 , C07K2317/31 , C07K2317/52 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/64 , C07K2317/73 , C07K2317/92 , C07K2317/94
Abstract: The invention provides novel heterodimeric proteins including heterodimeric antibodies.
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公开(公告)号:US20210309762A1
公开(公告)日:2021-10-07
申请号:US17086213
申请日:2020-10-30
Applicant: Xencor, Inc.
Inventor: Matthew Bernett , Seung Chu , Gregory Moore , John Desjarlais
Abstract: The invention provides novel heterodimeric proteins including heterodimeric antibodies.
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公开(公告)号:US20210253736A1
公开(公告)日:2021-08-19
申请号:US17233083
申请日:2021-04-16
Applicant: Xencor, Inc.
Inventor: John Desjarlais , Alex Nisthal , Seung Chu
Abstract: The present invention relates to novel antigen binding domains and heterodimeric antibodies that bind Fibroblast Activation Protein (FAP).
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公开(公告)号:US20210102003A1
公开(公告)日:2021-04-08
申请号:US17124371
申请日:2020-12-16
Applicant: Xencor, Inc.
Inventor: Matthew J. Bernett , Gregory Moore , John Desjarlais , Seung Chu , Rumana Rashid , Umesh Muchhal , Sung-Hyung Lee
Abstract: The present invention is directed to novel heterodimeric antibodies.
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公开(公告)号:US10889653B2
公开(公告)日:2021-01-12
申请号:US14952714
申请日:2015-11-25
Applicant: Xencor, Inc.
Inventor: Matthew J. Bernett , Gregory Moore , John Desjarlais , Seung Chu , Rumana Rashid , Umesh Muchhal , Sung-Hyung Lee
Abstract: The present invention is directed to novel heterodimeric antibodies.
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公开(公告)号:US10544187B2
公开(公告)日:2020-01-28
申请号:US14217166
申请日:2014-03-17
Applicant: Xencor, Inc.
Inventor: Seung Chu , Matthew Bernett , Dilki Wickramarachchi , John Desjarlais
Abstract: The present invention relates to methods and compositions for modulating T cells. The modulation includes suppressing or inducing regulatory T cells or cytotoxic T cells.
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