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    FUSION PACING INTERVAL DETERMINATION
    13.
    发明申请
    FUSION PACING INTERVAL DETERMINATION 有权
    FUSION PACING INTERVAL确定

    公开(公告)号：US20100198291A1

    公开(公告)日：2010-08-05

    申请号：US12363025

    申请日：2009-01-30

    申请人： Aleksandre T. Sambelashvili ,  Thomas J. Mullen ,  Berthold Stegemann

    发明人： Aleksandre T. Sambelashvili ,  Thomas J. Mullen ,  Berthold Stegemann

    IPC分类号： A61N1/365

    CPC分类号： A61N1/3627 ,  A61N1/36514 ,  A61N1/3684 ,  A61N1/3688

    摘要： Delivery of fusion pacing therapy to a later depolarizing ventricle (V2) of a heart of a patient may be timed based on the depolarization of the V2 during at least one prior cardiac cycle. In some examples, a V2 pacing pulse is delivered upon the expiration of a pacing interval that begins at detection of an atrial sense or pace event (AP/S). The pacing interval may be substantially equal to the duration of time between an AP/S and a V2 sensing event of at least one prior cardiac cycle decremented by an adjusted pre-excitation interval (PEI). In another example, the V2 pacing pulse is delivered at the expiration of a pacing interval that begins upon detection of a V2 sensing event of a prior cardiac cycle. The pacing interval may be substantially equal to a duration of time at least two subsequent V2 sensing events decremented by the adjusted PEI.

    摘要翻译： 将融合起搏治疗递送到患者心脏的后期去极化心室（V2）可以基于在至少一个在先的心动周期期间的V2的去极化来计时。 在一些示例中，在起搏间隔期满后，在起搏时间间隔期间，起搏脉搏是在心房感觉或步速事件（AP / S）的检测开始时发送的。 所述起搏间隔可以基本上等于在调整的预激励间隔（PEI）减小的至少一个先前心动周期的AP / S和V2感测事件之间的持续时间。 在另一示例中，V2起搏脉冲在起搏间隔的期满时被递送，起搏间隔开始于检测到先前的心动周期的V2感测事件。 起搏间隔可以基本上等于由调整后的PEI递减的至少两个后续V2感测事件的持续时间。

    PACING THERAPY ADJUSTMENT BASED ON VENTRICULO-ATRIAL DELAY
    17.
    发明申请
    PACING THERAPY ADJUSTMENT BASED ON VENTRICULO-ATRIAL DELAY 有权
    基于静脉血管延迟的PACING治疗调整

    公开(公告)号：US20100198293A1

    公开(公告)日：2010-08-05

    申请号：US12363439

    申请日：2009-01-30

    申请人： Daniel R. Kaiser ,  Nicholas D. Skadsberg ,  Steven R. Hornberger ,  Thomas J. Mullen

    发明人： Daniel R. Kaiser ,  Nicholas D. Skadsberg ,  Steven R. Hornberger ,  Thomas J. Mullen

    IPC分类号： A61N1/365

    CPC分类号： A61N1/368 ,  A61N1/3622 ,  A61N1/3682

    摘要： Techniques for adjusting pacing therapy based on ventriculo-atrial delay are described herein. These techniques may be used to control ventricular filling times during the delivery of pacing therapy. In some examples, a device or system delivers pre-excitation fusion pacing therapy to a ventricular chamber, determines a ventriculo-atrial delay interval for the ventricular chamber for at least one cardiac cycle, and adjusts the pacing therapy delivered by the implantable medical device to compensate for decreased ventricular filling time when the ventriculo-atrial delay interval is less than a threshold. In some examples, the device or system may adjust the pacing therapy by decreasing a pacing rate of the implantable medical device, increasing a pre-excitation interval for pacing of the ventricular chamber, and/or switching from a fusion pacing mode to a biventricular pacing mode.

    摘要翻译： 本文描述了基于心房 - 心房延迟来调节起搏治疗的技术。 这些技术可用于控制起搏治疗期间的心室充盈时间。 在一些示例中，装置或系统将预激发融合起搏治疗递送至心室，确定心室至少一个心动周期的心房 - 心房延迟间隔，并调整由可植入医疗装置递送的起搏疗法 补偿当心室 - 心房延迟间隔小于阈值时心室充盈时间减少。 在一些示例中，装置或系统可以通过降低可植入医疗装置的起搏速率，增加心室的起搏间隔和/或从融合起搏模式切换到双心室起搏来调节起搏治疗 模式。

    System and method for ventricular pacing with AV interval modulation
    18.
    发明授权
    System and method for ventricular pacing with AV interval modulation 有权
    使用AV间期调制的心室起搏的系统和方法

    公开(公告)号：US07738955B2

    公开(公告)日：2010-06-15

    申请号：US11115605

    申请日：2005-04-27

    申请人： Michael O. Sweeney ,  David A. Casavant ,  Robert A. Betzold ,  Paul A. Belk ,  Thomas J. Mullen ,  John C. Stroebel

    发明人： Michael O. Sweeney ,  David A. Casavant ,  Robert A. Betzold ,  Paul A. Belk ,  Thomas J. Mullen ,  John C. Stroebel

    IPC分类号： A61N1/372

    CPC分类号： A61N1/368 ,  A61N1/3682

    摘要： A pacing protocol is provided that reduces or minimizes ventricular pacing in favor of intrinsic conduction. When operating in a mode that provides ventricular pacing, a series of conduction checks are performed to determine if intrinsic conduction has returned. These conduction checks occur according to a predetermined pattern that generally includes longer intervals between subsequent attempts. The AV interval provided for dual chamber based pacing is modulated and generally moves from a larger value to a nominal value as the interval between unsuccessful conduction checks increases.

    摘要翻译： 提供起搏方案，其减少或最小化心室起搏以有利于内在传导。 当以提供心室起搏的模式操作时，执行一系列导通检查以确定是否内部传导已经返回。 这些传导检查根据通常在后续尝试之间具有较长间隔的预定模式进行。 为双室起搏提供的AV间隔被调制，并且通常从较大的值移动到不成功的传导检查之间的间隔增加到标称值。

    Method and apparatus for determining an efficacious atrioventricular delay interval
    19.
    发明授权
    Method and apparatus for determining an efficacious atrioventricular delay interval 有权
    用于确定有效房室延迟间隔的方法和装置

    公开(公告)号：US07715917B2

    公开(公告)日：2010-05-11

    申请号：US11004543

    申请日：2004-12-03

    申请人： Edward Chinchoy ,  Nirav V. Sheth ,  Kathryn E. Hilpisch ,  Thomas J. Mullen ,  John E. Burnes

    发明人： Edward Chinchoy ,  Nirav V. Sheth ,  Kathryn E. Hilpisch ,  Thomas J. Mullen ,  John E. Burnes

    IPC分类号： A61N1/00

    CPC分类号： A61N1/368 ,  A61N1/3627 ,  A61N1/3682 ,  A61N1/3684

    摘要： Determining an optimal atrioventricular interval is of interest for proper delivery of cardiac resynchronization therapy. Although device optimization is gradually and more frequently being performed through a referral process with which the patient undergoes an echocardiographic optimization, the decision of whether to optimize or not is still generally reserved for the implanting physician. Recent abstracts have suggested a formulaic approach for setting A-V interval based on intrinsic electrical sensing, that may possess considerable appeal to clinicians versus a patient average nominal A-V setting of 100 ms. The present invention presents a methods of setting nominal device settings based on entering patient cardiac demographics to determine what A-V setting may be appropriate. The data is based on retrospective analysis of the MIRACLE trial to determine what major factors determined baseline A-V settings.

    摘要翻译： 确定最佳房室间隔对于正确递送心脏再同步治疗是有意义的。 尽管通过与患者经历超声心动图优化的转诊过程逐渐且更频繁地进行装置优化，但仍然通常为植入医生保留是否优化的决定。 最近的摘要提出了一种基于固有电学感测设置A-V间隔的公式化方法，这可能对临床医生具有相当大的吸引力，而患者平均标称A-V设置为100 ms。 本发明提供了一种基于输入患者心脏人口统计学来设定标称装置设置以确定什么A-V设置可能适合的方法。 数据基于MIRACLE试验的回顾性分析，以确定确定基线A-V设置的主要因素。