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公开(公告)号：US07076298B2
公开(公告)日：2006-07-11
申请号：US10171231
申请日：2002-06-14
申请人： Vasant Padmanabhan , Walter H. Olson , Rahul Mehra , Xiaohong Zhou , Thomas J. Mullen , William J. George
发明人： Vasant Padmanabhan , Walter H. Olson , Rahul Mehra , Xiaohong Zhou , Thomas J. Mullen , William J. George
IPC分类号： A61N1/36
CPC分类号： A61N1/3622
摘要： An implantable medical device that includes a microprocessor that characterizes cardiac activity of a patient to enable the implantable medical device to deliver therapy in response to an identified arrhythmia event. A monitor/controller monitors the characterized cardiac activity and the delivered therapy, and controls activation of triggered overdrive pacing subsequent to the delivered therapy.
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公开(公告)号：US20070276453A1
公开(公告)日：2007-11-29
申请号：US11837811
申请日：2007-08-13
申请人： Michael Hill , Gary King , Thomas Mullen , Xiaohong Zhou , Rahul Mehra
发明人： Michael Hill , Gary King , Thomas Mullen , Xiaohong Zhou , Rahul Mehra
IPC分类号： A61N1/36
CPC分类号： A61N1/36114 , A61N1/0504 , A61N1/36017 , A61N1/36021 , A61N1/36071
摘要： A method and apparatus are provided for protecting cardiac tissue from insult. The method comprises identifying the occurrence of an insult, such as a heart attack, and delivering electrical stimulation to one or more predetermined nerves in a patient's body in response to identifying the occurrence of the insult. The stimulation may be provided to peripheral nerves, intrinsic cardiac nerves, sympathetic ganglia, cranial nerves, and may generally be directed to the vertebral column, or within the chest wall of the patient.
摘要翻译： 提供了一种用于保护心脏组织免受侮辱的方法和装置。 所述方法包括识别呃等的发生，例如心脏病发作，并且响应于识别侮辱的发生而向患者身体中的一个或多个预定神经传递电刺激。 刺激可以提供给外周神经，内在的心脏神经，交感神经节，颅神经，并且通常可以被引导到脊柱或患者的胸壁内。
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公开(公告)号：US20120109240A1
公开(公告)日：2012-05-03
申请号：US12915877
申请日：2010-10-29
CPC分类号： A61N1/3706 , A61B5/046 , A61B5/0464 , A61B5/4836 , A61N1/3621
摘要： Methods and/or devices for initiating an automatic adjustment of arrhythmia detection parameters (e.g., upon delivery of cardiac therapy after detection of VT/VF).
摘要翻译： 用于启动心律失常检测参数的自动调整的方法和/或装置（例如，在检测到VT / VF之后递送心脏治疗）。
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4.发明授权公开(公告)号：US06922585B2
公开(公告)日：2005-07-26
申请号：US10117465
申请日：2002-04-05
申请人： Xiaohong Zhou , Vinod Sharma , Walter H. Olson
发明人： Xiaohong Zhou , Vinod Sharma , Walter H. Olson
IPC分类号： A61B5/0452 , A61B5/0402 , A61B5/046 , A61B5/0464 , A61N1/362 , A61N1/37 , A61N1/39
CPC分类号： A61B5/4035 , A61B5/046 , A61B5/0464 , A61N1/3622 , A61N1/3962
摘要： An implantable medical device and method are provided for assessing autonomic tone and risk factors associated with arrhythmias and, based on this assessment, an early recurrence of ventricular tachycardia or ventricular fibrillation is predicted. Specifically, changes in R—R interval, heart rate variability, patient activity, and myocardial ischemia are measured prior to and after a detected an arrhythmia episode. A recurrence score is calculated as a weighted sum of measured parameters and compared to a prediction criterion. The prediction criterion may be a preset threshold score or an individualized episode template based on previously calculated recurrence scores associated with recurring episodes. Stored parameters and episode-related data may be downloaded for offline analyses for optimizing prediction criteria and monitoring patient status.
摘要翻译： 提供了一种用于评估与心律失常相关的自主神经和风险因素的可植入医疗装置和方法，并且基于该评估，预测了室性心动过速或心室颤动的早期复发。 具体地，在检测到心律失常发作之前和之后测量R-R间期，心率变异性，患者活动和心肌缺血的变化。 计算复发得分作为测量参数的加权和并与预测标准进行比较。 预测标准可以是基于先前计算的与重复发作相关联的复发评分的预设阈值评分或个体化发作模板。 可以下载存储的参数和与剧集相关的数据用于离线分析，以优化预测标准和监测患者状态。
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5.发明授权Method for determining a metric of non-sustained arrhythmia occurrence for use in arrhythmia prediction and automatic adjustment of arrhythmia detection parameters 失效确定用于心律失常预测和心律失常检测参数自动调整的非持续性心律失常发生度量的方法公开(公告)号：US07027856B2
公开(公告)日：2006-04-11
申请号：US10261316
申请日：2002-09-30
IPC分类号： A61B5/0452
CPC分类号： A61B5/0452 , A61N1/3956
摘要： An implantable medical device and associated method are provided for detecting non-sustained arrhythmias and determining a metric of non-sustained arrhythmias. The metric may be used for predicting the occurrence of a sustained arrhythmia or for automatically adjusting the parameters used for detecting a sustained arrhythmia.
摘要翻译： 提供可植入医疗装置和相关方法用于检测非持续性心律失常并确定非持续性心律失常的度量。 该度量可以用于预测持续性心律失常的发生或用于自动调整用于检测持续性心律失常的参数。
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公开(公告)号：US07221979B2
公开(公告)日：2007-05-22
申请号：US10426610
申请日：2003-04-30
IPC分类号： A61N1/00
CPC分类号： A61N1/36071 , A61N1/205 , A61N1/36021
摘要： A method and apparatus for delivering corrective therapy through hormone regulation is provided. Inhibition of sympathetic fibers by spinal cord stimulation is used to regulate the levels of hormones such as catecholamines, renin, and calcitonin gene-related peptide. The invention utilizes a closed or open loop feedback system in which physiological parameters such as the concentrations of hormones and sympathetic indicators such as heart rate and urine production are monitored and used to determine the appropriate level of neurostimulation. The site of electrical stimulation includes, but is not limited to, the spinal cord at levels T7–L2 and the associated neural fibers within a region of the T7–L2 dermatomes
摘要翻译： 提供了一种通过激素调节进行矫正治疗的方法和装置。 通过脊髓刺激抑制交感神经纤维用于调节激素水平，如儿茶酚胺，肾素和降钙素基因相关肽。 本发明利用封闭或开环反馈系统，其中监测诸如心率和尿液产生之间的激素和交感神经指标的生理参数，并用于确定适当的神经刺激水平。 电刺激部位包括（但不限于）T7-L2级别的脊髓和T7-L2皮肌的区域内的相关神经纤维
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公开(公告)号：US08417334B2
公开(公告)日：2013-04-09
申请号：US10039307
申请日：2001-10-26
IPC分类号： A61N1/365
CPC分类号： A61N1/36114 , A61N1/3627
摘要： A method and apparatus are used to provide therapy to a patient experiencing ventricular dysfunction or heart failure. At least one electrode is located in a region associated with nervous tissue, such as nerve bundles T1-T4, in a patient's body. Electrical stimulation is applied to the at least one electrode to improve the cardiac efficiency of the patient's heart. One or more predetermined physiologic parameters of the patient are monitored, and the electrical stimulation is adjusted based on the one or more predetermined physiologic parameters.
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8.发明授权Methods and apparatus for sensing cardiac activity via neurological stimulation therapy system or medical electrical lead 有权通过神经系统刺激治疗系统或医用电导体感测心脏活动的方法和装置公开(公告)号：US07672733B2
公开(公告)日：2010-03-02
申请号：US11116970
申请日：2005-04-28
CPC分类号： A61N1/0551 , A61N1/36114 , A61N1/36135
摘要： According to the present invention at least a pair of neurological stimulation electrodes are disposed in, on, about, adjacent and/or within excitable neural tissue of a subject. Cardiac activity of a patient is detected using one or more electrodes adapted for delivery of a neurological stimulation therapy (NST). Following detection of certain types of cardiac activity one or more of the plurality of stimulation electrodes deliver or withhold NST, if desired in synchrony with the cardiac activity or in response to the detected cardiac activity. The NST delivered includes without limitation subcutaneous stimulation, peripheral, TENS and/or vagal nerve stimulation therapy or the like.
摘要翻译： 根据本发明，至少一对神经刺激电极设置在受试者的可兴奋神经组织的内部，之上，大约，相邻和/或之内。 使用适于递送神经刺激疗法（NST）的一个或多个电极检测患者的心脏活动。 在检测到某些类型的心脏活动之后，如果需要，多个刺激电极中的一个或多个刺激电极传递或阻止NST，如果需要与心脏活动同步或响应于检测到的心脏活动。 提供的NST包括但不限于皮下刺激，外周，TENS和/或迷走神经刺激疗法等。
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公开(公告)号：US20080140150A1
公开(公告)日：2008-06-12
申请号：US11751813
申请日：2007-05-22
IPC分类号： A61N1/05
CPC分类号： A61N1/36071 , A61N1/205 , A61N1/36021
摘要： A method and apparatus for delivering corrective therapy through hormone regulation is provided. Inhibition of sympathetic fibers by spinal cord stimulation is used to regulate the levels of hormones such as catecholamines, renin, and calcitonin gene-related peptide. The invention utilizes a closed or open loop feedback system in which physiological parameters such as the concentrations of hormones and sympathetic indicators such as heart rate and urine production are monitored and used to determine the appropriate level of neurostimulation. The site of electrical stimulation includes, but is not limited to, the spinal cord at levels T7-L2 and the associated neural fibers within a region of the T7-L2 dermatomes
摘要翻译： 提供了一种通过激素调节进行矫正治疗的方法和装置。 通过脊髓刺激抑制交感神经纤维用于调节激素水平，如儿茶酚胺，肾素和降钙素基因相关肽。 本发明利用封闭或开环反馈系统，其中监测诸如心率和尿液产生之间的激素和交感神经指标的生理参数，并用于确定适当的神经刺激水平。 电刺激部位包括（但不限于）T7-L2级别的脊髓和T7-L2皮肌的区域内的相关神经纤维
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10.发明授权公开(公告)号：US07218964B2
公开(公告)日：2007-05-15
申请号：US10035319
申请日：2001-10-26
IPC分类号： A61N1/372
CPC分类号： A61N1/36114 , A61N1/3627
摘要： A method and apparatus to provide therapy to a patient for protecting cardiac tissue from insult is disclosed. The method comprises delivering closed loop electrical stimulation to one or more predetermined portions of a portion of excitable tissue of the spinal cord of a patient; and monitoring one or more physiologic indices of the body. That is, a closed-loop feedback controller is used to apply electrical stimulation to preselected regions of the spinal cord of a patient's body based upon one or more aspects of the physiologic indices.
摘要翻译： 公开了一种向患者提供治疗以保护心脏组织免受侮辱的方法和装置。 该方法包括将闭环电刺激递送到患者脊髓的可激发组织的一部分的一个或多个预定部分; 并监测身体的一个或多个生理指标。 也就是说，使用闭环反馈控制器基于生理指标的一个或多个方面对患者身体的脊髓的预选区域施加电刺激。
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